{"id":"https://openalex.org/W2116723965","doi":"https://doi.org/10.1172/jci74604","title":"Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression","display_name":"Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression","publication_year":2014,"publication_date":"2014-05-15","ids":{"openalex":"https://openalex.org/W2116723965","doi":"https://doi.org/10.1172/jci74604","mag":"2116723965","pmid":"https://pubmed.ncbi.nlm.nih.gov/24837436","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4089467"},"language":"en","primary_location":{"id":"doi:10.1172/jci74604","doi":"https://doi.org/10.1172/jci74604","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci74604","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4089467","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yujin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yujin Zhang","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021861465","display_name":"Vladim\u00edr Berka","orcid":"https://orcid.org/0000-0003-1047-9863","observed_orcids":["https://orcid.org/0000-0003-1047-9863"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Berka","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091532437","display_name":"Anren Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anren Song","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085695622","display_name":"Kaiqi Sun","orcid":"https://orcid.org/0000-0002-9406-6742","observed_orcids":["https://orcid.org/0000-0002-9406-6742"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaiqi Sun","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Central South University","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110687815","display_name":"Weiru Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Weiru Zhang","raw_affiliation_strings":["Central South University","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101620878","display_name":"Ning Chen","orcid":"https://orcid.org/0000-0003-3360-1921","observed_orcids":["https://orcid.org/0000-0003-3360-1921"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Chen Ning","raw_affiliation_strings":["Central South University","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069893180","display_name":"Chonghua Li","orcid":"https://orcid.org/0000-0003-2741-6666","observed_orcids":["https://orcid.org/0000-0003-2741-6666"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chonghua Li","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101984361","display_name":"Qibo Zhang","orcid":"https://orcid.org/0000-0002-1497-7707","observed_orcids":["https://orcid.org/0000-0002-1497-7707"]},"institutions":[{"id":"https://openalex.org/I4210123764","display_name":"Metabolon (United States)","ror":"https://ror.org/033qhvk72","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qibo Zhang","raw_affiliation_strings":["Metabolon Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolon Inc","institution_ids":["https://openalex.org/I4210123764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035453308","display_name":"Mikhail V. Bogdanov","orcid":"https://orcid.org/0000-0002-7176-8127","observed_orcids":["https://orcid.org/0000-0002-7176-8127"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikhail Bogdanov","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103343256","display_name":"Danny C. Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123764","display_name":"Metabolon (United States)","ror":"https://ror.org/033qhvk72","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danny C. Alexander","raw_affiliation_strings":["Metabolon Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolon Inc","institution_ids":["https://openalex.org/I4210123764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108090844","display_name":"Michael V. Milburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123764","display_name":"Metabolon (United States)","ror":"https://ror.org/033qhvk72","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael V. Milburn","raw_affiliation_strings":["Metabolon Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolon Inc","institution_ids":["https://openalex.org/I4210123764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058370128","display_name":"Mostafa H. Ahmed","orcid":"https://orcid.org/0000-0002-6864-9549","observed_orcids":["https://orcid.org/0000-0002-6864-9549"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mostafa H. Ahmed","raw_affiliation_strings":["Virginia Commonwealth University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Han Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han Lin","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091710616","display_name":"Modupe Idowu","orcid":"https://orcid.org/0000-0001-8561-173X","observed_orcids":["https://orcid.org/0000-0001-8561-173X"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Modupe Idowu","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433054","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0001-6990-5324","observed_orcids":["https://orcid.org/0000-0001-6990-5324","https://orcid.org/0009-0004-3645-4482"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066832003","display_name":"Gregory James Kato","orcid":"https://orcid.org/0000-0003-4465-3217","observed_orcids":["https://orcid.org/0000-0003-4465-3217"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory J. Kato","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062721001","display_name":"Osheiza