{"id":"https://openalex.org/W2115777622","doi":"https://doi.org/10.1111/j.1365-2184.1974.tb00907.x","title":"CONTINUOUS LABELLING STUDIES ON MOUSE SKIN AND INTESTINE","display_name":"CONTINUOUS LABELLING STUDIES ON MOUSE SKIN AND INTESTINE","publication_year":1974,"publication_date":"1974-05-01","ids":{"openalex":"https://openalex.org/W2115777622","doi":"https://doi.org/10.1111/j.1365-2184.1974.tb00907.x","mag":"2115777622","pmid":"https://pubmed.ncbi.nlm.nih.gov/4837676"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2184.1974.tb00907.x","doi":"https://doi.org/10.1111/j.1365-2184.1974.tb00907.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2184.1974.tb00907.x","pdf_url":null,"source":{"id":"https://openalex.org/S86484535","display_name":"Cell Proliferation","issn_l":"0960-7722","issn":["0960-7722","1365-2184"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Proliferation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2115777622"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111709939","display_name":"Christopher S. Potten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher S. Potten","raw_affiliation_strings":["Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101991152","display_name":"L\u00e1szl\u00f3 Kov\u00e1cs","orcid":"https://orcid.org/0000-0002-7337-5626","observed_orcids":["https://orcid.org/0000-0002-7337-5626"]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["GB","HU"],"is_corresponding":false,"raw_author_name":"Laszlo Kovacs","raw_affiliation_strings":["Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester","University Research Team of Medical Radiology, Hungarian Academy of Sciences, 78 Ullo\u0308i ucta, Budapest, Hungary, IAEA Research Fellow (HUN/7119)","University Research Team of Medical Radiology, Hungarian Academy of Sciences, 78 Ull\u00f6i ucta, Budapest, Hungary, IAEA Research Fellow (HUN/7119)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]},{"raw_affiliation_string":"University Research Team of Medical Radiology, Hungarian Academy of Sciences, 78 Ullo\u0308i ucta, Budapest, Hungary, IAEA Research Fellow (HUN/7119)","institution_ids":["https://openalex.org/I7597260"]},{"raw_affiliation_string":"University Research Team of Medical Radiology, Hungarian Academy of Sciences, 78 Ull\u00f6i ucta, Budapest, Hungary, IAEA Research Fellow (HUN/7119)","institution_ids":["https://openalex.org/I7597260"]}]},{"author_position":"last","author":{"id":null,"display_name":"Elizabeth Hamilton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119250","display_name":"University of Virginia Hospital","ror":"https://ror.org/02f588d44","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210119250"]},{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Elizabeth Hamilton","raw_affiliation_strings":["Division of Radiobiology and Biophysics, Departments of Pediatrics and Radiology, University of Virginia Hospital, Charlottesville, Virginia 22901, U.S.A","Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiobiology and Biophysics, Departments of Pediatrics and Radiology, University of Virginia Hospital, Charlottesville, Virginia 22901, U.S.A","institution_ids":["https://openalex.org/I4210119250","https://openalex.org/I4210134211","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5111709939"],"corresponding_institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":6.379,"has_fulltext":false,"cited_by_count":231,"citation_normalized_percentile":{"value":0.95800227,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"7","issue":"3","first_page":"271","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/labeling-index","display_name":"labeling index","score":0.7089999914169312},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8999999761581421},{"id":"https://openalex.org/keywords/crypt-stem-cells","display_name":"crypt stem cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/dorsal-skin","display_name":"dorsal skin","score":0.6050000190734863},{"id":"https://openalex.org/keywords/jejunum","display_name":"jejunum","score":0.8650000095367432},{"id":"https://openalex.org/keywords/colon","display_name":"colon","score":0.9950000047683716},{"id":"https://openalex.org/keywords/steady-state","display_name":"steady state","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.8671011924743652},{"id":"https://openalex.org/C2780523633","wikidata":"https://www.wikidata.org/wiki/Q380709","display_name":"Labelling","level":2,"score":0.7508124113082886},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5800888538360596},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.5734819769859314},{"id":"https://openalex.org/C2776280935","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Large