{"id":"https://openalex.org/W2115411982","doi":"https://doi.org/10.1160/th09-12-0855","title":"New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases","display_name":"New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2115411982","doi":"https://doi.org/10.1160/th09-12-0855","mag":"2115411982","pmid":"https://pubmed.ncbi.nlm.nih.gov/20664911"},"language":"en","primary_location":{"id":"doi:10.1160/th09-12-0855","doi":"https://doi.org/10.1160/th09-12-0855","is_oa":false,"landing_page_url":"https://doi.org/10.1160/th09-12-0855","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029271049","display_name":"Ana K. Oliveira","orcid":"https://orcid.org/0000-0001-6837-5739","observed_orcids":["https://orcid.org/0000-0001-6837-5739"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Oliveira","raw_affiliation_strings":["Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008238830","display_name":"Adriana Franco Paes Leme","orcid":"https://orcid.org/0000-0001-7959-147X","observed_orcids":["https://orcid.org/0000-0001-7959-147X"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana Paes Leme","raw_affiliation_strings":["Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091741771","display_name":"Amanda F. Asega","orcid":"https://orcid.org/0009-0005-4487-5110","observed_orcids":["https://orcid.org/0009-0005-4487-5110"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Amanda Asega","raw_affiliation_strings":["Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Antonio Camargo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio Camargo","raw_affiliation_strings":["Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041069370","display_name":"Jay W. Fox","orcid":"https://orcid.org/0000-0003-4600-1132","observed_orcids":["https://orcid.org/0000-0003-4600-1132"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Fox","raw_affiliation_strings":["Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010809600","display_name":"Solange M.T. Serrano","orcid":"https://orcid.org/0000-0001-8994-1904","observed_orcids":["https://orcid.org/0000-0001-8994-1904"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Solange Serrano","raw_affiliation_strings":["Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio Especial de Toxinologia Aplicada/CAT-CEPID, Instituto Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010809600"],"corresponding_institution_ids":["https://openalex.org/I2800423888"],"apc_list":null,"apc_paid":null,"fwci":2.5154,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.89792616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"104","issue":"09","first_page":"485","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snake-venom-metalloproteinases","display_name":"snake venom metalloproteinases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.8870000243186951},{"id":"https://openalex.org/keywords/bothrops-jararaca","display_name":"Bothrops jararaca","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bothrops-jararaca-venom","display_name":"Bothrops jararaca venom","score":0.5600000023841858},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/carbohydrate-moiety","display_name":"carbohydrate moiety","score":0.7269999980926514},{"id":"https://openalex.org/keywords/extracellular-matrix-proteins","display_name":"extracellular matrix proteins","score":0.7540000081062317},{"id":"https://openalex.org/keywords/fibrinogen-degradation","display_name":"fibrinogen degradation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8450000286102295},{"id":"https://openalex.org/keywords/collagen-degradation","display_name":"collagen degradation","score":0.5580000281333923},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.7170000076293945},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.7966018319129944},{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.7395864725112915},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6172515153884888},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5719863176345825},{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.5566672086715698},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5453464984893799},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.517087459564209},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5138033032417297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5053970813751221},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.49694445729255676},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4539300501346588},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.43198850750923157},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.42618539929389954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3288177251815796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3079723119735718},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.268505722284317},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2527439296245575},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.15675246715545654}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003435","descriptor_name":"Crotalid Venoms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003435","descriptor_name":"Crotalid Venoms","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017837","descriptor_name":"Bothrops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1160/th09-12-0855","doi":"https://doi.org/10.1160/th09-12-0855","is_oa":false,"landing_page_url":"https://doi.org/10.1160/th09-12-0855","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:20664911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20664911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G436901187","display_name":"Estudo