{"id":"https://openalex.org/W2116835533","doi":"https://doi.org/10.1021/bi0614131","title":"Gene Selection, Alternative Splicing, and Post-translational Processing Regulate Neuroligin Selectivity for \u03b2-Neurexins","display_name":"Gene Selection, Alternative Splicing, and Post-translational Processing Regulate Neuroligin Selectivity for \u03b2-Neurexins","publication_year":2006,"publication_date":"2006-10-01","ids":{"openalex":"https://openalex.org/W2116835533","doi":"https://doi.org/10.1021/bi0614131","mag":"2116835533","pmid":"https://pubmed.ncbi.nlm.nih.gov/17042500"},"language":"en","primary_location":{"id":"doi:10.1021/bi0614131","doi":"https://doi.org/10.1021/bi0614131","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0614131","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035691434","display_name":"Davide Comoletti","orcid":"https://orcid.org/0000-0003-2081-6376","observed_orcids":["https://orcid.org/0000-0003-2081-6376"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davide Comoletti","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102243181","display_name":"Robyn E. Flynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robyn E. Flynn","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041387318","display_name":"Antony A. Boucard","orcid":"https://orcid.org/0000-0002-5538-0464","observed_orcids":["https://orcid.org/0000-0002-5538-0464"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antony A. Boucard","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054673621","display_name":"Borries Demeler","orcid":"https://orcid.org/0000-0002-2414-9518","observed_orcids":["https://orcid.org/0000-0002-2414-9518"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Borries Demeler","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052840536","display_name":"Virgil R. Schirf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virgil Schirf","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108247671","display_name":"Jianxin Shi","orcid":"https://orcid.org/0009-0006-2013-6345","observed_orcids":["https://orcid.org/0009-0006-2013-6345"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianxin Shi","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006322283","display_name":"Lori L. Jennings","orcid":"https://orcid.org/0000-0001-5130-8417","observed_orcids":["https://orcid.org/0000-0001-5130-8417"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori L. Jennings","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013670338","display_name":"Helen R. Newlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen R. Newlin","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111931611","display_name":"Thomas Christian S\u00fcdhof","orcid":"https://orcid.org/0000-0003-3361-9275","observed_orcids":["https://orcid.org/0000-0003-3361-9275"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas C. S\u00fcdhof","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004460355","display_name":"Palmer Taylor","orcid":"https://orcid.org/0000-0002-3081-131X","observed_orcids":["https://orcid.org/0000-0002-3081-131X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Palmer Taylor","raw_affiliation_strings":["Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of CaliforniaSan Diego, La Jolla, California 92093-0636, Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, and Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004460355"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I165951966","https://openalex.org/I36258959","https://openalex.org/I867280407"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.6002,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.93890274,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"45","issue":"42","first_page":"12816","last_page":"12827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.050599999725818634,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroligins","display_name":"neuroligins","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neuroligin-1","display_name":"neuroligin-1","score":0.6759999990463257},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9589999914169312},{"id":"https://openalex.org/keywords/protein-protein-binding-affinity","display_name":"protein-protein binding affinity","score":0.6399999856948853},{"id":"https://openalex.org/keywords/postsynaptic-proteins","display_name":"postsynaptic proteins","score":0.6449999809265137},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gene-selection","display_name":"gene selection","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2779790309","wikidata":"https://www.wikidata.org/wiki/Q4316446","display_name":"Neuroligin","level":4,"score":0.9222127199172974},{"id":"https://openalex.org/C2778162979","wikidata":"https://www.wikidata.org/wiki/Q4316431","display_name":"Neurexin","level":4,"score":0.9141318798065186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6053188443183899},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5707701444625854},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.44569703936576843},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4048479497432709},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3832230865955353},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.37313318252563477},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.22644299268722534},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12940895557403564}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi0614131","doi":"https://doi.org/10.1021/bi0614131","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0614131","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:17042500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17042500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.521.7947","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.521.7947","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.liralab.it/IIT_school/files/paper_Camoletti2.