{"id":"https://openalex.org/W2115385894","doi":null,"title":"Are metalloproteins and acute phase reactants associated with cardiovascular disease in end-stage renal failure?","display_name":"Are metalloproteins and acute phase reactants associated with cardiovascular disease in end-stage renal failure?","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2115385894","mag":"2115385894","pmid":"https://pubmed.ncbi.nlm.nih.gov/10945571"},"language":"en","primary_location":{"id":"pmid:10945571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10945571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075454822","display_name":"Helen Grania Healy","orcid":"https://orcid.org/0000-0003-4342-5300","observed_orcids":["https://orcid.org/0000-0003-4342-5300"]},"institutions":[{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"H Healy","raw_affiliation_strings":["Department of Renal Medicine, Royal Brisbane Hospital, Queensland, Australia. healyh@health.qld.gov.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Renal Medicine, Royal Brisbane Hospital, Queensland, Australia. healyh@health.qld.gov.au","institution_ids":["https://openalex.org/I2799393793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009621253","display_name":"David Martin Reith","orcid":"https://orcid.org/0000-0002-2447-365X","observed_orcids":["https://orcid.org/0000-0002-2447-365X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Reith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045232687","display_name":"Christopher Ll. Morgan","orcid":"https://orcid.org/0000-0001-8796-7406","observed_orcids":["https://orcid.org/0000-0001-8796-7406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033618343","display_name":"Alan E Clague","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Clague","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012261854","display_name":"Justin Westhuyzen","orcid":"https://orcid.org/0000-0002-4812-8973","observed_orcids":["https://orcid.org/0000-0002-4812-8973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Westhuyzen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5221,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.66769059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"30","issue":"3","first_page":"295","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/metalloproteins","display_name":"metalloproteins","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ceruloplasmin","display_name":"ceruloplasmin","score":0.8289999961853027},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.8429999947547913},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.8849999904632568},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/peripheral-vascular-disease","display_name":"peripheral vascular disease","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dialysis-duration","display_name":"dialysis duration","score":0.7960000038146973},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.7599999904632568},{"id":"https://openalex.org/keywords/iron-status","display_name":"iron status","score":0.6970000267028809},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.906000018119812},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5899999737739563},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C28452662","wikidata":"https://www.wikidata.org/wiki/Q422752","display_name":"Ceruloplasmin","level":2,"score":0.8305259346961975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.663791298866272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5608958601951599},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5606337189674377},{"id":"https://openalex.org/C3019040382","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"End stage renal disease","level":3,"score":0.5488427877426147},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.5434503555297852},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.5088591575622559},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5084618330001831},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.4969995319843292},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.48880788683891296},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4682173728942871},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.46220991015434265},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.42025452852249146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4172179102897644},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2103392779827118},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10945571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10945571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.939.4413","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.939.4413","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