{"id":"https://openalex.org/W2116372744","doi":"https://doi.org/10.1586/eri.11.122","title":"Immunomodulatory therapy for sepsis: an update","display_name":"Immunomodulatory therapy for sepsis: an update","publication_year":2011,"publication_date":"2011-10-27","ids":{"openalex":"https://openalex.org/W2116372744","doi":"https://doi.org/10.1586/eri.11.122","mag":"2116372744","pmid":"https://pubmed.ncbi.nlm.nih.gov/22029521"},"language":"en","primary_location":{"id":"doi:10.1586/eri.11.122","doi":"https://doi.org/10.1586/eri.11.122","is_oa":false,"landing_page_url":"https://doi.org/10.1586/eri.11.122","pdf_url":null,"source":{"id":"https://openalex.org/S185628608","display_name":"Expert Review of Anti-infective Therapy","issn_l":"1478-7210","issn":["1478-7210","1744-8336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anti-infective Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022103982","display_name":"Eirini Christaki","orcid":"https://orcid.org/0000-0002-8152-6367","observed_orcids":["https://orcid.org/0000-0002-8152-6367"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Eirini Christaki","raw_affiliation_strings":["Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece. eirini.christaki@gmail.com","Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, RI, USA","Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece. eirini.christaki@gmail.com","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]},{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069152790","display_name":"Panagiota Anyfanti","orcid":"https://orcid.org/0000-0002-5658-4629","observed_orcids":["https://orcid.org/0000-0002-5658-4629"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiota Anyfanti","raw_affiliation_strings":["Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece; Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece","Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece; Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025379878","display_name":"Steven M. Opal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M Opal","raw_affiliation_strings":["Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, RI, USA; Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, RI, USA","Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, RI, USA; Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9823,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.68882979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"11","first_page":"1013","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/activated-protein-c","display_name":"activated protein C","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6660000085830688},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6869999766349792},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.5879999995231628},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/sepsis-pathophysiology","display_name":"sepsis pathophysiology","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8775930404663086},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5918485522270203},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5800883769989014},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.5664408206939697},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.542393684387207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5288152694702148},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5161479711532593},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.49528899788856506},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4477229714393616},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4332064688205719},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39600157737731934},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3301193118095398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29120445251464844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1717652678489685},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1586/eri.11.122","doi":"https://doi.org/10.1586/eri.11.122","is_oa":false,"landing_page_url":"https://doi.org/10.1586/eri.11.122","pdf_url":null,"source":{"id":"https://openalex.org/S185628608","display_name":"Expert Review of Anti-infective Therapy","issn_l":"1478-7210","issn":["1478-7210","1744-8336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anti-infective