{"id":"https://openalex.org/W2116008650","doi":null,"title":"Signal Transduction in Mast Cell Migration","display_name":"Signal Transduction in Mast Cell Migration","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2116008650","mag":"2116008650"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-1474","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1474","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1474","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111602132","display_name":"Magnus Sundstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Magnus Sundstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111602132"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cell-migration","display_name":"mast cell migration","score":0.9929999709129333},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mastocytosis","display_name":"mastocytosis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hmc-1-cell-line","display_name":"HMC-1 cell line","score":0.8840000033378601},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.7739999890327454},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9179999828338623},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.8149999976158142},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.843999981880188},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mast-cell-accumulation","display_name":"mast cell accumulation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mast-cell-lines","display_name":"mast cell lines","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.8496530055999756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5983569025993347},{"id":"https://openalex.org/C122862929","wikidata":"https://www.wikidata.org/wiki/Q18048437","display_name":"Interleukin 33","level":4,"score":0.546447217464447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5402109622955322},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5051835179328918},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4430423974990845},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.44041967391967773},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.4360368251800537},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.4346253275871277},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.41652292013168335},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37941455841064453},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3222507834434509},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2734290659427643},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1653735637664795},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.1576043665409088},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11342334747314453},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.1076364517211914},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.10282498598098755}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-1474","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1474","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2116008650","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/7915","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-1474","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1474","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":224,"referenced_works":["https://openalex.org/W11751756","https://openalex.org/W34467361","https://openalex.org/W65045043","https://openalex.org/W101749175","https://openalex.org/W130474040","https://openalex.org/W137971093","https://openalex.org/W154745092","https://openalex.org/W184526982","https://openalex.org/W195988415","https://openalex.org/W235541509","https://openalex.org/W256605437","https://openalex.org/W279932454","https://openalex.org/W1428006903","https://openalex.org/W1485952297","https://openalex.org/W1486872989","https://openalex.org/W1493400757","https://openalex.org/W1503484830","https://openalex.org/W1504271198","https://openalex.org/W1507654024","https://openalex.org/W1508470956","https://openalex.org/W1511722376","https://openalex.org/W1514031343","https://openalex.org/W1519269060","https://openalex.org/W1528496162","https://openalex.org/W1530655559","https://openalex.org/W1531495231","https://openalex.org/W1534849356","https://openalex.org/W1548908535","https://openalex.org/W1550035003","https://openalex.org/W1552274890","https://openalex.org/W1552835744","https://openalex.org/W1563224204","https://openalex.org/W1570625730","https://openalex.org/W1570863417","https://openalex.org/W1575606714","https://openalex.org/W1577145787","https://openalex.org/W1579093659","https://openalex.org/W1588122907","https://openalex.org/W1590210001","https://openalex.org/W1590890399","https://openalex.org/W1592402132","https://openalex.org/W1593199101","https://openalex.org/W1599496006","https://openalex.org/W1600203168","https://openalex.org/W1601094160","https://openalex.org/W1609684706","https://openalex.org