{"id":"https://openalex.org/W2116343151","doi":"https://doi.org/10.1210/en.2002-221086","title":"Structural and Functional Evidence for the Interaction of Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins with Vitronectin","display_name":"Structural and Functional Evidence for the Interaction of Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins with Vitronectin","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W2116343151","doi":"https://doi.org/10.1210/en.2002-221086","mag":"2116343151","pmid":"https://pubmed.ncbi.nlm.nih.gov/12810534"},"language":"en","primary_location":{"id":"doi:10.1210/en.2002-221086","doi":"https://doi.org/10.1210/en.2002-221086","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2002-221086","pdf_url":"https://academic.oup.com/endo/article-pdf/144/7/2807/11128557/endo2807.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/144/7/2807/11128557/endo2807.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080542549","display_name":"Jennifer Ann Kricker","orcid":"https://orcid.org/0000-0002-0757-1936","observed_orcids":["https://orcid.org/0000-0002-0757-1936"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jennifer A. Kricker","raw_affiliation_strings":["Tissue BioRegeneration and Integration Program (J.A.K., C.L.T., A.C.H., Z.U.), School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue BioRegeneration and Integration Program (J.A.K., C.L.T., A.C.H., Z.U.), School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108528752","display_name":"Chris L. Towne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chris L. Towne","raw_affiliation_strings":["Tissue BioRegeneration and Integration Program (J.A.K., C.L.T., A.C.H., Z.U.), School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue BioRegeneration and Integration Program (J.A.K., C.L.T., A.C.H., Z.U.), School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072514779","display_name":"Sue M. Firth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sue M. Firth","raw_affiliation_strings":["Kolling Institute of Medical Research (S.M.F.), University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kolling Institute of Medical Research (S.M.F.), University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084121268","display_name":"Adrian C. Herington","orcid":"https://orcid.org/0000-0002-7736-887X","observed_orcids":["https://orcid.org/0000-0002-7736-887X"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adrian C. Herington","raw_affiliation_strings":["Tissue BioRegeneration and Integration Program (J.A.K., C.L.T., A.C.H., Z.U.), School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue BioRegeneration and Integration Program (J.A.K., C.L.T., A.C.H., Z.U.), School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002695142","display_name":"Zee Upton","orcid":"https://orcid.org/0000-0002-9928-5864","observed_orcids":["https://orcid.org/0000-0002-9928-5864"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zee Upton","raw_affiliation_strings":["Tissue BioRegeneration and Integration Program (J.A.K., C.L.T., A.C.H., Z.U.), School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue BioRegeneration and Integration Program (J.A.K., C.L.T., A.C.H., Z.U.), School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia","institution_ids":["https://openalex.org/I160993911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.3865,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.89464397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"144","issue":"7","first_page":"2807","last_page":"2815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor","display_name":"insulin-like growth factor","score":0.8500000238418579},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.878000020980835},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.9700000286102295},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8560000061988831},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9649999737739563},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.8529999852180481},{"id":"https://openalex.org/keywords/igfbp-4","display_name":"IGFBP-4","score":0.9390000104904175},{"id":"https://openalex.org/keywords/igfbp-5","display_name":"IGFBP-5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/heparin-binding-domain","display_name":"heparin-binding domain","score":0.9940000176429749},{"id":"https://openalex.org/keywords/integrin-binding","display_name":"integrin binding","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/igf-binding","display_name":"IGF binding","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.7686841487884521},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.6541662812232971},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6024739146232605},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5903320908546448},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.5694091320037842},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.49145805835723877},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47159823775291443},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.4568730890750885},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.45649921894073486},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4550938308238983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4467235803604126},{"id":"https://openalex.org/C80862487","wikidata":"https://www.wikidata.org/wiki/Q415679","display_name":"Somatomedin","level":4,"score":0.43999147415161133},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.39021623134613037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3836126923561096},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.356731116771698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2973894476890564},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.22292110323905945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12436646223068237},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018974","descriptor_name":"Insulin-Like Growth Factor Binding Protein 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018974","descriptor_name":"Insulin-Like Growth Factor Binding Protein 4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018975","descriptor_name":"Insulin-Like Growth Factor Binding Protein 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018975","descriptor_name":"Insulin-Like Growth Factor Binding Protein 5","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1210/en.2002-221086","doi":"https://doi.org/10.1210/en.2002-221086","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2002-221086","pdf_url":"https://academic.oup.com/endo/article-pdf/144/7/2807/11128557/endo2807.