{"id":"https://openalex.org/W2115218756","doi":"https://doi.org/10.1016/j.smrv.2004.08.001","title":"The basic physiology and pathophysiology of melatonin","display_name":"The basic physiology and pathophysiology of melatonin","publication_year":2004,"publication_date":"2004-12-16","ids":{"openalex":"https://openalex.org/W2115218756","doi":"https://doi.org/10.1016/j.smrv.2004.08.001","mag":"2115218756","pmid":"https://pubmed.ncbi.nlm.nih.gov/15649735"},"language":"en","primary_location":{"id":"doi:10.1016/j.smrv.2004.08.001","doi":"https://doi.org/10.1016/j.smrv.2004.08.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.smrv.2004.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S28482811","display_name":"Sleep Medicine Reviews","issn_l":"1087-0792","issn":["1087-0792","1532-2955"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep Medicine Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102123058","display_name":"Bruno Claustrat","orcid":"https://orcid.org/0009-0002-2764-2145","observed_orcids":["https://orcid.org/0009-0002-2764-2145"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Bruno Claustrat","raw_affiliation_strings":["Centre de M\u00e9decine Nucl\u00e9aire, Service de Radioanalyse, H\u00f4pital Neuro-Cardiologique, 59 Boulevard Pinel, 69394 Lyon Cedex 03, France. bruno.claustrat@chu-lyon.fr","Centre de M\u00e9decine Nucl\u00e9aire, Service de Radioanalyse, H\u00f4pital Neuro-Cardiologique, 59 Boulevard Pinel, 69394 Lyon Cedex 03, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de M\u00e9decine Nucl\u00e9aire, Service de Radioanalyse, H\u00f4pital Neuro-Cardiologique, 59 Boulevard Pinel, 69394 Lyon Cedex 03, France. bruno.claustrat@chu-lyon.fr","institution_ids":["https://openalex.org/I4210100596"]},{"raw_affiliation_string":"Centre de M\u00e9decine Nucl\u00e9aire, Service de Radioanalyse, H\u00f4pital Neuro-Cardiologique, 59 Boulevard Pinel, 69394 Lyon Cedex 03, France","institution_ids":["https://openalex.org/I4210100596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111699629","display_name":"Jocelyne Brun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jocelyne Brun","raw_affiliation_strings":["Centre de M\u00e9decine Nucl\u00e9aire, Service de Radioanalyse, H\u00f4pital Neuro-Cardiologique, 59 Boulevard Pinel, 69394 Lyon Cedex 03, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de M\u00e9decine Nucl\u00e9aire, Service de Radioanalyse, H\u00f4pital Neuro-Cardiologique, 59 Boulevard Pinel, 69394 Lyon Cedex 03, France","institution_ids":["https://openalex.org/I4210100596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107241976","display_name":"Guy Chazot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy Chazot","raw_affiliation_strings":["Service de Neurologie, H\u00f4pital Neuro-Cardiologique, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, H\u00f4pital Neuro-Cardiologique, Lyon, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102123058"],"corresponding_institution_ids":["https://openalex.org/I4210100596"],"apc_list":{"value":5950,"currency":"USD","value_usd":5950},"apc_paid":null,"fwci":1.7961,"has_fulltext":false,"cited_by_count":990,"citation_normalized_percentile":{"value":0.86428571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"11","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11963","display_name":"Impact of Light on Environment and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2306","display_name":"Global and Planetary Change"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.996999979019165},{"id":"https://openalex.org/keywords/pineal-gland","display_name":"pineal gland","score":0.9819999933242798},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7289999723434448},{"id":"https://openalex.org/keywords/suprachiasmatic-nucleus","display_name":"suprachiasmatic nucleus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/photoperiod","display_name":"photoperiod","score":0.8999999761581421},{"id":"https://openalex.org/keywords/seasonal-rhythms","display_name":"seasonal rhythms","score":0.656000018119812},{"id":"https://openalex.org/keywords/melatonin-secretion","display_name":"melatonin secretion","score":0.5600000023841858},{"id":"https://openalex.org/keywords/core-body-temperature","display_name":"core body temperature","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sleep-wake-cycle","display_name":"sleep-wake cycle","score":0.9380000233650208},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.8730000257492065},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/glucose-regulation","display_name":"glucose regulation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9769413471221924},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8222237229347229},{"id":"https://openalex.org/C201176492","wikidata":"https://www.wikidata.org/wiki/Q6546168","display_name":"Light effects on circadian rhythm","level":4,"score":0.6912749409675598},{"id":"https://openalex.org/C88160501","wikidata":"https://www.wikidata.org/wiki/Q5223563","display_name":"Dark therapy","level":3,"score":0.5893619060516357},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5761107206344604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5736718773841858},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5670403242111206},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.5535531044006348},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.47250616550445557},{"id":"https://openalex.org/C55969652","wikidata":"https://www.wikidata.org/wiki/Q259028","display_name":"photoperiodism","level":2,"score":0.46585139632225037},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.41694363951683044},{"id":"https://openalex.org/C2779317972","wikidata":"https://www.wikidata.org/wiki/Q1156516","display_name":"Suprachiasmatic nucleus","level":3,"score":0.30489659309387207},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.27698951959609985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17819851636886597}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017440","descriptor_name":"Photoperiod","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.smrv.2004.08.001","doi":"https://doi.org/10.1016/j.smrv.2004.08.