{"id":"https://openalex.org/W2116554151","doi":"https://doi.org/10.1128/jvi.00543-11","title":"CD4+T Lymphocytes Are Critical Mediators of Tumor Immunity to Simian Virus 40 Large Tumor Antigen Induced by Vaccination with Plasmid DNA","display_name":"CD4+T Lymphocytes Are Critical Mediators of Tumor Immunity to Simian Virus 40 Large Tumor Antigen Induced by Vaccination with Plasmid DNA","publication_year":2011,"publication_date":"2011-05-19","ids":{"openalex":"https://openalex.org/W2116554151","doi":"https://doi.org/10.1128/jvi.00543-11","mag":"2116554151","pmid":"https://pubmed.ncbi.nlm.nih.gov/21593176","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126588"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00543-11","doi":"https://doi.org/10.1128/jvi.00543-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00543-11","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126588","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070776549","display_name":"Joel F. Aldrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel F. Aldrich","raw_affiliation_strings":["Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 6591, Lubbock, TX 79430, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 6591, Lubbock, TX 79430, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050022897","display_name":"Devin B. Lowe","orcid":"https://orcid.org/0000-0001-8025-7866","observed_orcids":["https://orcid.org/0000-0001-8025-7866"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devin B. Lowe","raw_affiliation_strings":["Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111693043","display_name":"Michael H. Shearer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Shearer","raw_affiliation_strings":["Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034397282","display_name":"Richard E. Winn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Winn","raw_affiliation_strings":["Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109048340","display_name":"Cynthia Jumper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia A. Jumper","raw_affiliation_strings":["Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070238702","display_name":"Robert K. Bright","orcid":"https://orcid.org/0000-0003-2735-6624","observed_orcids":["https://orcid.org/0000-0003-2735-6624"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert K. Bright","raw_affiliation_strings":["Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108463595","display_name":"Ronald C. Kennedy","orcid":"https://orcid.org/0000-0002-4257-9714","observed_orcids":["https://orcid.org/0000-0002-4257-9714"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald C. Kennedy","raw_affiliation_strings":["Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I926076166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4255,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63178368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"85","issue":"14","first_page":"7216","last_page":"7224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sv40-large-t-antigen","display_name":"SV40 large T antigen","score":0.902999997138977},{"id":"https://openalex.org/keywords/plasmid-dna-vaccination","display_name":"plasmid DNA immunization","score":0.7839999794960022},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.8769999742507935},{"id":"https://openalex.org/keywords/th1-th2-response","display_name":"Th1/Th2 immune response","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.859000027179718},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7620000243186951},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.5220000147819519},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8017579317092896},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6589639782905579},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6411676406860352},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6232794523239136},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.594114363193512},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.5219782590866089},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5138342976570129},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5026514530181885},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.4863341450691223},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4443168044090271},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.4349222779273987},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.429293155670166},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.42383596301078796},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3976622223854065},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3507273197174072}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000957","descriptor_name":"Antigens, Viral, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.00543-11","doi":"https://doi.org/10.1128/jvi.00543-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00543-11","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2256701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126588","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3126588","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126588","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:21593176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21593176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2256701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126588","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1411449516","display_name":null,"funder_award_id":"RR12317","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6191747451","display_name":"Baboon