{"id":"https://openalex.org/W2116089455","doi":"https://doi.org/10.1681/asn.v111134","title":"Serum Total Homocysteine and Cardiovascular Disease Occurrence in Chronic, Stable Renal Transplant Recipients","display_name":"Serum Total Homocysteine and Cardiovascular Disease Occurrence in Chronic, Stable Renal Transplant Recipients","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2116089455","doi":"https://doi.org/10.1681/asn.v111134","mag":"2116089455","pmid":"https://pubmed.ncbi.nlm.nih.gov/10616849"},"language":"en","primary_location":{"id":"doi:10.1681/asn.v111134","doi":"https://doi.org/10.1681/asn.v111134","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.v111134","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"DIDIER DUCLOUX","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136727","display_name":"H\u00f4pital Saint-Jacques","ror":"https://ror.org/03n6qxm88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978","https://openalex.org/I4210136727"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"DIDIER DUCLOUX","raw_affiliation_strings":["Department of Nephrology and Renal Transplantation, Saint Jacques Hospital, Besan\u00e7on, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Renal Transplantation, Saint Jacques Hospital, Besan\u00e7on, France","institution_ids":["https://openalex.org/I4210136727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"GE[Combining Acute Accent]RARD MOTTE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136727","display_name":"H\u00f4pital Saint-Jacques","ror":"https://ror.org/03n6qxm88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978","https://openalex.org/I4210136727"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"GE[Combining Acute Accent]RARD MOTTE","raw_affiliation_strings":["Department of Nephrology and Renal Transplantation, Saint Jacques Hospital, Besan\u00e7on, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Renal Transplantation, Saint Jacques Hospital, Besan\u00e7on, France","institution_ids":["https://openalex.org/I4210136727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069911188","display_name":"Bruno Challier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136727","display_name":"H\u00f4pital Saint-Jacques","ror":"https://ror.org/03n6qxm88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978","https://openalex.org/I4210136727"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"BRUNO CHALLIER","raw_affiliation_strings":["Department of Medical Information, Saint Jacques Hospital, Besan\u00e7on, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Information, Saint Jacques Hospital, Besan\u00e7on, France","institution_ids":["https://openalex.org/I4210136727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040573218","display_name":"ROGER GIBEY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136727","display_name":"H\u00f4pital Saint-Jacques","ror":"https://ror.org/03n6qxm88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978","https://openalex.org/I4210136727"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"ROGER GIBEY","raw_affiliation_strings":["Department of Biochemistry, Saint Jacques Hospital, Besan\u00e7on, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Saint Jacques Hospital, Besan\u00e7on, France","institution_ids":["https://openalex.org/I4210136727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111586464","display_name":"Jean\u2010Marc Chalopin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136727","display_name":"H\u00f4pital Saint-Jacques","ror":"https://ror.org/03n6qxm88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978","https://openalex.org/I4210136727"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"JEAN-MARC CHALOPIN","raw_affiliation_strings":["Department of Nephrology and Renal Transplantation, Saint Jacques Hospital, Besan\u00e7on, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Renal Transplantation, Saint Jacques Hospital, Besan\u00e7on, France","institution_ids":["https://openalex.org/I4210136727"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111586464"],"corresponding_institution_ids":["https://openalex.org/I4210136727"],"apc_list":null,"apc_paid":null,"fwci":16.5699,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.99541122,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"134","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-homocysteine","display_name":"total homocysteine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.878000020980835},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.7620000243186951},{"id":"https://openalex.org/keywords/creatinine","display_name":"creatinine","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.4339999854564667},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.44600000977516174},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.930752694606781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8279708623886108},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.7588412761688232},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.737445592880249},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6165584921836853},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5812046527862549},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5725322961807251},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5713749527931213},{"id":"https://openalex.org/C2992666275","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Renal