{"id":"https://openalex.org/W2115865500","doi":"https://doi.org/10.4049/jimmunol.1400620","title":"SHP-1 Plays a Crucial Role in CD40 Signaling Reciprocity","display_name":"SHP-1 Plays a Crucial Role in CD40 Signaling Reciprocity","publication_year":2014,"publication_date":"2014-09-04","ids":{"openalex":"https://openalex.org/W2115865500","doi":"https://doi.org/10.4049/jimmunol.1400620","mag":"2115865500","pmid":"https://pubmed.ncbi.nlm.nih.gov/25187664"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1400620","doi":"https://doi.org/10.4049/jimmunol.1400620","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1400620","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082245764","display_name":"Tabish Hasan Khan","orcid":"https://orcid.org/0000-0002-0143-7496","observed_orcids":["https://orcid.org/0000-0002-0143-7496"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tabish Hasan Khan","raw_affiliation_strings":["National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","institution_ids":["https://openalex.org/I4210104670"]},{"raw_affiliation_string":"*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085697733","display_name":"Neetu Srivastava","orcid":"https://orcid.org/0000-0001-7315-6258","observed_orcids":["https://orcid.org/0000-0001-7315-6258"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Neetu Srivastava","raw_affiliation_strings":["National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","institution_ids":["https://openalex.org/I4210104670"]},{"raw_affiliation_string":"*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ankita Srivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ankita Srivastava","raw_affiliation_strings":["National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","institution_ids":["https://openalex.org/I4210104670"]},{"raw_affiliation_string":"*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108751343","display_name":"Archana Sareen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Archana Sareen","raw_affiliation_strings":["National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","institution_ids":["https://openalex.org/I4210104670"]},{"raw_affiliation_string":"*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023913397","display_name":"Ramkumar Mathur","orcid":"https://orcid.org/0000-0002-9317-2631","observed_orcids":["https://orcid.org/0000-0002-9317-2631"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ram K Mathur","raw_affiliation_strings":["National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","institution_ids":["https://openalex.org/I4210104670"]},{"raw_affiliation_string":"*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012883477","display_name":"Ajit G. Chande","orcid":"https://orcid.org/0000-0003-2210-5180","observed_orcids":["https://orcid.org/0000-0003-2210-5180"]},"institutions":[{"id":"https://openalex.org/I4210157422","display_name":"Advanced Centre for Treatment, Research and Education in Cancer","ror":"https://ror.org/05b9pgt88","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698","https://openalex.org/I4210157422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ajit G Chande","raw_affiliation_strings":["Advanced Centre for Treatment Research and Education in Cancer , Kharghar, Navi Mumbai 410 210 ,","Advanced Centre for Treatment Research and Education in Cancer, Kharghar, Navi Mumbai 410 210, India; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Centre for Treatment Research and Education in Cancer , Kharghar, Navi Mumbai 410 210 ,","institution_ids":["https://openalex.org/I4210157422"]},{"raw_affiliation_string":"Advanced Centre for Treatment Research and Education in Cancer, Kharghar, Navi Mumbai 410 210, India; and","institution_ids":["https://openalex.org/I4210157422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006510459","display_name":"Musti V. Krishnasastry","orcid":"https://orcid.org/0000-0001-7746-3167","observed_orcids":["https://orcid.org/0000-0001-7746-3167"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Krishnasastry V Musti","raw_affiliation_strings":["National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","institution_ids":["https://openalex.org/I4210104670"]},{"raw_affiliation_string":"*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107896694","display_name":"Somenath Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41549804","display_name":"Vidyasagar University","ror":"https://ror.org/027jsza11","country_code":"IN","type":"education","lineage":["https://openalex.org/I41549804"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Somenath