{"id":"https://openalex.org/W2115774367","doi":"https://doi.org/10.1093/jac/17.4.463","title":"Variation in the potentiation of \u03b2-lactam antibiotic activity by clavulanic acid and sulbactam against multiply antibiotic-resistant bacteria","display_name":"Variation in the potentiation of \u03b2-lactam antibiotic activity by clavulanic acid and sulbactam against multiply antibiotic-resistant bacteria","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2115774367","doi":"https://doi.org/10.1093/jac/17.4.463","mag":"2115774367","pmid":"https://pubmed.ncbi.nlm.nih.gov/3011724"},"language":"en","primary_location":{"id":"doi:10.1093/jac/17.4.463","doi":"https://doi.org/10.1093/jac/17.4.463","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/17.4.463","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105836632","display_name":"Kenneth E. Aldridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E. Aldridge","raw_affiliation_strings":["Department of Medicine, LSU Medical Center New Orleans, Louisiana 70112, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, LSU Medical Center New Orleans, Louisiana 70112, U.S.A","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061893002","display_name":"Charles V. Sanders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles V. Sanders","raw_affiliation_strings":["Department of Medicine, LSU Medical Center New Orleans, Louisiana 70112, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, LSU Medical Center New Orleans, Louisiana 70112, U.S.A","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041364996","display_name":"Robert L. Marier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Marier","raw_affiliation_strings":["Department of Medicine, LSU Medical Center New Orleans, Louisiana 70112, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, LSU Medical Center New Orleans, Louisiana 70112, U.S.A","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":1.4366,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.76122316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"17","issue":"4","first_page":"463","last_page":"469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clavulanic-acid","display_name":"clavulanic acid","score":0.9490000009536743},{"id":"https://openalex.org/keywords/sulbactam","display_name":"sulbactam","score":1.0},{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.9570000171661377},{"id":"https://openalex.org/keywords/antibiotic-potentiation","display_name":"antibiotic potentiation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6039999723434448},{"id":"https://openalex.org/keywords/beta-lactamase-producing-bacteria","display_name":"beta-lactamase-producing bacteria","score":0.8460000157356262},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9700000286102295},{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":1.0},{"id":"https://openalex.org/keywords/bacteroides-fragilis","display_name":"Bacteroides fragilis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococci","display_name":"methicillin-resistant staphylococci","score":0.9520000219345093},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.984000027179718},{"id":"https://openalex.org/keywords/coagulase-negative-staphylococci","display_name":"coagulase-negative staphylococci","score":0.9810000061988831},{"id":"https://openalex.org/keywords/inoculum-size","display_name":"inoculum size","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2778478555","wikidata":"https://www.wikidata.org/wiki/Q423393","display_name":"Sulbactam","level":5,"score":0.8639501333236694},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8276554346084595},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.7953979969024658},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7625789642333984},{"id":"https://openalex.org/C2780246119","wikidata":"https://www.wikidata.org/wiki/Q221817","display_name":"Bacteroides fragilis","level":3,"score":0.6712121963500977},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5022122859954834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4982595443725586},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.48702412843704224},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.47983571887016296},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.44615134596824646},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.36495858430862427},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.296237975358963},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.19125831127166748},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.1431218385696411},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002969","descriptor_name":"Clavulanic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010397","descriptor_name":"Penicillanic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013407","descriptor_name":"Sulbactam","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019818","descriptor_name":"Clavulanic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jac/17.4.463","doi":"https://doi.org/10.1093/jac/17.4.463","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/17.4.463","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:3011724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3011724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412335611","https://openalex.org/W2077895584","https://openalex.org/W2049694574","https://openalex.org/W2063779640","https://openalex.org/W1995073829","https://openalex.org/W2418927437","https://openalex.org/W2162364967","https://openalex.org/W2023232901","https://openalex.org/W2394828094","https://openalex.org/W2035410589"],"abstract_inverted_index":{"Using":[0],"a":[1,31],"broth":[2],"microdilution":[3],"method,":[4],"we":[5],"studied":[6],"120":[7],"strains":[8,59,96],"of":[9,18,30,33,60,68,75,97,117],"beta-lactamase-producing":[10],"clinical":[11],"isolates":[12],"to":[13],"determine":[14],"the":[15,27,58,66,73,79,83,106,124,132,141],"potentiating":[16],"effect":[17,88],"clavulanic":[19],"acid":[20],"and":[21,41,52,63,94],"sulbactam":[22],"(both":[23],"beta-lactamase":[24],"inhibitors)":[25],"on":[26],"antibacterial":[28],"activity":[29,74,101],"variety":[32],"beta-lactam":[34],"antibiotics.":[35],"All":[36],"antibiotics":[37,77],"were":[38],"tested":[39],"alone":[40],"in":[42],"combination":[43],"with":[44,112],"each":[45],"inhibitor":[46],"simultaneously":[47],"using":[48],"low":[49,80],"(10(5)":[50],"cfu/ml)":[51,55],"high":[53,84],"(10(7)":[54],"inocula.":[56],"Against":[57],"Escherichia":[61],"coli":[62,93],"Haemophilus":[64],"influenzae":[65],"addition":[67],"both":[69,109],"inhibitors":[70,107,133],"significantly":[71,103],"potentiated":[72],"most":[76,95],"at":[78,108],"inoculum.":[81],"At":[82],"inoculum,":[85],"however,":[86],"this":[87],"was":[89,102,120,134],"abrogated":[90],"against":[91],"E.":[92],"H.":[98],"influenzae.":[99],"Antibiotic":[100,115],"enhanced":[104],"by":[105,123,131],"inoculum":[110],"sizes":[111],"Bacteroides":[113],"fragilis.":[114],"resistance":[116],"Pseudomonas":[118],"aeruginosa":[119],"little":[121],"affected":[122],"inhibitors.":[125],"Among":[126],"methicillin-resistant":[127],"staphylococci,":[128],"antibiotic":[129],"potentiation":[130],"more":[135],"significant":[136],"for":[137],"Staphylococcus":[138],"aureus":[139],"than":[140],"coagulase-negative":[142],"staphylococci.":[143]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
