{"id":"https://openalex.org/W2116304552","doi":"https://doi.org/10.1085/jgp.201411246","title":"Structure\u2013activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects","display_name":"Structure\u2013activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects","publication_year":2014,"publication_date":"2014-09-29","ids":{"openalex":"https://openalex.org/W2116304552","doi":"https://doi.org/10.1085/jgp.201411246","mag":"2116304552","pmid":"https://pubmed.ncbi.nlm.nih.gov/25267914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4178936"},"language":"en","primary_location":{"id":"doi:10.1085/jgp.201411246","doi":"https://doi.org/10.1085/jgp.201411246","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.201411246","pdf_url":"https://rupress.org/jgp/article-pdf/144/4/321/1231225/jgp_201411246.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jgp/article-pdf/144/4/321/1231225/jgp_201411246.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088037931","display_name":"L\u00e1szl\u00f3 Csan\u00e1dy","orcid":"https://orcid.org/0000-0002-6547-5889","observed_orcids":["https://orcid.org/0000-0002-6547-5889"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"L\u00e1szl\u00f3 Csan\u00e1dy","raw_affiliation_strings":["Department of Medical Biochemistry 1 and 2","MTA-SE Ion Channel Research Group, Semmelweis University, Budapest H-1094, Hungary 1 and 2","Department of Medical Biochemistry and MTA-SE Ion Channel Research Group, Semmelweis University, Budapest H-1094, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry 1 and 2","institution_ids":[]},{"raw_affiliation_string":"MTA-SE Ion Channel Research Group, Semmelweis University, Budapest H-1094, Hungary 1 and 2","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I7597260"]},{"raw_affiliation_string":"Department of Medical Biochemistry and MTA-SE Ion Channel Research Group, Semmelweis University, Budapest H-1094, Hungary","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I7597260"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001553647","display_name":"Be\u00e1ta T\u00f6r\u0151csik","orcid":"https://orcid.org/0000-0002-9838-3710","observed_orcids":["https://orcid.org/0000-0002-9838-3710"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Be\u00e1ta T\u00f6r\u00f6csik","raw_affiliation_strings":["Department of Medical Biochemistry 1 and 2","MTA-SE Ion Channel Research Group, Semmelweis University, Budapest H-1094, Hungary 1 and 2","Department of Medical Biochemistry and MTA-SE Ion Channel Research Group, Semmelweis University, Budapest H-1094, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry 1 and 2","institution_ids":[]},{"raw_affiliation_string":"MTA-SE Ion Channel Research Group, Semmelweis University, Budapest H-1094, Hungary 1 and 2","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I7597260"]},{"raw_affiliation_string":"Department of Medical Biochemistry and MTA-SE Ion Channel Research Group, Semmelweis University, Budapest H-1094, Hungary","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I7597260"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088037931"],"corresponding_institution_ids":["https://openalex.org/I101202996","https://openalex.org/I7597260"],"apc_list":null,"apc_paid":null,"fwci":1.3345,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.82461763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"144","issue":"4","first_page":"321","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cftr-potentiators","display_name":"CFTR potentiators","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nppb","display_name":"NPPB","score":0.9789999723434448},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8109999895095825},{"id":"https://openalex.org/keywords/deltaf508-cftr","display_name":"\u0394F508-CFTR","score":0.8069999814033508},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/nucleotide-binding-domain","display_name":"nucleotide-binding domain","score":0.6859999895095825},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.5419999957084656},{"id":"https://openalex.org/keywords/open-probability","display_name":"open probability","score":0.625},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/chloride-channels","display_name":"chloride channels","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C164718446","wikidata":"https://www.wikidata.org/wiki/Q7234839","display_name":"Potentiator","level":2,"score":0.9617634415626526},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.6478562951087952},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.543622612953186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4643770754337311},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.46353983879089355},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4614146947860718},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.44573262333869934},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.3872290849685669},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3361222743988037},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3343013823032379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28095245361328125},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23525506258010864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23241734504699707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21762654185295105},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009579","descriptor_name":"Nitrobenzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1085/jgp.201411246","doi":"https://doi.org/10.1085/jgp.201411246","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.201411246","pdf_url":"https://rupress.org/jgp/article-pdf/144/4/321/1231225/jgp_201411246.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4178936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4178936","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"},{"id":"pmid:25267914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25267914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"Journal Article"},{"id":"pmh:oai:real.mtak.hu:20610","doi":null,"is_oa":false,"landing_page_url":"http://real.mtak.hu/20610/1/MTMT2761953.pdf","pdf_url":"http://real.mtak.hu/20610/1/MTMT2761953.