intestine","level":2,"score":0.52486252784729},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.5213728547096252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4778680205345154},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4379037916660309},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40337085723876953},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33177441358566284},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.29526644945144653},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22244369983673096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21664324402809143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1266699731349945},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012588","descriptor_name":"Scintillation Counting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2184.1974.tb00907.x","doi":"https://doi.org/10.1111/j.1365-2184.1974.tb00907.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2184.1974.tb00907.x","pdf_url":null,"source":{"id":"https://openalex.org/S86484535","display_name":"Cell Proliferation","issn_l":"0960-7722","issn":["0960-7722","1365-2184"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Proliferation","raw_type":"journal-article"},{"id":"pmid:4837676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4837676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and tissue kinetics","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1974-1345","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1974/346","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1974","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W58996224","https://openalex.org/W1270909884","https://openalex.org/W1522240561","https://openalex.org/W1896066594","https://openalex.org/W1917131652","https://openalex.org/W1974681019","https://openalex.org/W1976183272","https://openalex.org/W1976399234","https://openalex.org/W1994874018","https://openalex.org/W1996861493","https://openalex.org/W1999916071","https://openalex.org/W2013905700","https://openalex.org/W2031281003","https://openalex.org/W2035046719","https://openalex.org/W2036755567","https://openalex.org/W2041517566","https://openalex.org/W2052348990","https://openalex.org/W2078895306","https://openalex.org/W2079506023","https://openalex.org/W2085521350","https://openalex.org/W2101156532","https://openalex.org/W2139017715","https://openalex.org/W2152405926","https://openalex.org/W2152450115","https://openalex.org/W2333081930"],"related_works":["https://openalex.org/W2042893569","https://openalex.org/W2040757796","https://openalex.org/W2043982180","https://openalex.org/W2085548404","https://openalex.org/W2139017715","https://openalex.org/W1982047582","https://openalex.org/W1973870711","https://openalex.org/W1522240561","https://openalex.org/W1992101709","https://openalex.org/W2152405926"],"abstract_inverted_index":{"ABSTRACT":[0],"Data":[1],"are":[2],"presented":[3],"for":[4,32,115],"changes":[5],"in":[6,14,22,63,104],"absolute":[7],"radioactivity":[8],"levels":[9],"and":[10,19,43,51,91,121,125],"labelling":[11],"indices":[12],"(LI)":[13],"three":[15],"tissues:":[16],"jejunum,":[17],"colon":[18],"dorsal":[20],"skin":[21,80],"the":[23,44,64,69,92,99,108],"mouse":[24],"during":[25],"conditions":[26],"of":[27,41,94,107],"repeated":[28],"(every":[29],"3":[30],"hr":[31],"168":[33],"hr)":[34],"3H\u2010TdR":[35],"(5":[36],"\u03bcCi)":[37],"injections.":[38],"The":[39,49,79,111],"lengths":[40],"S":[42],"cell":[45,71,77],"cycle":[46],"were":[47,55],"estimated.":[48],"crypt":[50,65,75],"mucosal":[52],"transit":[53],"times":[54],"evaluated.":[56],"There":[57],"is":[58],"a":[59,74,87,105,126],"slowly":[60],"cycling":[61],"subpopulation":[62],"which":[66],"may":[67],"be":[68,84],"goblet":[70],"precursors":[72],"or":[73,97],"stem":[76],"population.":[78],"LI":[81],"data":[82,114],"cannot":[83],"fitted":[85],"by":[86],"single":[88],"straight":[89],"line":[90],"procedure":[93],"continuously":[95],"handling":[96],"injecting":[98],"animals":[100],"appears":[101],"to":[102],"result":[103],"disturbance":[106],"steady":[109],"state.":[110],"liquid":[112],"scintillation":[113],"all":[116],"samples":[117],"showed":[118],"some":[119],"consistent":[120],"surprisingly":[122],"large":[123],"fluctuations":[124],"clear":[127],"deviation":[128],"from":[129],"linear":[130],"uptake":[131],"with":[132],"increasing":[133],"time.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
