{"id":"https://openalex.org/W2115806147","doi":"https://doi.org/10.2174/156800909787580999","title":"Targeted Therapy for Advanced Prostate Cancer: Inhibition of the PI3K/Akt/mTOR Pathway","display_name":"Targeted Therapy for Advanced Prostate Cancer: Inhibition of the PI3K/Akt/mTOR Pathway","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2115806147","doi":"https://doi.org/10.2174/156800909787580999","mag":"2115806147","pmid":"https://pubmed.ncbi.nlm.nih.gov/19275762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2921605"},"language":"en","primary_location":{"id":"doi:10.2174/156800909787580999","doi":"https://doi.org/10.2174/156800909787580999","is_oa":true,"landing_page_url":"https://doi.org/10.2174/156800909787580999","pdf_url":"http://www.eurekaselect.com/article/13795","source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.eurekaselect.com/article/13795","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027920712","display_name":"Todd Matthew Morgan","orcid":"https://orcid.org/0000-0002-1140-0603","observed_orcids":["https://orcid.org/0000-0002-1140-0603"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Morgan","raw_affiliation_strings":["Department of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014179355","display_name":"Theodore D. Koreckij","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Koreckij","raw_affiliation_strings":["Department of Urology , University of Washington School of Medicine , Seattle , WA , 98195 , USA","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology , University of Washington School of Medicine , Seattle , WA , 98195 , USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018745405","display_name":"Eva Corey","orcid":"https://orcid.org/0000-0002-9244-3807","observed_orcids":["https://orcid.org/0000-0002-9244-3807"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eva Corey","raw_affiliation_strings":["Department of Urology , 1959 NE Pacific , BB-1115 , Box 356510 , Seattle , Washington , 98195 , USA;","Department of Urology , University of Washington School of Medicine , Seattle , WA , 98195 , USA","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology , 1959 NE Pacific , BB-1115 , Box 356510 , Seattle , Washington , 98195 , USA;","institution_ids":[]},{"raw_affiliation_string":"Department of Urology , University of Washington School of Medicine , Seattle , WA , 98195 , USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018745405"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":1.218,"has_fulltext":true,"cited_by_count":284,"citation_normalized_percentile":{"value":0.77204601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"2","first_page":"237","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-prostate-cancer","display_name":"advanced prostate cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.8539999723434448},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/akt-inhibitors","display_name":"AKT inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.9440000057220459},{"id":"https://openalex.org/keywords/signal-transduction-inhibitors","display_name":"signal transduction inhibitors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5860000252723694},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9980000257492065},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8883861899375916},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7851389050483704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6819992065429688},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6560550928115845},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6263179183006287},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5053906440734863},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4987211227416992},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48222315311431885},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.4816505014896393},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.44051674008369446},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4240758419036865},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3882342576980591},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3345109224319458},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3222878575325012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13357889652252197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051058","descriptor_name":"Oncogene Protein v-akt","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051058","descriptor_name":"Oncogene Protein v-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/156800909787580999","doi":"https://doi.org/10.2174/156800909787580999","is_oa":true,"landing_page_url":"https://doi.org/10.2174/156800909787580999","pdf_url":"http://www.eurekaselect.com/article/13795","source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},{"id":"pmid:19275762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19275762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current