{"id":"https://openalex.org/W2115685550","doi":"https://doi.org/10.1146/annurev.med.51.1.115","title":"New Horizons in the Treatment of Autoimmune Diseases: Immunoablation and Stem Cell Transplantation","display_name":"New Horizons in the Treatment of Autoimmune Diseases: Immunoablation and Stem Cell Transplantation","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2115685550","doi":"https://doi.org/10.1146/annurev.med.51.1.115","mag":"2115685550","pmid":"https://pubmed.ncbi.nlm.nih.gov/10774456"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.med.51.1.115","doi":"https://doi.org/10.1146/annurev.med.51.1.115","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.med.51.1.115","pdf_url":null,"source":{"id":"https://openalex.org/S16909082","display_name":"Annual Review of Medicine","issn_l":"0066-4219","issn":["0066-4219","1545-326X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113615726","display_name":"Alberto M. Marmont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alberto M. Marmont","raw_affiliation_strings":["Department of Hematology (DEMA), S. Martino\u2019s HospitalPiazzale Rosanna Benzi , 16132, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology (DEMA), S. Martino\u2019s HospitalPiazzale Rosanna Benzi , 16132, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113615726"],"corresponding_institution_ids":["https://openalex.org/I4210146472"],"apc_list":null,"apc_paid":null,"fwci":3.6701,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.96666667,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"51","issue":"1","first_page":"115","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/post-transplant-recurrence","display_name":"post-transplant relapse","score":0.7329999804496765},{"id":"https://openalex.org/keywords/refractory-autoimmune-disease","display_name":"refractory autoimmune disease","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.8249840140342712},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.8008745908737183},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6894162893295288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6869572997093201},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5382499694824219},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.48332715034484863},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46542757749557495},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.231443852186203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13071772456169128},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.med.51.1.115","doi":"https://doi.org/10.1146/annurev.med.51.1.115","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.med.51.1.115","pdf_url":null,"source":{"id":"https://openalex.org/S16909082","display_name":"Annual Review of Medicine","issn_l":"0066-4219","issn":["0066-4219","1545-326X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Medicine","raw_type":"journal-article"},{"id":"pmid:10774456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10774456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of medicine","raw_type":"Journal Article"},{"id":"mag:2181510731","doi":null,"is_oa":false,"landing_page_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.med.51.1.115","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W24911164","https://openalex.org/W47086436","https://openalex.org/W58231318","https://openalex.org/W79382124","https://openalex.org/W93783673","https://openalex.org/W102571836","https://openalex.org/W118686632","https://openalex.org/W148001558","https://openalex.org/W175238850","https://openalex.org/W185686096","https://openalex.org/W201613167","https://openalex.org/W204784857","https://openalex.org/W596306200","https://openalex.org/W1491226958","https://openalex.org/W1502187742","https://openalex.org/W1535560730","https://openalex.org/W1569581528","https://openalex.org/W1659193542","https://openalex.org/W1683467081","https://openalex.org/W1877303819","https://openalex.org/W1883328448","https://openalex.org/W1951445762","https://openalex.org/W1966388921","https://openalex.org/W1966700293","https://openalex.org/W1966758498","https://openalex.org/W1967492978","https://openalex.org/W1968030467","https://openalex.org/W1971449558","https://openalex.org/W1977536011","https://openalex.org/W1984550182","https://openalex.org/W1987840608","https://openalex.org/W1989180597","https://openalex.org/W1989594428","https://openalex.org/W1991208047","https://openalex.org/W1993450847","https://openalex.org/W2001063019","https://openalex.org/W2003050807","https