{"id":"https://openalex.org/W2116180802","doi":null,"title":"Nuclear localization of protein kinase C- induces thyroid hormone receptor-1 expression in the cardiomyocyte","display_name":"Nuclear localization of protein kinase C- induces thyroid hormone receptor-1 expression in the cardiomyocyte","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2116180802","mag":"2116180802"},"language":"en","primary_location":{"id":"mag:2116180802","doi":null,"is_oa":false,"landing_page_url":"https://ajpheart.physiology.org/content/ajpheart/290/1/h381.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013217555","display_name":"\u00c1gnes Kenessey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00c1gnes Kenessey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103627906","display_name":"Elizabeth Ann Sullivan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Ann Sullivan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019876328","display_name":"Kaie Ojamaa","orcid":"https://orcid.org/0000-0002-0130-7456","observed_orcids":["https://orcid.org/0000-0002-0130-7456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaie Ojamaa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0130-7456","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9059,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.76937611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6899999976158142},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ischemic-cardiomyopathy","display_name":"ischemic cardiomyopathy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/thyroid-hormone-transporters","display_name":"thyroid hormone transporters","score":0.8029999732971191},{"id":"https://openalex.org/keywords/deiodinases","display_name":"deiodinases","score":0.8679999709129333},{"id":"https://openalex.org/keywords/thyroid-hormone-signaling","display_name":"thyroid hormone signaling","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.773385226726532},{"id":"https://openalex.org/C149574134","wikidata":"https://www.wikidata.org/wiki/Q18031987","display_name":"Thyroid hormone receptor beta","level":5,"score":0.7654324173927307},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7549506425857544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7411759495735168},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7400650382041931},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.7305803894996643},{"id":"https://openalex.org/C160860887","wikidata":"https://www.wikidata.org/wiki/Q18031986","display_name":"Thyroid hormone receptor alpha","level":5,"score":0.6592901349067688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4824979305267334},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48129335045814514},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.4464668929576874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3102080821990967},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2116180802","doi":null,"is_oa":false,"landing_page_url":"https://ajpheart.physiology.org/content/ajpheart/290/1/h381.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W201874790","https://openalex.org/W379853218","https://openalex.org/W1639524097","https://openalex.org/W1995135039","https://openalex.org/W1996573898","https://openalex.org/W2002637742","https://openalex.org/W2004922458","https://openalex.org/W2006418305","https://openalex.org/W2006584250","https://openalex.org/W2013279903","https://openalex.org/W2029120861","https://openalex.org/W2029546557","https://openalex.org/W2030688800","https://openalex.org/W2039490994","https://openalex.org/W2040382523","https://openalex.org/W2052128932","https://openalex.org/W2054791134","https://openalex.org/W2065417808","https://openalex.org/W2077168161","https://openalex.org/W2079047912","https://openalex.org/W2095564610","https://openalex.org/W2096912742","https://openalex.org/W2102038264","https://openalex.org/W2105395690","https://openalex.org/W2107854036","https://openalex.org/W2119706727","https://openalex.org/W2123857698","https://openalex.org/W2132412402","https://openalex.org/W2133338733","https://openalex.org/W2136924194","https://openalex.org/W2150063597","https://openalex.org/W2153430526","https://openalex.org/W2160488497","https://openalex.org/W2165779745","https://openalex.org/W2166733596","https://openalex.org/W2168251353","https://openalex.org/W2169197998","https://openalex.org/W2169617094","https://openalex.org/W2286512859","https://openalex.org/W2297620948","https://openalex.org/W2325705904","https://openalex.org/W2418809996","https://openalex.org/W2521896158","https://openalex.org/W4366064120"],"related_works":["https://openalex.org/W2194236779","https://openalex.org/W7100742094","https://openalex.org/W7098610036","https://openalex.org/W1617051758","https://openalex.org/W2107854036","https://openalex.org/W2133338733","https://openalex.org/W2102038264","https://openalex.org/W2136924194","https://openalex.org/W2105395690","https://openalex.org/W2020990732"],"abstract_inverted_index":{"dium":[0],"may":[1,9,117,134],"be":[2,135],"impaired":[3],"in":[4,12,26,51,91,103,111,147],"the":[5,52,92,104,107],"failing":[6],"heart,":[7],"which":[8],"include":[10],"alterations":[11,110],"nuclear":[13],"thyroid":[14,32,100,124,132,140],"hormone":[15,101,119,125],"receptors":[16],"(TRs)":[17],"and":[18,39,49,56,84,121],"their":[19],"transcriptional":[20],"coregulators,":[21],"or":[22,28],"alternatively,":[23],"a":[24],"decrease":[25],"serum":[27],"tissue":[29,129],"levels":[30,77],"of":[31,35,46,69,78,98,131,139],"hormones.":[33],"Studies":[34],"patients":[36],"with":[37],"ischemic":[38],"dilated":[40],"cardiomyopathy":[41],"have":[42],"reported":[43],"contradictory":[44],"results":[45],"both":[47],"increases":[48],"decreases":[50],"TR":[53,57,80],"mRNA":[54,76],"isoforms,":[55],"protein":[58],"data":[59],"are":[60],"lacking":[61],"(7,":[62],"23,":[63],"39).":[64],"An":[65],"experimental":[66],"animal":[67],"model":[68],"pathological":[70,115],"cardiac":[71],"hypertrophy":[72],"has":[73,144],"shown":[74,146],"that":[75,88,109],"three":[79],"isoforms":[81],"were":[82],"downregulated,":[83],"it":[85],"was":[86],"concluded":[87],"this":[89],"resulted":[90],"hypertrophic":[93],"phenotype":[94],"(24).":[95],"Recent":[96],"identification":[97],"specific":[99],"transporters":[102,113],"myocardium":[105],"raises":[106],"possibility":[108],"these":[112],"under":[114],"conditions":[116],"affect":[118],"uptake":[120],"thus":[122],"cardiacspecific":[123],"function":[126],"(14).":[127],"Alternatively,":[128],"content":[130],"hormones":[133],"decreased":[136],"by":[137],"induction":[138],"hormone-degrading":[141],"deiodinases":[142],"as":[143],"been":[145]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
