{"id":"https://openalex.org/W2115485185","doi":"https://doi.org/10.1002/prot.21850","title":"Binding of sulfonium\u2010ion analogues of di\u2010epi\u2010swainsonine and 8\u2010epi\u2010lentiginosine to Drosophila Golgi \u03b1\u2010mannosidase II: The role of water in inhibitor binding","display_name":"Binding of sulfonium\u2010ion analogues of di\u2010epi\u2010swainsonine and 8\u2010epi\u2010lentiginosine to Drosophila Golgi \u03b1\u2010mannosidase II: The role of water in inhibitor binding","publication_year":2007,"publication_date":"2007-12-12","ids":{"openalex":"https://openalex.org/W2115485185","doi":"https://doi.org/10.1002/prot.21850","mag":"2115485185","pmid":"https://pubmed.ncbi.nlm.nih.gov/18076078"},"language":"en","primary_location":{"id":"doi:10.1002/prot.21850","doi":"https://doi.org/10.1002/prot.21850","is_oa":false,"landing_page_url":"https://doi.org/10.1002/prot.21850","pdf_url":null,"source":{"id":"https://openalex.org/S121161810","display_name":"Proteins Structure Function and Bioinformatics","issn_l":"0887-3585","issn":["0887-3585","1097-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins: Structure, Function, and Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033237174","display_name":"Nag S. Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nag S. Kumar","raw_affiliation_strings":["Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6","Authors Nag S. Kumar and Douglas A. Kuntz contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Authors Nag S. Kumar and Douglas A. Kuntz contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041094828","display_name":"D.A. Kuntz","orcid":"https://orcid.org/0000-0003-3584-4804","observed_orcids":["https://orcid.org/0000-0003-3584-4804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas A. Kuntz","raw_affiliation_strings":["Authors Nag S. Kumar and Douglas A. Kuntz contributed equally to this work","Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Canada M5G 1L7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors Nag S. Kumar and Douglas A. Kuntz contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Canada M5G 1L7","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102813216","display_name":"Xin Wen","orcid":"https://orcid.org/0000-0001-5256-1166","observed_orcids":["https://orcid.org/0000-0001-5256-1166"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wen","raw_affiliation_strings":["Institute of Elemento-Organic Chemistry and Department of Chemical Biology, Nankai University, Tianjin, China, 300071"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Elemento-Organic Chemistry and Department of Chemical Biology, Nankai University, Tianjin, China, 300071","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110225942","display_name":"B. Mario Pinto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"B. Mario Pinto","raw_affiliation_strings":["B. Mario Pinto, Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6===","David R. Rose, Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7===","Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B. Mario Pinto, Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6===","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"David R. Rose, Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7===","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074180325","display_name":"David R. Rose","orcid":"https://orcid.org/0000-0002-7033-4394","observed_orcids":["https://orcid.org/0000-0002-7033-4394"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David R. Rose","raw_affiliation_strings":["B. Mario Pinto, Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6===","David R. Rose, Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7===","Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7","Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Canada M5G 1L7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B. Mario Pinto, Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6===","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"David R. Rose, Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7===","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Canada M5G 1L7","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074180325","https://openalex.org/A5110225942"],"corresponding_institution_ids":["https://openalex.org/I18014758","https://openalex.org/I185261750"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.8521,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.6918794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"71","issue":"3","first_page":"1484","last_page":"1496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/swainsonine","display_name":"swainsonine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/glycosidase-inhibitors","display_name":"glycosidase inhibitors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bound-water","display_name":"bound water","score":0.6690000295639038},{"id":"https://openalex.org/keywords/inhibitor-binding-mode","display_name":"inhibitor binding mode","score":0.6420000195503235},{"id":"https://openalex.org/keywords/sulfonium-salts","display_name":"sulfonium salts","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2777040163","wikidata":"https://www.wikidata.org/wiki/Q423240","display_name":"Sulfonium","level":3,"score":0.9256881475448608},{"id":"https://openalex.org/C2775928797","wikidata":"https://www.wikidata.org/wiki/Q415324","display_name":"Swainsonine","level":2,"score":0.9201178550720215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.771486759185791},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6707378029823303},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5588908791542053},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.5458966493606567},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.48971298336982727},{"id":"https://openalex.org/C2777174400","wikidata":"https://www.wikidata.org/wiki/Q6750944","display_name":"Mannosidase","level":3,"score":0.4732804000377655},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.460803747177124},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4447750747203827},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.4378040134906769},{"id":"https://openalex.org/C7947691","wikidata":"https://www.wikidata.org/wiki/Q567575","display_name":"Anomer","level":2,"score":0.43575990200042725},{"id":"https://openalex.org/C196032511","wikidata":"https://www.wikidata.org/wiki/Q375795","display_name":"Glycoside