{"id":"https://openalex.org/W2115385276","doi":"https://doi.org/10.1128/iai.00741-12","title":"Nocardia farcinica Activates Human Dendritic Cells and Induces Secretion of Interleukin-23 (IL-23) Rather than IL-12p70","display_name":"Nocardia farcinica Activates Human Dendritic Cells and Induces Secretion of Interleukin-23 (IL-23) Rather than IL-12p70","publication_year":2012,"publication_date":"2012-09-18","ids":{"openalex":"https://openalex.org/W2115385276","doi":"https://doi.org/10.1128/iai.00741-12","mag":"2115385276","pmid":"https://pubmed.ncbi.nlm.nih.gov/22988018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3497403"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00741-12","doi":"https://doi.org/10.1128/iai.00741-12","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00741-12","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3497403","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083834671","display_name":"Martin Eisenbl\u00e4tter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Eisenbl\u00e4tter","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060952487","display_name":"A. Buchal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ariane Buchal","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050494565","display_name":"Hermine Gayum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hermine Gayum","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061114734","display_name":"Edith Jasny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edith Jasny","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023498941","display_name":"Pablo Renner Viveros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pablo Renner Viveros","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","Institute of Tropical Medicine and International Health, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Tropical Medicine and International Health, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052119608","display_name":"Timo Ulrichs","orcid":"https://orcid.org/0000-0002-8123-6714","observed_orcids":["https://orcid.org/0000-0002-8123-6714"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timo Ulrichs","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028123583","display_name":"Thomas Schneider","orcid":"https://orcid.org/0000-0003-1125-0518","observed_orcids":["https://orcid.org/0000-0003-1125-0518"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Schneider","raw_affiliation_strings":["Medical Clinic I, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Clinic I, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110435290","display_name":"Ralf R. Schumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf R. Schumann","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110036565","display_name":"Janine Zweigner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janine Zweigner","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073700728","display_name":"Ralf Ignatius","orcid":"https://orcid.org/0000-0001-9020-8312","observed_orcids":["https://orcid.org/0000-0001-9020-8312"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Ignatius","raw_affiliation_strings":["Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","Institute of Tropical Medicine and International Health, Charit\u00e9-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Hygiene, Department of Infection Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Tropical Medicine and International Health, Charit\u00e9-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":0.5197,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62985967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"80","issue":"12","first_page":"4195","last_page":"4202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nocardia-farcinica","display_name":"Nocardia farcinica","score":1.0},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.875},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.9010000228881836},{"id":"https://openalex.org/keywords/interleukin-12p70","display_name":"interleukin-12p70","score":0.9430000185966492},{"id":"https://openalex.org/keywords/interleukin-12-p40","display_name":"interleukin-12p40","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.800000011920929},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.8100000023841858},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bacterial-cell-wall","display_name":"bacterial cell wall","score":0.47999998927116394},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7861523628234863},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7288532853126526},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6606185436248779},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6127720475196838},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5756101608276367},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5729594230651855},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5531632900238037},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4835953116416931},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.4830227792263031},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.46034812927246094},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.45206013321876526},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.42343753576278687},{"id":"https://openalex.org/C2779448432","wikidata":"https://www.wikidata.org/wiki/Q135175","display_name":"Nocardia","level":3,"score":0.4229114353656769},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40429359674453735},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2652016282081604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06847143173217773},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009615","descriptor_name":"Nocardia","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009615","descriptor_name":"Nocardia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D053762","descriptor_name":"Interleukin-12 Subunit p40","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/iai.00741-12","doi":"https://doi.org/10.1128/iai.00741-12","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00741-12","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2666489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3497403","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3497403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3497403","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:22988018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22988018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.846.2995","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.846.2995","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://iai.asm.org/content/80/12/4195.