{"id":"https://openalex.org/W2115309987","doi":"https://doi.org/10.1093/jac/dkr195","title":"Daptomycin resistance mechanisms in clinically derived Staphylococcus aureus strains assessed by a combined transcriptomics and proteomics approach","display_name":"Daptomycin resistance mechanisms in clinically derived Staphylococcus aureus strains assessed by a combined transcriptomics and proteomics approach","publication_year":2011,"publication_date":"2011-05-28","ids":{"openalex":"https://openalex.org/W2115309987","doi":"https://doi.org/10.1093/jac/dkr195","mag":"2115309987","pmid":"https://pubmed.ncbi.nlm.nih.gov/21622973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133485"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkr195","doi":"https://doi.org/10.1093/jac/dkr195","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/dkr195","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133485","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031875302","display_name":"Adrien Fischer","orcid":"https://orcid.org/0000-0002-5437-4804","observed_orcids":["https://orcid.org/0000-0002-5437-4804"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Adrien Fischer","raw_affiliation_strings":["Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland. adrien.fischer@genomic.ch","Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland. adrien.fischer@genomic.ch","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011420009","display_name":"Soo\u2010Jin Yang","orcid":"https://orcid.org/0000-0003-3253-8190","observed_orcids":["https://orcid.org/0000-0003-3253-8190"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soo-Jin Yang","raw_affiliation_strings":["LA Biomedical Research Institute, Torrance, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LA Biomedical Research Institute, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012131316","display_name":"Arnold S. Bayer","orcid":"https://orcid.org/0000-0003-1968-0192","observed_orcids":["https://orcid.org/0000-0003-1968-0192"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold S. Bayer","raw_affiliation_strings":["Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA","Geffen School of Medicine at UCLA, Los Angeles, CA, USA","LA Biomedical Research Institute, Torrance, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"LA Biomedical Research Institute, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038182276","display_name":"Ali R. Vaezzadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali R. Vaezzadeh","raw_affiliation_strings":["Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086596632","display_name":"S\u00e9bastien Herzig","orcid":"https://orcid.org/0000-0002-9329-2860","observed_orcids":["https://orcid.org/0000-0002-9329-2860"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Herzig","raw_affiliation_strings":["Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011658344","display_name":"Ludwig Stenz","orcid":"https://orcid.org/0000-0002-2339-9451","observed_orcids":["https://orcid.org/0000-0002-2339-9451"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ludwig Stenz","raw_affiliation_strings":["Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004068707","display_name":"Myriam Girard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Myriam Girard","raw_affiliation_strings":["Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017445754","display_name":"George Sakoulas","orcid":"https://orcid.org/0000-0002-6063-6217","observed_orcids":["https://orcid.org/0000-0002-6063-6217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Sakoulas","raw_affiliation_strings":["Sharp Medical Center, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharp Medical Center, San Diego, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069327263","display_name":"Alexander Scherl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexander Scherl","raw_affiliation_strings":["BPRG, University Hospitals of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPRG, University Hospitals of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021031438","display_name":"Michael R. Yeaman","orcid":"https://orcid.org/0000-0002-9468-5252","observed_orcids":["https://orcid.org/0000-0002-9468-5252"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Yeaman","raw_affiliation_strings":["Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA","Geffen School of Medicine at UCLA, Los Angeles, CA, USA","LA Biomedical Research Institute, Torrance, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"LA Biomedical Research Institute, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086481621","display_name":"Richard A. Proctor","orcid":"https://orcid.org/0000-0003-3011-7958","observed_orcids":["https://orcid.org/0000-0003-3011-7958"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Proctor","raw_affiliation_strings":["University of Wisconsin School of Medicine, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088214706","display_name":"Jacques Schrenzel","orcid":"https://orcid.org/0000-0001-5464-7764","observed_orcids":["https://orcid.org/0000-0001-5464-7764"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jacques Schrenzel","raw_affiliation_strings":["Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010055797","display_name":"Patrice Fran\u00e7ois","orcid":"https://orcid.org/0000-0002-0540-750X","observed_orcids":["https://orcid.org/0000-0002-0540-750X"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrice