{"id":"https://openalex.org/W2115294635","doi":"https://doi.org/10.1091/mbc.e11-08-0731","title":"Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells","display_name":"Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells","publication_year":2012,"publication_date":"2012-01-06","ids":{"openalex":"https://openalex.org/W2115294635","doi":"https://doi.org/10.1091/mbc.e11-08-0731","mag":"2115294635","pmid":"https://pubmed.ncbi.nlm.nih.gov/22219382","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290643"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e11-08-0731","doi":"https://doi.org/10.1091/mbc.e11-08-0731","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e11-08-0731","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2115294635"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3290643/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073163069","display_name":"Jason Yi","orcid":"https://orcid.org/0000-0001-5131-6767","observed_orcids":["https://orcid.org/0000-0001-5131-6767"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Yi","raw_affiliation_strings":["Department of Biology, University of North Carolina, Chapel Hill, NC 27599","Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Chapel Hill, NC 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025885614","display_name":"Xufeng Wu","orcid":"https://orcid.org/0000-0002-9723-7965","observed_orcids":["https://orcid.org/0000-0002-9723-7965"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xufeng S. Wu","raw_affiliation_strings":["Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010850157","display_name":"Travis J. Crites","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis Crites","raw_affiliation_strings":["Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077641368","display_name":"John A. Hammer","orcid":"https://orcid.org/0000-0002-2496-5179","observed_orcids":["https://orcid.org/0000-0002-2496-5179"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John A. Hammer","raw_affiliation_strings":["Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5077641368"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":null,"apc_paid":null,"fwci":7.0802,"has_fulltext":true,"cited_by_count":274,"citation_normalized_percentile":{"value":0.98465523,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"23","issue":"5","first_page":"834","last_page":"852"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.673799991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.673799991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2168000042438507,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retrograde-actin-flow","display_name":"actin retrograde flow","score":0.8989999890327454},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9779999852180481},{"id":"https://openalex.org/keywords/supramolecular-activation-cluster","display_name":"supramolecular activation cluster","score":0.8080000281333923},{"id":"https://openalex.org/keywords/lamellipodia","display_name":"lamellipodia","score":0.8510000109672546},{"id":"https://openalex.org/keywords/myosin-iia","display_name":"myosin IIA","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.638277530670166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5588797926902771},{"id":"https://openalex.org/C2776041460","wikidata":"https://www.wikidata.org/wiki/Q5201339","display_name":"Cytochalasin D","level":4,"score":0.5120709538459778},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5009088516235352},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49974775314331055},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.4934186041355133},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.49142324924468994},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.47986167669296265},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.4645991027355194},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.3937879204750061},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.2815130352973938},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.21523362398147583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1871928870677948},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10329174995422363},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000205","descriptor_name":"Actomyosin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015638","descriptor_name":"Cytochalasin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024507","descriptor_name":"Nonmuscle Myosin Type IIA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047630","descriptor_name":"Depsipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1091/mbc.e11-08-0731","doi":"https://doi.org/10.1091/mbc.e11-08-0731","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e11-08-0731","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3290643","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3290643/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3290643/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2356774","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290643","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22219382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22219382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:r781wp33c","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/790z-gn50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Regulation, 23(5)","raw_type":"Article"},{"id":"doi:10.17615/790z-gn50","doi":"https://doi.org/10.17615/790z-gn50","is_oa":true,"landing_page_url":"https://doi.org/10.17615/790z-gn50","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.805.1129","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.805.1129","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9d/36/834.PMC3290643.