{"id":"https://openalex.org/W2116844293","doi":"https://doi.org/10.1186/1471-2407-11-203","title":"P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation","display_name":"P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation","publication_year":2011,"publication_date":"2011-05-27","ids":{"openalex":"https://openalex.org/W2116844293","doi":"https://doi.org/10.1186/1471-2407-11-203","mag":"2116844293","pmid":"https://pubmed.ncbi.nlm.nih.gov/21615965","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3120805"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-11-203","doi":"https://doi.org/10.1186/1471-2407-11-203","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-11-203","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-203","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-203","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077159167","display_name":"Kelly A. Avery\u2010Kiejda","orcid":"https://orcid.org/0000-0003-2285-9118","observed_orcids":["https://orcid.org/0000-0003-2285-9118"]},"institutions":[{"id":"https://openalex.org/I4210146798","display_name":"Calvary Mater Newcastle Hospital","ror":"https://ror.org/04kbz1397","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210146798"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kelly A Avery-Kiejda","raw_affiliation_strings":["Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia","Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia","institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070596901","display_name":"Nikola A. Bowden","orcid":"https://orcid.org/0000-0002-6047-1694","observed_orcids":["https://orcid.org/0000-0002-6047-1694"]},"institutions":[{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nikola A Bowden","raw_affiliation_strings":["Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034549592","display_name":"Amanda J. Croft","orcid":"https://orcid.org/0009-0001-9285-2408","observed_orcids":["https://orcid.org/0009-0001-9285-2408"]},"institutions":[{"id":"https://openalex.org/I4210146798","display_name":"Calvary Mater Newcastle Hospital","ror":"https://ror.org/04kbz1397","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210146798"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amanda J Croft","raw_affiliation_strings":["Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia","Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia","institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060084944","display_name":"Lyndee L. Scurr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]},{"id":"https://openalex.org/I4210137518","display_name":"Westmead Institute","ror":"https://ror.org/03wtqwa04","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210137518"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lyndee L Scurr","raw_affiliation_strings":["Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia","Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705","https://openalex.org/I4210137518"]},{"raw_affiliation_string":"Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000223381","display_name":"Carla F. Kairupan","orcid":"https://orcid.org/0000-0002-6835-3908","observed_orcids":["https://orcid.org/0000-0002-6835-3908"]},"institutions":[{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carla F Kairupan","raw_affiliation_strings":["Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027361412","display_name":"Katie A. Ashton","orcid":"https://orcid.org/0009-0006-2193-4138","observed_orcids":["https://orcid.org/0009-0006-2193-4138"]},"institutions":[{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Katie A Ashton","raw_affiliation_strings":["Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056125067","display_name":"Bente A. Talseth\u2010Palmer","orcid":"https://orcid.org/0000-0003-0286-7161","observed_orcids":["https://orcid.org/0000-0003-0286-7161"]},"institutions":[{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bente A Talseth-Palmer","raw_affiliation_strings":["Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069277796","display_name":"Helen Rizos","orcid":"https://orcid.org/0000-0002-2094-9198","observed_orcids":["https://orcid.org/0000-0002-2094-9198"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]},{"id":"https://openalex.org/I4210137518","display_name":"Westmead Institute","ror":"https://ror.org/03wtqwa04","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210137518"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Helen Rizos","raw_affiliation_strings":["Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia","Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705","https://openalex.org/I4210137518"]},{"raw_affiliation_string":"Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072813429","display_name":"Xu Dong Zhang","orcid":"https://orcid.org/0000-0001-9457-8003","observed_orcids":["https://orcid.org/0000-0001-9457-8003"]},"institutions":[{"id":"https://openalex.org/I4210146798","display_name":"Calvary Mater Newcastle Hospital","ror":"https://ror.org/04kbz1397","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210146798"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xu D Zhang","raw_affiliation_strings":["Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia","Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia","institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016817677","display_name":"Rodney