{"id":"https://openalex.org/W2115474152","doi":"https://doi.org/10.1093/brain/awh539","title":"Glucose metabolism in early onset versus late onset Alzheimer's disease: an SPM analysis of 120 patients","display_name":"Glucose metabolism in early onset versus late onset Alzheimer's disease: an SPM analysis of 120 patients","publication_year":2005,"publication_date":"2005-05-11","ids":{"openalex":"https://openalex.org/W2115474152","doi":"https://doi.org/10.1093/brain/awh539","mag":"2115474152","pmid":"https://pubmed.ncbi.nlm.nih.gov/15888536"},"language":"en","primary_location":{"id":"doi:10.1093/brain/awh539","doi":"https://doi.org/10.1093/brain/awh539","is_oa":false,"landing_page_url":"https://doi.org/10.1093/brain/awh539","pdf_url":null,"source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005858096","display_name":"Eun Jin Kim","orcid":"https://orcid.org/0009-0008-9621-0585","observed_orcids":["https://orcid.org/0009-0008-9621-0585"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"E. J. Kim","raw_affiliation_strings":["Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-gu, Seoul 135-710, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-gu, Seoul 135-710, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007973529","display_name":"S. S. Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. S. Cho","raw_affiliation_strings":["Department of Nuclear Medicine , Seoul National University College of Medicine ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine , Seoul National University College of Medicine ,","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018649609","display_name":"Yong Jeong","orcid":"https://orcid.org/0000-0002-5907-3787","observed_orcids":["https://orcid.org/0000-0002-5907-3787"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Y. Jeong","raw_affiliation_strings":["College of Medicine , Kyung Hee University , Seoul ,","Department of Neurology , University of Florida and Veterans Affairs Medical Center , Gainesville , FL , USA","[University of Florida]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine , Kyung Hee University , Seoul ,","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Neurology , University of Florida and Veterans Affairs Medical Center , Gainesville , FL , USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"[University of Florida]","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067999737","display_name":"K. C. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"K. C. Park","raw_affiliation_strings":["Department of Neurology ,","Department of Neurology , Samsung Medical Center , Sungkyunkwan University School of Medicine , 50 Ilwon-dong , Kangnam-gu , Seoul 135-710 , Korea","Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology ,","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology , Samsung Medical Center , Sungkyunkwan University School of Medicine , 50 Ilwon-dong , Kangnam-gu , Seoul 135-710 , Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103562489","display_name":"S. J. Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. J. Kang","raw_affiliation_strings":["Department of Neurology ,","Sungkyunkwan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology ,","institution_ids":[]},{"raw_affiliation_string":"Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"E. Kang","raw_affiliation_strings":["Department of Psychology , Kangwon National University , Chuncheon , Korea and","Kangwon National University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology , Kangwon National University , Chuncheon , Korea and","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Kangwon National University;","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037821864","display_name":"Seung\u2010Jae Kim","orcid":"https://orcid.org/0000-0001-9955-4254","observed_orcids":["https://orcid.org/0000-0001-9955-4254"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. E. Kim","raw_affiliation_strings":["Department of Nuclear Medicine , Seoul National University College of Medicine ,","Seoul National Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine , Seoul National University College of Medicine ,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul National Univ","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698380","display_name":"Kyung Hee Lee","orcid":"https://orcid.org/0000-0003-2964-8356","observed_orcids":["https://orcid.org/0000-0003-2964-8356","https://orcid.org/0009-0003-5646-0006"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"K. H. Lee","raw_affiliation_strings":["Department of Nuclear Medicine , Samsung Medical Center , Sungkyunkwan University School of Medicine ,","Sungkyunkwan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine , Samsung Medical Center , Sungkyunkwan University School of Medicine ,","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073565046","display_name":"D L Na","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"D. L. Na","raw_affiliation_strings":["Department of Neurology ,","Sungkyunkwan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology ,","institution_ids":[]},{"raw_affiliation_string":"Sungkyunkwan University","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5005858096"],"corresponding_institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"],"apc_list":{"value":4224,"currency":"GBP","value_usd":5570},"apc_paid":null,"fwci":3.207,"has_fulltext":true,"cited_by_count":232,"citation_normalized_percentile":{"value":0.9111265,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"128","issue":"8","first_page":"1790","last_page":"1801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/early-onset-alzheimer-s-disease","display_name":"early-onset Alzheimer's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hypometabolism","display_name":"hypometabolism","score":0.8100000023841858},{"id":"https://openalex.org/keywords/dementia-severity","display_name":"dementia severity","score":0.953000009059906},{"id":"https://openalex.org/keywords/clinical-dementia-rating","display_name":"Clinical Dementia Rating","score":0.9670000076293945},{"id":"https://openalex.org/keywords/functional-reserve","display_name":"functional