{"id":"https://openalex.org/W2116451502","doi":"https://doi.org/10.1054/bjoc.2000.1339","title":"Serum midkine levels are increased in patients with various types of carcinomas","display_name":"Serum midkine levels are increased in patients with various types of carcinomas","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2116451502","doi":"https://doi.org/10.1054/bjoc.2000.1339","mag":"2116451502","pmid":"https://pubmed.ncbi.nlm.nih.gov/10952771","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2363529"},"language":"en","primary_location":{"id":"doi:10.1054/bjoc.2000.1339","doi":"https://doi.org/10.1054/bjoc.2000.1339","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2000.1339","pdf_url":"https://www.nature.com/articles/6691339.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6691339.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039250768","display_name":"Shinya Ikematsu","orcid":"https://orcid.org/0000-0001-9239-6345","observed_orcids":["https://orcid.org/0000-0001-9239-6345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ikematsu","raw_affiliation_strings":["Meiji Cell Technology Center, 540 Naruda, Odawara, 250-0862, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Cell Technology Center, 540 Naruda, Odawara, 250-0862, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Yano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114911","display_name":"Meiji (Japan)","ror":"https://ror.org/027tjex48","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210114911"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Yano","raw_affiliation_strings":["Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","Meiji Cell Technology Center, Odawara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","institution_ids":[]},{"raw_affiliation_string":"Meiji Cell Technology Center, Odawara, Japan","institution_ids":["https://openalex.org/I4210114911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057938171","display_name":"Kuniaki Aridome","orcid":"https://orcid.org/0000-0002-3868-8926","observed_orcids":["https://orcid.org/0000-0002-3868-8926"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Aridome","raw_affiliation_strings":["Department of Surgery, Faculty of Medicine, Kagoshima University, 8\u201335\u20131, Sakuragaoka, 890, Kagoshima, Japan","Department of Surgery, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Faculty of Medicine, Kagoshima University, 8\u201335\u20131, Sakuragaoka, 890, Kagoshima, Japan","institution_ids":["https://openalex.org/I107139324"]},{"raw_affiliation_string":"Department of Surgery, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Kikuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Kikuchi","raw_affiliation_strings":["Department of Medical Technology, University of Occupational and Environmental Health, 1\u20131 Iseigaoka, Yahatanishi-ku, 807\u20130804, Kitakyushu, Japan","Department of Medical Technology, University of Occupational and Environmental Health, Yahatanishi-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Technology, University of Occupational and Environmental Health, 1\u20131 Iseigaoka, Yahatanishi-ku, 807\u20130804, Kitakyushu, Japan","institution_ids":["https://openalex.org/I188700360"]},{"raw_affiliation_string":"Department of Medical Technology, University of Occupational and Environmental Health, Yahatanishi-ku, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085497614","display_name":"Hideshi Kumai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114911","display_name":"Meiji (Japan)","ror":"https://ror.org/027tjex48","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210114911"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Kumai","raw_affiliation_strings":["Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","Meiji Cell Technology Center, Odawara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","institution_ids":[]},{"raw_affiliation_string":"Meiji Cell Technology Center, Odawara, Japan","institution_ids":["https://openalex.org/I4210114911"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Nagano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114911","display_name":"Meiji (Japan)","ror":"https://ror.org/027tjex48","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210114911"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Nagano","raw_affiliation_strings":["Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","Meiji Cell Technology Center, Odawara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","institution_ids":[]},{"raw_affiliation_string":"Meiji Cell Technology Center, Odawara, Japan","institution_ids":["https://openalex.org/I4210114911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039878364","display_name":"Kohji Okamoto","orcid":"https://orcid.org/0000-0002-9170-717X","observed_orcids":["https://orcid.org/0000-0002-9170-717X"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Okamoto","raw_affiliation_strings":["Department of Surgery, University of Occupational and Environmental Health, 1\u20131 Iseigaoka, Yahatanishi-ku, 807\u20130804, Kitakyushu, Japan","Department of