J. Scott","orcid":"https://orcid.org/0000-0001-7724-3404","observed_orcids":["https://orcid.org/0000-0001-7724-3404"]},"institutions":[{"id":"https://openalex.org/I4210087646","display_name":"Hunter Medical Research Institute","ror":"https://ror.org/0020x6414","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210087646"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rodney J Scott","raw_affiliation_strings":["Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle at the Hunter Medical Research Institute, Newcastle, Australia","institution_ids":["https://openalex.org/I4210087646","https://openalex.org/I78757542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055038393","display_name":"Peter Hersey","orcid":"https://orcid.org/0000-0002-3064-737X","observed_orcids":["https://orcid.org/0000-0002-3064-737X"]},"institutions":[{"id":"https://openalex.org/I4210146798","display_name":"Calvary Mater Newcastle Hospital","ror":"https://ror.org/04kbz1397","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210146798"]},{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Peter Hersey","raw_affiliation_strings":["Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia","Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia","institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"]},{"raw_affiliation_string":"Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia","institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5055038393"],"corresponding_institution_ids":["https://openalex.org/I4210146798","https://openalex.org/I78757542"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":5.5137,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.96824756,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"203","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8939999938011169},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/p53-target-genes","display_name":"p53 target genes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.527999997138977},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/melanoma-cell-lines","display_name":"melanoma cell lines","score":0.7009999752044678},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.953000009059906},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8397910594940186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6841296553611755},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6534226536750793},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6036263108253479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.553854763507843},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5001919269561768},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48015254735946655},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.47569000720977783},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.47095781564712524},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4432958662509918},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.4359402060508728},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4277704358100891},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39420098066329956},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.35444071888923645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24677154421806335},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.163201242685318}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2407-11-203","doi":"https://doi.org/10.1186/1471-2407-11-203","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-11-203","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-203","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmid:21615965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21615965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3120805","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3120805/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.290.4162","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.290.4162","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/db/3d/BMC_Cancer_2011_May_27_11_203.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:66eec717184740768d9f7c6d15207fb1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/66eec717184740768d9f7c6d15207fb1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 11, Iss 1, p 203 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/28958423","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/P53_in_human_melanoma_fails_to_regulate_target_genes_associated_with_apoptosis_and_the_cell_cycle_and_may_contribute_to_proliferation/28958423","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:uon:13895","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.13/1041356","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-11-203","doi":"https://doi.org/10.1186/1471-2407-11-203","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-11-203","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-11-203","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"},{"id":"https://openalex.org/F4320320501","display_name":"Cancer Australia","ror":"https://ror.org/00510tw04"},{"id":"https://openalex.org/F4320320543","display_name":"Cancer Institute NSW","ror":"https://ror.org/029a54f25"},{"id":"https://openalex.org/F4320320549","display_name":"Cure Cancer Australia Foundation","ror":"https://ror.org/03yqfnv74"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116844293.pdf","grobid_xml":"https://content.openalex.org/works/W2116844293.