://openalex.org/W2004040420","https://openalex.org/W2009191772","https://openalex.org/W2010565211","https://openalex.org/W2013058855","https://openalex.org/W2014174376","https://openalex.org/W2015214829","https://openalex.org/W2015829773","https://openalex.org/W2016193783","https://openalex.org/W2017722301","https://openalex.org/W2019396852","https://openalex.org/W2019429109","https://openalex.org/W2023807520","https://openalex.org/W2023997333","https://openalex.org/W2033881017","https://openalex.org/W2034247777","https://openalex.org/W2034661055","https://openalex.org/W2035966634","https://openalex.org/W2036119276","https://openalex.org/W2036913446","https://openalex.org/W2039703250","https://openalex.org/W2043017297","https://openalex.org/W2044798559","https://openalex.org/W2045809408","https://openalex.org/W2050239182","https://openalex.org/W2053573626","https://openalex.org/W2053818890","https://openalex.org/W2054893648","https://openalex.org/W2063241534","https://openalex.org/W2066122901","https://openalex.org/W2066758773","https://openalex.org/W2067259149","https://openalex.org/W2076790865","https://openalex.org/W2087152359","https://openalex.org/W2088018063","https://openalex.org/W2091016873","https://openalex.org/W2093085786","https://openalex.org/W2094181094","https://openalex.org/W2097669496","https://openalex.org/W2098487604","https://openalex.org/W2102248390","https://openalex.org/W2113929691","https://openalex.org/W2116860084","https://openalex.org/W2127983802","https://openalex.org/W2128139507","https://openalex.org/W2129260452","https://openalex.org/W2131165782","https://openalex.org/W2137798261","https://openalex.org/W2137977289","https://openalex.org/W2148022337","https://openalex.org/W2148449018","https://openalex.org/W2153735369","https://openalex.org/W2157632927","https://openalex.org/W2171158942","https://openalex.org/W2318916721","https://openalex.org/W2323322070","https://openalex.org/W2328596461","https://openalex.org/W2334624221","https://openalex.org/W2351185044","https://openalex.org/W2396355640","https://openalex.org/W2405831334","https://openalex.org/W2407278011","https://openalex.org/W2412786546","https://openalex.org/W2417624139","https://openalex.org/W2428424635","https://openalex.org/W2428777389","https://openalex.org/W2435672067","https://openalex.org/W2441681412","https://openalex.org/W2477178646","https://openalex.org/W2486832245","https://openalex.org/W2492397993","https://openalex.org/W2607741101","https://openalex.org/W2745409930","https://openalex.org/W3007389590","https://openalex.org/W4231277324","https://openalex.org/W4239396513","https://openalex.org/W6655221154"],"related_works":["https://openalex.org/W2181510731","https://openalex.org/W2323096401","https://openalex.org/W1966185766","https://openalex.org/W2049567096","https://openalex.org/W4232953911","https://openalex.org/W2406438194","https://openalex.org/W2065295314","https://openalex.org/W2556453507","https://openalex.org/W2146337479","https://openalex.org/W2317666420"],"abstract_inverted_index":{"The":[0,26],"prevalence":[1],"of":[2,18,28,57,118],"autoimmune":[3],"diseases":[4],"(ADs)":[5],"in":[6,50,109],"Western":[7],"countries":[8],"is":[9,22,45,88],"estimated":[10],"to":[11,42],"be":[12],"from":[13,54],"3-7%,":[14],"and":[15,53,62,111,121],"the":[16,68,102,113],"treatment":[17],"severe,":[19],"relapsing/refractory":[20],"cases":[21,56],"still":[23],"not":[24],"satisfactory.":[25],"concept":[27],"utilizing":[29],"intense":[30],"immunosuppression":[31],"followed":[32],"by":[33],"allogeneic":[34,97,120],"or":[35],"even":[36],"autologous":[37,122],"hemolymphopoietic":[38],"stem":[39,106],"cells":[40],"(HSCs)":[41],"treat":[43],"AD":[44,110],"based":[46],"on":[47],"encouraging":[48],"results":[49,117],"experimental":[51,103],"animals":[52],"serendipitous":[55],"patients":[58],"with":[59,93],"both":[60,119],"ADs":[61],"malignancies":[63],"who":[64],"were":[65],"allotransplanted":[66],"for":[67,84,105],"latter.":[69],"However,":[70],"rare":[71],"unexpected":[72],"relapses":[73],"despite":[74],"donor":[75],"immune":[76],"engraftment":[77],"have":[78],"been":[79],"reported":[80],"following":[81],"HSC":[82,123],"transplantation":[83,87,108],"AD.":[85],"Autologous":[86],"a":[89],"more":[90],"feasible":[91],"procedure":[92],"lower":[94],"toxicity":[95],"than":[96],"transplantation.":[98],"This":[99],"article":[100],"analyzes":[101],"basis":[104],"cell":[107],"discusses":[112],"most":[114],"important":[115],"clinical":[116],"transplants.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}