{"id":"https://openalex.org/W2115682164","doi":"https://doi.org/10.1186/1756-8722-7-22","title":"A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors","display_name":"A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors","publication_year":2014,"publication_date":"2014-03-11","ids":{"openalex":"https://openalex.org/W2115682164","doi":"https://doi.org/10.1186/1756-8722-7-22","mag":"2115682164","pmid":"https://pubmed.ncbi.nlm.nih.gov/24612546","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4007625"},"language":"en","primary_location":{"id":"doi:10.1186/1756-8722-7-22","doi":"https://doi.org/10.1186/1756-8722-7-22","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-8722-7-22","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/1756-8722-7-22","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/1756-8722-7-22","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100409969","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-5093-4325","observed_orcids":["https://orcid.org/0000-0002-5093-4325"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Shanghai Allist Pharmaceuticals, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Allist Pharmaceuticals, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076296804","display_name":"Junning Cao","orcid":"https://orcid.org/0000-0002-3146-9413","observed_orcids":["https://orcid.org/0000-0002-3146-9413"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junning Cao","raw_affiliation_strings":["Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. cao_junning@hotmail.com","Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. cao_junning@hotmail.com","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Li","raw_affiliation_strings":["Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376952","display_name":"Yifan Zhang","orcid":"https://orcid.org/0000-0002-9164-8309","observed_orcids":["https://orcid.org/0000-0002-9164-8309"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Zhang","raw_affiliation_strings":["Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115588715","display_name":"Zhiyu Chen","orcid":"https://orcid.org/0009-0003-4316-0952","observed_orcids":["https://orcid.org/0009-0003-4316-0952"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyu Chen","raw_affiliation_strings":["Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045982091","display_name":"Wei Peng","orcid":"https://orcid.org/0009-0003-7526-1360","observed_orcids":["https://orcid.org/0009-0003-7526-1360"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Peng","raw_affiliation_strings":["Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073681238","display_name":"Si Sun","orcid":"https://orcid.org/0000-0002-8424-5763","observed_orcids":["https://orcid.org/0000-0002-8424-5763"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si Sun","raw_affiliation_strings":["Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110407353","display_name":"Naiqing Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Naiqing Zhao","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiachen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiachen Wang","raw_affiliation_strings":["Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110054746","display_name":"Dafang Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dafang Zhong","raw_affiliation_strings":["Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100782560","display_name":"Xiaofang Zhang","orcid":"https://orcid.org/0000-0002-3171-2671","observed_orcids":["https://orcid.org/0000-0002-3171-2671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaofang Zhang","raw_affiliation_strings":["Shanghai Allist Pharmaceuticals, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Allist Pharmaceuticals, Shanghai, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101629514","display_name":"Jing Zhang","orcid":"https://orcid.org/0000-0002-4060-2183","observed_orcids":["https://orcid.org/0000-0002-4060-2183"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhang","raw_affiliation_strings":["Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","Shanghai Allist Pharmaceuticals, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Allist Pharmaceuticals, Shanghai, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5076296804"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":3.2763,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.93487341,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0737999975681305,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irreversible-kinase-inhibitors","display_name":"irreversible kinase inhibitors","score":0.703000009059906},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.843999981880188},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erbb4","display_name":"ErbB4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/advanced-solid-tumors","display_name":"advanced solid tumors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.953000009059906},{"id":"https://openalex.org/keywords/food-effects-on-drug-absorption","display_name":"food effect on absorption","score":0.7300000190734863},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5460000038146973},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6660000085830688},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5210000276565552},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7319999933242798},{"id":"https://openalex.org/keywords/recommended-phase-ii-dose","display_name":"recommended phase 2 dose","score":0.7239999771118164},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.6159999966621399},{"id":"https://openalex.org/keywords/partial-response","display_name":"partial response","score":0.5189999938011169},{"id":"https://openalex.org/keywords/stable-disease","display_name":"stable