.annclinlabsci.org/content/30/3/295.full.pdf","raw_type":"text"},{"id":"mag:2115385894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10945571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W80193839","https://openalex.org/W1621595817","https://openalex.org/W1789149097","https://openalex.org/W1934678104","https://openalex.org/W1965106723","https://openalex.org/W1971861437","https://openalex.org/W1972164300","https://openalex.org/W1981579574","https://openalex.org/W1981727187","https://openalex.org/W1994691990","https://openalex.org/W2002499171","https://openalex.org/W2010110222","https://openalex.org/W2018576224","https://openalex.org/W2024769251","https://openalex.org/W2032700523","https://openalex.org/W2033648279","https://openalex.org/W2041413195","https://openalex.org/W2068949553","https://openalex.org/W2080398857","https://openalex.org/W2090306478","https://openalex.org/W2091693528","https://openalex.org/W2107009419","https://openalex.org/W2146858278","https://openalex.org/W2161136053","https://openalex.org/W2162502194","https://openalex.org/W2265791998","https://openalex.org/W2266086759","https://openalex.org/W2302785252","https://openalex.org/W2410085699","https://openalex.org/W2465217402"],"related_works":["https://openalex.org/W7099997462","https://openalex.org/W1976040639","https://openalex.org/W2410670474","https://openalex.org/W2801549157","https://openalex.org/W13870451","https://openalex.org/W2943114048","https://openalex.org/W1510891855","https://openalex.org/W2094556676","https://openalex.org/W2331176231","https://openalex.org/W7098455399"],"abstract_inverted_index":{"End-stage":[0],"renal":[1],"failure":[2],"(ESRF)":[3],"is":[4],"associated":[5,37,260,279,306],"with":[6,38,56,111,181,261,280,307],"a":[7,281],"higher":[8,131,169],"risk":[9,19,40,178,233,263,283,309],"of":[10,48,71,75,96,133,284],"cardiovascular":[11],"disease":[12,61],"(CVD)":[13],"than":[14],"predicted":[15],"by":[16,83],"the":[17,23,33,108,171,185,231],"major":[18],"factors.":[20],"We":[21],"investigate":[22],"hypothesis":[24],"that":[25],"metalloproteins":[26,76],"such":[27],"as":[28],"transferrin":[29,204,245,300],"and":[30,32,77,86,100,117,150,208,223,241,252,269,299],"ceruloplasmin":[31,134,265],"inflammatory":[34],"response":[35],"are":[36],"CVD":[39,57,112,127,172,177,262,285,308],"in":[41,170,184,293,310],"this":[42,45],"population.":[43],"In":[44,214,296],"cross-sectional":[46],"study":[47],"81":[49],"subjects":[50,67,128,180],"stable":[51],"on":[52,120,225,243],"haemodialysis":[53],"(HD),":[54],"43":[55],"and/or":[58],"peripheral":[59],"vascular":[60],"(PAD)":[62],"were":[63,81,113,230,274],"compared":[64,82],"to":[65,167,258,290],"38":[66],"without":[68],"clinical":[69],"evidence":[70],"CVD/PAD.":[72],"Serum":[73],"concentrations":[74,102,132,183],"acute":[78],"phase":[79],"reactants":[80],"univariate":[84],"analysis":[85],"logistic":[87,216],"regression":[88,217],"modelling.":[89],"Body":[90],"mass":[91],"index,":[92],"gender":[93],"ratios,":[94],"prevalence":[95],"diabetes,":[97],"iron":[98,163,205,246,301],"status,":[99],"homocysteine":[101],"did":[103],"not":[104],"differ":[105],"significantly":[106,130],"between":[107],"groups.":[109],"Those":[110],"older":[114],"(P<":[115],"0.001)":[116,222],"had":[118,129],"been":[119],"dialysis":[121,226],"for":[122,179,193,198,203,212,235,239],"longer":[123],"(P":[124,174,220,227,249,254,266,271],"=":[125,140,148,160,175,221,228,250,255,267,272],"0.004).":[126],"(325":[135],"vs":[136,144,156],"284":[137],"mg/L,":[138,158],"P":[139,147,159],"0.011),":[141],"copper":[142,253,298],"(18.2":[143],"15.7":[145],"micromol/L,":[146],"0.002),":[149],"C-reactive":[151],"protein":[152],"(CRP)":[153],"(median":[154],"9.0":[155],"3.8":[157],"0.002).":[161],"Transferrin":[162],"binding":[164,206,247,302],"capacity":[165,248,303],"tended":[166],"be":[168,259,305],"group":[173],"0.088).":[176],"serum":[182],"upper":[186],"tertile":[187],"was":[188,278],"increased":[189],"9.4-fold":[190],"(CI":[191,196,201,210],"2.8-31.0)":[192],"copper,":[194],"4.2-fold":[195],"1.5-12.2)":[197],"ceruloplasmin,":[199],"3.9-fold":[200],"1.3-12.1)":[202],"capacity,":[207],"2.3-fold":[209],"0.9-6.1)":[211],"CRP.":[213],"multivariate":[215],"models,":[218],"age":[219,240],"time":[224,242],"0.002)":[229],"strongest":[232],"factors":[234],"CVD.":[236],"After":[237],"adjustment":[238],"dialysis,":[244],"0.013)":[251],"0.019)":[256],"continued":[257],"but":[264],"0.065)":[268],"CRP":[270],"0.634)":[273],"not.":[275],"Total":[276],"cholesterol":[277],"lower":[282],"(ie":[286],"protective),":[287],"presumably":[288],"due":[289],"cholesterol-lowering":[291],"therapy":[292],"high-risk":[294],"patients.":[295],"conclusion,":[297],"may":[304],"HD":[311],"subjects.":[312]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}