{"id":"https://openalex.org/W2115678488","doi":"https://doi.org/10.1111/j.1365-2249.2004.02360.x","title":"IL-12 enhances the generation of tumour antigen-specific Th1 CD4 T cells duringex vivoexpansion","display_name":"IL-12 enhances the generation of tumour antigen-specific Th1 CD4 T cells duringex vivoexpansion","publication_year":2004,"publication_date":"2004-01-22","ids":{"openalex":"https://openalex.org/W2115678488","doi":"https://doi.org/10.1111/j.1365-2249.2004.02360.x","mag":"2115678488","pmid":"https://pubmed.ncbi.nlm.nih.gov/14738463","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1808930"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.2004.02360.x","doi":"https://doi.org/10.1111/j.1365-2249.2004.02360.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2004.02360.x","pdf_url":"https://academic.oup.com/cei/article-pdf/135/2/322/42145491/j.1365-2249.2004.02360.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cei/article-pdf/135/2/322/42145491/j.1365-2249.2004.02360.x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K L KNUTSON","raw_affiliation_strings":["Tumor Vaccine Group, Division of Oncology, University of Washington, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Vaccine Group, Division of Oncology, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039848435","display_name":"Mary Lenora Disis","orcid":"https://orcid.org/0000-0001-7653-4648","observed_orcids":["https://orcid.org/0000-0001-7653-4648"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M L DISIS","raw_affiliation_strings":["Tumor Vaccine Group, Division of Oncology, University of Washington, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Vaccine Group, Division of Oncology, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031005364"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":1.3113,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.79792076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"135","issue":"2","first_page":"322","last_page":"329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9679999947547913},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ex-vivo-t-cell-expansion","display_name":"ex vivo T cell expansion","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cd4-t-helper-cells","display_name":"CD4+ T helper cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.9179999828338623},{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"peptide vaccine","score":0.7279999852180481},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6638904809951782},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6004588007926941},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5692323446273804},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5495976209640503},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5214583277702332},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5083279013633728},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49796390533447266},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.45153433084487915},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35427379608154297},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.29984205961227417},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2249.2004.02360.x","doi":"https://doi.org/10.1111/j.1365-2249.2004.02360.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2004.02360.x","pdf_url":"https://academic.oup.com/cei/article-pdf/135/2/322/42145491/j.1365-2249.2004.02360.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1808930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1808930","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:14738463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14738463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2249.2004.02360.x","doi":"https://doi.org/10.1111/j.1365-2249.2004.02360.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2004.02360.x","pdf_url":"https://academic.oup.com/cei/article-pdf/135/2/322/42145491/j.1365-2249.2004.02360.x.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3164105189","display_name":"HER2  VACCINATION FOR THE TREATMENT OF CANCER","funder_award_id":"R01CA085374","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7865177195","display_name":"MIDCAREER INVESTIGATOR AWARD IN PATIENT ORIENTED RESEARC","funder_award_id":"K24CA085218","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115678488.pdf","grobid_xml":"https://content.openalex.org/works/W2115678488.