{"id":"https://openalex.org/W2116407692","doi":"https://doi.org/10.2337/diacare.26.8.2410","title":"Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes","display_name":"Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2116407692","doi":"https://doi.org/10.2337/diacare.26.8.2410","mag":"2116407692","pmid":"https://pubmed.ncbi.nlm.nih.gov/12882871"},"language":"en","primary_location":{"id":"doi:10.2337/diacare.26.8.2410","doi":"https://doi.org/10.2337/diacare.26.8.2410","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diacare.26.8.2410","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034303175","display_name":"Maggie C.Y. Ng","orcid":"https://orcid.org/0000-0002-4133-2007","observed_orcids":["https://orcid.org/0000-0002-4133-2007"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Maggie C.Y. Ng","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057813640","display_name":"Shaochin Lee","orcid":"https://orcid.org/0000-0001-5096-405X","observed_orcids":["https://orcid.org/0000-0001-5096-405X"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Shao-Chin Lee","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103963544","display_name":"Wing\u2010Yee So","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Wing-Yee So","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110253665","display_name":"Peter C.Y. Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Peter C.Y. Tong","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109928518","display_name":"Clive Stewart Cockram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Clive S. Cockram","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036805172","display_name":"Julia Critchley","orcid":"https://orcid.org/0000-0002-5248-4188","observed_orcids":["https://orcid.org/0000-0002-5248-4188"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Julian A.J.H. Critchley","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091832416","display_name":"Juliana C.N. Chan","orcid":"https://orcid.org/0000-0003-1325-1194","observed_orcids":["https://orcid.org/0000-0003-1325-1194"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Juliana C.N. Chan","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3923,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.91980161,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"26","issue":"8","first_page":"2410","last_page":"2415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldose-reductase-gene","display_name":"aldose reductase gene","score":0.925000011920929},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/diabetic-microvascular-complications","display_name":"diabetic microvascular complications","score":0.9259999990463257},{"id":"https://openalex.org/keywords/urinary-albumin-excretion-rate","display_name":"urinary albumin excretion rate","score":0.9380000233650208},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6159999966621399},{"id":"https://openalex.org/keywords/phenotypic-heterogeneity","display_name":"phenotypic heterogeneity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.6890000104904175},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6600000262260437},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.5979999899864197},{"id":"https://openalex.org/keywords/waist-to-hip-ratio","display_name":"waist-to-hip ratio","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8511916995048523},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.717614471912384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6944748759269714},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.6468016505241394},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.6454111337661743},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.6418841481208801},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6143571734428406},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5884162187576294},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5250499248504639},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4768058955669403},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4157399535179138}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006723","descriptor_name":"Hong Kong","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diacare.26.8.2410","doi":"https://doi.org/10.2337/diacare.26.8.2410","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diacare.26.8.2410","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:12882871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12882871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322170","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86"},{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W341171029","https://openalex.org/W569951484","https://openalex.org/W1480085532","https://openalex.org/W1941704261","https://openalex.org/W1963542379","https://openalex.org/W1968219575","https://openalex.org/W1981218811","https://openalex.org/W1988