{"id":"https://openalex.org/W2116106546","doi":"https://doi.org/10.1158/0008-5472.933.65.3","title":"Combined Haploinsufficiency for ATM and RAD9 as a Factor in Cell Transformation, Apoptosis, and DNA Lesion Repair Dynamics","display_name":"Combined Haploinsufficiency for ATM and RAD9 as a Factor in Cell Transformation, Apoptosis, and DNA Lesion Repair Dynamics","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2116106546","doi":"https://doi.org/10.1158/0008-5472.933.65.3","mag":"2116106546","pmid":"https://pubmed.ncbi.nlm.nih.gov/15705893"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.933.65.3","doi":"https://doi.org/10.1158/0008-5472.933.65.3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.933.65.3","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/3/933/2539509/933-938.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/65/3/933/2539509/933-938.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111602472","display_name":"Lubomir B. Smilenov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lubomir B. Smilenov","raw_affiliation_strings":["Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","Center for Radiological Research, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Center for Radiological Research, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009696243","display_name":"Howard B. Lieberman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Howard B. Lieberman","raw_affiliation_strings":["Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113776784","display_name":"Stephen Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Stephen A. Mitchell","raw_affiliation_strings":["Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089919045","display_name":"Ronald A. Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Ronald A. Baker","raw_affiliation_strings":["Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053785009","display_name":"Kevin M. Hopkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Kevin M. Hopkins","raw_affiliation_strings":["Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011597168","display_name":"Eric J. Hall","orcid":"https://orcid.org/0000-0003-4564-657X","observed_orcids":["https://orcid.org/0000-0003-4564-657X"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Eric J. Hall","raw_affiliation_strings":["Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Rigshospitalet, University Hospital, Copenhagen, Denmark, TopoTarget A/S, Copenhagen, Denmark, SAIC-Frederic, National Cancer Institute at Frederic, MD, Developmental Therapeutics Program, National Cancer Institute at Frederik, MD","institution_ids":["https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6519,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.82124244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"65","issue":"3","first_page":"933","last_page":"938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.9039999842643738},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.9789999723434448},{"id":"https://openalex.org/keywords/rad9","display_name":"Rad9","score":0.9980000257492065},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/radiation-induced-transformation","display_name":"radiation-induced transformation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7850000262260437},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.7870000004768372},{"id":"https://openalex.org/keywords/heterozygosity","display_name":"heterozygosity","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.8932923078536987},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5454654097557068},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5073997378349304},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4670397639274597},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46558988094329834},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4527847468852997},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4467490315437317},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.4419183135032654},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3908063769340515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3062439560890198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24742195010185242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23193228244781494},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13036873936653137},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0985877513885498},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08301287889480591},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07875043153762817},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.933.65.3","doi":"https://doi.org/10.1158/0008-5472.933.65.3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.933.65.3","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/3/933/2539509/933-938.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:15705893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15705893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.657.5045","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.657.5045","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://raraf.org/journal/cr65-933.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.933.65.3","doi":"https://doi.org/10.1158/0008-5472.933.65.3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.933.65.3","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/3/933/2539509/933-938.