{"id":"https://openalex.org/W2115332175","doi":"https://doi.org/10.1161/01.res.47.5.757","title":"Role of prostacyclin in the preservation of ischemic myocardial tissue in the perfused cat heart.","display_name":"Role of prostacyclin in the preservation of ischemic myocardial tissue in the perfused cat heart.","publication_year":1980,"publication_date":"1980-11-01","ids":{"openalex":"https://openalex.org/W2115332175","doi":"https://doi.org/10.1161/01.res.47.5.757","mag":"2115332175","pmid":"https://pubmed.ncbi.nlm.nih.gov/6998595"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.47.5.757","doi":"https://doi.org/10.1161/01.res.47.5.757","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.47.5.757","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.47.5.757","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.47.5.757","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110090505","display_name":"H Araki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Araki","raw_affiliation_strings":["H Araki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Araki","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Lefer","raw_affiliation_strings":["A M Lefer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A M Lefer","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2019,"has_fulltext":true,"cited_by_count":117,"citation_normalized_percentile":{"value":0.96415715,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"47","issue":"5","first_page":"757","last_page":"763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.7310000061988831},{"id":"https://openalex.org/keywords/creatine-kinase-release","display_name":"creatine kinase release","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.6890000104904175},{"id":"https://openalex.org/keywords/6-keto-pgf1alpha","display_name":"6-keto-PGF1 alpha","score":0.6940000057220459},{"id":"https://openalex.org/keywords/langendorff-preparation","display_name":"isolated perfused heart","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.3050000071525574},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.7049999833106995},{"id":"https://openalex.org/keywords/resting-tension","display_name":"resting tension","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2781103887","wikidata":"https://www.wikidata.org/wiki/Q20817139","display_name":"Iloprost","level":3,"score":0.8845542669296265},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.7737189531326294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7378798127174377},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.424385666847229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4227992594242096},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41422322392463684}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.res.47.5.757","doi":"https://doi.org/10.1161/01.res.47.5.757","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.47.5.757","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.47.5.757","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:6998595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6998595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"mag:3146931533","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/res.47.5.6998595","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation Research","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.res.47.5.757","doi":"https://doi.org/10.1161/01.res.47.5.757","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.47.5.757","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.47.5.757","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115332175.pdf","grobid_xml":"https://content.openalex.org/works/W2115332175.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1541054247","https://openalex.org/W1595778460","https://openalex.org/W1608744359","https://openalex.org/W1984590673","https://openalex.org/W1994153882","https://openalex.org/W2013549667","https://openalex.org/W2021403302","https://openalex.org/W2030431606","https://openalex.org/W2046892105","https://openalex.org/W2051057617","https://openalex.org/W2060165833","https://openalex.org/W2061167372","https://openalex.org/W2070867052","https://openalex.org/W2074158660","https://openalex.org/W2089706358","https://openalex.org/W2103379524","https://openalex.org/W2161132712","https://openalex.org/W2274127265","https://openalex.org/W2395565651","https://openalex.org/W2423124747"],"related_works":["https://openalex.org/W1994153882","https://openalex.org/W2068139644","https://openalex.org/W2409669740","https://openalex.org/W2070373595","https://openalex.org/W2125066355","https://openalex.org/W2413315841","https://openalex.org/W2060142776","https://openalex.org/W2025935406","https://openalex.org/W1974769861","https://openalex.org/W2011691751"],"abstract_inverted_index":{"Prostacyclin":[0],"(PGI":[1],"2":[2,41,148,201,226,232],")":[3,17],"and":[4,13,42,63,99,140,155,173,183,249],"some":[5],"of":[6,33,58,73,76,94,116,132,146,171,224,251,254],"its":[7,214,242,252],"major":[8],"breakdown":[9],"products":[10,223],"(6-keto-PGFi,,,":[11],"6-keto-PGEi,":[12],"13,14-dihydro":[14],"6,15-diketo-PGFi":[15],"a":[16,91,102,129],"were":[18],"studied":[19],"in":[20,49,66,90,113,158,189,199,235,238],"an":[21,30,111],"isolated":[22],"perfused":[23,69],"cat":[24],"heart":[25,36,64],"preparation":[26],"during":[27],"myocardial":[28,236],"ischemia.At":[29],"infusion":[31,149],"rate":[32,65],"10":[34],"ng/g":[35],"weight":[37],"per":[38],"minute,":[39],"PGI":[40,200,225],"the":[43,55,59,107,151,156,190],"related":[44],"compounds":[45,100],"caused":[46],"no":[47],"changes":[48],"perfusion":[50,80],"pressure,":[51],"contractile":[52,60],"force":[53,61],"(CF),":[54],"first":[56],"derivative":[57],"(dF/dt),":[62],"control":[67],"hearts":[68,109,127,203],"at":[70,81],"coronary":[71,255],"flows":[72],"20-35":[74],"ml/min.Induction":[75],"global":[77],"ischemia":[78,192,237],"by":[79],"0.6":[82],"to":[83,210],"0.7":[84],"ml/min":[85],"for":[86],"120":[87],"minutes":[88],"resulted":[89],"significant":[92],"release":[93,154],"creatine":[95],"kinase":[96],"(CK)":[97],"activity":[98,195],"having":[101],"free":[103],"amino-nitrogen":[104,160],"group":[105],"into":[106],"perfusate.Ischemic":[108],"exhibited":[110],"increase":[112,157],"resting":[114],"tension":[115,162],"2.3":[117],"\u00b1":[118,122,138,144,168,181,185,205,217],"0.2":[119],"g,":[120],"mean":[121],"SEM.Upon":[123],"reperfusion,":[124],"untreated":[125,191],"ischemic":[126],"showed":[128],"partial":[130],"restoration":[131],"mechanical":[133],"performance,":[134],"CF":[135,172],"=":[136,142],"43":[137],"5%,":[139],"dF/dt":[141,174],"40":[143],"5%":[145],"control.PGI":[147],"inhibited":[150],"ischemic-induced":[152],"CK":[153,194],"perfusate":[159],"concentration.Resting":[161],"also":[163],"remained":[164],"low":[165],"(i.e.,":[166],"0.8":[167],"0.1":[169],"g).Recovery":[170],"upon":[175],"reperfusion":[176],"was":[177,196],"significantly":[178,197],"higher":[179,198],"(86":[180],"8%":[182],"88":[184],"10%,":[186],"respectively)":[187],"than":[188],"group.Myocardial":[193],"-infused":[202],"(35.8":[204],"2.6":[206],"IU/mg":[207],"protein)":[208],"compared":[209],"those":[211],"infused":[212],"with":[213],"vehicle":[215],"(26.3":[216],"2.8,":[218],"P":[219],"<":[220],"0.01).'":[221],"Breakdown":[222],"only":[227],"slightly":[228],"protected":[229],"against":[230],"ischemia.PGI":[231],"is":[233],"beneficial":[234],"vitro,":[239],"even":[240],"without":[241],"well":[243],"known":[244],"action":[245],"preventing":[246],"platelet":[247],"aggregation":[248],"independent":[250],"induction":[253],"vasodilation.CircRes":[256],"47:":[257],"757-763,":[258],"1980":[259]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
