{"id":"https://openalex.org/W2116045918","doi":null,"title":"Immunohistochemical comparison of Lea, monosialosyl Lea (CA 19-9), and disialosyl Lea antigens in human colorectal and pancreatic tissues.","display_name":"Immunohistochemical comparison of Lea, monosialosyl Lea (CA 19-9), and disialosyl Lea antigens in human colorectal and pancreatic tissues.","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W2116045918","mag":"2116045918","pmid":"https://pubmed.ncbi.nlm.nih.gov/3288336"},"language":"en","primary_location":{"id":"pmid:3288336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3288336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090463240","display_name":"Steven H. Itzkowitz","orcid":"https://orcid.org/0000-0002-0436-5416","observed_orcids":["https://orcid.org/0000-0002-0436-5416"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Itzkowitz","raw_affiliation_strings":["Gastrointestinal Research Laboratory, Veterans Administration Medical Center, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Research Laboratory, Veterans Administration Medical Center, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090614836","display_name":"Mei Yuan","orcid":"https://orcid.org/0000-0002-4729-4216","observed_orcids":["https://orcid.org/0000-0002-4729-4216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Yuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111748185","display_name":"Y Fukushi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Fukushi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018847323","display_name":"Haebeom Lee","orcid":"https://orcid.org/0000-0002-1594-6670","observed_orcids":["https://orcid.org/0000-0002-1594-6670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026202331","display_name":"Zhang Shi","orcid":"https://orcid.org/0000-0001-7739-7497","observed_orcids":["https://orcid.org/0000-0001-7739-7497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z R Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112384094","display_name":"V R Zurawski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Zurawski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070398233","display_name":"Sen\u2010itiroh Hakomori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hakomori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039898931","display_name":"Y S Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y S Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6637,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.84936076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"48","issue":"13","first_page":"3834","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lea-antigen","display_name":"Lea antigen","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.972000002861023},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.6299999952316284},{"id":"https://openalex.org/keywords/sialyltransferase","display_name":"sialyltransferase","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.8600000143051147},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.9120000004768372},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/adenomatous-polyps","display_name":"adenomatous polyps","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hyperplastic-polyps","display_name":"hyperplastic polyps","score":0.9200000166893005},{"id":"https://openalex.org/keywords/alpha2-6-sialylation","display_name":"\u03b12,6-sialylation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/antigen-masking","display_name":"antigen masking","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.770188570022583},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6035380363464355},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5855599641799927},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5667511224746704},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.5296977162361145},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.467158704996109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4025253653526306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3409440517425537},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32422351837158203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.245449036359787},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19962918758392334}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006001","descriptor_name":"Glycoconjugates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007410","descriptor_name":"Intestinal Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007417","descriptor_name":"Intestinal Polyps","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007983","descriptor_name":"Lewis Blood Group Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015295","descriptor_name":"Antigens, Tumor-Associated, Carbohydrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3288336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3288336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2116045918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3288336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3568352201","display_name":"INCOMPATIBLE