reserve","score":0.6060000061988831},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5528860688209534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5297514200210571},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5075749158859253},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.48277774453163147},{"id":"https://openalex.org/C2781340033","wikidata":"https://www.wikidata.org/wiki/Q5326566","display_name":"Early-onset Alzheimer's disease","level":4,"score":0.46151280403137207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4285024404525757}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044882","descriptor_name":"Glucose Metabolism Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D044882","descriptor_name":"Glucose Metabolism Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/brain/awh539","doi":"https://doi.org/10.1093/brain/awh539","is_oa":false,"landing_page_url":"https://doi.org/10.1093/brain/awh539","pdf_url":null,"source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmid:15888536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15888536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Comparative Study"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/26972","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10371/26972","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W7508719","https://openalex.org/W1822779864","https://openalex.org/W1857184078","https://openalex.org/W1969211751","https://openalex.org/W1970133453","https://openalex.org/W1978119032","https://openalex.org/W1984462809","https://openalex.org/W1986868047","https://openalex.org/W1989451265","https://openalex.org/W1991059506","https://openalex.org/W1991952617","https://openalex.org/W1999343631","https://openalex.org/W2002676789","https://openalex.org/W2006370463","https://openalex.org/W2008002833","https://openalex.org/W2010827885","https://openalex.org/W2013395460","https://openalex.org/W2016537454","https://openalex.org/W2017130071","https://openalex.org/W2020389720","https://openalex.org/W2023131797","https://openalex.org/W2026407962","https://openalex.org/W2027497683","https://openalex.org/W2030500443","https://openalex.org/W2032768837","https://openalex.org/W2033456903","https://openalex.org/W2037196565","https://openalex.org/W2038640104","https://openalex.org/W2050210881","https://openalex.org/W2052742260","https://openalex.org/W2053116984","https://openalex.org/W2054659083","https://openalex.org/W2054826790","https://openalex.org/W2056966839","https://openalex.org/W2061155471","https://openalex.org/W2062825859","https://openalex.org/W2063237661","https://openalex.org/W2064691186","https://openalex.org/W2070390701","https://openalex.org/W2070490664","https://openalex.org/W2072371192","https://openalex.org/W2074265252","https://openalex.org/W2081093524","https://openalex.org/W2093119661","https://openalex.org/W2105976707","https://openalex.org/W2106528101","https://openalex.org/W2120068364","https://openalex.org/W2128708438","https://openalex.org/W2136250824","https://openalex.org/W2137897073","https://openalex.org/W2147292818","https://openalex.org/W2148628103","https://openalex.org/W2156220037","https://openalex.org/W2169060615","https://openalex.org/W2376273711","https://openalex.org/W3127623214","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2347564221","https://openalex.org/W2137897073","https://openalex.org/W1996853079","https://openalex.org/W1978919116","https://openalex.org/W2346144267","https://openalex.org/W2074853630","https://openalex.org/W1986868047","https://openalex.org/W2042795487","https://openalex.org/W2050190016","https://openalex.org/W2788981510"],"abstract_inverted_index":{"The":[0,192,216],"aims":[1],"of":[2,26,34,40,60,75,100,120,135,168,176,234,267],"this":[3],"cross-sectional":[4],"study":[5],"were":[6,142],"(i)":[7],"to":[8,30,84,229],"compare":[9],"the":[10,32,76,89,95,105,147,166,179,200,212,231,248,254,265,271],"overall":[11],"glucose":[12,35,118,169,268],"metabolism":[13,36,170,269],"between":[14],"early":[15,44,66,121,148,184,201,220,255],"onset":[16,19,45,48,67,74,122,137,149,185,189,202,214,221,225,256,273],"and":[17,28,78,131,158,162],"late":[18,47,73,136,188,213,224,272],"Alzheimer's":[20,49,68,123,190],"disease":[21,124],"in":[22,43,129,144,155,183,187,199,211,219,223,241,244,264],"a":[23,38,52,174,260],"large":[24],"sample":[25],"patients;":[27],"(ii)":[29],"investigate":[31],"pattern":[33],"as":[37,173],"function":[39,175],"dementia":[41,101,145],"severity":[42,233],"versus":[46],"disease,":[50,69,77],"using":[51],"statistical":[53,115],"parametric":[54],"mapping":[55],"(SPM)":[56],"analysis.":[57],"Subjects":[58],"consisted":[59],"four":[61],"groups:":[62],"74":[63],"patients":[64,71,125,226,257],"with":[65,72,104],"46":[70],"two":[79],"control":[80],"groups":[81,141],"age":[82],"matched":[83],"each":[85],"patient":[86],"group.":[87,215],"All":[88],"subjects":[90],"underwent":[91],"2-[(18)F]fluoro-2-deoxy-d-glucose":[92],"(FDG)-PET":[93],"under":[94],"same":[96,232],"scanning":[97],"conditions.":[98],"Severity":[99],"was":[102,112,126,171,181],"rated":[103],"Clincial":[106],"Dementia":[107],"Rating":[108],"(CDR).":[109],"Voxel-based":[110],"SPM99":[111],"used":[113],"for":[114],"analyses.":[116],"Overall":[117],"hypometabolism":[119,154,218],"much":[127],"greater":[128,217,238],"magnitude":[130],"extent":[132],"than":[133,186,222,243,270],"that":[134,253],"patients,":[138],"though":[139],"both":[140],"similar":[143,205],"severity:":[146],"group":[150],"showed":[151],"more":[152,261],"severe":[153],"parietal,":[156],"frontal":[157],"subcortical":[159],"(basal":[160],"ganglia":[161],"thalamus)":[163],"areas.":[164],"When":[165],"decline":[167,194,250],"compared":[172],"CDR":[177,197,209],"stage,":[178],"slope":[180],"steeper":[182],"disease.":[191],"rapid":[193,262],"occurred":[195,207],"at":[196,208],"0.5-1":[198],"group,":[203],"whereas":[204],"changes":[206],"2-3":[210],"is":[227],"required":[228],"reach":[230],"dementia,":[235],"probably":[236],"reflecting":[237],"functional":[239],"reserve":[240],"younger":[242],"older":[245],"subjects.":[246],"Alternatively,":[247],"metabolic":[249],"curve":[251],"suggests":[252],"may":[258],"take":[259],"course":[263],"reduction":[266],"patients.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":20}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
