{"id":"https://openalex.org/W2115189900","doi":null,"title":"CHARACTERIZATION OF DROSOPHILA HOMOLOGUES OF ACTIVATED Cdc42 ASSOCIATED KINASE (ACK)","display_name":"CHARACTERIZATION OF DROSOPHILA HOMOLOGUES OF ACTIVATED Cdc42 ASSOCIATED KINASE (ACK)","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2115189900","mag":"2115189900"},"language":"en","primary_location":{"id":"pmh:oai:summit.sfu.ca:node-5719","doi":null,"is_oa":true,"landing_page_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5719/etd1680.pdf","pdf_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5719/etd1680.pdf","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5719/etd1680.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103162315","display_name":"Xing Xu","orcid":"https://orcid.org/0009-0006-5582-253X","observed_orcids":["https://orcid.org/0009-0006-5582-253X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xing Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103162315"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.08020000159740448,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ack","display_name":"ACK","score":0.6919999718666077},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.7889999747276306},{"id":"https://openalex.org/keywords/non-receptor-tyrosine-kinase","display_name":"non-receptor tyrosine kinase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.828000009059906},{"id":"https://openalex.org/keywords/genetic-redundancy","display_name":"gene redundancy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mutant-characterization","display_name":"mutant characterization","score":0.4309999942779541},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.8383853435516357},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.6729480028152466},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.669991135597229},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5904443860054016},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5169838666915894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5011136531829834},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.4858362376689911},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.47662270069122314},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.47129881381988525},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.46861252188682556},{"id":"https://openalex.org/C24901178","wikidata":"https://www.wikidata.org/wiki/Q7118116","display_name":"PAK1","level":3,"score":0.44180095195770264},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.42053452134132385},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.41884154081344604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37285280227661133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34499555826187134},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:summit.sfu.ca:node-5719","doi":null,"is_oa":true,"landing_page_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5719/etd1680.pdf","pdf_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5719/etd1680.pdf","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:summit.sfu.ca:5719","doi":null,"is_oa":false,"landing_page_url":"http://summit.sfu.ca/item/5719","pdf_url":null,"source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2115189900","doi":null,"is_oa":false,"landing_page_url":"https://summit.sfu.ca/item/5719","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:summit.sfu.ca:node-5719","doi":null,"is_oa":true,"landing_page_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5719/etd1680.pdf","pdf_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5719/etd1680.pdf","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115189900.pdf","grobid_xml":"https://content.openalex.org/works/W2115189900.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W1535427487","https://openalex.org/W1536893509","https://openalex.org/W1567217875","https://openalex.org/W1820076796","https://openalex.org/W1854589240","https://openalex.org/W1875840637","https://openalex.org/W1910936647","https://openalex.org/W1912436781","https://openalex.org/W1942409195","https://openalex.org/W1965757939","https://openalex.org/W1968400644","https://openalex.org/W1972985327","https://openalex.org/W1975304472","https://openalex.org/W1979027806","https://openalex.org/W1980821707","https://openalex.org/W1982178099","https://openalex.org/W1992111877","https://openalex.org/W1992277590","https://openalex.org/W1994528729","https://openalex.org/W2000966286","https://openalex.org/W2001438210","https://openalex.org