{"id":"https://openalex.org/W2116726257","doi":"https://doi.org/10.1038/bjc.1995.433","title":"DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?","display_name":"DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2116726257","doi":"https://doi.org/10.1038/bjc.1995.433","mag":"2116726257","pmid":"https://pubmed.ncbi.nlm.nih.gov/7547240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2034035"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.1995.433","doi":"https://doi.org/10.1038/bjc.1995.433","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1995.433","pdf_url":"https://www.nature.com/articles/bjc1995433.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/bjc1995433.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072692879","display_name":"Evelien Smitskamp-Wilms","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Smitskamp-Wilms","raw_affiliation_strings":["Department of Oncology, Free University Hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022063365","display_name":"Giuseppe Giaccone","orcid":"https://orcid.org/0000-0002-7392-1965","observed_orcids":["https://orcid.org/0000-0002-7392-1965","https://orcid.org/0000-0002-5023-7562"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"G Giaccone","raw_affiliation_strings":["Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105878379","display_name":"Herbert M. Pinedo","orcid":"https://orcid.org/0000-0002-8980-371X","observed_orcids":["https://orcid.org/0000-0002-8980-371X"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"HM Pinedo","raw_affiliation_strings":["Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"BFAM van der Laan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BFAM van der Laan","raw_affiliation_strings":["Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","Damage and Repair in Cancer Development and Cancer Treatment (DARE)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Damage and Repair in Cancer Development and Cancer Treatment (DARE)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035296183","display_name":"Godefridus J. Peters","orcid":"https://orcid.org/0000-0002-5447-2877","observed_orcids":["https://orcid.org/0000-0002-5447-2877"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"GJ Peters","raw_affiliation_strings":["Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":6.0199,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.95749302,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"72","issue":"4","first_page":"917","last_page":"921"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dt-diaphorase","display_name":"DT-diaphorase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/eo9","display_name":"EO9","score":0.6570000052452087},{"id":"https://openalex.org/keywords/bioreductive-activation","display_name":"bioreductive activation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nadph-cytochrome-p450-reductase","display_name":"NADPH-cytochrome P450 reductase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cytochrome-b5-reductase","display_name":"cytochrome b5 reductase","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7760000228881836},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-tissue","display_name":"tumor tissue","score":0.453000009059906},{"id":"https://openalex.org/keywords/normal-tissue","display_name":"normal tissue","score":0.531000018119812},{"id":"https://openalex.org/keywords/hypoxic-tumors","display_name":"hypoxic tumors","score":0.6159999966621399},{"id":"https://openalex.org/keywords/drug-sensitivity-biomarkers","display_name":"drug sensitivity biomarkers","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.629406750202179},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5462909936904907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4451613426208496},{"id":"https://openalex.org/C2779384962","wikidata":"https://www.wikidata.org/wiki/Q5201346","display_name":"Cytochrome b5","level":4,"score":0.4419528841972351},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.4133303165435791},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3889486789703369},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3330954909324646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.310464471578598}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001388","descriptor_name":"Aziridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045563","descriptor_name":"Indolequinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/bjc.1995.433","doi":"https://doi.org/10.1038/bjc.1995.433","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1995.433","pdf_url":"https://www.nature.com/articles/bjc1995433.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2034035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2034035","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:7547240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7547240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/ab783b4a-964f-491b-b605-53be6cac570a","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/ab783b4a-964f-491b-b605-53be6cac570a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SMITSKAMPWILMS, E, GIACCONE, G, PINEDO, HM, VAN DER LAAN, B F A M & PETERS, GJ 1995, 'DT-DIAPHORASE ACTIVITY IN NORMAL AND NEOPLASTIC HUMAN TISSUES - AN INDICATOR FOR SENSITIVITY TO BIOREDUCTIVE AGENTS', British Jounal of Cancer, vol. 72, no. 4, pp. 917-921.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/ab783b4a-964f-491b-b605-53be6cac570a","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/ab783b4a-964f-491b-b605-53be6cac570a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Jounal of Cancer, 72(4), 917 - 921. Nature Publishing Group","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/bjc.1995.433","doi":"https://doi.org/10.1038/bjc.1995.433","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1995.433","pdf_url":"https://www.nature.com/articles/bjc1995433.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116726257.pdf","grobid_xml":"https://content.openalex.org/works/W2116726257.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W207953313","https://openalex.org/W589975069","https://openalex.org/W1542506717","https://openalex.org/W1819220629","https://openalex.org/W1878680865","https://openalex.org/W1963953060","https://openalex.org/W1966586194","https://openalex.org/W1967544359","https://openalex.org/W1979578283","https://openalex.org/W2002314190","https://openalex.org/W2007306449","https://openalex.org/W2008258984","https://openalex.org/W2012848712","https://openalex.org/W2016498120","https://openalex.org/W2020178430","https://openalex.org/W2025039508","https://openalex.org/W2027794884","https://openalex.org/W2031138237","https://openalex.org/W2033389135","https://openalex.org/W2043316231","https://openalex.org/W2043702533","https://openalex.org/W2047221518","https://openalex.org/W2047788442","https://openalex.org/W2051479405","https://openalex.org/W2051620476","https://openalex.org/W2056500964","https://openalex.org/W2062444423","https://openalex.org/W2082628228","https://openalex.org/W2091781196","https://openalex.org/W2105934527","https://openalex.org/W2113138482","https://openalex.org/W2115063003","https://openalex.org/W2128635872","https://openalex.org/W2150531682","https://openalex.org/W2150843159","https://openalex.org/W2200673464","https://openalex.org/W2315622565","https://openalex.org/W2417498213"],"related_works":["https://openalex.org/W2056232588","https://openalex.org/W7100011680","https://openalex.org/W1976725946","https://openalex.org/W7029311574","https://openalex.org/W2033389135","https://openalex.org/W7018710076","https://openalex.org/W2082628228","https://openalex.org/W2091781196","https://openalex.org/W2027794884","https://openalex.org/W2007306449"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