hydrolase","level":3,"score":0.4148902893066406},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3165658712387085},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.23454567790031433},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.191144198179245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18017539381980896},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10214966535568237}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008361","descriptor_name":"Mannosidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008361","descriptor_name":"Mannosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008361","descriptor_name":"Mannosidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013452","descriptor_name":"Sulfonium Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013452","descriptor_name":"Sulfonium Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017026","descriptor_name":"Swainsonine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D017026","descriptor_name":"Swainsonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017026","descriptor_name":"Swainsonine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/prot.21850","doi":"https://doi.org/10.1002/prot.21850","is_oa":false,"landing_page_url":"https://doi.org/10.1002/prot.21850","pdf_url":null,"source":{"id":"https://openalex.org/S121161810","display_name":"Proteins Structure Function and Bioinformatics","issn_l":"0887-3585","issn":["0887-3585","1097-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins: Structure, Function, and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18076078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18076078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5242596989","display_name":"Macromolecular Diffraction Resource: MacCHESS","funder_award_id":"P41RR001646","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W58913418","https://openalex.org/W1542334133","https://openalex.org/W1583741151","https://openalex.org/W1705855583","https://openalex.org/W1710565104","https://openalex.org/W1966498983","https://openalex.org/W1966805618","https://openalex.org/W1970471992","https://openalex.org/W1974723095","https://openalex.org/W1984236474","https://openalex.org/W1987768201","https://openalex.org/W1995017064","https://openalex.org/W1995017303","https://openalex.org/W1997362085","https://openalex.org/W2001641653","https://openalex.org/W2008517160","https://openalex.org/W2012619409","https://openalex.org/W2014548034","https://openalex.org/W2017469968","https://openalex.org/W2018849208","https://openalex.org/W2024172063","https://openalex.org/W2025295232","https://openalex.org/W2037891557","https://openalex.org/W2038840577","https://openalex.org/W2040568491","https://openalex.org/W2049924450","https://openalex.org/W2051537631","https://openalex.org/W2051830714","https://openalex.org/W2060121821","https://openalex.org/W2062142225","https://openalex.org/W2065947481","https://openalex.org/W2074388996","https://openalex.org/W2076261290","https://openalex.org/W2077381233","https://openalex.org/W2085285145","https://openalex.org/W2102495530","https://openalex.org/W2106121486","https://openalex.org/W2122199548","https://openalex.org/W2127753803","https://openalex.org/W2128687047","https://openalex.org/W2140277678","https://openalex.org/W2144081223","https://openalex.org/W2158534713","https://openalex.org/W2163539354","https://openalex.org/W2413224828","https://openalex.org/W2950548677","https://openalex.org/W2951341620","https://openalex.org/W3027329178"],"related_works":["https://openalex.org/W1981643696","https://openalex.org/W200474764","https://openalex.org/W2025295232","https://openalex.org/W1987768201","https://openalex.org/W1999722013","https://openalex.org/W4402688718","https://openalex.org/W2611366920","https://openalex.org/W4399761615","https://openalex.org/W1976323077","https://openalex.org/W2000420690"],"abstract_inverted_index":{"Retaining":[0],"glycosidases":[1],"operate":[2],"by":[3,15,45,152,176],"a":[4,18,46,57,61],"two-step":[5],"catalytic":[6],"mechanism":[7],"in":[8,37,50,117,144,159,170],"which":[9,38,150],"the":[10,23,29,39,54,88,99,118,147,166,171],"transition":[11],"states":[12],"are":[13,130],"characterized":[14],"buildup":[16],"of":[17,28,95,98,101,135,161,178,184],"partial":[19],"positive":[20,63],"charge":[21,64],"at":[22],"anomeric":[24],"center.":[25],"Sulfonium-ion":[26],"analogues":[27],"naturally":[30],"occurring":[31],"glycosidase":[32,69],"inhibitors,":[33],"swainsonine":[34,116],"and":[35,103,137,165],"8-epi-lentiginosine,":[36],"bridgehead":[40],"nitrogen":[41],"atom":[42],"is":[43,157],"replaced":[44],"sulfonium-ion,":[47],"were":[48],"synthesized":[49],"order":[51],"to":[52,82,93,105],"test":[53],"hypothesis":[55],"that":[56,94,128],"sulfonium":[58],"salt":[59],"carrying":[60],"permanent":[62],"would":[65],"be":[66],"an":[67,112],"effective":[68],"inhibitor.":[70],"Initial":[71],"prediction":[72],"based":[73],"on":[74],"computational":[75],"docking":[76],"indicated":[77],"three":[78],"plausible":[79],"binding":[80,100],"modes":[81],"Drosophila":[83],"Golgi":[84],"alpha-mannosidase":[85],"II":[86],"(dGMII),":[87],"most":[89],"likely":[90],"being":[91],"close":[92],"swainsonine.":[96],"Observation":[97],"di-epi-thioswainsonine":[102],"8-epi-thiolentiginosine":[104],"dGMII":[106,126],"from":[107,115],"crystallographic":[108],"data,":[109],"however,":[110],"revealed":[111],"orientation":[113],"different":[114],"active":[119,172],"site.":[120],"Screening":[121],"these":[122],"two":[123,148],"compounds":[124],"against":[125],"shows":[127],"they":[129],"inhibitors":[131],"with":[132],"IC(50)":[133],"values":[134],"2.0":[136],"0.014":[138],"mM,":[139],"respectively.":[140],"This":[141],"dramatic":[142],"difference":[143],"affinity":[145],"between":[146],"compounds,":[149],"differ":[151],"only":[153],"one":[154],"hydroxyl":[155],"group,":[156],"rationalized":[158],"terms":[160],"bound":[162],"water":[163,167],"molecules":[164],"molecule":[168],"substructure":[169],"site,":[173],"as":[174],"identified":[175],"comparison":[177],"high":[179],"resolution":[180],"X-ray":[181],"crystal":[182],"structures":[183],"several":[185],"dGMII-inhibitor":[186],"complexes.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}