Fran\u00e7ois","raw_affiliation_strings":["Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5031875302"],"corresponding_institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":6.6914,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.97633669,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"66","issue":"8","first_page":"1696","last_page":"1711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daptomycin-resistance","display_name":"daptomycin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/endocarditis","display_name":"endocarditis","score":0.6019999980926514},{"id":"https://openalex.org/keywords/bacterial-envelope","display_name":"bacterial cell envelope","score":0.503000020980835},{"id":"https://openalex.org/keywords/cell-wall-autolysis","display_name":"cell wall autolysis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/teichoic-acid","display_name":"teichoic acid","score":0.890999972820282},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.49799999594688416},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.5149999856948853},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2778651397","wikidata":"https://www.wikidata.org/wiki/Q418747","display_name":"Daptomycin","level":5,"score":0.8906310796737671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7924572229385376},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.683418869972229},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5902234315872192},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5280410051345825},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.49046656489372253},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.48895561695098877},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.46922004222869873},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4355502724647522},{"id":"https://openalex.org/C2778253522","wikidata":"https://www.wikidata.org/wiki/Q899834","display_name":"Teichoic acid","level":4,"score":0.425216406583786},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3674522638320923},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.34239909052848816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23286473751068115},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.1602415144443512}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1093/jac/dkr195","doi":"https://doi.org/10.1093/jac/dkr195","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/dkr195","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2411525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133485","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3133485","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133485","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Antimicrob Chemother","raw_type":"Text"},{"id":"pmid:21622973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21622973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:aou:unige:23524","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:23524","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of antimicrobial chemotherapy, vol. 66, no. 8 (2011) p. 1696-1711","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doc.rero.ch:301593","doi":null,"is_oa":false,"landing_page_url":"http://doc.rero.ch/record/301593/files/dkr195.pdf","pdf_url":"http://doc.rero.ch/record/301593/files/dkr195.pdf","source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:jac:dkr195v1","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkr195v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:unige.ch:unige:23524","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:23524","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0305-7453","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2411525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133485","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4902493587","display_name":null,"funder_award_id":"AI-039108","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6789107384","display_name":"Mechanisms of Staphylococcal Co-Resistance to Daptomycin and Host Defense Peptide","funder_award_id":"R01AI039108","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W1500639773","https://openalex.org/W1521568565","https://openalex.org/W1583738858","https://openalex.org/W1646666744","https://openalex.org/W1920924307","https://openalex.org/W1966479702","https://openalex.org/W1970783326","https://openalex.org/W1979932265","https://openalex.org/W1982477315","https://openalex.org/W1989277551","https://openalex.org/W1993525773","https://openalex.org/W1998816689","https://openalex.org/W2001079530","https://openalex.org/W2003757150","https://openalex.org/W2004783061","https://openalex.org/W2005769132","https://openalex.org/W2005864342","https://openalex.org/W2018935611","https://openalex.org/W2020891936","https://openalex.org/W2029935652","https://openalex.org/W2037918377","https://openalex.org/W2040560524","https://openalex.org/W2047724045","https://openalex.org/W2047951064","https://openalex.org/W2050302554","https://openalex.org/W2068037991","https://openalex.org/W2068687253","https://openalex.org/W2071572071","https://openalex.org/W2076160098","https://openalex.org/W2079221894","https://openalex.org/W2085324690","https://openalex.org/W2089388387","https://openalex.org/W2092196558","https://openalex.org/W2093643135","https://openalex.org/W2095192490","https://openalex.org/W2096057003","https://openalex.org/W2096803605","https://openalex.org/W2098704098","https://openalex.org/W2099359726","https://openalex.org/W2099883798","https://openalex.org/W2103532199","https://openalex.org/W2107650019","https://openalex.org/W2110077808","https://openalex.org/W2110815814","https://openalex.org/W2111158975","