{"id":"https://openalex.org/W2115676371","doi":"https://doi.org/10.1016/s1010-7940(03)00408-1","title":"Transcriptional profiling and growth kinetics of endothelium reveals differences between cells derived from porcine aorta versus aortic valve\u2606","display_name":"Transcriptional profiling and growth kinetics of endothelium reveals differences between cells derived from porcine aorta versus aortic valve\u2606","publication_year":2003,"publication_date":"2003-09-12","ids":{"openalex":"https://openalex.org/W2115676371","doi":"https://doi.org/10.1016/s1010-7940(03)00408-1","mag":"2115676371","pmid":"https://pubmed.ncbi.nlm.nih.gov/14500070"},"language":"en","primary_location":{"id":"doi:10.1016/s1010-7940(03)00408-1","doi":"https://doi.org/10.1016/s1010-7940(03)00408-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1010-7940(03)00408-1","pdf_url":"https://academic.oup.com/ejcts/article-pdf/24/4/527/17808702/24-4-527.pdf","source":{"id":"https://openalex.org/S10542796","display_name":"European Journal of Cardio-Thoracic Surgery","issn_l":"1010-7940","issn":["1010-7940","1873-734X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cardio-Thoracic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ejcts/article-pdf/24/4/527/17808702/24-4-527.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112813836","display_name":"Robert Saeid Farivar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R.Saeid Farivar","raw_affiliation_strings":["Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. sfarivar@partners.org","Division of Cardiac Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. sfarivar@partners.org","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Cardiac Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113610829","display_name":"Lawrence H. Cohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence H. Cohn","raw_affiliation_strings":["Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037340155","display_name":"Edward G. Soltesz","orcid":"https://orcid.org/0000-0002-1231-8329","observed_orcids":["https://orcid.org/0000-0002-1231-8329"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward G. Soltesz","raw_affiliation_strings":["Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomislav Mihaljevic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomislav Mihaljevic","raw_affiliation_strings":["Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108407056","display_name":"James D. Rawn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Rawn","raw_affiliation_strings":["Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074998209","display_name":"John G. Byrne","orcid":"https://orcid.org/0009-0003-7156-6845","observed_orcids":["https://orcid.org/0009-0003-7156-6845"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. Byrne","raw_affiliation_strings":["Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112813836"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3273,"currency":"EUR","value_usd":3699},"apc_paid":null,"fwci":1.5372,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.85536533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"4","first_page":"527","last_page":"534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valvular-endothelial-cells","display_name":"valvular endothelial cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/aortic-endothelial-cells","display_name":"aortic endothelial cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.828000009059906},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.5799999833106995},{"id":"https://openalex.org/keywords/aortic-valve-calcification","display_name":"aortic valve calcification","score":0.7369999885559082},{"id":"https://openalex.org/keywords/aortic-calcification","display_name":"aortic calcification","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ephrin-signaling","display_name":"ephrin signaling","score":0.6110000014305115},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor-receptor","display_name":"platelet-derived growth factor receptor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vegf-b","display_name":"VEGF-B","score":0.890999972820282},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.6150000095367432},{"id":"https://openalex.org/keywords/gelatin","display_name":"gelatin","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6049551367759705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5677051544189453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5459333062171936},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4715538024902344},{"id":"https://openalex.org/C15215337","wikidata":"https://www.wikidata.org/wiki/Q18032325","display_name":"Vascular endothelial growth factor B","level":5,"score":0.4318186342716217},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4223119914531708},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.4135095477104187},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.3487294018268585},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2699049711227417},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.23836401104927063},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22778472304344177},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1483561098575592},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07932937145233154},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07332706451416016},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1010-7940(03)00408-1","doi":"https://doi.org/10.1016/s1010-7940(03)00408-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1010-7940(03)00408-1","pdf_url":"https://academic.oup.com/ejcts/article-pdf/24/4/527/17808702/24-4-527.pdf","source":{"id":"https://openalex.org/S10542796","display_name":"European