Surgery, University of Occupational and Environmental Health, Yahatanishi-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Occupational and Environmental Health, 1\u20131 Iseigaoka, Yahatanishi-ku, 807\u20130804, Kitakyushu, Japan","institution_ids":["https://openalex.org/I188700360"]},{"raw_affiliation_string":"Department of Surgery, University of Occupational and Environmental Health, Yahatanishi-ku, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081861880","display_name":"M. Oda","orcid":"https://orcid.org/0000-0001-8366-9233","observed_orcids":["https://orcid.org/0000-0001-8366-9233"]},"institutions":[{"id":"https://openalex.org/I4210114911","display_name":"Meiji (Japan)","ror":"https://ror.org/027tjex48","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210114911"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Oda","raw_affiliation_strings":["Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","Meiji Cell Technology Center, Odawara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","institution_ids":[]},{"raw_affiliation_string":"Meiji Cell Technology Center, Odawara, Japan","institution_ids":["https://openalex.org/I4210114911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111428699","display_name":"Sadatoshi Sakuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114911","display_name":"Meiji (Japan)","ror":"https://ror.org/027tjex48","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210114911"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Sakuma","raw_affiliation_strings":["Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","Meiji Cell Technology Center, Odawara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Cell Technology Center, 540 Naruda, Odawara, 250\u20130862, Japan","institution_ids":[]},{"raw_affiliation_string":"Meiji Cell Technology Center, Odawara, Japan","institution_ids":["https://openalex.org/I4210114911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111968750","display_name":"Takashi Aikou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Aikou","raw_affiliation_strings":["Department of Surgery, Faculty of Medicine, Kagoshima University, 8\u201335\u20131, Sakuragaoka, 890, Kagoshima, Japan","Department of Surgery, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Faculty of Medicine, Kagoshima University, 8\u201335\u20131, Sakuragaoka, 890, Kagoshima, Japan","institution_ids":["https://openalex.org/I107139324"]},{"raw_affiliation_string":"Department of Surgery, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077700276","display_name":"Hideki Muramatsu","orcid":"https://orcid.org/0000-0002-8801-0021","observed_orcids":["https://orcid.org/0000-0002-8801-0021"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Muramatsu","raw_affiliation_strings":["Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466\u20138550, Nagoya, Japan","Department of Biochemistry, Nagoya University, School of Medicine, Showa-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466\u20138550, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Department of Biochemistry, Nagoya University, School of Medicine, Showa-ku, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109945670","display_name":"Kenji Kadomatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kadomatsu","raw_affiliation_strings":["Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466\u20138550, Nagoya, Japan","Department of Biochemistry, Nagoya University, School of Medicine, Showa-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466\u20138550, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Department of Biochemistry, Nagoya University, School of Medicine, Showa-ku, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113567662","display_name":"Takuya Muramatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Muramatsu","raw_affiliation_strings":["Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466\u20138550, Nagoya, Japan","Department of Biochemistry, Nagoya University, School of Medicine, Showa-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466\u20138550, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Department of Biochemistry, Nagoya University, School of Medicine, Showa-ku, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":3.0725,"has_fulltext":true,"cited_by_count":199,"citation_normalized_percentile":{"value":0.91878926,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"83","issue":"6","first_page":"701","last_page":"706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.05790000036358833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/midkine","display_name":"midkine","score":1.0},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/carcinoma","display_name":"carcinoma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/heparin-binding-growth-factors","display_name":"heparin-binding growth factors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8289999961853027},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-staging","display_name":"tumor