/W1636878974","https://openalex.org/W1638151543","https://openalex.org/W1644900513","https://openalex.org/W1645519732","https://openalex.org/W1652780616","https://openalex.org/W1663371441","https://openalex.org/W1664836047","https://openalex.org/W1680126513","https://openalex.org/W1705770238","https://openalex.org/W1783032344","https://openalex.org/W1788785930","https://openalex.org/W1795089629","https://openalex.org/W1818076359","https://openalex.org/W1828661048","https://openalex.org/W1845412871","https://openalex.org/W1854589240","https://openalex.org/W1862349412","https://openalex.org/W1884631150","https://openalex.org/W1896134422","https://openalex.org/W1911518888","https://openalex.org/W1912462612","https://openalex.org/W1950481374","https://openalex.org/W1964806452","https://openalex.org/W1964822816","https://openalex.org/W1965695376","https://openalex.org/W1966931906","https://openalex.org/W1967265143","https://openalex.org/W1969563780","https://openalex.org/W1970113458","https://openalex.org/W1970129719","https://openalex.org/W1976321898","https://openalex.org/W1976755134","https://openalex.org/W1979398938","https://openalex.org/W1979582578","https://openalex.org/W1986936995","https://openalex.org/W1988784360","https://openalex.org/W1990095143","https://openalex.org/W1991175004","https://openalex.org/W1993233738","https://openalex.org/W1998783767","https://openalex.org/W2000415265","https://openalex.org/W2000551045","https://openalex.org/W2000998080","https://openalex.org/W2001144373","https://openalex.org/W2001421696","https://openalex.org/W2001961027","https://openalex.org/W2003288227","https://openalex.org/W2004619982","https://openalex.org/W2005792688","https://openalex.org/W2006993291","https://openalex.org/W2007206244","https://openalex.org/W2008760033","https://openalex.org/W2008940139","https://openalex.org/W2010503112","https://openalex.org/W2010684388","https://openalex.org/W2011838221","https://openalex.org/W2014082408","https://openalex.org/W2015492609","https://openalex.org/W2016085259","https://openalex.org/W2018171716","https://openalex.org/W2019248775","https://openalex.org/W2019838514","https://openalex.org/W2019941955","https://openalex.org/W2021680936","https://openalex.org/W2023194647","https://openalex.org/W2024510824","https://openalex.org/W2025639998","https://openalex.org/W2032359283","https://openalex.org/W2033872369","https://openalex.org/W2034184306","https://openalex.org/W2034200063","https://openalex.org/W2034203371","https://openalex.org/W2037010084","https://openalex.org/W2037695813","https://openalex.org/W2037751628","https://openalex.org/W2038774594","https://openalex.org/W2039037540","https://openalex.org/W2041831485","https://openalex.org/W2042793661","https://openalex.org/W2045204290","https://openalex.org/W2045577652","https://openalex.org/W2045593483","https://openalex.org/W2047773927","https://openalex.org/W2048993739","https://openalex.org/W2050560415","https://openalex.org/W2051518322","https://openalex.org/W2051853465","https://openalex.org/W2054154416","https://openalex.org/W2054846695","https://openalex.org/W2055000429","https://openalex.org/W2056175166","https://openalex.org/W2057126981","https://openalex.org/W2058107714","https://openalex.org/W2058872987","https://openalex.org/W2061443292","https://openalex.org/W2062010118","https://openalex.org/W2062199188","https://openalex.org/W2062241862","https://openalex.org/W2063436204","https://openalex.org/W2063778211","https://openalex.org/W2064435481","https://openalex.org/W2064934740","https://openalex.org/W2068959750","https://openalex.org/W2071008257","https://openalex.org/W2072109254","https://openalex.org/W2072814893","https://openalex.org/W2075501121","https://openalex.org/W2075758761","https://openalex.org/W2079100569","https://openalex.org/W2079517510","https://openalex.org/W2081166085","https://openalex.org/W2081592351","https://openalex.org/W2082317371","https://openalex.org/W2084000386","https://openalex.org/W2088310945","https://openalex.org/W2089276418","https://openalex.org/W2090149923","https://openalex.org/W2097071478","https://openalex.org/W2098419353","https://openalex.org/W2101307456","https://openalex.org/W2101429849","https://openalex.org/W2102385086","https://openalex.org/W2104923755","https://openalex.org/W2104943404","https://openalex.org/W2112811492","https://openalex.org/W2122081319","https://openalex.org/W2126440693","https://openalex.org/W2129379081","https://openalex.org/W2130708019","https://openalex.org/W2131607618","https://openalex.org/W2134860029","https://openalex.org/W2135882030","https://openalex.org/W2136896400","https://openalex.org/W2139524845","https://openalex.org/W2140922568","https://openalex.org/W2143052000","https://openalex.org/W2143576013","https://openalex.org/W2146440075","https://openalex.org/W2149604229","https://openalex.org/W2151489147","https://openalex.org/W2151900782","https://openalex.org/W2155699400","https://