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2862748896","display_name":null,"funder_award_id":"R37-MH52804-08","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3109222642","display_name":"DETECTION AND MODELS OF TOXICANT EXPOSURE","funder_award_id":"P42ES010337","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6365291411","display_name":"Function of Neurexins","funder_award_id":"R37MH052804","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G937414207","display_name":"KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION","funder_award_id":"R37GM018360","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1513458886","https://openalex.org/W1851321823","https://openalex.org/W1966969649","https://openalex.org/W1969244755","https://openalex.org/W1973570145","https://openalex.org/W1979774735","https://openalex.org/W1986493103","https://openalex.org/W1990122129","https://openalex.org/W1993415479","https://openalex.org/W1994542213","https://openalex.org/W1995958002","https://openalex.org/W1996092810","https://openalex.org/W1998937775","https://openalex.org/W2004747469","https://openalex.org/W2012425632","https://openalex.org/W2015262258","https://openalex.org/W2023179463","https://openalex.org/W2030346297","https://openalex.org/W2036879415","https://openalex.org/W2038872732","https://openalex.org/W2043002682","https://openalex.org/W2046165746","https://openalex.org/W2046958135","https://openalex.org/W2051434331","https://openalex.org/W2053810673","https://openalex.org/W2054235364","https://openalex.org/W2055400338","https://openalex.org/W2055474304","https://openalex.org/W2064352628","https://openalex.org/W2065857393","https://openalex.org/W2069294211","https://openalex.org/W2072086952","https://openalex.org/W2075542768","https://openalex.org/W2085958374","https://openalex.org/W2100414555","https://openalex.org/W2101407138","https://openalex.org/W2108339073","https://openalex.org/W2109936378","https://openalex.org/W2125147395","https://openalex.org/W2130227585","https://openalex.org/W2130421403","https://openalex.org/W2134295716","https://openalex.org/W2137207996","https://openalex.org/W2143076554","https://openalex.org/W2146039550"],"related_works":["https://openalex.org/W7095304910","https://openalex.org/W1968912036","https://openalex.org/W2064352628","https://openalex.org/W2047505167","https://openalex.org/W2124032631","https://openalex.org/W1990122129","https://openalex.org/W1993415479","https://openalex.org/W2055474304","https://openalex.org/W1992257474","https://openalex.org/W2054235364"],"abstract_inverted_index":{"Neuroligins":[0],"1-4":[1],"are":[2],"postsynaptic":[3],"transmembrane":[4],"proteins":[5],"capable":[6],"of":[7,36,46,54,58,70,80,98,106,121,164],"initiating":[8],"presynaptic":[9],"maturation":[10],"via":[11],"interactions":[12],"with":[13,77,160],"beta-neurexin.":[14],"Both":[15],"neuroligins":[16,38,72,94,174],"and":[17,60,90,147],"beta-neurexins":[18,48],"have":[19],"alternatively":[20],"spliced":[21],"inserts":[22],"in":[23,112,128],"their":[24,81],"extracellular":[25,34,44],"domains.":[26],"Using":[27],"analytical":[28],"ultracentrifugation,":[29],"we":[30],"determined":[31],"that":[32,142,169],"the":[33,37,43,47,78,122,132,136,173],"domains":[35,45],"sediment":[39],"as":[40,118],"dimers,":[41],"whereas":[42],"appear":[49],"monomeric.":[50],"Sedimentation":[51],"velocity":[52],"experiments":[53],"titrated":[55],"stoichiometry":[56],"ratios":[57],"beta-neurexin":[59,113],"neuroligin":[61,157],"suggested":[62],"a":[63,96,119,155,161],"2:2":[64],"complex":[65],"formation.":[66],"The":[67],"recognition":[68,158],"properties":[69],"individual":[71],"toward":[73],"beta-neurexin-1":[74],"(NX1beta),":[75],"along":[76],"influence":[79],"splice":[82,109,125],"inserts,":[83],"were":[84],"explored":[85],"by":[86],"surface":[87],"plasmon":[88],"resonance":[89],"affinity":[91],"chromatography.":[92],"Different":[93],"display":[95],"range":[97],"NX1beta":[99],"affinities":[100,165],"spanning":[101],"more":[102],"than":[103],"2":[104],"orders":[105],"magnitude.":[107],"Whereas":[108],"insert":[110,126],"4":[111],"appears":[114],"to":[115,151,154],"act":[116],"only":[117],"modulator":[120],"neuroligin/beta-neurexin":[123],"association,":[124],"B":[127],"neuroligin-1":[129],"(NL1)":[130],"is":[131,170],"key":[133],"element":[134],"regulating":[135],"NL1/NX1beta":[137],"binding.":[138],"Our":[139],"data":[140],"indicate":[141],"gene":[143],"selection,":[144],"mRNA":[145],"splicing,":[146],"post-translational":[148],"modifications":[149],"combine":[150],"give":[152],"rise":[153],"controlled":[156],"code":[159],"rank":[162],"ordering":[163],"for":[166,172],"particular":[167],"neurexins":[168],"conserved":[171],"across":[175],"mammalian":[176],"species.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}