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W704268","https://openalex.org/W1493803609","https://openalex.org/W1524571013","https://openalex.org/W1574083581","https://openalex.org/W1593769975","https://openalex.org/W1755076441","https://openalex.org/W1966298207","https://openalex.org/W1970322693","https://openalex.org/W1976873804","https://openalex.org/W1978335031","https://openalex.org/W1982097971","https://openalex.org/W1983914017","https://openalex.org/W1986541287","https://openalex.org/W1992177486","https://openalex.org/W1994015824","https://openalex.org/W1997919830","https://openalex.org/W2008887283","https://openalex.org/W2009489886","https://openalex.org/W2010077871","https://openalex.org/W2014385820","https://openalex.org/W2017673293","https://openalex.org/W2023961264","https://openalex.org/W2024604828","https://openalex.org/W2026007913","https://openalex.org/W2034059961","https://openalex.org/W2038783205","https://openalex.org/W2042041600","https://openalex.org/W2044806647","https://openalex.org/W2048797704","https://openalex.org/W2049137769","https://openalex.org/W2053833990","https://openalex.org/W2054264611","https://openalex.org/W2063669247","https://openalex.org/W2064100919","https://openalex.org/W2065955521","https://openalex.org/W2070032322","https://openalex.org/W2071104644","https://openalex.org/W2073168217","https://openalex.org/W2088172536","https://openalex.org/W2107014487","https://openalex.org/W2107277218","https://openalex.org/W2109391503","https://openalex.org/W2129335039","https://openalex.org/W2132195808","https://openalex.org/W2136381907","https://openalex.org/W2139878826","https://openalex.org/W2146226600","https://openalex.org/W2152315800","https://openalex.org/W2154853638","https://openalex.org/W2155852899","https://openalex.org/W2156749394","https://openalex.org/W2159633569","https://openalex.org/W2165361723","https://openalex.org/W2165516755","https://openalex.org/W2171407623","https://openalex.org/W2322670200","https://openalex.org/W4210963749","https://openalex.org/W4244151305"],"related_works":["https://openalex.org/W7097462918","https://openalex.org/W1968300343","https://openalex.org/W7111903635","https://openalex.org/W2055467066","https://openalex.org/W7100558761","https://openalex.org/W7095515954","https://openalex.org/W3000616967","https://openalex.org/W2970774940","https://openalex.org/W2054940630","https://openalex.org/W2159633569"],"abstract_inverted_index":{"BACKGROUND:":[0],"Metastatic":[1],"melanoma":[2,45,77,81,124,127,140,172,196,244,262,274,299],"represents":[3],"a":[4,32,86,201],"major":[5],"clinical":[6],"problem.":[7],"Its":[8],"incidence":[9],"continues":[10],"to":[11,64,84,162,176,232,310],"rise":[12],"in":[13,44,73,101,119,123,133,139,147,171,195,217,236,243,250,254,266,273,277,289,298],"western":[14],"countries":[15],"and":[16,79,108,126,264,291,300],"there":[17,199],"are":[18,295],"currently":[19],"no":[20],"curative":[21],"treatments.":[22],"While":[23],"mutation":[24],"of":[25,35,38,42,69,89,95,151,181,204,220,230,248,261,271,306,313],"the":[26,66,134,148,228,237,311],"P53":[27,43,70,91,115,152,160,177,182,191,205,215,231,249,272,285,307],"tumour":[28],"suppressor":[29],"gene":[30,193,223,255],"is":[31,46],"common":[33],"feature":[34],"many":[36],"types":[37],"cancer,":[39],"mutational":[40],"inactivation":[41],"uncommon;":[47],"however,":[48],"its":[49],"function":[50],"often":[51],"appears":[52],"abnormal.":[53],"METHODS:":[54],"In":[55],"this":[56,302],"study":[57],"whole":[58,221],"genome":[59,222],"bead":[60],"arrays":[61],"were":[62,121,137,200,259],"used":[63],"examine":[65],"transcript":[67,149],"expression":[68,94,150,170,194,210,224,256],"target":[71,116,153,192,206,286],"genes":[72,97,154,207,234,287],"extracts":[74,102],"from":[75,104],"82":[76],"metastases":[78,125],"6":[80],"cell":[82,128,135,141,156,238,292],"lines,":[83,129],"provide":[85],"global":[87],"assessment":[88],"aberrant":[90,303],"function.":[92],"The":[93,111],"these":[96],"was":[98,144,173,211,240],"also":[99],"examined":[100],"derived":[103],"diploid":[105],"human":[106],"melanocytes":[107,251],"fibroblasts.":[109],"RESULTS:":[110],"results":[112,282],"indicated":[113,226],"that":[114,168,227,258,284,301],"transcripts":[117],"involved":[118,132,235,288],"apoptosis":[120,290],"under-expressed":[122],"while":[130],"those":[131,163],"cycle":[136,239,293],"over-expressed":[138],"lines.":[142],"There":[143],"little":[145],"difference":[146],"between":[155],"lines":[157],"with":[158,164],"null/mutant":[159],"compared":[161],"wild-type":[165],"P53,":[166],"suggesting":[167],"altered":[169,213],"not":[174],"related":[175],"status.":[178],"Similarly,":[179],"down-regulation":[180],"by":[183,214],"short-hairpin":[184],"RNA":[185],"(shRNA)":[186],"had":[187],"limited":[188],"effect":[189],"on":[190],"cells,":[197],"whereas":[198],"large":[202],"number":[203],"whose":[208],"mRNA":[209],"significantly":[212,241],"inhibition":[216,247],"melanocytes.":[218],"Analysis":[219],"profiles":[225,257],"ability":[229],"regulate":[233],"reduced":[242],"cells.":[245],"Moreover,":[246],"induced":[252],"changes":[253],"characteristic":[260],"cells":[263,275],"resulted":[265,276],"increased":[267],"proliferation.":[268,279],"Conversely,":[269],"knockdown":[270],"decreased":[278],"CONCLUSIONS:":[280],"These":[281],"indicate":[283],"regulation":[294],"aberrantly":[296],"expressed":[297],"functional":[304],"activity":[305],"may":[308],"contribute":[309],"proliferation":[312],"melanoma.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}