Therapy","raw_type":"journal-article"},{"id":"pmid:22029521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22029521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of anti-infective therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":178,"referenced_works":["https://openalex.org/W207315991","https://openalex.org/W1480571016","https://openalex.org/W1494575416","https://openalex.org/W1499659307","https://openalex.org/W1541957757","https://openalex.org/W1542715374","https://openalex.org/W1549568102","https://openalex.org/W1564183378","https://openalex.org/W1566182873","https://openalex.org/W1570331116","https://openalex.org/W1588147454","https://openalex.org/W1592367324","https://openalex.org/W1592616574","https://openalex.org/W1834782762","https://openalex.org/W1843830281","https://openalex.org/W1914860920","https://openalex.org/W1948103997","https://openalex.org/W1964122395","https://openalex.org/W1964949922","https://openalex.org/W1967196868","https://openalex.org/W1972458687","https://openalex.org/W1976557086","https://openalex.org/W1977166847","https://openalex.org/W1977905350","https://openalex.org/W1978667507","https://openalex.org/W1978994300","https://openalex.org/W1979944645","https://openalex.org/W1980045113","https://openalex.org/W1984332693","https://openalex.org/W1986652059","https://openalex.org/W1987612522","https://openalex.org/W1989000067","https://openalex.org/W1989954453","https://openalex.org/W1990924485","https://openalex.org/W1991885269","https://openalex.org/W1993349268","https://openalex.org/W1993714448","https://openalex.org/W1995228412","https://openalex.org/W1996044520","https://openalex.org/W1997389827","https://openalex.org/W1999246265","https://openalex.org/W2000738142","https://openalex.org/W2003877973","https://openalex.org/W2005192120","https://openalex.org/W2005229991","https://openalex.org/W2007283811","https://openalex.org/W2010008904","https://openalex.org/W2010039244","https://openalex.org/W2020261835","https://openalex.org/W2020303910","https://openalex.org/W2022745533","https://openalex.org/W2024348167","https://openalex.org/W2024815256","https://openalex.org/W2027065937","https://openalex.org/W2027161938","https://openalex.org/W2027752637","https://openalex.org/W2031039655","https://openalex.org/W2031530186","https://openalex.org/W2031924525","https://openalex.org/W2034394906","https://openalex.org/W2036535596","https://openalex.org/W2039145048","https://openalex.org/W2040017248","https://openalex.org/W2040620884","https://openalex.org/W2042821764","https://openalex.org/W2043276558","https://openalex.org/W2044322051","https://openalex.org/W2045989280","https://openalex.org/W2048559240","https://openalex.org/W2048722868","https://openalex.org/W2048933053","https://openalex.org/W2050192510","https://openalex.org/W2050582522","https://openalex.org/W2052320243","https://openalex.org/W2053113468","https://openalex.org/W2053189438","https://openalex.org/W2053361390","https://openalex.org/W2053682732","https://openalex.org/W2053976322","https://openalex.org/W2054107809","https://openalex.org/W2054641153","https://openalex.org/W2055640092","https://openalex.org/W2055902416","https://openalex.org/W2056411965","https://openalex.org/W2057529688","https://openalex.org/W2057979643","https://openalex.org/W2058174439","https://openalex.org/W2060695664","https://openalex.org/W2064854026","https://openalex.org/W2065022251","https://openalex.org/W2065611483","https://openalex.org/W2067892766","https://openalex.org/W2067970770","https://openalex.org/W2069368135","https://openalex.org/W2070434578","https://openalex.org/W2072827325","https://openalex.org/W2075323804","https://openalex.org/W2076981287","https://openalex.org/W2077023339","https://openalex.org/W2079354146","https://openalex.org/W2080224523","https://openalex.org/W2081073452","https://openalex.org/W2085040323","https://openalex.org/W2088792593","https://openalex.org/W2090023887","https://openalex.org/W2090215853","https://openalex.org/W2090538273","https://openalex.org/W2091330377","https://openalex.org/W2094265468","https://openalex.org/W2095218541","https://openalex.org/W2096900830","https://openalex.org/W2098433374","https://openalex.org/W2100536943","https://openalex.org/W2100730128","https://openalex.org/W2104010066","https://openalex.org/W2104134630","https://openalex.org/W2104709352","https