Roy","raw_affiliation_strings":["Vidyasagar University , Midnapore 721 102 ,","\u2021Vidyasagar University, Midnapore 721 102, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vidyasagar University , Midnapore 721 102 ,","institution_ids":["https://openalex.org/I41549804"]},{"raw_affiliation_string":"\u2021Vidyasagar University, Midnapore 721 102, India","institution_ids":["https://openalex.org/I41549804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111383807","display_name":"Robin Mukhopadhyaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157422","display_name":"Advanced Centre for Treatment, Research and Education in Cancer","ror":"https://ror.org/05b9pgt88","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698","https://openalex.org/I4210157422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Robin Mukhopadhyaya","raw_affiliation_strings":["Advanced Centre for Treatment Research and Education in Cancer , Kharghar, Navi Mumbai 410 210 ,","Advanced Centre for Treatment Research and Education in Cancer, Kharghar, Navi Mumbai 410 210, India; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Centre for Treatment Research and Education in Cancer , Kharghar, Navi Mumbai 410 210 ,","institution_ids":["https://openalex.org/I4210157422"]},{"raw_affiliation_string":"Advanced Centre for Treatment Research and Education in Cancer, Kharghar, Navi Mumbai 410 210, India; and","institution_ids":["https://openalex.org/I4210157422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024742527","display_name":"Bhaskar Saha","orcid":"https://orcid.org/0000-0002-5833-7912","observed_orcids":["https://orcid.org/0000-0002-5833-7912"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Bhaskar Saha","raw_affiliation_strings":["National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science , Ganeshkhind, Pune 411 007 ,","institution_ids":["https://openalex.org/I4210104670"]},{"raw_affiliation_string":"*National Centre for Cell Science, Ganeshkhind, Pune 411 007, India;","institution_ids":["https://openalex.org/I4210104670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024742527","https://openalex.org/A5085697733","https://openalex.org/A5108751343"],"corresponding_institution_ids":["https://openalex.org/I4210104670"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.9021,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.71248213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"193","issue":"7","first_page":"3644","last_page":"3653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cd40-signaling","display_name":"CD40 signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/leishmania-major","display_name":"Leishmania major","score":0.7310000061988831},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9290000200271606},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.5799999833106995},{"id":"https://openalex.org/keywords/lyn-kinase","display_name":"Lyn kinase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8920000195503235},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9449999928474426},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.894497275352478},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8411312103271484},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.7249921560287476},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.6367050409317017},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6317982077598572},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5407997965812683},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.43613719940185547},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4222352206707001},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41458356380462646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37957489490509033},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.15135616064071655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14107882976531982},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07535898685455322},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.0},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018320","descriptor_name":"Leishmania