{"id":"https://openalex.org/W2115484172","doi":null,"title":"Mast cells, disease and gastrointestinal cancer: A comprehensive review of recent findings.","display_name":"Mast cells, disease and gastrointestinal cancer: A comprehensive review of recent findings.","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2115484172","mag":"2115484172","pmid":"https://pubmed.ncbi.nlm.nih.gov/22943044","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3431027"},"language":"en","primary_location":{"id":"pmid:22943044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22943044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational gastrointestinal cancer","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3431027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081703728","display_name":"Kyle Hodges","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyle Hodges","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055423864","display_name":"Lindsey Leann Kennedy","orcid":"https://orcid.org/0000-0001-9224-8940","observed_orcids":["https://orcid.org/0000-0001-9224-8940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lindsey Kennedy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008932925","display_name":"Fanyin Meng","orcid":"https://orcid.org/0000-0002-7602-9091","observed_orcids":["https://orcid.org/0000-0002-7602-9091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fanyin Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029205234","display_name":"Gianfranco D. Alpini","orcid":"https://orcid.org/0000-0002-6658-3021","observed_orcids":["https://orcid.org/0000-0002-6658-3021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianfranco Alpini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030400303","display_name":"Heather Francis","orcid":"https://orcid.org/0000-0002-3466-3545","observed_orcids":["https://orcid.org/0000-0002-3466-3545","https://orcid.org/0000-0001-5428-641X"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Francis","raw_affiliation_strings":["Texas A&M, Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M, Health Science Center","institution_ids":["https://openalex.org/I125029298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6892,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.82842573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"2","first_page":"138","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":1.0},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mast-cell-activation","display_name":"mast cell activation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.6909999847412109},{"id":"https://openalex.org/keywords/allergic-reactions","display_name":"allergic reactions","score":0.828000009059906},{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gastric-polyps","display_name":"gastric polyps","score":0.7950000166893005},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.902999997138977},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.42899999022483826},{"id":"https://openalex.org/keywords/mast-cell-mediators","display_name":"mast cell mediators","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6836391687393188},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6321825981140137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6303398609161377},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5572063326835632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5565335154533386},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49736812710762024},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.46388086676597595},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4286196827888489},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4162255525588989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33724915981292725},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28759682178497314},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2538958787918091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08284500241279602}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:22943044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22943044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational gastrointestinal cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2430917","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3431027","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3431027","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3431027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Transl Gastrointest Cancer","raw_type":"Text"},{"id":"mag:2115484172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22943044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2430917","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3431027","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1761912709","display_name":"TOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSIS","funder_award_id":"R01DK058411","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7962286298","display_name":"Role of Sensory Neuropeptides in the Regulation of Biliary Function","funder_award_id":"R01DK076898","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":132,"referenced_works":["https://openalex.org/W24802265","https://openalex.org/W45169267","https://openalex.org/W162712135","https://openalex.org/W190980777","https://openalex.org/W598855324","https://openalex.org/W1496293490","https://openalex.org/W1503619884","https://openalex.org/W1511722376","https://openalex.org/W1544233162","https://openalex.org/W1568696684","https://openalex.org/W1627878190","https://openalex.org/W1677000101","https://openalex.org/W1687166873","https://openalex.org/W1940828351","https://openalex.org/W1963525180","https://openalex.org/W1963992704","https://openalex.org/W1966292953","https://openalex.org/W1969963120","https://openalex.org/W1970332798","https://openalex.org/W1970653879","https://openalex.org/W1972134636","https://openalex.org/W1973117758","https://openalex.org/W1974371579","https://openalex.org/W1974618890","https://openalex.org/W1974997229","https://openalex.org/W1975423828","https://openalex.org/W1976246912","https://openalex.org/W1977313091","https://openalex.org/W1979198726","https://openalex.org/W1979304701","https://openalex.org/W1982708256","https://openalex.org/W1982709334","https://openalex.org/W1983114375","https://openalex.org/W1984865466","https://openalex.org/W1985049017","https://openalex.org/W1987946408","https://openalex.org/W1992149176","https://openalex.org/W1992904489","https://openalex.org/W1997967342","https://openalex.org/W1999000125","https://openalex.org/W2000648336","https://openalex.org/W2002228338","https://openalex.org/W2004046308","https://openalex.org/W2004455131","https://openalex.org/W2007713789","https://openalex.org/W2013291652","https://openalex.org/W2014557893","https://openalex.org/W2016276631","https://openalex.org/W2016787771","https://openalex.org/W2016801684","https://openalex.org/W2017434802","https://openalex.org/W2018211030","https://openalex.org/W2018531873","https://openalex.org/W2020307752","https://openalex.org/W2021019784","https://openalex.org/W2023460263","https://openalex.org/W2028190708","https://openalex.org/W2028374643","https://openalex.org/W2029830646","https://openalex.org/W2033366643","https://openalex.org/W2037695813","https://openalex.org/W2040224022","https://openalex.org/W2041621456","https://openalex.org/W2041937465","https://openalex.org/W2042912493","https://openalex.org/W2046214587","https://openalex.org/W2047071002","https://openalex.org/W2048338120","https://openalex.org/W2051784480","https://openalex.org/W2053956977","https://openalex.org/W2054197038","https://openalex.org/W2054566387","https://openalex.org/W2055670234","https://openalex.org/W2056163222","https://openalex.org/W2057861610","https://openalex.org/W2058285264","https://openalex.org/W2059540285","https://openalex.org/W2060387717","https://openalex.org/W2061443292","https://openalex.org/W2065579351","https://openalex.org/W2069771199","https://openalex.org/W2070402163","https://openalex.org/W2071624194","https://openalex.org/W2077555941","https://openalex.org/W2081166085","https://openalex.org/W2083270957","https://openalex.org/W2084380710","https://openalex.org/W2085241614","https://openalex.org/W2085852125","https://openalex.org/W2085921243","https://openalex.org/W2086585598","https://openalex.org/W2086619383","https://openalex.org/W2089539926","https://openalex.org/W2090726140","https://openalex.org/W2091439605","https://openalex.org/W2092393850","https://openalex.org/W2093260288","https://openalex.org/W2095634270","https://openalex.org/W2100516030","https://openalex.org/W2104027407","https://openalex.org/W2106713576","https://openalex.org/W2108139380","https://openalex.org/W2112802424","https://openalex.org/W2118240561","https://openalex.org/W2119495257","https://openalex.org/W2120681057","https://openalex.org/W2120823996","https://openalex.org/W2121075675","https://openalex.org/W2125236241","https://openalex.org/W2134866540","https://openalex.org/W2143596626","https://openalex.org/W2145248653","https://openalex.org/W2147923982","https://openalex.org/W2149604229","https://openalex.org/W2158415064","https://openalex.org/W2158965678","https://openalex.org/W2161245089","https://openalex.org/W2162216569","https://openalex.org/W2165142370","https://openalex.org/W2166211643","https://openalex.org/W2166597823","https://openalex.org/W2166731175","https://openalex.org/W2168849655","https://openalex.org/W2170248440","https://openalex.org/W2172263281","https://openalex.org/W2185223750","https://openalex.org/W2186241669","https://openalex.org/W2294458921","https://openalex.org/W2322550664","https://openalex.org/W2333039284","https://openalex.org/W2405853341","https://openalex.org/W2407363715"],"related_works":["https://openalex.org/W1486037823","https://openalex.org/W4247894782","https://openalex.org/W2413052155","https://openalex.org/W7095417491","https://openalex.org/W2143413473","https://openalex.org/W4415272284","https://openalex.org/W4251127640","https://openalex.org/W2411209757","https://openalex.org/W1931151238","https://openalex.org/W25554836"],"abstract_inverted_index":{"Paul":[0],"Ehrlich,":[1],"a":[2],"German":[3],"scientist,":[4],"discovered":[5],"what":[6],"is":[7,162],"known":[8,76],"as":[9,122,137,148,183,185,258,274],"the":[10,14,26,36,39,78,96,126,191,198,215,264],"mast":[11,129,157,175,202,222,242,255],"cell":[12,109,203,223],"in":[13,25,55,118,133,159,171,180,236,244],"late":[15],"1800's,":[16],"which":[17,62,94,220],"has":[18],"proven":[19],"to":[20,86],"be":[21],"an":[22],"important":[23,54],"player":[24],"immune":[27,231],"system":[28],"of":[29,38,58,89,105,154,193,197,211],"vertebrates.":[30],"Mast":[31,108],"cells":[32,130,158,176,243],"are":[33,53,72,111,131,208,268],"ubiquitous":[34],"throughout":[35],"tissues":[37],"human":[40,245],"body":[41],"and":[42,48,68,91,103,113,144,156,218,230,270],"play":[43],"numerous":[44],"roles,":[45],"both":[46,181],"beneficial":[47],"destructive.":[49],"We":[50],"know":[51],"they":[52,80,188,267,272],"our":[56],"army":[57],"immunity":[59],"warrior":[60],"cells,":[61,256],"defend":[63],"us":[64],"against":[65],"viruses,":[66],"bacteria":[67],"parasitic":[69],"invaders.":[70],"They":[71],"also":[73,250],"very":[74],"well":[75,166,184],"for":[77],"havoc":[79],"wreak,":[81],"causing":[82],"uncomfortable":[83,145],"symptoms":[84],"due":[85],"their":[87,169,212,259,261],"release":[88],"histamine":[90],"other":[92],"mediators":[93],"cause":[95],"all":[97],"too":[98],"familiar":[99],"itching,":[100],"sneezing,":[101],"urticaria":[102],"rhinorrhea":[104],"allergic":[106,172],"responses.":[107,173],"activities":[110],"diverse":[112,134],"include":[114],"painful":[115],"inflammatory":[116],"reactions":[117],"autoimmune":[119],"conditions":[120,146],"such":[121,136,147,257],"rheumatoid":[123],"arthritis.":[124],"In":[125],"gastrointestinal":[127],"system,":[128],"implicated":[132,179],"actions":[135],"increased":[138],"gastric":[139],"acid":[140],"secretion,":[141],"polyp":[142],"formation":[143],"Irritable":[149],"Bowel":[150],"Syndrome.":[151],"The":[152,233],"role":[153,170],"immunology":[155],"these":[160],"areas":[161],"intriguing":[163],"but":[164],"less":[165],"understood":[167],"than":[168],"Because":[174],"have":[177,189],"been":[178,190],"physiologic":[182],"pathogenic":[186],"processes,":[187],"subjects":[192],"avid":[194],"study.":[195],"Review":[196],"current":[199],"literature":[200],"on":[201,225,241],"biology":[204],"reveals":[205],"that":[206],"there":[207],"many":[209],"studies":[210,234],"presence":[213],"within":[214,263],"tumor":[216,226,228],"microenvironment":[217],"evidence,":[219],"supports":[221],"influence":[224],"angiogenesis,":[227],"invasion,":[229],"suppression.":[232],"reviewed":[235],"this":[237],"article":[238],"concentrate":[239],"largely":[240],"GI":[246],"malignancies.":[247],"This":[248],"review":[249],"provides":[251],"background":[252],"information":[253],"regarding":[254],"origination,":[260],"location":[262],"body,":[265],"how":[266,271],"activated":[269],"function":[273],"mediators.":[275]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