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:12810534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12810534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.qut.edu.au:10057","doi":null,"is_oa":true,"landing_page_url":"https://eprints.qut.edu.au/10057/1/10057.pdf","pdf_url":"https://eprints.qut.edu.au/10057/1/10057.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology","raw_type":"Contribution to Journal"},{"id":"pmh:oai:infoscience.epfl.ch:88411","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/88411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:88411","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/88411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1210/en.2002-221086","doi":"https://doi.org/10.1210/en.2002-221086","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2002-221086","pdf_url":"https://academic.oup.com/endo/article-pdf/144/7/2807/11128557/endo2807.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116343151.pdf","grobid_xml":"https://content.openalex.org/works/W2116343151.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W91439320","https://openalex.org/W130038521","https://openalex.org/W1571638637","https://openalex.org/W1579811372","https://openalex.org/W1590202185","https://openalex.org/W1848943739","https://openalex.org/W1961301813","https://openalex.org/W1972393959","https://openalex.org/W1973474133","https://openalex.org/W1976353100","https://openalex.org/W1983284888","https://openalex.org/W1993807494","https://openalex.org/W1995626607","https://openalex.org/W2000268063","https://openalex.org/W2003440778","https://openalex.org/W2006345660","https://openalex.org/W2015843482","https://openalex.org/W2017007759","https://openalex.org/W2017608169","https://openalex.org/W2018633162","https://openalex.org/W2024395602","https://openalex.org/W2025071348","https://openalex.org/W2029662652","https://openalex.org/W2037868177","https://openalex.org/W2049480315","https://openalex.org/W2054156770","https://openalex.org/W2063049842","https://openalex.org/W2072514327","https://openalex.org/W2083434885","https://openalex.org/W2086037609","https://openalex.org/W2086590750","https://openalex.org/W2088007215","https://openalex.org/W2122737594","https://openalex.org/W2124562185","https://openalex.org/W2128583672","https://openalex.org/W2154782902","https://openalex.org/W2398960089","https://openalex.org/W2417333941","https://openalex.org/W2433223931","https://openalex.org/W2607429329","https://openalex.org/W6664157249","https://openalex.org/W6712185465","https://openalex.org/W6716821954"],"related_works":["https://openalex.org/W70766503","https://openalex.org/W2099890896","https://openalex.org/W7097473709","https://openalex.org/W2069202122","https://openalex.org/W51956250","https://openalex.org/W2122737594","https://openalex.org/W17360667","https://openalex.org/W1589685049","https://openalex.org/W2124286199","https://openalex.org/W2051383123"],"abstract_inverted_index":{"Previous":[0],"studies":[1,109],"demonstrated":[2,22,168],"that":[3,49,113,191],"IGF-II":[4],"binds":[5,12],"directly":[6],"to":[7,18,23,90,96,135,146,153,188],"vitronectin":[8],"(VN),":[9],"whereas":[10,98],"IGF-I":[11,53,95,154,174,186],"poorly.":[13],"However,":[14],"binding":[15,35,69,93,108,134,187,193],"of":[16,29,81,94,120,132,158,171,182],"VN":[17,55,72,150,189],"integrins":[19],"has":[20,194],"been":[21],"be":[24,60,147],"essential":[25],"for":[26],"a":[27,50,104,172],"range":[28],"IGF-I-stimulated":[30],"biological":[31],"effects,":[32],"including":[33],"IGF":[34,39],"protein":[36],"(IGFBP)-5":[37],"production,":[38],"type-1":[40],"receptor":[41],"autophosphorylation,":[42],"and":[43,54,58,73,79,85,100,116,144,190],"cell":[44,137],"migration.":[45],"Thus,":[46],"we":[47],"hypothesized":[48],"link":[51],"between":[52],"must":[56],"occur":[57],"may":[59],"mediated":[61],"through":[62],"IGFBPs.":[63,82],"This":[64],"was":[65,142,151,167],"tested":[66],"using":[67],"competitive":[68],"assays":[70],"with":[71,110],"(125)iodine-labeled":[74],"IGFs":[75,133],"in":[76,124,139,155,184,197],"the":[77,117,129,156,180],"absence":[78],"presence":[80,157],"IGFBP-4,":[83],"IGFBP-5,":[84],"nonglycosylated":[86],"IGFBP-3":[87,102,121],"were":[88],"shown":[89],"significantly":[91],"enhance":[92],"VN,":[97,136],"IGFBP-2":[99],"glycosylated":[101],"had":[103],"smaller":[105],"effect.":[106],"Furthermore,":[107],"analogs":[111],"indicate":[112,179],"glycosylation":[114],"status":[115],"heparin-binding":[118],"domain":[119],"are":[122],"important":[123],"this":[125,166,192],"interaction.":[126],"To":[127],"examine":[128],"functional":[130,195],"significance":[131],"migration":[138],"MCF7":[140],"cells":[141],"measured":[143],"found":[145],"enhanced":[148],"when":[149],"prebound":[152],"IGFBP-5.":[159],"The":[160],"effect":[161],"required":[162],"IGF:IGFBP:VN":[163],"complex":[164],"formation;":[165],"by":[169],"use":[170],"non-IGFBP-binding":[173],"analog.":[175],"Together,":[176],"these":[177],"data":[178],"importance":[181],"IGFBPs":[183],"modulating":[185],"consequences":[196],"cells.":[198]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}