{"id":"https://openalex.org/W2116416993","doi":null,"title":"Hepatic failure and hepatorenal syndrome secondary to erlotinib. Safety reminder.","display_name":"Hepatic failure and hepatorenal syndrome secondary to erlotinib. Safety reminder.","publication_year":2008,"publication_date":"2008-11-03","ids":{"openalex":"https://openalex.org/W2116416993","mag":"2116416993","pmid":"https://pubmed.ncbi.nlm.nih.gov/18981559"},"language":"en","primary_location":{"id":"pmid:18981559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18981559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"News"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110323346","display_name":"M. W. Saif","orcid":"https://orcid.org/0000-0001-8154-957X","observed_orcids":["https://orcid.org/0000-0001-8154-957X","https://orcid.org/0000-0003-0599-4991"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Muhammad Wasif Saif","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110323346"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"6","first_page":"748","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.1687999963760376,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.07209999859333038,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hepatorenal-syndrome","display_name":"hepatorenal syndrome","score":0.7200000286102295},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.796999990940094},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.7519999742507935},{"id":"https://openalex.org/keywords/liver-insufficiency","display_name":"liver insufficiency","score":0.7149999737739563},{"id":"https://openalex.org/keywords/chemotherapy-dosing","display_name":"chemotherapy dosing","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.843999981880188},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6039999723434448},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8730584979057312},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6231114864349365},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5727554559707642},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.539881706237793},{"id":"https://openalex.org/C2908939727","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Hepatic dysfunction","level":2,"score":0.5169219970703125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4896617531776428},{"id":"https://openalex.org/C2776988256","wikidata":"https://www.wikidata.org/wiki/Q247131","display_name":"Hepatorenal syndrome","level":3,"score":0.48676466941833496},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4561265707015991},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.44755107164382935},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4304021894931793},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.42274409532546997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39124900102615356},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3296945095062256},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.10732093453407288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004348","descriptor_name":"Drug Labeling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D006530","descriptor_name":"Hepatorenal Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017093","descriptor_name":"Liver Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:18981559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18981559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"News"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W122825480","https://openalex.org/W1931508686","https://openalex.org/W1963592300","https://openalex.org/W1985211051","https://openalex.org/W2002341729","https://openalex.org/W2103134643","https://openalex.org/W2115497785","https://openalex.org/W2117918529","https://openalex.org/W2118520585","https://openalex.org/W2123035611","https://openalex.org/W2138297714","https://openalex.org/W2154778258","https://openalex.org/W2158134441","https://openalex.org/W2158664495","https://openalex.org/W2162724777","https://openalex.org/W2163866397","https://openalex.org/W2176100822","https://openalex.org/W2182918865"],"related_works":["https://openalex.org/W7097325214","https://openalex.org/W7099633333","https://openalex.org/W2784652931","https://openalex.org/W1998644344","https://openalex.org/W2008463741","https://openalex.org/W7095686730","https://openalex.org/W4301477716","https://openalex.org/W2176100822","https://openalex.org/W2039408467","https://openalex.org/W2896979044"],"abstract_inverted_index":{"There":[0],"have":[1,42],"been":[2],"constant":[3],"debates":[4],"regarding":[5],"the":[6,29,52,93],"issues":[7],"of":[8,15,54,95],"chemotherapy":[9],"use":[10,53],"and":[11,31,88,116],"dosing":[12,75],"in":[13,18,58],"setting":[14],"liver":[16,43,117],"insufficiency":[17,82],"patients":[19,40,60,79],"with":[20,80,105,108],"solid":[21],"malignancies.":[22],"Many":[23],"chemotherapeutic":[24],"agents":[25],"are":[26,64,72,83,113],"metabolized":[27],"by":[28],"liver,":[30],"it":[32],"is":[33,100,119],"also":[34],"relatively":[35],"common":[36],"for":[37,67],"advanced":[38],"cancer":[39],"to":[41,46],"dysfunction":[44,118],"secondary":[45],"metastatic":[47],"disease.":[48],"Some":[49],"literature":[50],"reviews":[51],"specific":[55],"cytotoxic":[56],"drugs":[57],"such":[59,96],"[1]":[61],"but":[62],"data":[63],"still":[65],"lacking":[66],"most":[68,78],"agents.":[69],"Hence,":[70],"there":[71],"no":[73],"formal":[74],"recommendations.":[76],"Furthermore,":[77],"hepatic":[81],"excluded":[84],"from":[85],"clinical":[86],"trials":[87],"case":[89],"review":[90],"series,":[91],"perpetuating":[92],"lack":[94],"information.":[97],"This":[98],"situation":[99],"further":[101],"complexed":[102],"when":[103],"dealing":[104],"a":[106],"patient":[107],"pancreatic":[109],"cancer,":[110],"where":[111],"options":[112],"extremely":[114],"limited":[115],"very":[120],"common.":[121]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}