{"id":"https://openalex.org/W2116541578","doi":"https://doi.org/10.1002/jbm.a.35225","title":"The crosslinking degree controls the mechanical, rheological, and swelling properties of hyaluronic acid microparticles","display_name":"The crosslinking degree controls the mechanical, rheological, and swelling properties of hyaluronic acid microparticles","publication_year":2014,"publication_date":"2014-05-15","ids":{"openalex":"https://openalex.org/W2116541578","doi":"https://doi.org/10.1002/jbm.a.35225","mag":"2116541578","pmid":"https://pubmed.ncbi.nlm.nih.gov/24828883"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.35225","doi":"https://doi.org/10.1002/jbm.a.35225","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.35225","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016906487","display_name":"Andr\u00e9a Arruda Martins Shimojo","orcid":"https://orcid.org/0000-0002-7015-2283","observed_orcids":["https://orcid.org/0000-0002-7015-2283"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9a Arruda Martins Shimojo","raw_affiliation_strings":["Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058863455","display_name":"Aline Mara Barbosa Pires","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aline Mara Barbosa Pires","raw_affiliation_strings":["Department of Engineering of Materials and Bioprocesses School of Chemical Engineering, University of Campinas (UNICAMP) 13083\u2010970 Campinas SP Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering of Materials and Bioprocesses School of Chemical Engineering, University of Campinas (UNICAMP) 13083\u2010970 Campinas SP Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033650918","display_name":"Rafael Lichy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael Lichy","raw_affiliation_strings":["Department of Engineering of Materials and Bioprocesses School of Chemical Engineering, University of Campinas (UNICAMP) 13083\u2010970 Campinas SP Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering of Materials and Bioprocesses School of Chemical Engineering, University of Campinas (UNICAMP) 13083\u2010970 Campinas SP Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109948130","display_name":"Ana Am\u00e9lia Rodrigues","orcid":"https://orcid.org/0000-0003-4407-8291","observed_orcids":["https://orcid.org/0000-0003-4407-8291"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Am\u00e9lia Rodrigues","raw_affiliation_strings":["Department of Orthopaedic and Traumatology, Faculty of Medical Sciences University of Campinas (UNICAMP) 13083\u2010887 Campinas SP Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic and Traumatology, Faculty of Medical Sciences University of Campinas (UNICAMP) 13083\u2010887 Campinas SP Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077901406","display_name":"Maria Helena Andrade Santana","orcid":"https://orcid.org/0000-0002-2258-4911","observed_orcids":["https://orcid.org/0000-0002-2258-4911"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Maria Helena Andrade Santana","raw_affiliation_strings":["Department of Engineering of Materials and Bioprocesses School of Chemical Engineering, University of Campinas (UNICAMP) 13083\u2010970 Campinas SP Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering of Materials and Bioprocesses School of Chemical Engineering, University of Campinas (UNICAMP) 13083\u2010970 Campinas SP Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077901406"],"corresponding_institution_ids":["https://openalex.org/I181391015"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.7726,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.60559553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"103","issue":"2","first_page":"730","last_page":"737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crosslink-density","display_name":"crosslink density","score":0.9620000123977661},{"id":"https://openalex.org/keywords/divinyl-sulfone","display_name":"divinyl sulfone","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hydrogel-rheology","display_name":"hydrogel rheology","score":0.7239999771118164},{"id":"https://openalex.org/keywords/swelling-behavior","display_name":"swelling behavior","score":0.7749999761581421},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/extrusion-force","display_name":"extrusion force","score":0.875},{"id":"https://openalex.org/keywords/shear-thinning","display_name":"shear thinning","score":0.878000020980835},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.656000018119812},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cartilage-diseases","display_name":"cartilage diseases","score":0.5929999947547913},{"id":"https://openalex.org/keywords/joint-diseases","display_name":"joint