cancer drug targets","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2007362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2921605","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2921605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2921605","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Cancer Drug Targets","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2174/156800909787580999","doi":"https://doi.org/10.2174/156800909787580999","is_oa":true,"landing_page_url":"https://doi.org/10.2174/156800909787580999","pdf_url":"http://www.eurekaselect.com/article/13795","source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2577379633","display_name":"Mechanisms and Markers of Prostate Cancer Metastases","funder_award_id":"P01CA085859","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3635404519","display_name":null,"funder_award_id":"P01 CA 85859-01A1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3804952138","display_name":"Roles of Nemo-like kinase in CaP and its effects on androgen receptor signaling","funder_award_id":"R01CA125395","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000099545","display_name":null,"funder_award_id":"CA-097186","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000881195","display_name":"The Pacific Northwest Prostate Cancer SPORE","funder_award_id":"P50CA097186","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115806147.pdf","grobid_xml":"https://content.openalex.org/works/W2115806147.grobid-xml"},"referenced_works_count":146,"referenced_works":["https://openalex.org/W1539817070","https://openalex.org/W1566131344","https://openalex.org/W1579890798","https://openalex.org/W1587932799","https://openalex.org/W1599972517","https://openalex.org/W1787826185","https://openalex.org/W1797700808","https://openalex.org/W1845534504","https://openalex.org/W1888905687","https://openalex.org/W1893347245","https://openalex.org/W1964305994","https://openalex.org/W1966268953","https://openalex.org/W1967279903","https://openalex.org/W1969910813","https://openalex.org/W1972943971","https://openalex.org/W1978981032","https://openalex.org/W1980006154","https://openalex.org/W1982228585","https://openalex.org/W1982768187","https://openalex.org/W1984418041","https://openalex.org/W1985143543","https://openalex.org/W1985775278","https://openalex.org/W1986093999","https://openalex.org/W1986235662","https://openalex.org/W1987105275","https://openalex.org/W1995197723","https://openalex.org/W1995492935","https://openalex.org/W1997714593","https://openalex.org/W1998394615","https://openalex.org/W1998786498","https://openalex.org/W2002127663","https://openalex.org/W2006027129","https://openalex.org/W2007212167","https://openalex.org/W2010309554","https://openalex.org/W2016601849","https://openalex.org/W2017362326","https://openalex.org/W2018539716","https://openalex.org/W2021012077","https://openalex.org/W2022926655","https://openalex.org/W2025319771","https://openalex.org/W2025836954","https://openalex.org/W2027505569","https://openalex.org/W2030019992","https://openalex.org/W2031646904","https://openalex.org/W2033057983","https://openalex.org/W2035521896","https://openalex.org/W2037622469","https://openalex.org/W2043103956","https://openalex.org/W2044505245","https://openalex.org/W2046234516","https://openalex.org/W2046867705","https://openalex.org/W2047155047","https://openalex.org/W2049372779","https://openalex.org/W2051945122","https://openalex.org/W2054227402","https://openalex.org/W2055662495","https://openalex.org/W2065591579","https://openalex.org/W2068297530","https://openalex.org/W2068319312","https://openalex.org/W2068427129","https://openalex.org/W2076627331","https://openalex.org/W2077485734","https://openalex.org/W2080100938","https://openalex.org/W2080439368","https://openalex.org/W2083149585","https://openalex.org/W2085892106","https://openalex.org/W2090422260","https://openalex.org/W2090802890","https://openalex.org/W2090850110","https://openalex.org/W2093345318","https://openalex.org/W2095561162","https://openalex.org/W2095804402","https://openalex.org/W2098169745","https://openalex.org/W2098176107","https://openalex.org/W2100256432","https://openalex.org/W2102148658","https://openalex.org/W2104364638","https://openalex.org/W2104746018","https://openalex.org/W2105373880","https://openalex.org/W2105439521","https://openalex.org/W2107275684","https://openalex.org/W2107558077","https://openalex.org/W2108957971","https://openalex.org/W2109475857","https://openalex.org/W2109806675","https://openalex.org/W2109881523","https://openalex.org/W2114704791","https://openalex.org/W2117905749","https://openalex.org/W2118120822","https://openalex.org/W2118436380","https://openalex.org/W2118681564","https://openalex.org/W2118756223","https://openalex.org/W2119299101","https://openalex.org/W2120129511","https://openalex.org/W2120292596","https://openalex.org/W2123003149","https://openalex