Journal of Cardio-Thoracic Surgery","issn_l":"1010-7940","issn":["1010-7940","1873-734X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cardio-Thoracic Surgery","raw_type":"journal-article"},{"id":"pmid:14500070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14500070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s1010-7940(03)00408-1","doi":"https://doi.org/10.1016/s1010-7940(03)00408-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1010-7940(03)00408-1","pdf_url":"https://academic.oup.com/ejcts/article-pdf/24/4/527/17808702/24-4-527.pdf","source":{"id":"https://openalex.org/S10542796","display_name":"European Journal of Cardio-Thoracic Surgery","issn_l":"1010-7940","issn":["1010-7940","1873-734X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cardio-Thoracic Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G29088776","display_name":"Role of nitric oxide in xenotransplant cardiac rejection","funder_award_id":"5f32hl067539-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3141750605","display_name":null,"funder_award_id":"1F32 HL67539-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115676371.pdf","grobid_xml":"https://content.openalex.org/works/W2115676371.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W66976633","https://openalex.org/W243787638","https://openalex.org/W1538796336","https://openalex.org/W1912969096","https://openalex.org/W1970376393","https://openalex.org/W1975523415","https://openalex.org/W1976359979","https://openalex.org/W1983028975","https://openalex.org/W2000705732","https://openalex.org/W2035595755","https://openalex.org/W2039017944","https://openalex.org/W2048820067","https://openalex.org/W2059818123","https://openalex.org/W2068477710","https://openalex.org/W2070210870","https://openalex.org/W2082667445","https://openalex.org/W2088864248","https://openalex.org/W2094395747","https://openalex.org/W2137336518","https://openalex.org/W2152446319","https://openalex.org/W2162575643","https://openalex.org/W2409893680","https://openalex.org/W2460816575","https://openalex.org/W2467220770","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2026528246","https://openalex.org/W7100195620","https://openalex.org/W1985382259","https://openalex.org/W2799893038","https://openalex.org/W4310542601","https://openalex.org/W2678414315","https://openalex.org/W2018314802","https://openalex.org/W7097191174","https://openalex.org/W4415788443","https://openalex.org/W7148512963"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Valvular":[1],"tissue":[2],"and":[3,23,37,44,47,65,77,91,97,110,139,165,182,225,274,281,304,313],"aorta":[4],"calcify":[5],"at":[6],"different":[7,279],"rates":[8],"when":[9],"placed":[10],"as":[11,199,201],"fresh":[12],"homografts":[13],"or":[14,259,270],"cryopreserved":[15],"allografts.":[16],"Furthermore,":[17,250],"differences":[18,49,107,288],"between":[19,108],"valvular":[20,111,210],"endothelial":[21,25,39,67,99,137,144,163,172,213,221,235,245,252,263,276],"cells":[22,26,40,138,164,214,236,246,253,264,277],"aortic":[24,38,66,98,109,136,162,244,262,275],"are":[27],"not":[28],"well":[29,200],"appreciated.":[30],"We":[31,69,81],"established":[32],"primary":[33,60],"cultures":[34,61],"of":[35,62,158,168,176,203,217,219,286,299,308],"valve":[36,64,96,143,171,234,251,302,310],"derived":[41],"from":[42,73],"swine":[43],"tested":[45],"transcriptional":[46,280],"proliferative":[48,267,282],"on":[50,59,95,121,135,142,161,257,268],"various":[51,122],"extracellular":[52,123],"matrices.":[53,124],"METHODS:":[54],"Transcriptional":[55],"profiling":[56],"was":[57,116],"performed":[58],"porcine":[63],"cells.":[68,100,145,173,211],"extracted":[70],"total":[71],"RNA":[72],"both":[74,148,196],"cell":[75,119,149,186,197,222,227],"types":[76,150],"created":[78],"cDNA":[79],"libraries.":[80],"scored":[82],"for":[83,185],"847":[84,127],"genes":[85,128,160],"important":[86],"in":[87,170,195,209,294,305],"signal":[88],"transduction":[89],"pathways,":[90],"measured":[92],"their":[93,113],"expression":[94],"To":[101],"determine":[102],"if":[103],"there":[104],"were":[105,132,151,215,265],"functional":[106],"cells,":[112],"growth":[114,191,206,223],"rate":[115],"determined":[117],"by":[118],"counting":[120],"RESULTS:":[125],"Of":[126],"investigated,":[129],"69":[130],"(8.1%)":[131],"transcriptionally":[133],"active":[134],"89":[140],"(10.5%)":[141],"Common":[146],"to":[147],"55":[152],"genes,":[153],"which":[154],"represents":[155],"79.7%":[156],"(55/69)":[157],"activated":[159],"61.8%":[166],"(55/89)":[167],"those":[169],"Remarkable":[174],"features":[175],"the":[177,204,295,306,309],"analysis":[178,231],"included":[179],"Ephrin":[180],"ligand":[181],"receptor":[183,208],"specificity":[184],"type,":[187],"a":[188],"potential":[189],"fibroblast":[190],"factor":[192,207],"autocrine":[193],"loop":[194],"types,":[198],"upregulation":[202,218],"platelet-derived":[205],"Aortic":[212],"noteworthy":[216],"vascular":[220,226],"factor-B":[224],"adhesion":[228],"molecule.":[229],"Proliferation":[230],"revealed":[232],"that":[233],"grew":[237],"more":[238],"rapidly":[239,256],"(12-fold":[240],"over":[241,248],"control)":[242],"than":[243],"(3-fold":[247],"control).":[249],"proliferated":[254],"most":[255,266],"gelatin":[258],"collagen,":[260],"whereas":[261],"lysine":[269],"laminin.":[271],"CONCLUSIONS:":[272],"Valve":[273],"have":[278],"profiles.":[283],"The":[284],"knowledge":[285],"these":[287],"may":[289],"be":[290],"an":[291],"exploitable":[292],"strategy":[293],"future":[296],"rational":[297],"design":[298],"artificially":[300],"engineered":[301],"surfaces":[303],"study":[307],"antigenicity,":[311],"immunogenicity":[312],"structural":[314],"failure.":[315]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}