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1341906203","display_name":"Mechanisms of Radioresistance and Cell Cycle Progression","funder_award_id":"R01GM052493","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G222768804","display_name":null,"funder_award_id":"DE\u2010FG02\u2010","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G5024148642","display_name":"INDIVIDUAL GENETIC SUSCEPTIBILITY","funder_award_id":"FG02-03ER63629","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6870304921","display_name":"Mrad9 Radioresistance Gene","funder_award_id":"R01CA089816","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7506902747","display_name":"INDIVIDUAL GENETIC SUSCEPTIBLITY","funder_award_id":"NAG91519","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320308932","display_name":"Radiological Society of North America","ror":"https://ror.org/00rj4x019"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116106546.pdf","grobid_xml":"https://content.openalex.org/works/W2116106546.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W110294243","https://openalex.org/W1498188099","https://openalex.org/W1558103766","https://openalex.org/W1563743635","https://openalex.org/W1805263181","https://openalex.org/W1900147325","https://openalex.org/W1973813521","https://openalex.org/W1974441944","https://openalex.org/W1984055384","https://openalex.org/W1986719937","https://openalex.org/W1994848650","https://openalex.org/W1997439972","https://openalex.org/W2001077402","https://openalex.org/W2012759709","https://openalex.org/W2022811243","https://openalex.org/W2033200608","https://openalex.org/W2046928699","https://openalex.org/W2056231922","https://openalex.org/W2059566143","https://openalex.org/W2060067137","https://openalex.org/W2062546873","https://openalex.org/W2066969492","https://openalex.org/W2072683029","https://openalex.org/W2084266051","https://openalex.org/W2084883784","https://openalex.org/W2096632866","https://openalex.org/W2100641548","https://openalex.org/W2110948748","https://openalex.org/W2111772438","https://openalex.org/W2117298495","https://openalex.org/W2132222969","https://openalex.org/W2138172020","https://openalex.org/W2145339783","https://openalex.org/W2154581874","https://openalex.org/W2159969460","https://openalex.org/W2161554904","https://openalex.org/W2163183874","https://openalex.org/W2593504837"],"related_works":["https://openalex.org/W7096736681","https://openalex.org/W2109692972","https://openalex.org/W2146184790","https://openalex.org/W2057496292","https://openalex.org/W2169604945","https://openalex.org/W2967031979","https://openalex.org/W2017297714","https://openalex.org/W1981567601","https://openalex.org/W2004932721","https://openalex.org/W2061455523"],"abstract_inverted_index":{"Loss":[0],"of":[1,3,19,22,29,75,93,97,149,185,213],"function":[2],"oncogenes,":[4],"tumor":[5],"suppressor":[6],"genes":[7,12],"and":[8,65,129,152,169,197,216,226],"DNA":[9,53,68,109,137,164,200,220],"damage":[10,69,110,138],"processing":[11],"has":[13],"been":[14],"implicated":[15],"in":[16,52,62,218],"the":[17,26,41,73,94,133,195,204,211],"development":[18],"many":[20],"types":[21],"cancer,":[23],"but":[24],"for":[25,49,77,99,105,123,182,199],"vast":[27],"majority":[28],"cases,":[30],"there":[31],"is":[32,70,80],"no":[33],"link":[34],"to":[35,47,58,87,132,136,158],"specific":[36,231],"germ":[37],"line":[38],"mutations.":[39],"In":[40],"last":[42],"several":[43],"years,":[44],"heterozygosity":[45,98],"leading":[46],"haploinsufficiency":[48,76],"proteins":[50,154,215],"involved":[51],"repair":[54,112,167,201,221],"pathways":[55,106],"was":[56],"shown":[57],"play":[59],"a":[60,91,230],"role":[61],"genomic":[63],"instability":[64],"carcinogenesis":[66],"after":[67],"induced.":[71],"Because":[72],"effect":[74,96],"one":[78,124,184],"protein":[79],"relatively":[81],"small,":[82],"we":[83],"hypothesize":[84],"that":[85,107,144,191],"predisposition":[86],"cancer":[88],"could":[89],"be":[90],"result":[92],"additive":[95],"two":[100,126],"or":[101,113,125,178],"more":[102,156],"genes,":[103],"critical":[104],"control":[108],"signaling,":[111],"apoptosis.":[114],"To":[115],"address":[116],"this":[117],"issue,":[118],"primary":[119],"mouse":[120],"cells,":[121],"haploinsufficient":[122,181],"proteins,":[127],"ATM":[128,151],"RAD9,":[130],"related":[131],"cellular":[134],"response":[135],"were":[139],"examined.":[140],"The":[141],"results":[142],"show":[143],"cells":[145,180],"having":[146],"low":[147],"levels":[148],"both":[150,214],"RAD9":[153],"are":[155,170,190,224],"sensitive":[157],"transformation":[159],"by":[160,203],"radiation,":[161],"have":[162],"different":[163],"double-strand":[165],"break":[166],"dynamics":[168],"less":[171],"apoptotic":[172],"when":[173],"compared":[174],"with":[175],"wild-type":[176],"controls":[177],"those":[179],"only":[183],"these":[186],"proteins.":[187],"Our":[188],"conclusions":[189],"under":[192],"stress":[193],"conditions,":[194],"efficiency":[196],"capacity":[198],"mediated":[202],"ATM/RAD9":[205],"cell":[206],"signaling":[207],"network":[208,222],"depend":[209],"on":[210],"abundance":[212],"that,":[217],"general,":[219],"efficiencies":[223],"genotype-dependent":[225],"can":[227],"vary":[228],"within":[229],"range.":[232]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