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3290643","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3290643/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3290643/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5481837350","display_name":"Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches","funder_award_id":"R13GM085967","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115294635.pdf","grobid_xml":"https://content.openalex.org/works/W2115294635.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1562441478","https://openalex.org/W1568637259","https://openalex.org/W1963638410","https://openalex.org/W1971106165","https://openalex.org/W1974374103","https://openalex.org/W1979984478","https://openalex.org/W1981407611","https://openalex.org/W1981565131","https://openalex.org/W1982905247","https://openalex.org/W1984567041","https://openalex.org/W1985670883","https://openalex.org/W1987625947","https://openalex.org/W1987904129","https://openalex.org/W1992835639","https://openalex.org/W2006842890","https://openalex.org/W2012955553","https://openalex.org/W2014118715","https://openalex.org/W2018987816","https://openalex.org/W2029997281","https://openalex.org/W2030029307","https://openalex.org/W2031211599","https://openalex.org/W2031506032","https://openalex.org/W2035373939","https://openalex.org/W2046355418","https://openalex.org/W2057172252","https://openalex.org/W2061587215","https://openalex.org/W2068218481","https://openalex.org/W2075738656","https://openalex.org/W2083483039","https://openalex.org/W2089920144","https://openalex.org/W2091060631","https://openalex.org/W2091401847","https://openalex.org/W2094577052","https://openalex.org/W2096234619","https://openalex.org/W2099107111","https://openalex.org/W2101173100","https://openalex.org/W2111719518","https://openalex.org/W2115759372","https://openalex.org/W2126496496","https://openalex.org/W2126873850","https://openalex.org/W2127303707","https://openalex.org/W2127380650","https://openalex.org/W2127424425","https://openalex.org/W2139970775","https://openalex.org/W2145392559","https://openalex.org/W2148454908","https://openalex.org/W2152185625","https://openalex.org/W2152655368","https://openalex.org/W2158421588","https://openalex.org/W2159174417","https://openalex.org/W2161914739","https://openalex.org/W2169622416"],"related_works":["https://openalex.org/W2544486379","https://openalex.org/W7116775966","https://openalex.org/W2099107111","https://openalex.org/W2307390573","https://openalex.org/W2094476644","https://openalex.org/W2162389581","https://openalex.org/W2749729565","https://openalex.org/W2041827652","https://openalex.org/W2051692933"],"abstract_inverted_index":{"Actin":[0],"retrograde":[1,109,131,190],"flow":[2,110,132,191],"and":[3,21,30,45,62,72,85,114,125,136,179,192],"actomyosin":[4,87,115,141,185,193],"II":[5,88,116,142,186,194],"contraction":[6,118,144,196],"have":[7],"both":[8,151],"been":[9],"implicated":[10],"in":[11,111,119,133,145],"the":[12,56,91,94,105,112,120,134,146,173,177,203],"inward":[13],"movement":[14],"of":[15,96,107,176],"T":[16,37],"cell":[17],"receptor":[18,199],"(TCR)":[19],"microclusters":[20,100],"immunological":[22,204],"synapse":[23],"formation,":[24],"but":[25],"no":[26],"study":[27],"has":[28],"integrated":[29],"quantified":[31],"their":[32],"relative":[33],"contributions.":[34],"Using":[35,122],"Jurkat":[36],"cells":[38],"expressing":[39],"fluorescent":[40],"myosin":[41],"IIA":[42],"heavy":[43],"chain":[44],"F-tractin-a":[46],"novel":[47],"reporter":[48],"for":[49,155],"F-actin-we":[50],"now":[51],"provide":[52],"direct":[53],"evidence":[54],"that":[55,150,163,180],"distal":[57],"supramolecular":[58,64],"activation":[59,65],"cluster":[60,66,200],"(dSMAC)":[61],"peripheral":[63],"(pSMAC)":[67],"correspond":[68,101],"to":[69,104,127,138],"lamellipodial":[70],"(LP)":[71],"lamellar":[73],"(LM)":[74],"actin":[75,108,130,189],"networks,":[76],"respectively,":[77],"as":[78],"hypothesized":[79],"previously.":[80],"Our":[81],"images":[82],"reveal":[83],"concentric":[84],"contracting":[86],"arcs/rings":[89],"at":[90,172,202],"LM/pSMAC.":[92,121],"Moreover,":[93],"speeds":[95],"centripetally":[97],"moving":[98],"TCR":[99,157],"very":[102],"closely":[103],"rates":[106],"LP/dSMAC":[113,135],"arc":[117,143,195],"cytochalasin":[123],"D":[124],"jasplakinolide":[126],"selectively":[128,139],"inhibit":[129,140],"blebbistatin":[137],"LM/pSMAC,":[147],"we":[148,161],"demonstrate":[149],"forces":[152],"are":[153],"required":[154],"centripetal":[156],"microcluster":[158],"transport.":[159],"Finally,":[160],"show":[162],"leukocyte":[164],"function-associated":[165],"antigen":[166],"1":[167],"clusters":[168],"accumulate":[169],"over":[170],"time":[171],"inner":[174],"aspect":[175],"LM/pSMAC":[178],"this":[181],"accumulation":[182],"depends":[183],"on":[184],"contraction.":[187],"Thus":[188],"coordinately":[197],"drive":[198],"dynamics":[201],"synapse.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}