Research Resource Program","funder_award_id":"P40RR012317","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000274496","display_name":null,"funder_award_id":"RR-12317","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320319073","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1573700343","https://openalex.org/W1582422046","https://openalex.org/W1603510059","https://openalex.org/W1977149731","https://openalex.org/W1978942158","https://openalex.org/W1994278323","https://openalex.org/W1995404189","https://openalex.org/W1998205409","https://openalex.org/W1999476100","https://openalex.org/W2004764321","https://openalex.org/W2005189185","https://openalex.org/W2006685479","https://openalex.org/W2007445504","https://openalex.org/W2012129419","https://openalex.org/W2016708646","https://openalex.org/W2021503878","https://openalex.org/W2028036592","https://openalex.org/W2036616437","https://openalex.org/W2040128787","https://openalex.org/W2042031899","https://openalex.org/W2043476265","https://openalex.org/W2046041427","https://openalex.org/W2046319076","https://openalex.org/W2046717421","https://openalex.org/W2047008207","https://openalex.org/W2050548084","https://openalex.org/W2050754173","https://openalex.org/W2050899268","https://openalex.org/W2052363929","https://openalex.org/W2052937969","https://openalex.org/W2054553170","https://openalex.org/W2056186120","https://openalex.org/W2063497807","https://openalex.org/W2071651167","https://openalex.org/W2073023385","https://openalex.org/W2075009035","https://openalex.org/W2078588519","https://openalex.org/W2078597408","https://openalex.org/W2078974152","https://openalex.org/W2079078689","https://openalex.org/W2082554105","https://openalex.org/W2085105667","https://openalex.org/W2086542713","https://openalex.org/W2097915264","https://openalex.org/W2103791122","https://openalex.org/W2106694587","https://openalex.org/W2114146420","https://openalex.org/W2141448044","https://openalex.org/W2145138626","https://openalex.org/W2150839624","https://openalex.org/W2157605618","https://openalex.org/W2163105956","https://openalex.org/W2171541091"],"related_works":["https://openalex.org/W7100708715","https://openalex.org/W2474879917","https://openalex.org/W2163105956","https://openalex.org/W2103791122","https://openalex.org/W1991953735","https://openalex.org/W7098205108","https://openalex.org/W1999476100","https://openalex.org/W6987026730","https://openalex.org/W2081269096","https://openalex.org/W195381179"],"abstract_inverted_index":{"A":[0],"mechanistic":[1],"analysis":[2],"of":[3,28,44,83,100,109,115,133,143,161,168,187,211,229],"tumor":[4,16,51,94,116,175,214,218,231],"immunity":[5,52,95,176,215,232],"directed":[6,233],"toward":[7,234],"the":[8,36,45,162,184,226],"viral":[9],"oncoprotein":[10],"simian":[11],"virus":[12],"40":[13],"(SV40)":[14],"large":[15],"antigen":[17],"(Tag)":[18],"has":[19],"previously":[20],"been":[21],"described":[22],"by":[23,88,113],"our":[24,221],"laboratory":[25],"for":[26,49],"scenarios":[27],"recombinant":[29],"Tag":[30,61,70],"immunization":[31,55],"in":[32,118,139,158,177,183,196],"BALB/c":[33],"mice.":[34],"In":[35],"present":[37],"study,":[38],"we":[39],"performed":[40,138],"a":[41,63,89,97,122,198,209],"preliminary":[42],"characterization":[43],"immune":[46,164,179],"components":[47],"necessary":[48],"systemic":[50],"induced":[53],"upon":[54,105],"with":[56],"plasmid":[57],"DNA":[58,212],"encoding":[59],"SV40":[60,69,127,190],"as":[62,111],"transgene":[64],"(pCMV-Tag).":[65],"Antibody":[66],"responses":[67],"to":[68,126,189,204,216],"were":[71,86,137],"observed":[72],"via":[73,141],"indirect":[74],"enzyme-linked":[75],"immunosorbent":[76],"assay":[77],"following":[78],"three":[79],"intramuscular":[80],"(i.m.)":[81],"injections":[82,108],"pCMV-Tag":[84],"and":[85,130,148,181],"typified":[87],"mixed":[90],"Th1/Th2":[91],"response.":[92,165],"Complete":[93],"within":[96,208],"murine":[98],"model":[99,210],"pulmonary":[101],"metastasis":[102],"was":[103],"achieved":[104],"two":[106],"i.m.":[107],"pCMV-Tag,":[110],"assessed":[112],"examination":[114],"foci":[117],"mouse":[119],"lungs,":[120],"without":[121],"detectable":[123],"antibody":[124],"response":[125],"Tag.":[128,191],"Induction-phase":[129],"effector-phase":[131],"depletions":[132],"T":[134,154,170,206],"cell":[135],"subsets":[136],"vivo":[140],"administration":[142],"depleting":[144],"rat":[145],"monoclonal":[146],"antibodies,":[147],"these":[149],"experiments":[150],"demonstrated":[151],"that":[152,197],"CD4(+)":[153,205],"lymphocytes":[155,171,207],"are":[156,194],"required":[157],"both":[159],"phases":[160],"adaptive":[163],"Conversely,":[166],"depletion":[167],"CD8(+)":[169],"did":[172],"not":[173],"impair":[174],"either":[178],"phase":[180],"resulted":[182],"premature":[185],"production":[186],"antibodies":[188],"Our":[192],"findings":[193,222],"unique":[195],"dominant":[199],"role":[200],"could":[201],"be":[202],"ascribed":[203],"vaccine-induced":[213,230],"Tag-expressing":[217],"cells.":[219],"Additionally,":[220],"provide":[223],"insight":[224],"into":[225],"general":[227],"mechanisms":[228],"tumors":[235],"bearing":[236],"distinct":[237],"tumor-associated":[238],"antigens.":[239]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