https://openalex.org/W2112504474","https://openalex.org/W2113247851","https://openalex.org/W2113651812","https://openalex.org/W2115127793","https://openalex.org/W2115317294","https://openalex.org/W2118291047","https://openalex.org/W2118611827","https://openalex.org/W2119025417","https://openalex.org/W2120254858","https://openalex.org/W2120786299","https://openalex.org/W2122710851","https://openalex.org/W2122733482","https://openalex.org/W2123487967","https://openalex.org/W2123689798","https://openalex.org/W2125772544","https://openalex.org/W2126734480","https://openalex.org/W2129062666","https://openalex.org/W2129617994","https://openalex.org/W2131044290","https://openalex.org/W2131953542","https://openalex.org/W2132281308","https://openalex.org/W2135521668","https://openalex.org/W2141024122","https://openalex.org/W2144670882","https://openalex.org/W2146370523","https://openalex.org/W2146894318","https://openalex.org/W2148954461","https://openalex.org/W2150427869","https://openalex.org/W2150927648","https://openalex.org/W2151452450","https://openalex.org/W2151693231","https://openalex.org/W2153936789","https://openalex.org/W2155568318","https://openalex.org/W2156726015","https://openalex.org/W2156879228","https://openalex.org/W2157018267","https://openalex.org/W2158458733","https://openalex.org/W2158738872","https://openalex.org/W2159979739","https://openalex.org/W2162139256","https://openalex.org/W2165562761","https://openalex.org/W2167665502","https://openalex.org/W2168027235","https://openalex.org/W2168616277","https://openalex.org/W2169227086","https://openalex.org/W2169388619","https://openalex.org/W2169395930","https://openalex.org/W2170042074","https://openalex.org/W2170367123","https://openalex.org/W2170807180","https://openalex.org/W2171998389","https://openalex.org/W2314649741","https://openalex.org/W4241464497","https://openalex.org/W4296253506","https://openalex.org/W6678094324"],"related_works":["https://openalex.org/W3049271652","https://openalex.org/W2029505099","https://openalex.org/W1969834465","https://openalex.org/W1963707455","https://openalex.org/W7097619764","https://openalex.org/W2030101777","https://openalex.org/W2166920417","https://openalex.org/W4416581057","https://openalex.org/W2781152936","https://openalex.org/W2558685076"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,15],"development":[2],"of":[3,17,75,86,100,111,151,166,177,185,217,251,257],"daptomycin":[4,48],"resistance":[5,19],"in":[6,59,79,114,129,171,187,207,214,227,230,233],"Staphylococcus":[7],"aureus":[8,36,235],"is":[9,236],"associated":[10],"with":[11,44,108,140,225],"clinical":[12,161],"treatment":[13],"failures.":[14],"mechanism(s)":[16],"such":[18],"have":[20],"not":[21],"been":[22],"clearly":[23],"defined.":[24],"METHODS:":[25],"We":[26],"studied":[27],"an":[28],"isogenic":[29,159],"daptomycin-susceptible":[30],"(DAP(S))":[31],"and":[32,53,89,195,202,248,254],"daptomycin-resistant":[33],"(DAP(R))":[34],"S.":[35,234],"strain":[37,162],"pair":[38],"(616;":[39],"701)":[40],"from":[41,156],"a":[42,73,135,182,237],"patient":[43],"relapsing":[45],"endocarditis":[46],"during":[47],"treatment,":[49],"using":[50],"comparative":[51],"transcriptomic":[52],"proteomic":[54],"techniques.":[55],"RESULTS:":[56],"Minor":[57],"differences":[58,206],"the":[60,94,101,109,124,172,215,218,252],"genome":[61],"content":[62],"were":[63],"found":[64],"between":[65],"strains":[66,200],"by":[67],"DNA":[68],"hybridization.":[69],"Transcriptomic":[70],"analyses":[71],"identified":[72],"number":[74],"genes":[76,112],"differentially":[77],"expressed":[78],"important":[80],"functional":[81,189],"categories:":[82],"cell":[83,103,115,192],"division;":[84],"metabolism":[85],"bacterial":[87,146,212],"envelopes;":[88],"global":[90],"regulation.":[91],"Of":[92,148],"note,":[93],"DAP(R)":[95,173,232],"isolate":[96],"exhibited":[97],"reduced":[98],"expression":[99],"major":[102,205],"wall":[104,116],"autolysis":[105],"gene":[106,125,154],"coincident":[107],"up-regulation":[110],"involved":[113,128],"teichoic":[117],"acid":[118],"production.":[119],"Using":[120],"quantitative":[121],"(q)RT-PCR":[122],"on":[123],"cadre":[126,155],"putatively":[127],"cationic":[130],"peptide":[131],"resistance,":[132],"we":[133],"formulated":[134],"putative":[136],"regulatory":[137],"network":[138],"compatible":[139],"microarray":[141],"data":[142],"sets,":[143],"mainly":[144],"implicating":[145],"envelopes.":[147,259],"interest,":[149],"qRT-PCR":[150],"this":[152],"same":[153],"two":[157],"distinct":[158],"DAP(S)/DAP(R)":[160],"pairs":[163],"revealed":[164,181],"evidence":[165],"other":[167],"strain-dependent":[168,243],"networks":[169],"operative":[170],"phenotype.":[174],"Comparative":[175],"proteomics":[176],"616":[178,201],"versus":[179],"701":[180,203],"differential":[183],"abundance":[184],"proteins":[186],"various":[188],"categories,":[190],"including":[191],"wall-associated":[193],"targets":[194],"biofilm":[196],"formation":[197],"proteins.":[198],"Phenotypically,":[199],"showed":[204],"their":[208],"ability":[209],"to":[210],"develop":[211],"biofilms":[213],"presence":[216],"antibacterial":[219],"lipid,":[220],"oleic":[221],"acid.":[222],"CONCLUSIONS:":[223],"Compatible":[224],"previous":[226],"vitro":[228],"observations,":[229],"vivo-acquired":[231],"complex,":[238],"multistep":[239],"phenomenon":[240],"involving:":[241],"(i)":[242],"phenotypes;":[244],"(ii)":[245],"transcriptome":[246],"adaptation;":[247],"(iii)":[249],"modification":[250],"lipid":[253],"protein":[255],"contents":[256],"cellular":[258]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}