{"id":"https://openalex.org/W2115696508","doi":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","title":"Thrombin generation time is a novel parameter for monitoring enoxaparin therapy in patients with end\u2010stage renal disease","display_name":"Thrombin generation time is a novel parameter for monitoring enoxaparin therapy in patients with end\u2010stage renal disease","publication_year":2006,"publication_date":"2006-01-13","ids":{"openalex":"https://openalex.org/W2115696508","doi":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","mag":"2115696508","pmid":"https://pubmed.ncbi.nlm.nih.gov/16420568"},"language":"en","primary_location":{"id":"doi:10.1111/j.1538-7836.2006.01731.x","doi":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","pdf_url":null,"source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025270743","display_name":"Donald F. Brophy","orcid":"https://orcid.org/0000-0003-3447-8523","observed_orcids":["https://orcid.org/0000-0003-3447-8523"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D.F. BROPHY","raw_affiliation_strings":["Department of Pharmacy Practice, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA 23298, USA. dbrophy@vcu.edu","Department of Internal Medicine, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","Department of Pharmacy Practice, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","The Coagulation Special Studies Laboratory, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA 23298, USA. dbrophy@vcu.edu","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"Department of Internal Medicine, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"Department of Pharmacy Practice, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"The Coagulation Special Studies Laboratory, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E.J. MARTIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.J. MARTIN","raw_affiliation_strings":["Hemodyne, Inc., Richmond, VA, USA","The Coagulation Special Studies Laboratory, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemodyne, Inc., Richmond, VA, USA","institution_ids":[]},{"raw_affiliation_string":"The Coagulation Special Studies Laboratory, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113605813","display_name":"Todd W.B. Gehr","orcid":"https://orcid.org/0000-0003-2966-2545","observed_orcids":["https://orcid.org/0000-0003-2966-2545"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.W.B. GEHR","raw_affiliation_strings":["Department of Internal Medicine, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075128883","display_name":"Al M. Best","orcid":"https://orcid.org/0000-0002-6300-3925","observed_orcids":["https://orcid.org/0000-0002-6300-3925"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.M. BEST","raw_affiliation_strings":["Department of Biostatistics, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. PAUL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. PAUL","raw_affiliation_strings":["Department of Internal Medicine, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111713733","display_name":"Marcus E. Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.E. CARR","raw_affiliation_strings":["Hemodyne, Inc., Richmond, VA, USA","The Coagulation Special Studies Laboratory, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemodyne, Inc., Richmond, VA, USA","institution_ids":[]},{"raw_affiliation_string":"The Coagulation Special Studies Laboratory, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025270743"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.7396,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.85657807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"4","issue":"2","first_page":"372","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9480000138282776},{"id":"https://openalex.org/keywords/anticoagulation-monitoring","display_name":"anticoagulation monitoring","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anti-xa-activity","display_name":"anti-Xa activity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.9340000152587891},{"id":"https://openalex.org/keywords/antithrombotic-activity","display_name":"antithrombotic activity","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C3018972837","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin generation","level":4,"score":0.7373803853988647},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7282527685165405},{"id":"https://openalex.org/C3019040382","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"End stage renal disease","level":3,"score":0.6573137640953064},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6149584650993347},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5185521245002747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47779494524002075},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.42772001028060913},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.39437270164489746},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3750501871109009},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35833311080932617},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3252056837081909},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.13515421748161316},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000990","descriptor_name":"Antithrombin III","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013918","descriptor_name":"Thrombin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017984","descriptor_name":"Enoxaparin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1538-7836.2006.01731.x","doi":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","pdf_url":null,"source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:16420568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16420568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thrombosis and haemostasis : JTH","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1538-7836.2006.01731.x","doi":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2006.01731.x","pdf_url":null,"source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G227053939","display_name":"Development of a novel whole blood coagulation assay","funder_award_id":"1r41hl077964-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5966678231","display_name":"General Clinical Research Center","funder_award_id":"M01RR000065","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6155128184","display_name":null,"funder_award_id":"1R41 HL77964-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1489758714","https://openalex.org/W1509399724","https://openalex.org/W1540403899","https://openalex.org/W1978895866","https://openalex.org/W1984986740","https://openalex.org/W1990653367","https://openalex.org/W2012678334","https://openalex.org/W2016611112","https://openalex.org/W2019185582","https://openalex.org/W2019570438","https://openalex.org/W2027692320","https://openalex.org/W2029576247","https://openalex.org/W2031424136","https://openalex.org/W2033791065","https://openalex.org/W2041726150","https://openalex.org/W2049653899","https://openalex.org/W2063207586","https://openalex.org/W2073265922","https://openalex.org/W2076895726","https://openalex.org/W2080318130","https://openalex.org/W2083583837","https://openalex.org/W2127414127","https://openalex.org/W2144358734","https://openalex.org/W2147828132","https://openalex.org/W2153187399","https://openalex.org/W2158466772","https://openalex.org/W2168719124","https://openalex.org/W2184709903","https://openalex.org/W2283957630","https://openalex.org/W2395092750","https://openalex.org/W2399977644","https://openalex.org/W2407253528","https://openalex.org/W2408738795","https://openalex.org/W2416345779","https://openalex.org/W2589004289","https://openalex.org/W3145112846","https://openalex.org/W4232461495","https://openalex.org/W4285719527","https://openalex.org/W6646303202"],"related_works":["https://openalex.org/W2016611112","https://openalex.org/W2560128706","https://openalex.org/W2083583837","https://openalex.org/W1970626592","https://openalex.org/W2151403172","https://openalex.org/W3003273634","https://openalex.org/W3202640632","https://openalex.org/W1995314920","https://openalex.org/W2158466772","https://openalex.org/W2088625902"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}