transplant","level":3,"score":0.5221964716911316},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.5052297711372375},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4758814871311188},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4528246521949768},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.434481680393219}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017677","descriptor_name":"Age Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017678","descriptor_name":"Sex Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1681/asn.v111134","doi":"https://doi.org/10.1681/asn.v111134","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.v111134","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmid:10616849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10616849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1939259427","https://openalex.org/W1975357252","https://openalex.org/W1978891951","https://openalex.org/W2002691808","https://openalex.org/W2083659967","https://openalex.org/W2098872123","https://openalex.org/W2130956156","https://openalex.org/W2257551340","https://openalex.org/W2332685851","https://openalex.org/W2342150662","https://openalex.org/W2406641344","https://openalex.org/W2415131613","https://openalex.org/W3145894777"],"related_works":["https://openalex.org/W4233044068","https://openalex.org/W2083398971","https://openalex.org/W1696867062","https://openalex.org/W2130956156","https://openalex.org/W2787676987","https://openalex.org/W2067786324","https://openalex.org/W2066695131","https://openalex.org/W2251865836","https://openalex.org/W2047535815","https://openalex.org/W2083659967"],"abstract_inverted_index":{"Renal":[0],"transplant":[1,20,41,62,277],"recipients":[2,21],"have":[3,22],"disproportionately":[4],"high":[5],"rates":[6,291],"of":[7,26,66,106,159,218,271,283,286],"arteriosclerotic":[8],"outcomes,":[9],"and":[10,53,98,237],"recent":[11],"studies":[12,29,282],"provided":[13],"controlled":[14],"evidence":[15],"that":[16,31,185,259],"clinically":[17],"stable":[18,60,275],"renal":[19,40,61,276],"an":[23,212,264],"excess":[24],"prevalence":[25],"hyperhomocysteinemia.":[27],"Few":[28],"suggest":[30],"hyperhomocysteinemia":[32,67],"may":[33],"be":[34],"a":[35,188],"cardiovascular":[36,75,192],"risk":[37,76,189,195,266],"factor":[38,190,267],"in":[39,58,149,166,214,223,273,295],"recipients.":[42,63,278],"In":[43],"the":[44,48,269,284],"study":[45,257],"presented":[46],"here,":[47],"association":[49],"between":[50],"atherosclerotic":[51],"events":[52,143,155],"homocysteine":[54,92,281],"concentrations":[55],"was":[56,68,81,94,101,129,187],"examined":[57],"207":[59],"The":[64,78],"role":[65],"analyzed":[69],"with":[70,119],"respect":[71],"to":[72,88,132,204,211,232,245],"other":[73],"known":[74],"factors.":[77],"mean":[79],"follow-up":[80],"21.2":[82],"+/-":[83,172,176],"1.9":[84],"mo":[85],"(range,":[86],"14":[87],"26).":[89],"Mean":[90],"total":[91],"(tHcy)":[93],"21.1":[95],"+/-9.5":[96],"micromol/L":[97,221],"median":[99],"concentration":[100,121,134,239],"19":[102],"micromol/L.":[103],"Seventy":[104],"percent":[105],"patients":[107,151,167],"(n":[108],"=":[109,123,136],"153)":[110],"were":[111,147,164,250],"hyperhomocysteinemic":[112],"(values":[113],">15":[114],"micromol/L).":[115],"tHcy":[116,128,162,186,224,262,287],"correlated":[117],"negatively":[118],"folate":[120],"(r":[122,135],"-0.3;":[124],"P":[125,138,178,206,234,247],"<":[126,139,179,207,235,248],"0.01).":[127],"closely":[130],"related":[131],"creatinine":[133,238],"0.54;":[137],"0.001).":[140,180],"Cardiovascular":[141],"disease":[142],"(CVE)":[144],"including":[145],"death":[146],"observed":[148],"30":[150],"(14.5":[152],"%;":[153],"7.34":[154],"per":[156,220],"1000":[157],"person-months":[158],"follow-up).":[160],"Fasting":[161],"values":[163],"higher":[165],"who":[168],"experienced":[169],"CVE":[170,217,272,290],"(31.5":[171],"10.3":[173],"versus":[174],"17.8":[175],"7.5;":[177],"Cox":[181],"regression":[182],"analysis":[183],"showed":[184],"for":[191,216,254,268],"complications":[193],"(relative":[194],"[RR]":[196],"1.06;":[197],"95%":[198,229,242],"confidence":[199],"interval":[200],"(95%":[201],"CI),":[202],"1.04":[203],"1.09;":[205],"0.0001).":[208],"This":[209,256],"corresponds":[210],"increase":[213,222],"RR":[215],"6%":[219],"concentration.":[225],"Age":[226],"(RR":[227,240],"1.55;":[228],"CI,":[230,243],"1.09":[231],"2.19;":[233],"0.01)":[236,249],"1.34;":[241],"1.08":[244],"1.66;":[246],"also":[251],"independent":[252,265],"predictors":[253],"CVE.":[255],"demonstrates":[258],"elevated":[260],"fasting":[261],"is":[263],"development":[270],"chronic":[274],"Randomized,":[279],"placebo-controlled":[280],"effect":[285],"lowering":[288],"on":[289],"are":[292],"urgently":[293],"required":[294],"this":[296],"patient":[297],"population.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
