{"id":"https://openalex.org/W2115474397","doi":"https://doi.org/10.1007/bf01114812","title":"Export of proteins across membranes: The helix reversion hypothesis","display_name":"Export of proteins across membranes: The helix reversion hypothesis","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2115474397","doi":"https://doi.org/10.1007/bf01114812","mag":"2115474397","pmid":"https://pubmed.ncbi.nlm.nih.gov/2558738"},"language":"en","primary_location":{"id":"doi:10.1007/bf01114812","doi":"https://doi.org/10.1007/bf01114812","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01114812","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066661471","display_name":"Ujwal P. Shinde","orcid":"https://orcid.org/0000-0001-6229-2609","observed_orcids":["https://orcid.org/0000-0001-6229-2609"]},"institutions":[{"id":"https://openalex.org/I3125981224","display_name":"National Chemical Laboratory","ror":"https://ror.org/057mn3690","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3125981224","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"U. P. Shinde","raw_affiliation_strings":["Division of Chemical Engineering, National Chemical Laboratory, Pune 411 008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemical Engineering, National Chemical Laboratory, Pune 411 008, India","institution_ids":["https://openalex.org/I3125981224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016617970","display_name":"T.N.G. Row","orcid":"https://orcid.org/0000-0002-6324-3646","observed_orcids":["https://orcid.org/0000-0002-6324-3646"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"T. N. Guru Row","raw_affiliation_strings":["Division of Physical Chemistry, Indian Institute of Science, Bangalore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Physical Chemistry, Indian Institute of Science, Bangalore","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084282977","display_name":"Yogesh R. Mawal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3125981224","display_name":"National Chemical Laboratory","ror":"https://ror.org/057mn3690","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3125981224","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Y. R. Mawal","raw_affiliation_strings":["Division of Biochemical Sciences, Division of Chemical Engineering, National Chemical Laboratory, Pune 411 008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Sciences, Division of Chemical Engineering, National Chemical Laboratory, Pune 411 008, India","institution_ids":["https://openalex.org/I3125981224"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1960,"currency":"USD","value_usd":1960},"apc_paid":null,"fwci":0.5172,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.6343493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"6","first_page":"737","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.10379999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-export","display_name":"protein export","score":0.8709999918937683},{"id":"https://openalex.org/keywords/membrane-translocation","display_name":"membrane translocation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/leader-peptide","display_name":"leader peptide","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hairpin-conformation","display_name":"hairpin conformation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.7739999890327454},{"id":"https://openalex.org/keywords/membrane-insertion","display_name":"membrane insertion","score":0.628000020980835},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5912157893180847},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5855032205581665},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5552414059638977},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5401877164840698},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4783296585083008},{"id":"https://openalex.org/C70883133","wikidata":"https://www.wikidata.org/wiki/Q7318316","display_name":"Reversion","level":4,"score":0.44572651386260986},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.43984532356262207},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4201952815055847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3931194841861725},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3660030961036682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3385252356529236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32268935441970825},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.060176342725753784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018271","descriptor_name":"Signal Recognition Particle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021382","descriptor_name":"Protein Sorting Signals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/bf01114812","doi":"https://doi.org/10.1007/bf01114812","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01114812","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},{"id":"pmid:2558738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2558738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience reports","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.iisc.ac.in:29299","doi":null,"is_oa":false,"landing_page_url":"http://eprints.iisc.ac.in/29299/1/export.pdf","pdf_url":"http://eprints.iisc.ac.in/29299/1/export.pdf","source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1022.7662","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1022.7662","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bioscirep.org/content/ppbioscirep/9/6/737.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W124157494","https://openalex.org/W1967158227","https://openalex.org/W1975567952","https://openalex.org/W1986890416","https://openalex.org/W1991460989","https://openalex.org/W1991467177","https://openalex.org/W1997243880","https://openalex.org/W1997338044","https://openalex.org/W1999591998","https://openalex.org/W2001244497","https://openalex.org/W2009951300","https://openalex.org/W2014132117","https://openalex.org/W2046882513","https://openalex.org/W2056502094","https://openalex.org/W2058697482","https://openalex.org/W2067093784","https://openalex.org/W2070193853","https://openalex.org/W2072220895","https://openalex.org/W2074688701","https://openalex.org/W2108708484","https://openalex.org/W2128207929","https://openalex.org/W2146923243","https://openalex.org/W2156955619","https://openalex.org/W2158255239"],"related_works":["https://openalex.org/W7098505317","https://openalex.org/W1895980260","https://openalex.org/W2002662104","https://openalex.org/W2014132117","https://openalex.org/W2005966867","https://openalex.org/W1667874699","https://openalex.org/W1976534033","https://openalex.org/W1596987991","https://openalex.org/W1966369766","https://openalex.org/W2420587327"],"abstract_inverted_index":{"A":[0],"model":[1,64],"is":[2],"presented":[3],"which":[4,48],"explains":[5],"the":[6,10,17,22,41,57],"biological":[7],"role":[8],"of":[9,19,25,62,71],"leader":[11,38],"peptide":[12,39],"in":[13,40,66],"protein":[14,27,72],"export.":[15,73],"Along":[16],"lines":[18],"this":[20,63],"model,":[21],"conformational":[23],"changes":[24],"a":[26,32,44],"with":[28,68],"environment":[29],"serves":[30],"as":[31],"general":[33],"mechanism":[34],"for":[35],"translocation.":[36],"The":[37,59],"cytoplasm":[42],"takes":[43],"hairpin":[45],"like":[46],"conformation":[47],"reverts":[49],"to":[50],"an":[51],"extended":[52],"helix":[53],"upon":[54],"integration":[55],"into":[56],"membrane.":[58],"essential":[60],"features":[61],"are":[65],"accord":[67],"recent":[69],"results":[70]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}