major","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053824","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.1400620","doi":"https://doi.org/10.4049/jimmunol.1400620","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1400620","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:25187664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25187664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1509418451","https://openalex.org/W1653477942","https://openalex.org/W1965148949","https://openalex.org/W1969015290","https://openalex.org/W1977695981","https://openalex.org/W1978373343","https://openalex.org/W1983297411","https://openalex.org/W1990572032","https://openalex.org/W1992857382","https://openalex.org/W1993948601","https://openalex.org/W1994969460","https://openalex.org/W2008193652","https://openalex.org/W2015376574","https://openalex.org/W2020959389","https://openalex.org/W2023090622","https://openalex.org/W2030787952","https://openalex.org/W2031206420","https://openalex.org/W2031980581","https://openalex.org/W2042122259","https://openalex.org/W2054352267","https://openalex.org/W2057811708","https://openalex.org/W2059322072","https://openalex.org/W2066806519","https://openalex.org/W2068852897","https://openalex.org/W2086693436","https://openalex.org/W2098875897","https://openalex.org/W2109553638","https://openalex.org/W2130708019","https://openalex.org/W2145121719","https://openalex.org/W2145613542","https://openalex.org/W2159123408","https://openalex.org/W2163327572","https://openalex.org/W2167352194","https://openalex.org/W2170781554","https://openalex.org/W2306413099","https://openalex.org/W6698169028"],"related_works":["https://openalex.org/W2332141953","https://openalex.org/W2109553638","https://openalex.org/W1992857382","https://openalex.org/W4211177546","https://openalex.org/W2159123408","https://openalex.org/W4396785548","https://openalex.org/W2011847303","https://openalex.org/W2217676395","https://openalex.org/W1990572032","https://openalex.org/W2023131111"],"abstract_inverted_index":{"CD40":[0,41,62,229,245],"plays":[1],"dual":[2],"immunoregulatory":[3],"roles":[4,49],"in":[5,26,40,50,121,171,200],"Leishmania":[6],"major":[7,197],"infection":[8],"and":[9,20,54,129,136,145,218,232],"tumor":[10],"regression.":[11],"The":[12],"functional":[13],"duality":[14],"emerges":[15],"from":[16],"CD40-induced":[17,51,73,78,115,125,133,146,152,163,195,214],"reciprocal":[18,52,219],"p38MAPK":[19,70,79,134,153,215],"ERK-1/2":[21,67,97,147,220],"phosphorylations.":[22],"Because":[23],"phosphotyrosine-based":[24],"signaling":[25,53,230],"hematopoietic":[27],"cells":[28],"is":[29,37,246],"regulated":[30],"by":[31,83,88],"the":[32,151,172,185,194,242],"phosphotyrosine":[33],"phosphatase":[34],"SHP-1,":[35],"which":[36],"not":[38],"implied":[39],"signaling,":[42],"we":[43,205],"examined":[44],"whether":[45],"SHP-1":[46,65,74,84,89,99,116,126,130,143,178,189,212],"played":[47],"any":[48],"anti-leishmanial":[55],"function.":[56],"We":[57],"observed":[58,95],"that":[59],"a":[60,168,225,238],"weaker":[61],"stimulation":[63],"increased":[64,105,128],"activation.":[66,75],"inhibition":[68,85,100,109,113,131],"or":[69],"overexpression":[71],"inhibited":[72],"An":[76],"ultra-low-dose,":[77],"phosphorylation":[80,103,127,144,148],"was":[81,94],"enhanced":[82,114,132,142,193],"but":[86,104,111,149],"reduced":[87,101,110,150],"overexpression.":[90],"A":[91],"reverse":[92,159],"profile":[93],"with":[96],"phosphorylation.":[98,117],"syk":[102,108],"lyn":[106,112],"phosphorylation;":[107],"Corroborating":[118],"these":[119,162],"findings,":[120],"L.":[122,196],"major-infected":[123],"macrophages,":[124],"activation":[135,216],"inducible":[137],"NO":[138],"synthase":[139],"expression.":[140],"IL-10":[141,166],"phosphorylation,":[154],"whereas":[155],"anti-IL-10":[156],"Ab":[157],"exhibited":[158],"effects":[160],"on":[161],"functions,":[164],"identifying":[165],"as":[167,224,237],"crucial":[169],"element":[170],"SHP-1-MAPK":[173],"feedback":[174,209],"system.":[175],"Lentivirally":[176,187],"overexpressed":[177],"rendered":[179],"resistant":[180],"C57BL/6":[181],"mice":[182],"susceptible":[183,201],"to":[184],"infection.":[186],"expressed":[188],"short":[190],"hairpin":[191],"RNA":[192],"parasite":[198],"killing":[199],"BALB/c":[202],"mice.":[203],"Thus,":[204],"establish":[206],"an":[207],"SHP-1-centered":[208],"system":[210],"wherein":[211],"modulates":[213],"threshold":[217],"activation,":[221],"establishing":[222],"itself":[223],"critical":[226],"regulator":[227],"of":[228],"reciprocity":[231],"mechanistically":[233],"re-emphasizing":[234],"its":[235],"role":[236],"potential":[239],"target":[240],"against":[241],"diseases":[243],"where":[244],"involved.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
