{"id":"https://openalex.org/W2115929664","doi":"https://doi.org/10.1186/1297-9716-42-110","title":"Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom","display_name":"Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2115929664","doi":"https://doi.org/10.1186/1297-9716-42-110","mag":"2115929664","pmid":"https://pubmed.ncbi.nlm.nih.gov/22040234","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3224758"},"language":"en","primary_location":{"id":"doi:10.1186/1297-9716-42-110","doi":"https://doi.org/10.1186/1297-9716-42-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1297-9716-42-110","pdf_url":"https://veterinaryresearch.biomedcentral.com/counter/pdf/10.1186/1297-9716-42-110","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://veterinaryresearch.biomedcentral.com/counter/pdf/10.1186/1297-9716-42-110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017463196","display_name":"Wilfred Goldmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Wilfred Goldmann","raw_affiliation_strings":["The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK. Wilfred.goldmann@roslin.ed.ac.uk","The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK. Wilfred.goldmann@roslin.ed.ac.uk","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]},{"raw_affiliation_string":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003531952","display_name":"Kelly Ryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kelly Ryan","raw_affiliation_strings":["The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053930843","display_name":"Paula Stewart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paula Stewart","raw_affiliation_strings":["The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054887673","display_name":"David Parnham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Parnham","raw_affiliation_strings":["The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084372742","display_name":"Rosa Xicohtencatl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I721619","display_name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla","ror":"https://ror.org/03p2z7827","country_code":"MX","type":"education","lineage":["https://openalex.org/I721619"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rosa Xicohtencatl","raw_affiliation_strings":["Facultad de Medicina Veterinaria y Zootecnia, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina Veterinaria y Zootecnia, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, M\u00e9xico","institution_ids":["https://openalex.org/I721619"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nora Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I721619","display_name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla","ror":"https://ror.org/03p2z7827","country_code":"MX","type":"education","lineage":["https://openalex.org/I721619"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Nora Fernandez","raw_affiliation_strings":["Facultad de Medicina Veterinaria y Zootecnia, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina Veterinaria y Zootecnia, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, M\u00e9xico","institution_ids":["https://openalex.org/I721619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070624253","display_name":"Ginny C. Saunders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ginny Saunders","raw_affiliation_strings":["Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, UK","Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, UK","institution_ids":["https://openalex.org/I174729306"]},{"raw_affiliation_string":"Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, UK","institution_ids":["https://openalex.org/I174729306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042979326","display_name":"Otto Windl","orcid":"https://orcid.org/0000-0002-6595-6041","observed_orcids":["https://orcid.org/0000-0002-6595-6041"]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Otto Windl","raw_affiliation_strings":["Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, UK","Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, UK","institution_ids":["https://openalex.org/I174729306"]},{"raw_affiliation_string":"Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, UK","institution_ids":["https://openalex.org/I174729306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109234328","display_name":"Lorenzo Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lorenzo Gonz\u00e1lez","raw_affiliation_strings":["Animal Health and Veterinary Laboratories Agency, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Health and Veterinary Laboratories Agency, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, UK","institution_ids":["https://openalex.org/I174729306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019280027","display_name":"Alex Bossers","orcid":"https://orcid.org/0000-0002-6586-717X","observed_orcids":["https://orcid.org/0000-0002-6586-717X"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alex