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.smrv.2004.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S28482811","display_name":"Sleep Medicine Reviews","issn_l":"1087-0792","issn":["1087-0792","1532-2955"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep Medicine Reviews","raw_type":"journal-article"},{"id":"pmid:15649735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15649735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep medicine reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W66671411","https://openalex.org/W105688798","https://openalex.org/W121310929","https://openalex.org/W141312231","https://openalex.org/W230153807","https://openalex.org/W352145087","https://openalex.org/W1033262235","https://openalex.org/W1545462284","https://openalex.org/W1547975228","https://openalex.org/W1761390008","https://openalex.org/W1842332427","https://openalex.org/W1909891240","https://openalex.org/W1970095826","https://openalex.org/W1971603285","https://openalex.org/W1972225746","https://openalex.org/W1972726406","https://openalex.org/W1973993738","https://openalex.org/W1977934055","https://openalex.org/W1980732917","https://openalex.org/W1981467048","https://openalex.org/W1986396736","https://openalex.org/W1987090999","https://openalex.org/W1989301385","https://openalex.org/W1989645977","https://openalex.org/W1990867574","https://openalex.org/W1991691552","https://openalex.org/W1993122720","https://openalex.org/W1993593790","https://openalex.org/W1998299637","https://openalex.org/W2001237806","https://openalex.org/W2002361387","https://openalex.org/W2005016682","https://openalex.org/W2006761570","https://openalex.org/W2007964356","https://openalex.org/W2008342148","https://openalex.org/W2008425063","https://openalex.org/W2009077913","https://openalex.org/W2011080682","https://openalex.org/W2011104380","https://openalex.org/W2017537159","https://openalex.org/W2021165282","https://openalex.org/W2028132851","https://openalex.org/W2032232541","https://openalex.org/W2032779870","https://openalex.org/W2033056565","https://openalex.org/W2033269603","https://openalex.org/W2034132165","https://openalex.org/W2035950441","https://openalex.org/W2038215683","https://openalex.org/W2039085594","https://openalex.org/W2039236418","https://openalex.org/W2039379900","https://openalex.org/W2041599743","https://openalex.org/W2042162822","https://openalex.org/W2043842765","https://openalex.org/W2044341392","https://openalex.org/W2044510143","https://openalex.org/W2047591298","https://openalex.org/W2049014643","https://openalex.org/W2049958927","https://openalex.org/W2050926729","https://openalex.org/W2052394722","https://openalex.org/W2059518698","https://openalex.org/W2060272552","https://openalex.org/W2065225923","https://openalex.org/W2066072409","https://openalex.org/W2068066768","https://openalex.org/W2073618030","https://openalex.org/W2074658037","https://openalex.org/W2077129521","https://openalex.org/W2078184977","https://openalex.org/W2079582746","https://openalex.org/W2080096829","https://openalex.org/W2080605061","https://openalex.org/W2081628655","https://openalex.org/W2084434716","https://openalex.org/W2085189813","https://openalex.org/W2088294056","https://openalex.org/W2090568202","https://openalex.org/W2091093861","https://openalex.org/W2091385411","https://openalex.org/W2095671436","https://openalex.org/W2095783413","https://openalex.org/W2096090206","https://openalex.org/W2098353830","https://openalex.org/W2101686566","https://openalex.org/W2104625718","https://openalex.org/W2105516671","https://openalex.org/W2107597745","https://openalex.org/W2108507651","https://openalex.org/W2114922149","https://openalex.org/W2114983488","https://openalex.org/W2115908598","https://openalex.org/W2118812798","https://openalex.org/W2119709085","https://openalex.org/W2122583624","https://openalex.org/W2129181453","https://openalex.org/W2132420544","https://openalex.org/W2135167537","https://openalex.org/W2136149869","https://openalex.org/W2136350449","https://openalex.org/W2137975281","https://openalex.org/W2141119729","https://openalex.org/W2142393219","https://openalex.org/W2148317166","https://openalex.org/W2153462155","https://openalex.org/W2154805475","https://openalex.org/W2157835171","https://openalex.org/W2163920027","https://openalex.org/W2166816403","https://openalex.org/W2167215225","https://openalex.org/W2169767678","https://openalex.org/W2171135124","https://openalex.org/W2171671766","https://openalex.org/W2171732987","https://openalex.org/W2276323388","https://openalex.org/W2297851189","https://openalex.org/W2315501628","https://openalex.org/W2315871990","https://openalex.org/W2320413839","https://openalex.org/W2324935844","https://openalex.org/W2331067687","https://openalex.org/W2418916179","https://openalex.org/W2560497666","https://openalex.org/W2583247636","https://openalex.org/W2888863832","https://openalex.org/W3216624875"],"related_works":["https://openalex.org/W2036673125","https://openalex.org/W2204103332","https://openalex.org/W1995804066","https://openalex.org/W117416016","https://openalex.org/W2039590429","https://openalex.org/W7160840738","https://openalex.org/W2032640715","https://openalex.org/W65156464","https://openalex.org/W4205519136","https://openalex.org/W2049985521"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":34},{"year":2025,"cited_by_count":45},{"year":2024,"cited_by_count":53},{"year":2023,"cited_by_count":49},{"year":2022,"cited_by_count":61},{"year":2021,"cited_by_count":72},{"year":2020,"cited_by_count":68},{"year":2019,"cited_by_count":66},{"year":2018,"cited_by_count":55},{"year":2017,"cited_by_count":44},{"year":2016,"cited_by_count":42},{"year":2015,"cited_by_count":44},{"year":2014,"cited_by_count":59},{"year":2013,"cited_by_count":68},{"year":2012,"cited_by_count":46}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
