{"id":"https://openalex.org/W2115996245","doi":"https://doi.org/10.4049/jimmunol.163.1.337","title":"Schistosome-Infected IL-4 Receptor Knockout (KO) Mice, in Contrast to IL-4 KO Mice, Fail to Develop Granulomatous Pathology While Maintaining the Same Lymphokine Expression Profile","display_name":"Schistosome-Infected IL-4 Receptor Knockout (KO) Mice, in Contrast to IL-4 KO Mice, Fail to Develop Granulomatous Pathology While Maintaining the Same Lymphokine Expression Profile","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2115996245","doi":"https://doi.org/10.4049/jimmunol.163.1.337","mag":"2115996245","pmid":"https://pubmed.ncbi.nlm.nih.gov/10384133"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.163.1.337","doi":"https://doi.org/10.4049/jimmunol.163.1.337","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.1.337","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073562393","display_name":"Dragana Lj. Jankovic","orcid":"https://orcid.org/0000-0001-7360-1809","observed_orcids":["https://orcid.org/0000-0001-7360-1809"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dragana Jankovic","raw_affiliation_strings":["Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","*Immunobiology Section, Laboratory of Parasitic Diseases, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"*Immunobiology Section, Laboratory of Parasitic Diseases, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007182284","display_name":"Marika C. Kullberg","orcid":"https://orcid.org/0000-0003-2081-7029","observed_orcids":["https://orcid.org/0000-0003-2081-7029"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marika C Kullberg","raw_affiliation_strings":["Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","*Immunobiology Section, Laboratory of Parasitic Diseases, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"*Immunobiology Section, Laboratory of Parasitic Diseases, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044327796","display_name":"Nancy Noben-Trauth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Noben-Trauth","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109867155","display_name":"Patricia Caspar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia Caspar","raw_affiliation_strings":["Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","*Immunobiology Section, Laboratory of Parasitic Diseases, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"*Immunobiology Section, Laboratory of Parasitic Diseases, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061909361","display_name":"Jerrold Michael Ward","orcid":"https://orcid.org/0000-0002-6350-8982","observed_orcids":["https://orcid.org/0000-0002-6350-8982"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerrold M Ward","raw_affiliation_strings":["Animal Science Branch, National Cancer Institute, National Institutes of Health , Frederick, MD 21702","\u2021Animal Science Branch, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Science Branch, National Cancer Institute, National Institutes of Health , Frederick, MD 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"\u2021Animal Science Branch, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109218978","display_name":"Allen W. Cheever","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210137803","display_name":"Biomedical Research Institute","ror":"https://ror.org/03yr0pg70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137803"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen W Cheever","raw_affiliation_strings":["\u00a7Biomedical Research Institute, Rockville, MD 20852","Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","*Immunobiology Section, Laboratory of Parasitic Diseases, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Biomedical Research Institute, Rockville, MD 20852","institution_ids":["https://openalex.org/I4210137803"]},{"raw_affiliation_string":"Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"*Immunobiology Section, Laboratory of Parasitic Diseases, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110180932","display_name":"William E. Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E Paul","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016487212","display_name":"Alan Sher","orcid":"https://orcid.org/0000-0001-7053-2895","observed_orcids":["https://orcid.org/0000-0001-7053-2895"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Sher","raw_affiliation_strings":["Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","*Immunobiology Section, Laboratory of Parasitic Diseases, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"*Immunobiology Section, Laboratory of Parasitic Diseases, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016487212","https://openalex.org/A5073562393","https://openalex.org/A5109867155"],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":9.0572,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.98742431,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"163","issue":"1","first_page":"337","last_page":"342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.972000002861023},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/il-4-knockout-mice","display_name":"IL-4 knockout mice","score":0.9750000238418579},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.8240000009536743},{"id":"https://openalex.org/keywords/egg-granuloma","display_name":"egg granuloma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7689999938011169},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6404170989990234},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.6356287002563477},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5897558331489563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5822059512138367},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.564691424369812},{"id":"https://openalex.org/C2779237934","wikidata":"https://www.wikidata.org/wiki/Q7643652","display_name":"Mesenteric lymph nodes","level":3,"score":0.5213490724563599},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4999275207519531},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.4866274297237396},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4461357891559601},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.42888548970222473},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.41680338978767395},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35295891761779785},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.31827759742736816},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.2948429584503174},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.266706645488739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1293150782585144},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.08323606848716736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000909","descriptor_name":"Antibodies, Helminth","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008109","descriptor_name":"Liver