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repo.lib.semmelweis.hu:123456789/1103","doi":null,"is_oa":false,"landing_page_url":"http://repo.lib.semmelweis.hu//handle/123456789/1103","pdf_url":null,"source":{"id":"https://openalex.org/S4306402199","display_name":"Semmelweis University Repository (Semmelweis University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I101202996","host_organization_name":"Semmelweis University","host_organization_lineage":["https://openalex.org/I101202996"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1085/jgp.201411246","doi":"https://doi.org/10.1085/jgp.201411246","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.201411246","pdf_url":"https://rupress.org/jgp/article-pdf/144/4/321/1231225/jgp_201411246.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2951405611","display_name":"Mechanisms, Structure, and Regulation of CFTRs NBDs","funder_award_id":"R01DK051767","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116304552.pdf","grobid_xml":"https://content.openalex.org/works/W2116304552.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1524370537","https://openalex.org/W1901161002","https://openalex.org/W1975971473","https://openalex.org/W1977944550","https://openalex.org/W1988003798","https://openalex.org/W1995579048","https://openalex.org/W2004155358","https://openalex.org/W2004844038","https://openalex.org/W2006856042","https://openalex.org/W2011532795","https://openalex.org/W2020558888","https://openalex.org/W2035131077","https://openalex.org/W2035478373","https://openalex.org/W2039599894","https://openalex.org/W2039688935","https://openalex.org/W2043673791","https://openalex.org/W2045331285","https://openalex.org/W2051221113","https://openalex.org/W2053020161","https://openalex.org/W2058530636","https://openalex.org/W2059043844","https://openalex.org/W2064581901","https://openalex.org/W2067463439","https://openalex.org/W2071407356","https://openalex.org/W2080281443","https://openalex.org/W2084896237","https://openalex.org/W2093013713","https://openalex.org/W2102781109","https://openalex.org/W2114087686","https://openalex.org/W2115046089","https://openalex.org/W2124233675","https://openalex.org/W2124886725","https://openalex.org/W2140868856","https://openalex.org/W2148028731","https://openalex.org/W2156445984","https://openalex.org/W2169992673"],"related_works":["https://openalex.org/W2102781109","https://openalex.org/W6998917074","https://openalex.org/W2489339849","https://openalex.org/W4353055525","https://openalex.org/W2084896237","https://openalex.org/W2041207269","https://openalex.org/W2002825233","https://openalex.org/W2148269714","https://openalex.org/W2061687679","https://openalex.org/W2330332303"],"abstract_inverted_index":{"The":[0,79,123],"cystic":[1],"fibrosis":[2],"(CF)":[3],"transmembrane":[4],"conductance":[5],"regulator":[6],"(CFTR)":[7],"is":[8,115,141,152,199],"a":[9,32,117,224],"member":[10],"of":[11,25,50,85,99,120,126,130,135,150,159,168,179,187,191,205,234,246,258,285],"the":[12,26,61,131,169,177,183,196,227,244,262,267,273,278],"ATP-binding":[13],"cassette":[14],"transporter":[15],"superfamily":[16],"that":[17,55,155,219,230],"functions":[18],"as":[19],"an":[20,51],"epithelial":[21],"chloride":[22],"channel.":[23],"Gating":[24],"CFTR":[27,71,101,137,237,295],"ion":[28],"conduction":[29],"pore":[30,173,211,228],"involves":[31,157],"conserved":[33],"irreversible":[34],"cyclic":[35,193],"mechanism":[36],"driven":[37],"by":[38,143,166,208],"ATP":[39,58,67,206,279],"binding":[40],"and":[41,93,95,108,182,229,254],"hydrolysis":[42,68,207,280],"at":[43,223],"two":[44,57,248],"cytosolic":[45],"nucleotide-binding":[46],"domains":[47],"(NBDs):":[48],"formation":[49],"intramolecular":[52],"NBD":[53],"dimer":[54,64],"occludes":[56],"molecules":[59],"opens":[60],"pore,":[62],"whereas":[63,272],"disruption":[65],"after":[66],"closes":[69],"it.":[70],"dysfunction":[72],"resulting":[73],"from":[74],"inherited":[75],"mutations":[76],"causes":[77],"CF.":[78],"most":[80,132],"common":[81],"CF":[82,121],"mutation,":[83],"deletion":[84],"phenylalanine":[86],"508":[87],"(\u0394F508),":[88],"impairs":[89],"both":[90,176,257],"protein":[91],"folding":[92],"processing":[94],"channel":[96,180],"gating.":[97],"Development":[98],"\u0394F508":[100,136],"correctors":[102],"(to":[103,110],"increase":[104],"cell":[105],"surface":[106],"expression)":[107],"potentiators":[109,134],"enhance":[111],"open":[112],"probability,":[113],"Po)":[114],"therefore":[116],"key":[118],"focus":[119],"research.":[122],"practical":[124],"utility":[125],"5-nitro-2-(3-phenylpropylamino)benzoate":[127],"(NPPB),":[128],"one":[129,242],"efficacious":[133],"identified":[138],"to":[139,241],"date,":[140],"limited":[142],"its":[144,247],"pore-blocking":[145,263],"side":[146],"effect.":[147],"NPPB-mediated":[148],"stimulation":[149],"Po":[151,200],"unique":[153],"in":[154],"it":[156],"modulation":[158],"gating":[160,194,222],"transition":[161,170,268],"state":[162,171,269],"stability.":[163],"Although":[164],"stabilization":[165],"NPPB":[167,209,220,235,286],"for":[172,270,290],"opening":[174,181],"enhances":[175],"rate":[178,186],"very":[184],"slow":[185],"nonhydrolytic":[188],"closure,":[189,212],"because":[190],"CFTR's":[192],"mechanism,":[195],"net":[197],"effect":[198],"stimulation.":[201],"In":[202],"addition,":[203],"slowing":[204],"delays":[210],"further":[213],"enhancing":[214],"Po.":[215],"Here":[216],"we":[217],"show":[218],"stimulates":[221],"site":[225],"outside":[226],"these":[231],"individual":[232],"actions":[233],"on":[236],"are":[238],"fully":[239],"attributable":[240],"or":[243],"other":[245],"complementary":[249],"molecular":[250],"parts,":[251],"3-nitrobenzoate":[252],"(3NB)":[253],"3-phenylpropylamine":[255],"(3PP),":[256],"which":[259],"stimulate":[260],"Po:":[261],"3NB":[264],"selectively":[265,276],"stabilizes":[266],"opening,":[271],"nonblocking":[274],"3PP":[275],"slows":[277],"step.":[281],"Understanding":[282],"structure-activity":[283],"relationships":[284],"might":[287],"prove":[288],"useful":[289],"designing":[291],"potent,":[292],"clinically":[293],"relevant":[294],"potentiators.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