disease","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8618162870407104},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.7702795267105103},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.693767249584198},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6573307514190674},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.635864794254303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5688686966896057},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.4930691421031952},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.47998377680778503},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4732932448387146},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4516892731189728},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.43581101298332214}],"mesh":[{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1756-8722-7-22","doi":"https://doi.org/10.1186/1756-8722-7-22","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-8722-7-22","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/1756-8722-7-22","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2987832","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4007625","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4007625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4007625","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Hematol Oncol","raw_type":"Text"},{"id":"pmid:24612546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24612546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematology & oncology","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.1186/1756-8722-7-22","doi":"https://doi.org/10.1186/1756-8722-7-22","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-8722-7-22","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/1756-8722-7-22","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115682164.pdf","grobid_xml":"https://content.openalex.org/works/W2115682164.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1964321121","https://openalex.org/W1975275422","https://openalex.org/W1989931815","https://openalex.org/W1997852270","https://openalex.org/W2002937040","https://openalex.org/W2003984225","https://openalex.org/W2005202092","https://openalex.org/W2008322008","https://openalex.org/W2019864526","https://openalex.org/W2042254853","https://openalex.org/W2056512565","https://openalex.org/W2063391304","https://openalex.org/W2063851889","https://openalex.org/W2088145034","https://openalex.org/W2096786080","https://openalex.org/W2114095518","https://openalex.org/W2120718661","https://openalex.org/W2130616229","https://openalex.org/W2139799027","https://openalex.org/W2140334822","https://openalex.org/W2142752401","https://openalex.org/W2146404049","https://openalex.org/W2149952977","https://openalex.org/W2161692381","https://openalex.org/W2166084034","https://openalex.org/W2166700462","https://openalex.org/W2185378752","https://openalex.org/W2241983385","https://openalex.org/W2405151655","https://openalex.org/W2549494681","https://openalex.org/W2590988070","https://openalex.org/W4245265058"],"related_works":["https://openalex.org/W2599776453","https://openalex.org/W2104263132","https://openalex.org/W2156509877","https://openalex.org/W4393989413","https://openalex.org/W2096514095","https://openalex.org/W2114553148","https://openalex.org/W2598482545","https://openalex.org/W2244049209","https://openalex.org/W88663011","https://openalex.org/W4282939400"],"abstract_inverted_index":{"BACKGROUND:":[0],"AST1306":[1,243],"is":[2,20],"an":[3],"orally":[4],"active":[5],"irreversible":[6],"small":[7],"molecule":[8],"inhibitor":[9],"of":[10,39,46,266,342],"EGFR":[11],"(erbB1),":[12],"HER2":[13],"(erbB2)":[14],"and":[15,31,35,69,108,111,122,128,172,196,236,247,281,304,329],"HER4":[16],"(erbB4)":[17],"signaling.":[18],"This":[19],"a":[21],"phase":[22,71],"I,":[23],"open-label,":[24],"dose-escalation":[25,59],"study":[26],"to":[27,63,157,193,200,250],"evaluate":[28,158],"the":[29,44,65,126,153,159,179,206,260,273,286,327,332],"safety":[30],"tolerability,":[32],"pharmacokinetics":[33],"(PK),":[34],"preliminary":[36,343],"anti-tumor":[37,344],"effects":[38,45],"oral":[40],"AST1306.":[41],"In":[42,125],"addition":[43],"food":[47],"on":[48,326],"PK":[49,127,160,253,330],"was":[50,61,209,244,276,279,283,319,334],"tested.":[51],"METHODS:":[52],"A":[53],"modified":[54],"Fibonacci":[55],"3":[56,58,194,211],"plus":[57],"design":[60],"employed":[62],"determine":[64],"dose-limiting":[66],"toxicity":[67],"(DLT)":[68],"recommended":[70],"II":[72],"dose":[73,83,92,102,118,136,140,144,204,258],"(RP2D)":[74],"in":[75,100,116,138,214,321],"patients":[76,134,164,216,291],"with":[77,167,257,263,297,301,306,312,340],"advanced":[78],"solid":[79],"tumors.":[80],"The":[81,184,309],"following":[82],"levels":[84,93,103,119,141],"were":[85,155,165,190],"investigated:":[86],"once":[87],"daily":[88,98,114],"(QD)":[89],"at":[90,131,217],"two":[91,148],"(400-and":[94],"800":[95,230],"mg),":[96,110],"twice":[97],"(BID)":[99],"five":[101],"(600-,":[104],"800-,":[105],"1000-,":[106],"1200-":[107],"1500":[109,224],"three":[112,117,139],"times":[113],"(TID)":[115],"(800-,":[120],"1000-":[121],"1200":[123,237],"mg).":[124],"extension":[129],"study,":[130],"least":[132],"eight":[133],"per":[135],"cohort":[137],"(maximum":[142],"tolerated":[143],"[MTD],":[145],"one":[146],"or":[147],"doses":[149],"level":[150],"lower":[151],"than":[152],"MTD)":[154],"enrolled":[156],"profiles.":[161],"RESULTS:":[162],"Seventy-one":[163],"enrolled,":[166],"breast":[168,298],"(n":[169,175,221,227,233,240],"=":[170,176,222,228,234,241],"22)":[171],"lung":[173,302],"cancers":[174],"14)":[177],"being":[178],"most":[180,185],"common":[181],"primary":[182],"cancers.":[183],"frequent":[186],"drug-related":[187],"adverse":[188],"events":[189],"grade":[191,198,210],"1":[192,199,300,305],"diarrhea":[195,212],"rash,":[197],"2":[201],"fatigue.":[202],"During":[203],"escalation,":[205],"key":[207],"DLT":[208,328],"observed":[213],"5":[215,296],"1000":[218,337],"mg":[219,225,231,238,338],"BID":[220,226],"1),":[223,229],"TID":[232,239,339],"1)":[235],"2).":[242],"rapidly":[245],"absorbed":[246],"had":[248],"moderate":[249],"high":[251],"clearance.":[252],"concentration":[254],"parameters":[255],"increased":[256],"over":[259,268],"range":[261],"evaluated,":[262],"no":[264],"evidence":[265,341],"accumulation":[267],"time.":[269],"Under":[270],"fed":[271],"conditions,":[272],"mean":[274],"T(max)":[275],"prolonged,":[277],"C(max)":[278],"increased,":[280],"AUC(0-\u221e)":[282],"raised.":[284],"Of":[285],"55":[287],"evaluable":[288],"patients,":[289],"7":[290,322],"experienced":[292],"partial":[293],"responses,":[294],"including":[295],"cancer,":[299,303],"gastric":[307],"cancer.":[308],"best":[310],"response":[311],"stable":[313],"disease":[314],"for":[315],"\u2265":[316],"6":[317],"months":[318],"achieved":[320],"patients.":[323],"CONCLUSIONS:":[324],"Based":[325],"profile,":[331],"RP2D":[333],"defined":[335],"as":[336],"activity.":[345],"Further":[346],"studies":[347],"are":[348],"recommended.":[349]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