Y. Abdulmalik","orcid":"https://orcid.org/0000-0003-2497-4291","observed_orcids":["https://orcid.org/0000-0003-2497-4291"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Osheiza Y. Abdulmalik","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611740","display_name":"Wenzheng Zhang","orcid":"https://orcid.org/0000-0002-8771-0747","observed_orcids":["https://orcid.org/0000-0002-8771-0747"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenzheng Zhang","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005928599","display_name":"William Dowhan","orcid":"https://orcid.org/0000-0002-7252-3607","observed_orcids":["https://orcid.org/0000-0002-7252-3607"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Dowhan","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008276506","display_name":"Rodney Eugene Kellems","orcid":"https://orcid.org/0000-0001-8418-8116","observed_orcids":["https://orcid.org/0000-0001-8418-8116"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodney E. Kellems","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049362062","display_name":"Pumin Zhang","orcid":"https://orcid.org/0000-0003-4063-3008","observed_orcids":["https://orcid.org/0000-0003-4063-3008"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pumin Zhang","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013188041","display_name":"Jianping Jin","orcid":"https://orcid.org/0000-0003-2722-0591","observed_orcids":["https://orcid.org/0000-0003-2722-0591"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianping Jin","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028033960","display_name":"Martin K. Safo","orcid":"https://orcid.org/0000-0002-9536-1743","observed_orcids":["https://orcid.org/0000-0002-9536-1743"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Safo","raw_affiliation_strings":["Virginia Commonwealth University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037123591","display_name":"Ah\u2010Lim Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ah-Lim Tsai","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110215361","display_name":"Harinder S. Juneja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harinder S. Juneja","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009800945","display_name":"Yang Xia","orcid":"https://orcid.org/0000-0002-8059-6179","observed_orcids":["https://orcid.org/0000-0002-8059-6179"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Yang Xia","raw_affiliation_strings":["Central South University","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009800945"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I919571938"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":13.4206,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.99438812,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"124","issue":"6","first_page":"2750","last_page":"2761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sickling","display_name":"sickling","score":0.8849999904632568},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/sphingosine-kinase-1","display_name":"sphingosine kinase 1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bioactive-lipids","display_name":"bioactive lipids","score":0.7929999828338623},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8090000152587891},{"id":"https://openalex.org/keywords/s1p-receptors","display_name":"S1P receptors","score":0.621999979019165},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.8240662813186646},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.801413893699646},{"id":"https://openalex.org/C2777550365","wikidata":"https://www.wikidata.org/wiki/Q14913834","display_name":"Sphingosine kinase 1","level":5,"score":0.7254028916358948},{"id":"https://openalex.org/C2776549689","wikidata":"https://www.wikidata.org/wiki/Q24782485","display_name":"Sphingosine-1-phosphate receptor","level":5,"score":0.5997859835624695},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.552472710609436},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.5317189693450928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5249072313308716},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49918293952941895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4674312472343445},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.4667055606842041},{"id":"https://openalex.org/C2777700496","wikidata":"https://www.wikidata.org/wiki/Q7576797","display_name":"Sphingosine kinase","level":5,"score":0.44893088936805725},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.41393378376960754},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35143887996673584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3462187349796295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31162771582603455},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26030975580215454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15497153997421265}],"mesh":[{"descriptor_ui":"D000099157","descriptor_name":"Sphingosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci74604","doi":"https://doi.org/10.1172/jci74604","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci74604","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3061110","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4089467","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24837436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24837436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4089467","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4089467/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3061110","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4089467","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1604323074","display_name":"Metabolites, Sickle