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2666489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3497403","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321526","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1423791052","https://openalex.org/W1560296483","https://openalex.org/W1561864677","https://openalex.org/W1597799394","https://openalex.org/W1610529667","https://openalex.org/W1661544713","https://openalex.org/W1689132801","https://openalex.org/W1792374007","https://openalex.org/W1834886214","https://openalex.org/W1910498995","https://openalex.org/W1953802084","https://openalex.org/W1974555103","https://openalex.org/W1980789643","https://openalex.org/W1983635145","https://openalex.org/W2004465286","https://openalex.org/W2009219530","https://openalex.org/W2019306534","https://openalex.org/W2033074025","https://openalex.org/W2036767516","https://openalex.org/W2038663100","https://openalex.org/W2048000602","https://openalex.org/W2048622260","https://openalex.org/W2057809738","https://openalex.org/W2070737118","https://openalex.org/W2072074325","https://openalex.org/W2088041135","https://openalex.org/W2090197666","https://openalex.org/W2090640877","https://openalex.org/W2101706701","https://openalex.org/W2103541566","https://openalex.org/W2111695773","https://openalex.org/W2112222308","https://openalex.org/W2112791396","https://openalex.org/W2115855421","https://openalex.org/W2122791726","https://openalex.org/W2124237851","https://openalex.org/W2129706499","https://openalex.org/W2130112230","https://openalex.org/W2130340414","https://openalex.org/W2134570848","https://openalex.org/W2138091468","https://openalex.org/W2143370824","https://openalex.org/W2146396140","https://openalex.org/W2147489483","https://openalex.org/W2148044949","https://openalex.org/W2150532865","https://openalex.org/W2150927114","https://openalex.org/W2153455584","https://openalex.org/W2154941410","https://openalex.org/W2157136317","https://openalex.org/W2157759877","https://openalex.org/W2159112596","https://openalex.org/W2163776060","https://openalex.org/W2165412330","https://openalex.org/W2170857009","https://openalex.org/W2419408493","https://openalex.org/W4313026849"],"related_works":["https://openalex.org/W1545190178","https://openalex.org/W3001999570","https://openalex.org/W4322772640","https://openalex.org/W1945948326","https://openalex.org/W4299401102","https://openalex.org/W2124707045","https://openalex.org/W2415768012","https://openalex.org/W7097149123","https://openalex.org/W1999498760","https://openalex.org/W2083351896"],"abstract_inverted_index":{"Studying":[0],"the":[1,19,27,48,51,62,70,79,85,102,130,170,178,186,220],"interaction":[2,86],"of":[3,21,50,64,72,87,117,174,180,196,213,222],"dendritic":[4],"cells":[5,155],"(DCs)":[6],"with":[7,92],"bacteria":[8,39],"controlled":[9],"by":[10,66,76,189],"T-cell-mediated":[11,181],"immune":[12,73,182,244],"responses":[13,74],"may":[14,40,68,235],"reveal":[15],"novel":[16],"adjuvants":[17,46,65,230],"for":[18],"induction":[20,116,179],"cellular":[22,103],"immunity.":[23],"Murine":[24],"studies":[25],"and":[26,100,120,128,151,192,202],"observation":[28],"that":[29,37],"nocardias":[30],"infect":[31],"predominantly":[32],"immunosuppressed":[33],"patients":[34],"have":[35,55,236],"suggested":[36],"these":[38],"possess":[41],"an":[42],"adjuvant":[43,172],"potential.":[44],"Moreover,":[45],"on":[47,177,232],"basis":[49],"nocardial":[52],"cell":[53],"wall":[54],"been":[56],"applied":[57],"in":[58,98,110,156,165],"clinical":[59],"studies.":[60],"Since":[61],"handling":[63],"DCs":[67,91,124,133,191,208],"determine":[69],"type":[71],"induced":[75],"a":[77,144,238],"vaccine,":[78],"present":[80],"study":[81],"aimed":[82],"at":[83],"investigating":[84],"immature":[88],"human":[89],"monocyte-derived":[90],"live":[93],"or":[94],"inactivated":[95,136],"Nocardia":[96],"farcinica":[97,127,138,176,226],"vitro":[99],"determining":[101],"phenotypic":[104],"changes":[105],"as":[106,108,114],"well":[107],"alterations":[109],"characteristic":[111],"functions,":[112],"such":[113],"phagocytosis,":[115],"T-cell":[118],"proliferation,":[119],"cytokine":[121],"secretion.":[122],"Human":[123],"ingested":[125],"N.":[126,137,175,225],"eradicated":[129],"bacterium":[131,234],"intracellularly.":[132],"exposed":[134],"to":[135,241],"were":[139,162,216],"activated,":[140],"i.e.,":[141],"they":[142],"developed":[143],"mature":[145],"phenotype,":[146],"downregulated":[147],"their":[148],"phagocytic":[149],"capacity,":[150],"stimulated":[152],"allogeneic":[153],"T":[154],"mixed":[157],"leukocyte":[158],"reactions.":[159],"Soluble":[160],"factors":[161],"not":[163],"involved":[164],"this":[166,233],"process.":[167],"To":[168],"elucidate":[169],"potential":[171],"effect":[173],"responses,":[183],"we":[184],"characterized":[185],"cytokines":[187],"produced":[188],"nocardia-exposed":[190],"detected":[193],"substantial":[194],"amounts":[195,212,221],"tumor":[197],"necrosis":[198],"factor":[199],"alpha":[200],"(TNF-\u03b1)":[201],"interleukin-12":[203],"p40":[204],"(IL-12p40).":[205],"However,":[206],"nocardia-treated":[207],"secreted":[209],"only":[210,237],"small":[211],"IL-12p70,":[214],"which":[215],"significantly":[217],"smaller":[218],"than":[219],"IL-23.":[223],"Thus,":[224],"activates":[227],"DCs,":[228],"but":[229],"based":[231],"limited":[239],"capacity":[240],"induce":[242],"Th1":[243],"responses.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}