://openalex.org/W2105037209","https://openalex.org/W2105564248","https://openalex.org/W2106216921","https://openalex.org/W2106669943","https://openalex.org/W2107219732","https://openalex.org/W2108435955","https://openalex.org/W2109383171","https://openalex.org/W2111143066","https://openalex.org/W2112113435","https://openalex.org/W2112320613","https://openalex.org/W2115301416","https://openalex.org/W2115672224","https://openalex.org/W2116423522","https://openalex.org/W2117783767","https://openalex.org/W2118858814","https://openalex.org/W2120994495","https://openalex.org/W2124087884","https://openalex.org/W2126115734","https://openalex.org/W2126572493","https://openalex.org/W2129535379","https://openalex.org/W2130072278","https://openalex.org/W2130749913","https://openalex.org/W2131014933","https://openalex.org/W2132318885","https://openalex.org/W2133629433","https://openalex.org/W2137296011","https://openalex.org/W2137842935","https://openalex.org/W2138167941","https://openalex.org/W2138763270","https://openalex.org/W2139518083","https://openalex.org/W2140354576","https://openalex.org/W2140531400","https://openalex.org/W2141416944","https://openalex.org/W2141817221","https://openalex.org/W2142137375","https://openalex.org/W2144080450","https://openalex.org/W2144716650","https://openalex.org/W2145066257","https://openalex.org/W2145348062","https://openalex.org/W2148430259","https://openalex.org/W2150539814","https://openalex.org/W2152261051","https://openalex.org/W2152355255","https://openalex.org/W2155464214","https://openalex.org/W2155470233","https://openalex.org/W2157339124","https://openalex.org/W2157928866","https://openalex.org/W2158308422","https://openalex.org/W2159482201","https://openalex.org/W2159591164","https://openalex.org/W2160369507","https://openalex.org/W2160414927","https://openalex.org/W2163527419","https://openalex.org/W2167639932","https://openalex.org/W2168434514","https://openalex.org/W2168456558","https://openalex.org/W2289364577","https://openalex.org/W2314230197","https://openalex.org/W2916608302","https://openalex.org/W4237524633","https://openalex.org/W4297846776"],"related_works":["https://openalex.org/W2008574060","https://openalex.org/W2203344544","https://openalex.org/W2105906446","https://openalex.org/W1983327604","https://openalex.org/W2147622298","https://openalex.org/W4393354032","https://openalex.org/W4254475377","https://openalex.org/W2146145942","https://openalex.org/W2417013097","https://openalex.org/W2913386841"],"abstract_inverted_index":{"Currently":[0],"the":[1,17,24,46,79,96,123,143],"treatment":[2,144],"mainstay":[3],"of":[4,19,27,63,72,78,101,145],"sepsis":[5,53,80],"is":[6],"early":[7],"and":[8,23,37,92,104,125,131],"appropriate":[9],"antibiotic":[10],"therapy,":[11],"accompanied":[12],"by":[13,117,121],"aggressive":[14],"fluid":[15],"administration,":[16],"use":[18],"vasopressors":[20],"when":[21,39],"needed":[22],"prompt":[25],"initiation":[26],"measures":[28],"to":[29,112],"support":[30],"each":[31,61],"failing":[32],"organ.":[33],"Activated":[34],"protein":[35],"C":[36],"hydrocortisone,":[38],"used":[40],"accordingly":[41],"can":[42],"affect":[43,75],"mortality.":[44],"As":[45],"pathophysiologic":[47],"events":[48],"that":[49,59,110],"take":[50],"place":[51],"during":[52],"are":[54,66],"being":[55,67],"elucidated,":[56],"new":[57],"molecules":[58,74,133],"target":[60],"step":[62],"those":[64,73],"pathways":[65],"tested.":[68],"However,":[69],"a":[70,99],"lot":[71],"various":[76],"mediators":[77],"cascade":[81],"including":[82],"inflammatory":[83],"cytokines,":[84],"cellular":[85],"receptors,":[86],"nuclear":[87],"transcription":[88],"factors,":[89],"coagulation":[90],"activators":[91],"apoptosis":[93],"regulators.":[94],"Over":[95],"last":[97],"decade,":[98],"multitude":[100],"clinical":[102],"trials":[103],"animal":[105],"studies":[106],"have":[107,138],"investigated":[108],"strategies":[109],"aimed":[111],"restore":[113],"immune":[114,127],"homeostasis":[115],"either":[116],"reducing":[118],"inflammation":[119],"or":[120],"stimulating":[122],"innate":[124],"adaptive":[126],"responses.":[128],"Antibiotics,":[129],"statins":[130],"other":[132],"with":[134],"multipotent":[135],"immunomodulatory":[136],"actions":[137],"also":[139],"been":[140],"studied":[141],"in":[142],"sepsis.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}