Cell Disease, and Novel Therapeutics","funder_award_id":"R01HL113574","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1622721015","display_name":"Adenosine Signaling and Priapsim","funder_award_id":"R21DK077748","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1640661069","display_name":null,"funder_award_id":"HL119549","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1836482936","display_name":null,"funder_award_id":"12IRG9150001","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G2359426833","display_name":"Structure and Function of Stability-Enhanced Beta-Globin mRNAs","funder_award_id":"K01HL103186","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3204253110","display_name":null,"funder_award_id":"2009637520","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G3577803838","display_name":null,"funder_award_id":"HL119549","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4746167039","display_name":null,"funder_award_id":"Project 3","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5638354291","display_name":null,"funder_award_id":"Project 3","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5954987108","display_name":"Hypoxic Adenosine Responses","funder_award_id":"P01HL114457","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6360659856","display_name":"Radical Intermediates of Nitric Oxide Synthase & Myocardial Ischemia Reperfusion","funder_award_id":"R01HL095820","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7184274192","display_name":"Adenosine Signaling, Priapism and Sickle Cell Disease","funder_award_id":"R01DK083559","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1977708103","https://openalex.org/W1980270094","https://openalex.org/W1985337146","https://openalex.org/W1987432935","https://openalex.org/W1988204787","https://openalex.org/W1991427076","https://openalex.org/W1992577724","https://openalex.org/W1996605319","https://openalex.org/W2001317930","https://openalex.org/W2006754069","https://openalex.org/W2007991612","https://openalex.org/W2015949769","https://openalex.org/W2018146992","https://openalex.org/W2019209482","https://openalex.org/W2022770236","https://openalex.org/W2025774463","https://openalex.org/W2034607874","https://openalex.org/W2047607345","https://openalex.org/W2050640165","https://openalex.org/W2051036919","https://openalex.org/W2055105276","https://openalex.org/W2081550012","https://openalex.org/W2086832534","https://openalex.org/W2102832918","https://openalex.org/W2107637489","https://openalex.org/W2110375707","https://openalex.org/W2110657050","https://openalex.org/W2111191978","https://openalex.org/W2127123961","https://openalex.org/W2132228454","https://openalex.org/W2134340975","https://openalex.org/W2141171415","https://openalex.org/W2148239379","https://openalex.org/W2151217876","https://openalex.org/W2156921663","https://openalex.org/W2165143307","https://openalex.org/W2418686086"],"related_works":["https://openalex.org/W2511066372","https://openalex.org/W2980137168","https://openalex.org/W2979985914","https://openalex.org/W2554035497","https://openalex.org/W2611886098","https://openalex.org/W2200111217","https://openalex.org/W7127091365","https://openalex.org/W2554995996","https://openalex.org/W2783571004","https://openalex.org/W4246150854"],"abstract_inverted_index":{"Sphingosine-1-phosphate":[0],"(S1P)":[1],"is":[2,19,27,55],"a":[3,113,144],"bioactive":[4],"lipid":[5],"that":[6,53,74,124,143],"regulates":[7],"multicellular":[8],"functions":[9],"through":[10],"interactions":[11],"with":[12,65,109],"its":[13],"receptors":[14],"on":[15,122],"cell":[16,44],"surfaces.":[17],"S1P":[18,33,54,88,103,121,128,148],"enriched":[20],"and":[21,39,63,83,101,111,152,156],"stored":[22],"in":[23,32,36,58,90,99,104,131],"erythrocytes;":[24],"however,":[25],"it":[26],"not":[28],"clear":[29],"whether":[30],"alterations":[31],"are":[34],"involved":[35],"the":[37,59,91],"prevalent":[38],"debilitating":[40],"hemolytic":[41],"disorder":[42],"sickle":[43],"disease":[45,84,154],"(SCD).":[46],"Here,":[47],"using":[48],"metabolomic":[49],"screening,":[50],"we":[51,72,94],"found":[52],"highly":[56],"elevated":[57,75,96,117],"blood":[60,105],"of":[61,70,116,120,127,147],"mice":[62],"humans":[64],"SCD.":[66,162],"In":[67],"murine":[68],"models":[69],"SCD,":[71],"demonstrated":[73,112],"erythrocyte":[76,140],"sphingosine":[77],"kinase":[78],"1":[79],"(SPHK1)":[80],"underlies":[81],"sickling":[82,123,151],"progression":[85],"by":[86],"increasing":[87],"levels":[89],"blood.":[92],"Additionally,":[93],"observed":[95],"SPHK1":[97],"activity":[98],"erythrocytes":[100],"increased":[102],"collected":[106],"from":[107],"patients":[108],"SCD":[110],"direct":[114],"impact":[115],"SPHK1-mediated":[118,145],"production":[119],"was":[125],"independent":[126],"receptor":[129],"activation":[130],"isolated":[132],"erythrocytes.":[133],"Together,":[134],"our":[135],"findings":[136],"provide":[137],"insights":[138],"into":[139],"pathophysiology,":[141],"revealing":[142],"elevation":[146],"contributes":[149],"to":[150],"promotes":[153],"progression,":[155],"highlight":[157],"potential":[158],"therapeutic":[159],"opportunities":[160],"for":[161]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}