Diseases, Parasitic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008109","descriptor_name":"Liver Diseases, Parasitic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008109","descriptor_name":"Liver Diseases, Parasitic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008109","descriptor_name":"Liver Diseases, Parasitic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008643","descriptor_name":"Mesentery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010063","descriptor_name":"Ovum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010063","descriptor_name":"Ovum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012555","descriptor_name":"Schistosomiasis mansoni","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012555","descriptor_name":"Schistosomiasis mansoni","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012555","descriptor_name":"Schistosomiasis mansoni","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012555","descriptor_name":"Schistosomiasis mansoni","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019948","descriptor_name":"Receptors, Interleukin-4","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019948","descriptor_name":"Receptors, Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.163.1.337","doi":"https://doi.org/10.4049/jimmunol.163.1.337","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.1.337","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10384133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10384133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1494254017","https://openalex.org/W1502422472","https://openalex.org/W1537669972","https://openalex.org/W1549521886","https://openalex.org/W1559956988","https://openalex.org/W1562876419","https://openalex.org/W1585904443","https://openalex.org/W1594137577","https://openalex.org/W1595075646","https://openalex.org/W1600319253","https://openalex.org/W1600662889","https://openalex.org/W1609125121","https://openalex.org/W1611891187","https://openalex.org/W1612135387","https://openalex.org/W1634158134","https://openalex.org/W1705611457","https://openalex.org/W1845629018","https://openalex.org/W1965366343","https://openalex.org/W1994982942","https://openalex.org/W2031501484","https://openalex.org/W2041765961","https://openalex.org/W2043189165","https://openalex.org/W2045873742","https://openalex.org/W2056698790","https://openalex.org/W2065902165","https://openalex.org/W2081973949","https://openalex.org/W2084168776","https://openalex.org/W2095127706","https://openalex.org/W2107122759","https://openalex.org/W2120797502","https://openalex.org/W2121941042","https://openalex.org/W2123288507","https://openalex.org/W2129189963","https://openalex.org/W2139144899","https://openalex.org/W2140492247","https://openalex.org/W2141429703","https://openalex.org/W2158129229","https://openalex.org/W2165160101","https://openalex.org/W2171111656","https://openalex.org/W4313331220"],"related_works":["https://openalex.org/W2129189963","https://openalex.org/W1611891187","https://openalex.org/W2067517571","https://openalex.org/W1705611457","https://openalex.org/W832841042","https://openalex.org/W2126203283","https://openalex.org/W2160281115","https://openalex.org/W770073022","https://openalex.org/W2009140753","https://openalex.org/W2114145532"],"abstract_inverted_index":{"Th2":[0,40,156,182],"lymphocytes":[1],"have":[2],"been":[3],"postulated":[4],"to":[5,52,60,186,194,211,229],"play":[6],"a":[7,144,233],"major":[8],"role":[9],"in":[10,31,42,82,92,123,133,147,159,176,202,224,227],"the":[11,36,39,76,83,188,212],"immunopathology":[12],"induced":[13],"by":[14],"Schistosoma":[15],"mansoni":[16],"infection.":[17],"Nevertheless,":[18],"infected":[19,64,103,160],"IL-4":[20,54,61,96,177,191],"knockout":[21],"(KO)":[22],"and":[23,55,73,95,106,151,171],"wild-type":[24],"(wt)":[25],"mice":[26,67,98,163,193],"develop":[27],"egg":[28,43,85,111,196],"granulomas":[29,72],"comparable":[30],"size.":[32],"To":[33],"further":[34],"investigate":[35],"function":[37],"of":[38,78,141,190,206,209],"response":[41,183],"pathology":[44,223],"we":[45],"studied":[46],"IL-4Ralpha-deficient":[47,203],"mice,":[48],"which":[49,198],"are":[50],"nonresponsive":[51],"both":[53,139],"IL-13.":[56],"In":[57,101],"striking":[58],"contrast":[59],"KO":[62,66,97,124,162,178,192],"animals,":[63,143],"IL-4Ralpha":[65,161],"developed":[68,109],"only":[69,169],"minimal":[70],"hepatic":[71],"fibrosis":[74],"despite":[75],"presence":[77],"CD3+":[79],"T":[80],"cells":[81],"residual":[84,181],"lesions.":[86],"Moreover,":[87],"liver":[88],"lymphokine":[89],"mRNA":[90],"levels":[91],"these":[93,218],"animals":[94,108,204],"were":[99],"equivalent.":[100],"addition,":[102],"IL-4Ralpha-deficient,":[104],"IL-4-deficient,":[105],"wt":[107],"similar":[110],"Ag-specific":[112],"IgG":[113],"Ab":[114,153],"titers,":[115],"arguing":[116],"that":[117,173,221],"CD4-dependent":[118],"Th":[119],"activity":[120],"is":[121,184],"intact":[122],"mice.":[125],"As":[126],"expected,":[127],"IFN-gamma":[128],"secretion":[129],"was":[130,164,168],"strongly":[131],"up-regulated":[132],"mesenteric":[134],"lymph":[135],"node":[136],"cultures":[137],"from":[138],"groups":[140],"deficient":[142],"change":[145],"reflected":[146],"increased":[148],"serum":[149],"IgG2a":[150],"IgG2b":[152],"levels.":[154],"Surprisingly,":[155],"cytokine":[157,214],"production":[158],"not":[165],"abolished":[166],"but":[167],"reduced":[170],"resembled":[172],"previously":[174,234],"documented":[175],"animals.":[179],"This":[180],"likely":[185],"explain":[187],"ability":[189],"generate":[195],"granulomas,":[197],"cannot":[199],"be":[200],"formed":[201],"because":[205],"their":[207],"lack":[208],"responsiveness":[210],"same":[213],"ligands.":[215],"Taken":[216],"together,":[217],"findings":[219],"argue":[220],"tissue":[222],"schistosomiasis":[225],"requires,":[226],"addition":[228],"egg-specific":[230],"CD4+":[231],"lymphocytes,":[232],"unrecognized":[235],"IL-4Ralpha+":[236],"non-T":[237],"cell":[238],"effector":[239],"population.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