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W249403745","https://openalex.org/W1485135003","https://openalex.org/W1577612079","https://openalex.org/W1590352003","https://openalex.org/W1609634130","https://openalex.org/W1621615533","https://openalex.org/W1912153606","https://openalex.org/W1924089035","https://openalex.org/W1979969914","https://openalex.org/W1985770829","https://openalex.org/W1989064979","https://openalex.org/W2009648532","https://openalex.org/W2013988458","https://openalex.org/W2031477951","https://openalex.org/W2053184982","https://openalex.org/W2068473901","https://openalex.org/W2072710870","https://openalex.org/W2076440728","https://openalex.org/W2091387892","https://openalex.org/W2115122746","https://openalex.org/W2121136366","https://openalex.org/W2124403991","https://openalex.org/W2138128441","https://openalex.org/W2138733343","https://openalex.org/W2148177811","https://openalex.org/W2151246207","https://openalex.org/W2152773914","https://openalex.org/W2155778479","https://openalex.org/W2162332541","https://openalex.org/W2164486810","https://openalex.org/W2315098267","https://openalex.org/W6636700061","https://openalex.org/W6677699649","https://openalex.org/W6677893402","https://openalex.org/W6680316138","https://openalex.org/W6683942269"],"related_works":["https://openalex.org/W7098747224","https://openalex.org/W2013988458","https://openalex.org/W7101078998","https://openalex.org/W7073633833","https://openalex.org/W2137220693","https://openalex.org/W4313349607","https://openalex.org/W1490422978","https://openalex.org/W7160257366","https://openalex.org/W1558918513","https://openalex.org/W1974712478"],"abstract_inverted_index":{"CD4+":[0,61,90,244,271],"T":[1,27,55,62,69,91,109,134,190,225,245,272],"cells":[2,110,191],"are":[3],"essential":[4],"for":[5,34,236,266,274],"the":[6,51,102,128,163,211,221],"immune":[7],"response":[8,209],"against":[9,12],"cancer.":[10],"Vaccination":[11],"cancer":[13],"will":[14,30],"likely":[15],"only":[16,164],"be":[17,31,144,250],"effective":[18,74],"at":[19],"preventing":[20],"growth":[21],"of":[22,36,53,60,67,73,89,96,106,131,170,175,210,223,242,270],"micrometastatic":[23],"disease":[24,39],"while":[25],"adoptive":[26,54,278],"cell":[28,56,63,135,150,273],"therapy":[29,57],"better":[32],"suited":[33],"eradication":[35],"bulky":[37],"pre-existing":[38],"(Knutson":[40],"et":[41],"al.":[42],"Expert":[43],"Opin":[44],"Biol":[45],"Ther":[46],"2002;":[47],"2:55-66).":[48],"Problems":[49],"with":[50,99,116,158,178,258],"use":[52,275],"include":[58],"lack":[59,72],"help,":[64],"low":[65],"frequency":[66],"antigen-specific":[68,108,171,181,243],"cells,":[70],"and":[71,160,198,204,240],"ex":[75,86,103,237,267],"vivo":[76,87,104,238,268],"expansion":[77,88,269],"techniques.":[78],"In":[79],"this":[80],"study,":[81],"we":[82],"focused":[83],"on":[84,101],"improving":[85],"helper":[92,123],"cells.":[93,226],"The":[94,173,187,206],"effects":[95],"IL-12,":[97,176],"along":[98,177],"IL-2,":[100,179],"generation":[105,152],"HER-2/neu":[107],"were":[111,114],"examined.":[112],"Patients":[113],"immunized":[115],"a":[117,122,184],"peptide-based":[118],"vaccine":[119],"that":[120,230,247],"contained":[121],"epitope,":[124],"p776-790,":[125,138],"derived":[126],"from":[127],"intracellular":[129],"domain":[130],"HER-2/neu.":[132],"While":[133],"immunity":[136],"to":[137,194,217],"assessed":[139],"by":[140,153,196,252],"proliferation":[141,182],"assays,":[142],"could":[143],"readily":[145,193],"measured":[146],"in":[147,155,168,183,215,220,256,276],"short-term":[148],"cultures,":[149],"line":[151],"multiple":[154],"vitro":[156],"stimulation":[157],"peptide":[159],"IL-2":[161,254],"as":[162],"added":[165],"cytokine":[166,235],"resulted":[167],"loss":[169],"proliferation.":[172],"inclusion":[174],"restored":[180],"dose-dependent":[185],"fashion.":[186],"resulting":[188],"p776-790-specific":[189],"responded":[192],"antigen":[195],"proliferating":[197],"producing":[199],"type":[200],"I":[201],"cytokines":[202],"(IFN-gamma":[203],"TNF-alpha).":[205],"increased":[207],"proliferative":[208],"cultures":[212],"was":[213],"due":[214],"part":[216],"an":[218,233],"increase":[219],"number":[222],"HER-2/neu-specific":[224],"These":[227],"results":[228,262],"suggest":[229],"IL-12":[231],"is":[232],"important":[234,264],"recovery":[239],"maintenance":[241],"lymphocytes":[246],"would":[248],"otherwise":[249],"lost":[251],"using":[253],"alone":[255],"combination":[257],"antigen.":[259],"Furthermore,":[260],"these":[261],"have":[263],"implications":[265],"anti-tumour":[277],"immunotherapy.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}