Bossers","raw_affiliation_strings":["Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"last","author":{"id":null,"display_name":"James Foster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Foster","raw_affiliation_strings":["The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017463196"],"corresponding_institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":1.816,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.84974794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"42","issue":"1","first_page":"110","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classical-scrapie","display_name":"classical scrapie","score":0.8820000290870667},{"id":"https://openalex.org/keywords/goats","display_name":"goats","score":0.8259999752044678},{"id":"https://openalex.org/keywords/prnp-gene","display_name":"PRNP gene","score":0.7459999918937683},{"id":"https://openalex.org/keywords/prion-protein-polymorphism","display_name":"prion protein polymorphism","score":0.8840000033378601},{"id":"https://openalex.org/keywords/scrapie-resistance","display_name":"scrapie resistance","score":0.8980000019073486},{"id":"https://openalex.org/keywords/genetic-selection","display_name":"genetic selection","score":0.5699999928474426},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2778147599","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"PRNP","level":4,"score":0.9639596343040466},{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.9462988376617432},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7869420051574707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7591503858566284},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6854987144470215},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5503675937652588},{"id":"https://openalex.org/C194775826","wikidata":"https://www.wikidata.org/wiki/Q209542","display_name":"Herd","level":2,"score":0.4254513680934906},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.41068702936172485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3724204897880554},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2984841763973236},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.2186679244041443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10320988297462463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06260880827903748},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015511","descriptor_name":"Goat Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015511","descriptor_name":"Goat Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1297-9716-42-110","doi":"https://doi.org/10.1186/1297-9716-42-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1297-9716-42-110","pdf_url":"https://veterinaryresearch.biomedcentral.com/counter/pdf/10.1186/1297-9716-42-110","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2223836","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3224758","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3224758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3224758","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vet Res","raw_type":"Text"},{"id":"pmid:22040234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22040234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary research","raw_type":"Journal Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/417452","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/caprine-prion-genen-polymorphisms-are-associated-with-decreased-i","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 0928-4249","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:pure.ed.ac.uk:publications/db028d77-2f24-4612-ac8b-c7bd4311c9d9","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/db028d77-2f24-4612-ac8b-c7bd4311c9d9","pdf_url":"https://www.research.ed.ac.uk/en/publications/db028d77-2f24-4612-ac8b-c7bd4311c9d9","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Goldmann, W, Ryan, K, Stewart, P, Parnham, D, Xicohtencatl, R, Fernandez, N, Saunders, G, Windl, O, Gonzalez, L, A., B & Foster, J 2011, 'Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom', Veterinary Research, vol. 42, no. n/a, 110. https://doi.org/10.1186/1297-9716-42-110","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:4d0bfd85eb634492931c9ffb09d1bae8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4d0bfd85eb634492931c9ffb09d1bae8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary Research, Vol 42, Iss 1, p 110 (2011)","raw_type":"article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/417452","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/caprine-prion-genen-polymorphisms-are-associated-with-decreased-i","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary Research, 