openalex.org/W2156160133","https://openalex.org/W2156597055","https://openalex.org/W2161472286","https://openalex.org/W2161733130","https://openalex.org/W2162851671","https://openalex.org/W2163220652","https://openalex.org/W2164094961","https://openalex.org/W2165720262","https://openalex.org/W2166236102","https://openalex.org/W2171620774","https://openalex.org/W2171961734","https://openalex.org/W2172972738","https://openalex.org/W2183810936","https://openalex.org/W2197012898","https://openalex.org/W2232994425","https://openalex.org/W2253046940","https://openalex.org/W2262976102","https://openalex.org/W2266102693","https://openalex.org/W2296776321","https://openalex.org/W2297496700","https://openalex.org/W2317914677","https://openalex.org/W2325250004","https://openalex.org/W2335187016","https://openalex.org/W2336303117","https://openalex.org/W2388388295","https://openalex.org/W2398205484","https://openalex.org/W2400609710","https://openalex.org/W2408865772","https://openalex.org/W2410011135","https://openalex.org/W2411647852","https://openalex.org/W2418038137","https://openalex.org/W2490192303","https://openalex.org/W4296927411","https://openalex.org/W4313310009","https://openalex.org/W4313316693","https://openalex.org/W4313341535"],"related_works":["https://openalex.org/W563341132","https://openalex.org/W2030342411","https://openalex.org/W2029434537","https://openalex.org/W1994965327","https://openalex.org/W133695607","https://openalex.org/W374020002","https://openalex.org/W167584193","https://openalex.org/W319492083","https://openalex.org/W2071624194","https://openalex.org/W4224303155"],"abstract_inverted_index":{"Mast":[0],"cells":[1,5,20,68,141,271,287],"are":[2,159,195],"essential":[3,110],"effector":[4],"in":[6,24,37,47,60,69,90,126,161,187,249,258,308],"the":[7,38,58,70,86,103,107,120,165,188,259,262,297,309,328],"immune":[8],"system":[9],"as":[10,28,145,178,180],"they":[11],"release":[12],"several":[13],"inflammatory":[14,25],"mediators.":[15],"An":[16],"accumulation":[17,125,248],"of":[18,66,102,183,196,215,280,299,320],"mast":[19,34,61,67,77,93,112,123,136,199,246,273,313],"has":[21],"been":[22,143],"described":[23],"conditions":[26],"such":[27],"asthma":[29],"and":[30,40,89,117,119,156,168,204,272,306],"allergic":[31],"rhinitis.":[32],"Increased":[33],"cell":[35,62,78,82,105,113,124,137,200,247,274,314],"number,":[36],"skin":[39],"other":[41],"organs,":[42],"is":[43,64],"also":[44],"a":[45,49,146,226,277],"characteristic":[46],"mastocytosis,":[48],"disease":[50],"without":[51],"an":[52,254],"effective":[53],"treatment.":[54],"One":[55],"explanation":[56],"for":[57,111,198,218,245,261,312],"increase":[59],"number":[63],"migration":[65,114,201,281,315],"tissue.":[71],"In":[72,221,292],"our":[73,294],"studies":[74],"we":[75,153],"utilised":[76],"lines,":[79],"including":[80],"HMC-1;":[81],"lines":[83],"transfected":[84,270],"with":[85,286],"c-kit":[87],"gene;":[88],"vitro":[91],"developed":[92],"cells.":[94],"Our":[95,128],"aim":[96],"was":[97,211,234],"to":[98,131,213,252,268,276,326],"characterise,":[99],"two":[100,150,300],"variants":[101],"HMC-1":[104,140],"line;":[106],"signalling":[108,193,304],"pathways":[109,194,305],"towards":[115,202,282],"TGF-\u03b2":[116,203],"SCF;":[118],"mechanism":[121,244,329],"regulating":[122],"mastocytosis.":[127],"results":[129,295],"help":[130],"explain":[132],"inconsistent":[133],"findings":[134],"regarding":[135,174],"biology":[138],"when":[139],"have":[142],"used":[144,160],"model":[147],"system.":[148],"The":[149,206],"variants,":[151],"which":[152,232],"name":[154],"HMC-1560":[155,167],"HMC-1560,":[157,169],"816,":[158],"different":[162,172,301],"laboratories":[163],"around":[164],"world.":[166],"816":[170],"exhibited":[171],"characteristics":[173],"their":[175,181],"karyotype,":[176],"phenotype":[177],"well":[179],"set":[182],"activating":[184,255],"point":[185,256],"mutations":[186,307],"Kit":[189,263,290,310],"receptor.":[190,264,291],"Furthermore,":[191],"divergent":[192],"importance":[197,298],"SCF.":[205],"classical":[207],"MAP":[208,239,302],"kinase-signalling":[209],"cascade":[210],"found":[212],"be":[214,253],"major":[216],"relevance":[217],"TGF-\u03b2-induced":[219],"migration.":[220],"contrast,":[222],"this":[223],"pathway":[224],"had":[225],"modest":[227],"impact":[228],"on":[229,237],"SCF-induced":[230],"migration,":[231],"instead":[233],"highly":[235],"dependent":[236],"p38":[238],"kinase":[240,303],"signalling.":[241],"Finally,":[242],"one":[243],"mastocytosis":[250],"appeared":[251,267],"mutation":[257,266],"gene":[260],"This":[265,322],"prone":[269],"progenitors":[275],"higher":[278],"rate":[279],"SCF":[283],"if":[284],"compared":[285],"expressing":[288],"wt":[289],"conclusion,":[293],"show":[296],"receptor":[311],"induced":[316],"by":[317],"various":[318],"types":[319],"stimuli.":[321],"knowledge":[323],"helps":[324],"us":[325],"understand":[327]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