diseases","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.9072244167327881},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.8404846787452698},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.7199084758758545},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7172730565071106},{"id":"https://openalex.org/C2777521759","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microparticle","level":2,"score":0.669599711894989},{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.5454838275909424},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3779309391975403},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3722645044326782},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.32181355357170105},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.18252310156822205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.35225","doi":"https://doi.org/10.1002/jbm.a.35225","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.35225","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:24828883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24828883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1243809138","https://openalex.org/W1583378819","https://openalex.org/W1959532535","https://openalex.org/W1963966393","https://openalex.org/W1965172266","https://openalex.org/W1965581517","https://openalex.org/W1974725781","https://openalex.org/W1981014602","https://openalex.org/W1992432319","https://openalex.org/W1999277351","https://openalex.org/W1999652145","https://openalex.org/W2025570882","https://openalex.org/W2028573179","https://openalex.org/W2034106192","https://openalex.org/W2037361055","https://openalex.org/W2039727537","https://openalex.org/W2048668157","https://openalex.org/W2056471934","https://openalex.org/W2068456228","https://openalex.org/W2072331075","https://openalex.org/W2079671336","https://openalex.org/W2080952519","https://openalex.org/W2087849883","https://openalex.org/W2092575277","https://openalex.org/W2094498700","https://openalex.org/W2107709133","https://openalex.org/W2108376666","https://openalex.org/W2114918609","https://openalex.org/W2126765952","https://openalex.org/W2165694975"],"related_works":["https://openalex.org/W2078468860","https://openalex.org/W1975022941","https://openalex.org/W1992432319","https://openalex.org/W6885070335","https://openalex.org/W2142709003","https://openalex.org/W1975219023","https://openalex.org/W2896299507","https://openalex.org/W1982608488","https://openalex.org/W4381511965","https://openalex.org/W3203463440"],"abstract_inverted_index":{"Viscosupplements,":[0],"used":[1],"for":[2,22],"treating":[3],"joint":[4,16],"and":[5,18,25,55,71,137,169,173,188],"cartilage":[6],"diseases,":[7],"restore":[8],"the":[9,58,61,64,68,75,82,85,95,116,125,167,170,175,178],"rheological":[10,72],"properties":[11,73,101],"of":[12,33,60,74,84,89,105,119,127,161,177],"synovial":[13],"fluid,":[14],"regulate":[15],"homeostasis":[17],"act":[19],"as":[20,191],"scaffolds":[21],"cell":[23],"growth":[24],"tissue":[26],"regeneration.":[27],"Most":[28],"viscosupplements":[29],"are":[30,44],"hydrogels":[31,195],"composed":[32],"hyaluronic":[34],"acid":[35],"(HA)":[36],"microparticles":[37,43,107,132,153],"suspended":[38],"in":[39,121],"fluid":[40],"HA.":[41],"These":[42],"crosslinked":[45],"with":[46,79,99],"chemicals":[47],"to":[48,56,93,102,157,199,202],"assure":[49],"their":[50],"stability":[51],"against":[52],"enzyme":[53],"degradation":[54],"prolong":[57],"action":[59],"viscosupplement.":[62],"However,":[63],"crosslinking":[65,96],"also":[66,183],"modifies":[67],"mechanical,":[69],"swelling":[70,176],"HA":[76,120,131,152,179],"microparticle":[77,180],"hydrogels,":[78,181],"consequences":[80],"on":[81],"effectiveness":[83],"application.":[86],"The":[87,142,194],"aim":[88],"this":[90],"study":[91],"is":[92,115],"correlate":[94],"degree":[97],"(CD)":[98],"these":[100],"achieve":[103],"modulation":[104],"HA/DVS":[106,139],"through":[108],"CD":[109,128,143,165],"control.":[110],"Because":[111],"divinyl":[112],"sulfone":[113],"(DVS)":[114],"usual":[117],"crosslinker":[118],"viscosupplements,":[122],"we":[123],"examined":[124],"effects":[126],"by":[129],"preparing":[130],"at":[133],"1:1,":[134],"2:1,":[135],"3:1,":[136],"5:1":[138],"mass":[140],"ratios.":[141],"was":[144],"calculated":[145],"from":[146],"inductively":[147],"coupled":[148],"plasma":[149],"spectrometry":[150],"data.":[151],"were":[154,189,196],"previously":[155],"sized":[156],"a":[158],"mean":[159],"diameter":[160],"87.5":[162],"\u00b5m.":[163],"Higher":[164],"increased":[166],"viscoelasticity":[168],"extrusion":[171],"force":[172],"reduced":[174],"which":[182],"showed":[184],"Newtonian":[185],"pseudoplastic":[186],"behavior":[187],"classified":[190],"covalent":[192],"weak.":[193],"not":[197],"cytotoxic":[198],"fibroblasts":[200],"according":[201],"an":[203],"MTT":[204],"(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium":[205],"bromide)":[206],"assay.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}