staging","score":0.578000009059906},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C158074577","wikidata":"https://www.wikidata.org/wiki/Q14907402","display_name":"Midkine","level":4,"score":0.9687357544898987},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.7043954730033875},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5801492929458618},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5386855602264404},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5359663963317871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5318669080734253},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5295836925506592},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5150256156921387},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42685556411743164},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.395609974861145},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3674677908420563},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.2906268537044525},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2289542257785797},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12834975123405457}],"mesh":[{"descriptor_ui":"D000078792","descriptor_name":"Midkine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1054/bjoc.2000.1339","doi":"https://doi.org/10.1054/bjoc.2000.1339","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2000.1339","pdf_url":"https://www.nature.com/articles/6691339.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1506395","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2363529","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:10952771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10952771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2363529","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2363529/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1054/bjoc.2000.1339","doi":"https://doi.org/10.1054/bjoc.2000.1339","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2000.1339","pdf_url":"https://www.nature.com/articles/6691339.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116451502.pdf","grobid_xml":"https://content.openalex.org/works/W2116451502.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W151207798","https://openalex.org/W416505757","https://openalex.org/W1489760954","https://openalex.org/W1495565929","https://openalex.org/W1520098011","https://openalex.org/W1533264337","https://openalex.org/W1583603981","https://openalex.org/W1972334219","https://openalex.org/W1985886714","https://openalex.org/W1988909864","https://openalex.org/W1999958985","https://openalex.org/W2009828800","https://openalex.org/W2024018378","https://openalex.org/W2034477126","https://openalex.org/W2054131429","https://openalex.org/W2059453272","https://openalex.org/W2064378344","https://openalex.org/W2065452620","https://openalex.org/W2067812863","https://openalex.org/W2074030659","https://openalex.org/W2083710311","https://openalex.org/W2085109269","https://openalex.org/W2120131414","https://openalex.org/W2157939042","https://openalex.org/W2172286707","https://openalex.org/W2437323456"],"related_works":["https://openalex.org/W416505757","https://openalex.org/W1978004477","https://openalex.org/W2080114754","https://openalex.org/W1987582007","https://openalex.org/W2287252905","https://openalex.org/W4414913557","https://openalex.org/W2111989679","https://openalex.org/W2909639386","https://openalex.org/W302785622","https://openalex.org/W7099153491"],"abstract_inverted_index":{"The":[0,138],"level":[1,35,61],"of":[2,4,16,26,75,80,89,96,112,121],"expression":[3],"midkine":[5],"(MK),":[6],"a":[7,24,93,110,148,153],"heparin-binding":[8],"growth":[9],"factor,":[10],"is":[11],"increased":[12],"in":[13,36,65,119],"many":[14],"types":[15,88],"human":[17],"carcinomas.":[18],"An":[19],"enzyme-linked":[20],"immunoassay,":[21],"which":[22],"utilizes":[23],"combination":[25],"rabbit":[27],"and":[28,114,124],"chicken":[29],"antibodies":[30],"revealed":[31],"that":[32,142],"serum":[33,97,115,135,143],"MK":[34,60,98,116,136,144],"the":[37,66,76],"controls":[38],"(n":[39,69],"=":[40,70],"135)":[41],"was":[42,62,101],"0.154":[43],"+/-":[44,47],"0.076":[45],"(mean":[46],"SD)":[48],"ng":[49,57,84],"ml(-1)with":[50],"an":[51],"apparent":[52],"cut-off":[53],"value":[54],"as":[55,147],"0.5":[56,83],"ml(-1).":[58,85],"Serum":[59],"significantly":[63],"elevated":[64,134],"cancer":[67,90],"patients":[68,77,127],"150)":[71],"(P<":[72],"0.001);":[73],"87%":[74],"showed":[78,92,133],"levels":[79],"more":[81],"than":[82],"All":[86],"ten":[87],"examined":[91],"similar":[94],"profile":[95],"level.":[99,117],"There":[100],"no":[102],"or":[103],"weak":[104],"correlation":[105],"between":[106],"C-reactive":[107],"protein":[108],"level,":[109],"marker":[111,151],"inflammation,":[113],"Furthermore,":[118],"case":[120],"gastric":[122],"carcinoma":[123,131],"lung":[125],"carcinoma,":[126],"with":[128,152],"stage":[129],"I":[130],"already":[132],"levels.":[137],"present":[139],"results":[140],"indicated":[141],"could":[145],"serve":[146],"general":[149],"tumour":[150],"good":[154],"potential":[155],"for":[156],"clinical":[157],"application.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}