.org/W2124245112","https://openalex.org/W2126071672","https://openalex.org/W2127560071","https://openalex.org/W2129433088","https://openalex.org/W2131116203","https://openalex.org/W2133742377","https://openalex.org/W2136217164","https://openalex.org/W2136530530","https://openalex.org/W2139295697","https://openalex.org/W2139789491","https://openalex.org/W2142375064","https://openalex.org/W2142716359","https://openalex.org/W2144323242","https://openalex.org/W2146027649","https://openalex.org/W2146384083","https://openalex.org/W2148842373","https://openalex.org/W2149218373","https://openalex.org/W2149640439","https://openalex.org/W2150491978","https://openalex.org/W2150937214","https://openalex.org/W2152624764","https://openalex.org/W2153030011","https://openalex.org/W2153154305","https://openalex.org/W2153264091","https://openalex.org/W2153493705","https://openalex.org/W2153867442","https://openalex.org/W2154176338","https://openalex.org/W2155228264","https://openalex.org/W2155492508","https://openalex.org/W2155894543","https://openalex.org/W2156095111","https://openalex.org/W2158889317","https://openalex.org/W2159299299","https://openalex.org/W2159622045","https://openalex.org/W2161810908","https://openalex.org/W2163148645","https://openalex.org/W2164895949","https://openalex.org/W2164977235","https://openalex.org/W2168230338","https://openalex.org/W2170494050","https://openalex.org/W2261566286","https://openalex.org/W2318605753","https://openalex.org/W2410438300","https://openalex.org/W2517054293","https://openalex.org/W2901427526","https://openalex.org/W4238567307","https://openalex.org/W4241081284","https://openalex.org/W4251709542","https://openalex.org/W6632273344","https://openalex.org/W6641097993"],"related_works":["https://openalex.org/W162420458","https://openalex.org/W2334271578","https://openalex.org/W2008473350","https://openalex.org/W7122492686","https://openalex.org/W2483602080","https://openalex.org/W2319564781","https://openalex.org/W2155968314","https://openalex.org/W3188367623","https://openalex.org/W4281823708","https://openalex.org/W2391347045"],"abstract_inverted_index":{"A":[0],"large":[1],"number":[2],"of":[3,14,27,51,78,85,119,125,154,159,192,209,219,229],"novel":[4],"therapeutics":[5],"is":[6,105,115],"currently":[7],"undergoing":[8],"clinical":[9,174,184,227,248],"evaluation":[10],"for":[11,92],"the":[12,52,68,83,106,130,170,217,226,238],"treatment":[13,91],"prostate":[15,46,57,93,103,120,187,223,244],"cancer,":[16],"and":[17,41,144,152,165,172,206,225,246],"small":[18],"molecule":[19],"signal":[20],"transduction":[21],"inhibitors":[22,30,158,194],"are":[23,145,166,189],"a":[24,34,60,99],"promising":[25],"class":[26],"agents.":[28],"These":[29],"have":[31,134,162],"recently":[32],"become":[33],"standard":[35],"therapy":[36],"in":[37,45,56,102,117,129,169,173,186,195,222,243],"renal":[38],"cell":[39],"carcinoma":[40],"offer":[42],"significant":[43],"promise":[44],"cancer.":[47],"Through":[48],"an":[49],"understanding":[50],"key":[53],"pathways":[54],"involved":[55],"cancer":[58,94,104,188,224,245],"progression,":[59],"rational":[61],"drug":[62],"design":[63],"can":[64],"be":[65],"aimed":[66],"at":[67],"molecules":[69],"critical":[70],"to":[71,137],"cellular":[72],"signaling.":[73],"This":[74],"may":[75],"enable":[76],"administration":[77],"selective":[79],"therapies":[80],"based":[81],"on":[82,180],"expression":[84],"molecular":[86],"targets,":[87],"more":[88],"appropriately":[89],"individualizing":[90],"patients.":[95],"One":[96],"pathway":[97,133,161,221],"with":[98,147,176,197],"prominent":[100],"role":[101],"PI3K/Akt/mTOR":[107,113,131,241],"pathway.":[108],"Current":[109,183],"estimates":[110],"suggest":[111],"that":[112],"signaling":[114,132],"upregulated":[116],"30-50%":[118],"cancers,":[121],"often":[122],"through":[123],"loss":[124],"PTEN.":[126],"Molecular":[127],"changes":[128],"been":[135,163],"demonstrated":[136],"differentiate":[138],"benign":[139],"from":[140],"malignant":[141],"prostatic":[142],"epithelium":[143],"associated":[146],"increasing":[148],"tumor":[149],"stage,":[150],"grade,":[151],"risk":[153],"biochemical":[155],"recurrence.":[156],"Multiple":[157],"this":[160,220,234],"developed":[164],"being":[167],"assessed":[168],"laboratory":[171],"trials,":[175],"much":[177],"attention":[178],"focusing":[179],"mTOR":[181,193],"inhibition.":[182,232],"trials":[185,211],"assessing":[190],"efficacy":[191],"combination":[196],"multiple":[198],"targeted":[199,231],"or":[200],"traditional":[201],"chemotherapies,":[202],"including":[203],"bevacizumab,":[204],"gefitinib,":[205],"docetaxel.":[207],"Completion":[208],"these":[210],"will":[212],"provide":[213],"substantial":[214],"information":[215],"regarding":[216],"importance":[218],"implications":[228],"its":[230],"In":[233],"article":[235],"we":[236],"review":[237],"data":[239],"surrounding":[240],"inhibition":[242],"their":[247],"implications.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}