sobre a fun\u00e7\u00e3o do dom\u00ednio rico em ciste\u00ednas do fator hemorr\u00e1gico 3 (HF3), metaloproteinases do veneno da serpente Bothrops jararaca, na intera\u00e7\u00e3o com seus alvos celulares e plasm\u00e1ticos","funder_award_id":"04/15974-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G8840421801","display_name":"Center for Applied Toxinology","funder_award_id":"98/14307-9","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W23530191","https://openalex.org/W1538333669","https://openalex.org/W1545427707","https://openalex.org/W1565563859","https://openalex.org/W1591272093","https://openalex.org/W1888609755","https://openalex.org/W1939750459","https://openalex.org/W1965520907","https://openalex.org/W1967674281","https://openalex.org/W1969765250","https://openalex.org/W1974104033","https://openalex.org/W1979816412","https://openalex.org/W1981148940","https://openalex.org/W1984267713","https://openalex.org/W1985219531","https://openalex.org/W1989192235","https://openalex.org/W1991363427","https://openalex.org/W1992346641","https://openalex.org/W1993988581","https://openalex.org/W1994965374","https://openalex.org/W1995516187","https://openalex.org/W1997419150","https://openalex.org/W2000383671","https://openalex.org/W2003977686","https://openalex.org/W2007635285","https://openalex.org/W2008511690","https://openalex.org/W2009552835","https://openalex.org/W2018327701","https://openalex.org/W2030246164","https://openalex.org/W2034956882","https://openalex.org/W2035605729","https://openalex.org/W2039278322","https://openalex.org/W2044516757","https://openalex.org/W2050964385","https://openalex.org/W2053041551","https://openalex.org/W2055785948","https://openalex.org/W2077043569","https://openalex.org/W2082228931","https://openalex.org/W2082339460","https://openalex.org/W2090117493","https://openalex.org/W2092729970","https://openalex.org/W2094001578","https://openalex.org/W2097966029","https://openalex.org/W2100837269","https://openalex.org/W2106028065","https://openalex.org/W2111817213","https://openalex.org/W2145837099","https://openalex.org/W2146194904","https://openalex.org/W2164434522","https://openalex.org/W2345436650","https://openalex.org/W2411363425","https://openalex.org/W2471318429"],"related_works":["https://openalex.org/W2050557145","https://openalex.org/W2008511690","https://openalex.org/W2039123831","https://openalex.org/W2025516610","https://openalex.org/W3046807775","https://openalex.org/W7120662890","https://openalex.org/W2017283877","https://openalex.org/W1983481237","https://openalex.org/W2035605729","https://openalex.org/W1965520907"],"abstract_inverted_index":{"Haemorrhage":[0],"induced":[1],"by":[2,248],"snake":[3],"venom":[4],"metalloproteinases":[5],"(SVMPs)":[6],"is":[7,47,68,75],"a":[8,61,204],"complex":[9],"phenomenon":[10],"resulting":[11],"in":[12,206,223],"capillary":[13],"disruption":[14],"and":[15,35,40,50,71,84,99,102,115,124,134,154,163,179,215],"extravasation.":[16],"This":[17,191],"study":[18,192],"analysed":[19],"structural":[20,150],"elements":[21],"important":[22],"for":[23,241],"the":[24,72,126,212,216,243],"interaction":[25,208],"of":[26,31,77,80,90,139,149,152,196,199,211,218,245],"four":[27],"Bothrops":[28],"jararaca":[29],"SVMPs":[30,201,219],"different":[32,87],"domain":[33],"organisation":[34],"glycosylation":[36],"levels":[37],"with":[38,118,173,209],"plasma":[39],"extracellular":[41,213],"matrix":[42],"proteins:":[43],"HF3":[44,114,157,171],"(P-III":[45,57],"class)":[46,67],"highly":[48],"glycosylated":[49],"~80":[51],"times":[52],"more":[53],"haemorrhagic":[54,70,162,200],"than":[55],"bothropasin":[56,83,106,116,153],"class),":[58],"which":[59],"has":[60],"minor":[62],"carbohydrate":[63,197],"moiety;":[64],"BJ-PI":[65,85,140,155],"(P-I":[66],"not":[69,189,226],"DC":[73,127],"protein":[74,128],"composed":[76],"disintegrin-like/cysteine-rich":[78],"domains":[79],"bothropasin.":[81],"HF3,":[82],"showed":[86],"degradation":[88],"profiles":[89],"fibrinogen,":[91,119],"fibronectin,":[92,120],"vitronectin,":[93],"von":[94],"Willebrand":[95],"factor,":[96],"collagens":[97,122,132,177,187],"IV":[98],"VI,":[100,180],"laminin":[101],"Matrigel;":[103],"however,":[104,136],"only":[105,130],"degraded":[107],"collagen":[108],"I.":[109],"In":[110],"solid-phase":[111],"binding":[112,138],"assays":[113],"interacted":[117],"laminin,":[121],"I":[123,133,178],"VI;":[125,135],"bound":[129,172],"to":[131,141,176,220,228,231],"no":[137],"these":[142,186],"proteins":[143,222],"was":[144,188],"detected.":[145],"N-deglycosylation":[146],"caused":[147],"loss":[148],"stability":[151],"but":[156],"remained":[158],"intact,":[159],"although":[160,181],"its":[161,182],"fibrinogenolytic":[164],"activities":[165],"were":[166],"partially":[167],"impaired.":[168],"Nevertheless,":[169],"N-deglycosylated":[170],"higher":[174],"affinity":[175],"proteolytic":[183],"activity":[184],"upon":[185],"enhanced.":[190],"demonstrates":[193],"that":[194,235],"features":[195],"moieties":[198],"may":[202],"play":[203],"role":[205],"their":[207,229],"substrates":[210],"matrix,":[214],"ability":[217,230],"degrade":[221],"vitro":[224],"does":[225],"correlate":[227],"cause":[232],"haemorrhage,":[233],"suggesting":[234],"novel,":[236],"systemic":[237],"approaches":[238],"are":[239],"necessary":[240],"understanding":[242],"mechanism":[244],"haemorrhage":[246],"generation":[247],"SVMPs.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