BLOOD GROUP ANTIGENS IN COLON CANCER","funder_award_id":"R01CA042981","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W50722438","https://openalex.org/W129021991","https://openalex.org/W167666288","https://openalex.org/W1018473039","https://openalex.org/W1519346233","https://openalex.org/W1522206763","https://openalex.org/W1527496389","https://openalex.org/W1575885714","https://openalex.org/W1600578319","https://openalex.org/W1754937767","https://openalex.org/W1845453293","https://openalex.org/W1933489752","https://openalex.org/W1994581656","https://openalex.org/W2003897775","https://openalex.org/W2012509070","https://openalex.org/W2012643763","https://openalex.org/W2019918727","https://openalex.org/W2025244793","https://openalex.org/W2043539979","https://openalex.org/W2043732014","https://openalex.org/W2047215316","https://openalex.org/W2070396290","https://openalex.org/W2096990907","https://openalex.org/W2098001605","https://openalex.org/W2110834473","https://openalex.org/W2135755348","https://openalex.org/W2151224520","https://openalex.org/W2151455294","https://openalex.org/W2259718726","https://openalex.org/W2273673960","https://openalex.org/W2291744357","https://openalex.org/W2297875394","https://openalex.org/W2298332748","https://openalex.org/W2325741009","https://openalex.org/W2410521522","https://openalex.org/W2411507600","https://openalex.org/W4298813148","https://openalex.org/W4302914221"],"related_works":["https://openalex.org/W212992147","https://openalex.org/W1483158525","https://openalex.org/W2417868200","https://openalex.org/W7096132379","https://openalex.org/W2068593170","https://openalex.org/W2008244753","https://openalex.org/W2409023073","https://openalex.org/W2508267943","https://openalex.org/W1997254873","https://openalex.org/W2474416780"],"abstract_inverted_index":{"The":[0,55,175,224],"CA":[1,265],"19-9":[2,266],"antigen":[3,10,20,193,267],"is":[4,92,257],"a":[5,17,28,39,45,71,95,279],"monosialosyl":[6,64,118,241],"Lea":[7,68,91,103,107,119,129,143,242,250],"blood":[8],"group":[9],"which":[11,259],"has":[12],"been":[13],"shown":[14],"to":[15],"be":[16],"useful":[18],"tumor-associated":[19,96,286],"for":[21],"the":[22,60,80,126,138,150,169,207,210,235,238,246,262,273,283],"diagnosis":[23],"of":[24,31,62,73,79,137,166,173,177,197,204,221,226,240,248,264,285],"gastrointestinal":[25],"cancers.":[26],"Recently,":[27],"sialylated":[29],"derivative":[30],"this":[32,50],"antigen,":[33],"disialosyl":[34,67,90,102,142,249],"Lea,":[35,63,65],"was":[36,53,122,130,144,195],"isolated":[37],"from":[38],"colon":[40,170],"cancer":[41],"liver":[42],"metastasis":[43],"and":[44,66,76,82,114,180,190,218],"monoclonal":[46],"antibody":[47],"(FH7)":[48],"recognizing":[49],"novel":[51],"determinant":[52],"developed.":[54],"present":[56],"study":[57],"simultaneously":[58],"compared":[59],"expression":[61,104,108,194,284],"antigens":[69,212],"in":[70,109,134,146,191,234,245,261,281],"variety":[72],"nonmalignant,":[74],"premalignant,":[75],"malignant":[77],"tissues":[78],"colorectum":[81],"pancreas":[83],"with":[84],"an":[85,253],"aim":[86],"toward":[87],"elucidating":[88],"whether":[89],"expressed":[93,133,156,186,214,229],"as":[94,160],"antigen.":[97],"In":[98,206],"normal":[99,208,236],"colonic":[100,154],"mucosa,":[101],"closely":[105],"resembled":[106],"overall":[110],"frequency,":[111],"segmental":[112],"distribution,":[113],"cellular":[115],"localization":[116],"whereas":[117,141],"(CA":[120,243],"19-9)":[121,244],"essentially":[123],"absent.":[124],"Along":[125],"crypt":[127,140],"axis,":[128],"more":[131],"often":[132],"goblet":[135,147],"cells":[136,148,220],"upper":[139],"found":[145],"along":[149],"entire":[151],"crypt.":[152],"Fetal":[153],"mucosa":[155],"all":[157,182,222,230],"three":[158,188,211,231],"antigens,":[159,189],"did":[161],"most":[162],"colorectal":[163],"cancers":[164,228],"regardless":[165],"location":[167],"within":[168],"or":[171,202],"degree":[172,203],"differentiation.":[174],"majority":[176,225],"hyperplastic":[178],"polyps":[179,184],"practically":[181],"adenomatous":[183],"also":[185],"these":[187],"adenomas,":[192],"independent":[196],"polyp":[198],"size,":[199],"villous":[200],"morphology,":[201],"dysplasia.":[205],"pancreas,":[209],"were":[213],"on":[215],"ductal,":[216],"ductular":[217],"centroacinar":[219],"specimens.":[223],"pancreatic":[227],"antigens.":[232,287],"Thus,":[233],"colon,":[237],"absence":[239],"presence":[247],"suggests":[251],"that":[252,275],"alpha":[254],"2,6":[255],"sialyltransferase":[256],"active,":[258],"results":[260,270],"masking":[263],"expression.":[268],"These":[269],"further":[271],"support":[272],"concept":[274],"specific":[276],"sialyltransferases":[277],"play":[278],"role":[280],"regulating":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}