{"id":"https://openalex.org/W2115265274","doi":"https://doi.org/10.1016/s0014-2999(96)00888-6","title":"Investigation of the inhibitory effect of broussochalcone A on respiratory burst in neutrophils","display_name":"Investigation of the inhibitory effect of broussochalcone A on respiratory burst in neutrophils","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2115265274","doi":"https://doi.org/10.1016/s0014-2999(96)00888-6","mag":"2115265274","pmid":"https://pubmed.ncbi.nlm.nih.gov/9059855"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(96)00888-6","doi":"https://doi.org/10.1016/s0014-2999(96)00888-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(96)00888-6","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069321805","display_name":"Jih-Pyang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091773","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091773"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Jih-Pyang Wang","raw_affiliation_strings":["Department of Medical Research, Taichung Veterans General Hospital, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Taichung Veterans General Hospital, Taiwan","institution_ids":["https://openalex.org/I4210091773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111956074","display_name":"Lo\u2010Ti Tsao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091773","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091773"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lo-Ti Tsao","raw_affiliation_strings":["Department of Medical Research, Taichung Veterans General Hospital, 160 Chung Kung Road, Sec. 3, Taichung, Taiwan 407"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Taichung Veterans General Hospital, 160 Chung Kung Road, Sec. 3, Taichung, Taiwan 407","institution_ids":["https://openalex.org/I4210091773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113601770","display_name":"Shue\u2010Ling Raung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091773","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091773"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shue-Ling Raung","raw_affiliation_strings":["Department of Medical Research, Taichung Veterans General Hospital, 160 Chung Kung Road, Sec. 3, Taichung, Taiwan 407"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Taichung Veterans General Hospital, 160 Chung Kung Road, Sec. 3, Taichung, Taiwan 407","institution_ids":["https://openalex.org/I4210091773"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102867381","display_name":"Chun\u2010Nan Lin","orcid":"https://orcid.org/0000-0002-8488-1663","observed_orcids":["https://orcid.org/0000-0002-8488-1663"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Nan Lin","raw_affiliation_strings":["School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069321805"],"corresponding_institution_ids":["https://openalex.org/I4210091773"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.4451,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.53183962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"320","issue":"2-3","first_page":"201","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.11020000278949738,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenylated-chalcones","display_name":"prenylated chalcones","score":0.8679999709129333},{"id":"https://openalex.org/keywords/broussonetia-papyrifera","display_name":"Broussonetia papyrifera","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8640000224113464},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.9810000061988831},{"id":"https://openalex.org/keywords/protein-kinase-c-inhibition","display_name":"protein kinase C inhibition","score":0.7670000195503235},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.906000018119812},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.6169999837875366},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9319999814033508},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.9210000038146973},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8149999976158142},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C99971728","wikidata":"https://www.wikidata.org/wiki/Q838181","display_name":"Respiratory burst","level":2,"score":0.8545365929603577},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.7745901942253113},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.7332862615585327},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.685815691947937},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5702189207077026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5216660499572754},{"id":"https://openalex.org/C2779033064","wikidata":"https://www.wikidata.org/wiki/Q7251487","display_name":"Protein kinase inhibitor","level":4,"score":0.5079956650733948},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5041557550430298},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.48220622539520264},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4536074101924896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44375813007354736},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3580748438835144},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32065367698669434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2797654867172241}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002599","descriptor_name":"Chalcone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002599","descriptor_name":"Chalcone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012118","descriptor_name":"Resorcinols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015240","descriptor_name":"Phorbol 12,13-Dibutyrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015240","descriptor_name":"Phorbol 12,13-Dibutyrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016897","descriptor_name":"Respiratory Burst","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(96)00888-6","doi":"https://doi.org/10.1016/s0014-2999(96)00888-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(96)00888-6","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:9059855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9059855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W153397760","https://openalex.org/W303363201","https://openalex.org/W1491958169","https://openalex.org/W1494669487","https://openalex.org/W1510671746","https://openalex.org/W1522267111","https://openalex.org/W1553611124","https://openalex.org/W1589866689","https://openalex.org/W1594758412","https://openalex.org/W1595133660","https://openalex.org/W1601933856","https://openalex.org/W1661985738","https://openalex.org/W1734082729","https://openalex.org/W1749394363","https://openalex.org/W1750774965","https://openalex.org/W1801129364","https://openalex.org/W1964839077","https://openalex.org/W1965924973","https://openalex.org/W1973287769","https://openalex.org/W1984457008","https://openalex.org/W1991972636","https://openalex.org/W2020638663","https://openalex.org/W2038277405","https://openalex.org/W2073516337","https://openalex.org/W2087825791","https://openalex.org/W2089475281","https://openalex.org/W2101723197","https://openalex.org/W2141260882","https://openalex.org/W2161102001","https://openalex.org/W2174934515","https://openalex.org/W2266038146","https://openalex.org/W2314217713","https://openalex.org/W2418974924","https://openalex.org/W2501633378"],"related_works":["https://openalex.org/W2011185967","https://openalex.org/W2002061268","https://openalex.org/W2090249986","https://openalex.org/W2076985620","https://openalex.org/W2068658261","https://openalex.org/W2035460716","https://openalex.org/W1982953998","https://openalex.org/W2268381575","https://openalex.org/W4250642084","https://openalex.org/W2083453155"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}