42","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1297-9716-42-110","doi":"https://doi.org/10.1186/1297-9716-42-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1297-9716-42-110","pdf_url":"https://veterinaryresearch.biomedcentral.com/counter/pdf/10.1186/1297-9716-42-110","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.6735000014305115,"id":"https://metadata.un.org/sdg/2"},{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1718518320","display_name":"Nature of TSE infection and Routes of Transmission","funder_award_id":"BBS/E/D/05241340","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8236242795","display_name":null,"funder_award_id":"BBS/E/D/05241340","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334787","display_name":"Animal Health and Veterinary Laboratories Agency","ror":"https://ror.org/0378g3743"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115929664.pdf","grobid_xml":"https://content.openalex.org/works/W2115929664.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1968729092","https://openalex.org/W1977612821","https://openalex.org/W1987802048","https://openalex.org/W1994111832","https://openalex.org/W2009629060","https://openalex.org/W2016565903","https://openalex.org/W2024112495","https://openalex.org/W2050953418","https://openalex.org/W2084993091","https://openalex.org/W2103889571","https://openalex.org/W2107373007","https://openalex.org/W2116226826","https://openalex.org/W2117520729","https://openalex.org/W2125196937","https://openalex.org/W2129312008","https://openalex.org/W2131324280","https://openalex.org/W2132832871","https://openalex.org/W2143113093","https://openalex.org/W2146246590","https://openalex.org/W2149246722","https://openalex.org/W2153688562","https://openalex.org/W2156964954","https://openalex.org/W2157468951","https://openalex.org/W2164069584","https://openalex.org/W2164599456","https://openalex.org/W2171774421","https://openalex.org/W2337671914","https://openalex.org/W4211121722"],"related_works":["https://openalex.org/W3185592859","https://openalex.org/W3124287723","https://openalex.org/W7171804106","https://openalex.org/W4401356662","https://openalex.org/W7098763399","https://openalex.org/W4229739899","https://openalex.org/W7223182142","https://openalex.org/W2616333714","https://openalex.org/W2112111794","https://openalex.org/W2233469717"],"abstract_inverted_index":{"The":[0,152,195],"application":[1],"of":[2,19,36,68,83,102,115,126,138,163,197,222],"genetic":[3,220,250],"breeding":[4],"programmes":[5],"to":[6,92,111,188,211,238],"eradicate":[7],"transmissible":[8],"spongiform":[9],"encephalopathies":[10],"in":[11,42,44,55,74,117,130,141,148,192,200,214,227,242,245],"goats":[12,59,118,203],"is":[13],"an":[14],"important":[15],"aim":[16],"for":[17,123],"reasons":[18],"animal":[20],"welfare":[21],"as":[22,24],"well":[23,179],"human":[25],"food":[26,29],"safety":[27],"and":[28,64,94],"security.":[30],"Based":[31],"on":[32,39],"the":[33,45,61,66,81,84,103,124,166,246],"positive":[34,122],"impact":[35],"Prnp":[37,52,69,87,139,198,223],"genetics":[38],"sheep":[40],"scrapie":[41,116,240],"Europe":[43],"past":[46],"decade,":[47],"we":[48],"have":[49],"established":[50],"caprine":[51],"gene":[53],"variation":[54],"more":[56],"than":[57],"1100":[58],"from":[60],"United":[62,135,247],"Kingdom":[63,136,248],"studied":[65],"association":[67,82,101],"alleles":[70,147],"with":[71,89,107,174],"disease":[72],"phenotypes":[73],"150":[75],"scrapie-positive":[76],"goats.":[77],"This":[78],"investigation":[79],"confirms":[80],"Met142":[85,153],"encoding":[86,105,154,168,184],"allele":[88,106,155,161,169,183],"increased":[90],"resistance":[91,181],"preclinical":[93],"clinical":[95,113],"scrapie.":[96],"It":[97],"reveals":[98],"a":[99,108,157,178,208],"novel":[100,209],"Ser127":[104,167],"reduced":[109],"probability":[110],"develop":[112],"signs":[114],"that":[119,218,233],"are":[120],"already":[121],"accumulation":[125],"disease-specific":[127],"prion":[128],"protein":[129],"brain":[131],"or":[132],"periphery.":[133],"A":[134],"survey":[137],"genotypes":[140,199],"eight":[142],"common":[143],"breeds":[144],"revealed":[145,204],"eleven":[146],"over":[149],"thirty":[150],"genotypes.":[151],"had":[156],"high":[158,219],"overall":[159],"mean":[160],"frequency":[162,170],"22.6%,":[164],"whereas":[165],"was":[171,186],"considerably":[172],"lower":[173,239],"6.4%.":[175],"In":[176],"contrast,":[177],"known":[180],"associated":[182],"Lys222":[185],"found":[187,226],"be":[189,225,236],"rare":[190],"(0.9%)":[191],"this":[193],"survey.":[194],"analysis":[196],"Mexican":[201],"Criollas":[202],"nine":[205],"alleles,":[206],"including":[207],"Phe":[210],"Leu":[212],"substitution":[213],"codon":[215],"201,":[216],"confirming":[217],"variability":[221],"can":[224],"scrapie-free":[228],"populations.":[229],"Our":[230],"study":[231],"implies":[232],"it":[234],"should":[235],"feasible":[237],"prevalence":[241],"goat":[243],"herds":[244],"by":[249],"selection.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