181458","https://openalex.org/W1996424575","https://openalex.org/W1998660015","https://openalex.org/W2014314401","https://openalex.org/W2014445941","https://openalex.org/W2021703156","https://openalex.org/W2023362855","https://openalex.org/W2038876123","https://openalex.org/W2049325341","https://openalex.org/W2061008984","https://openalex.org/W2061685638","https://openalex.org/W2064954194","https://openalex.org/W2123946565","https://openalex.org/W2127793113","https://openalex.org/W2135732313","https://openalex.org/W2144911879","https://openalex.org/W2146830081","https://openalex.org/W2157575970","https://openalex.org/W2157606645","https://openalex.org/W2164523811","https://openalex.org/W2340171512","https://openalex.org/W2388146803","https://openalex.org/W2408808028","https://openalex.org/W4230993889"],"related_works":["https://openalex.org/W1998660015","https://openalex.org/W2119337947","https://openalex.org/W2040443828","https://openalex.org/W1980551994","https://openalex.org/W3035346421","https://openalex.org/W2171532585","https://openalex.org/W1597753823","https://openalex.org/W2146830081","https://openalex.org/W2355423376","https://openalex.org/W11719077"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"investigated":[2],"the":[3,22,26,47,100,135,172,179,212,255,278,288,350],"phenotypic":[4,335],"features":[5],"of":[6,25,35,54,102,114,178,254,277,339,353,359],"diabetic":[7,40,61,65,71,140,155,188,193,247,324,332,344,347,366],"microvascular":[8,367],"complications":[9],"and":[10,17,67,73,87,107,117,128,149,166,249,264,273,308,326,346,356],"their":[11],"association":[12],"with":[13,130,139,154,187,238,245,364],"a":[14,18,32,112,208,274],"(CA)(n)":[15,116,180,354],"microsatellite":[16],"C/T":[19,118],"polymorphism":[20,181,355],"at":[21],"5'":[23],"region":[24],"aldose":[27],"reductase":[28],"gene":[29],"(ALR2)":[30],"in":[31,92,185,337],"consecutive":[33],"cohort":[34],"738":[36],"Chinese":[37,329],"type":[38,330],"2":[39,331],"patients.":[41],"RESEARCH":[42],"DESIGN":[43],"AND":[44],"METHODS:":[45],"Of":[46],"entire":[48],"patient":[49],"cohort,":[50,137],"392":[51],"were":[52,120,182,319,361],"free":[53],"diabetes":[55],"complications,":[56],"or":[57,110],"uncomplicated,":[58],"159":[59],"had":[60,64,69,145,160,207,251],"nephropathy,":[62],"66":[63],"retinopathy,":[66],"121":[68],"both":[70,246,323,343],"nephropathy":[72,156,248,325,345],"retinopathy.":[74,327,348],"Nephropathy":[75],"was":[76,97,232],"defined":[77,98],"as":[78],"urinary":[79],"albumin":[80],"excretion":[81],"rate":[82],"(AER)":[83],">or=20":[84],"micro":[85,224],"g/min":[86],"albumin-to-creatinine":[88],"ratio":[89,300],">or=3.5":[90],"mg/mmol":[91],"two":[93],"urine":[94],"collections.":[95],"Retinopathy":[96],"by":[99,111,122,125,217,222],"presence":[101],"hemorrhages,":[103],"exudates,":[104],"laser":[105],"marks,":[106],"fibrous":[108],"proliferation":[109],"history":[113],"vitrectomy.":[115],"polymorphisms":[119],"examined":[121],"PCR":[123],"followed":[124],"capillary":[126],"electrophoresis":[127],"digestion":[129],"BfaI,":[131],"respectively.":[132],"RESULTS:":[133],"In":[134],"whole":[136],"patients":[138,186,237,333],"retinopathy":[141,189,194,250],"(n":[142,157,195],"=":[143,158,196,202,227,262,271,285,306,317],"187)":[144],"higher":[146,161,209,252],"blood":[147,162],"pressure":[148],"lower":[150,275],"BMI,":[151],"while":[152],"those":[153,170,191],"280)":[159],"pressure,":[163],"waist-to-hip":[164],"ratio,":[165],"lipid":[167],"profile":[168],"than":[169,190,211,287],"without":[171,192],"respective":[173],"complications.":[174,368],"The":[175,204,243],"z+6":[176,279],"carriers":[177,206,214],"less":[183],"common":[184],"551)":[197],"(4.3":[198],"vs.":[199,219,259,268,282],"9.3%,":[200],"P":[201,226,261,270,284,305,316],"0.04).":[203],"CT/TT":[205,309],"AER":[210],"CC":[213],"(30.2":[215],"x/divided":[216,221],"7.2":[218],"21.9":[220],"6.9":[223],"g/min,":[225],"0.03).":[228],"Further":[229],"subgroup":[230],"analysis":[231,294],"performed":[233],"after":[234],"excluding":[235],"uncomplicated":[236,289],"<5":[239],"years":[240],"disease":[241],"duration.":[242],"group":[244],"frequencies":[253],"z-2":[256,297,351],"allele":[257,266,280,352,358],"(25.7":[258],"16.9%,":[260],"0.03)":[263],"T":[265,357],"(26.4":[267],"18.5%,":[269],"0.04)":[272],"frequency":[276],"(1.7":[281],"5.5%,":[283],"0.054)":[286],"group.":[290],"Multiple":[291],"logistic":[292],"regression":[293],"confirmed":[295],"that":[296],"carrying":[298],"(odds":[299],"2.6,":[301],"95%":[302,313],"CI":[303,314],"1.20-5.83,":[304],"0.02)":[307,318],"genotypes":[310],"(OR":[311],"2.5,":[312],"1.19-5.19,":[315],"independent":[320],"predictors":[321],"for":[322,342],"CONCLUSIONS:":[328],"exhibited":[334],"differences":[336],"terms":[338],"risk":[340],"factors":[341],"Both":[349],"ALR2":[360],"independently":[362],"associated":[363],"severe":[365]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