/W2001779234","https://openalex.org/W2007917670","https://openalex.org/W2008038351","https://openalex.org/W2009234186","https://openalex.org/W2011756230","https://openalex.org/W2015493603","https://openalex.org/W2017012788","https://openalex.org/W2023417672","https://openalex.org/W2023915893","https://openalex.org/W2026617111","https://openalex.org/W2026632124","https://openalex.org/W2027810531","https://openalex.org/W2029231027","https://openalex.org/W2030487339","https://openalex.org/W2036019393","https://openalex.org/W2036123452","https://openalex.org/W2042584344","https://openalex.org/W2052909285","https://openalex.org/W2053257956","https://openalex.org/W2053912448","https://openalex.org/W2054760273","https://openalex.org/W2057698056","https://openalex.org/W2060717058","https://openalex.org/W2061152791","https://openalex.org/W2061179508","https://openalex.org/W2063076755","https://openalex.org/W2063167641","https://openalex.org/W2065868014","https://openalex.org/W2066818389","https://openalex.org/W2067161562","https://openalex.org/W2068423840","https://openalex.org/W2071344712","https://openalex.org/W2073934947","https://openalex.org/W2074228165","https://openalex.org/W2077792958","https://openalex.org/W2084996914","https://openalex.org/W2085420149","https://openalex.org/W2086140525","https://openalex.org/W2086689509","https://openalex.org/W2087172814","https://openalex.org/W2087395526","https://openalex.org/W2088564934","https://openalex.org/W2089613312","https://openalex.org/W2091154399","https://openalex.org/W2091322376","https://openalex.org/W2092340663","https://openalex.org/W2093226717","https://openalex.org/W2093844155","https://openalex.org/W2094735120","https://openalex.org/W2096791952","https://openalex.org/W2105746559","https://openalex.org/W2106868006","https://openalex.org/W2107625881","https://openalex.org/W2110643873","https://openalex.org/W2110767317","https://openalex.org/W2114618350","https://openalex.org/W2115630751","https://openalex.org/W2115819535","https://openalex.org/W2120448616","https://openalex.org/W2120613121","https://openalex.org/W2125300128","https://openalex.org/W2126892094","https://openalex.org/W2134073082","https://openalex.org/W2135802640","https://openalex.org/W2137712621","https://openalex.org/W2138387159","https://openalex.org/W2139663454","https://openalex.org/W2144634347","https://openalex.org/W2146055738","https://openalex.org/W2149966287","https://openalex.org/W2150391921","https://openalex.org/W2150461363","https://openalex.org/W2155824282","https://openalex.org/W2157934217","https://openalex.org/W2160265391","https://openalex.org/W2160571369","https://openalex.org/W2161814699","https://openalex.org/W2164923114","https://openalex.org/W2167047926","https://openalex.org/W2168091755","https://openalex.org/W2168137103","https://openalex.org/W2186225761","https://openalex.org/W2188990683","https://openalex.org/W2189539444","https://openalex.org/W2260832199","https://openalex.org/W2321311605","https://openalex.org/W2728956820","https://openalex.org/W3158295003"],"related_works":["https://openalex.org/W7098108113","https://openalex.org/W1041775993","https://openalex.org/W58763226","https://openalex.org/W2086140525","https://openalex.org/W7008554081","https://openalex.org/W2064778684","https://openalex.org/W2160571369","https://openalex.org/W2036181537","https://openalex.org/W2278859437","https://openalex.org/W2023645006"],"abstract_inverted_index":{"Cdc42":[0,33],"is":[1,34,119],"a":[2,109],"member":[3],"of":[4,9,56,62,66,74],"the":[5,93,105],"Rho":[6],"GTPase":[7],"family":[8,55],"proteins,":[10],"which":[11],"act":[12],"as":[13,41],"molecular":[14,106],"switches":[15],"to":[16,70,89],"turn":[17],"signal":[18],"transduction":[19],"pathways":[20],"on":[21],"or":[22],"off":[23],"by":[24],"alternating":[25],"between":[26],"active":[27],"GTP-bound":[28],"and":[29,49,77,95,108,139],"inactive":[30],"GDP-bound":[31],"states.":[32],"involved":[35],"in":[36,86,92,122,129],"diverse":[37],"biological":[38],"processes":[39],"such":[40],"actin":[42],"cytoskeletal":[43],"organization,":[44],"microtubule":[45],"dynamics,":[46],"axonal":[47,130],"guidance":[48],"epithelial":[50],"wound":[51],"repair.":[52],"The":[53,64,114],"ACK":[54],"non-receptor":[57],"tyrosine":[58],"kinases":[59],"function":[60],"downstream":[61],"Cdc42.":[63],"intent":[65],"this":[67],"study":[68],"was":[69,84],"characterize":[71],"Drosophila":[72],"homologues":[73],"ACK,":[75],"DACK":[76,94,98,118,132],"DPR2.":[78],"A":[79],"P":[80],"element":[81],"excision":[82],"approach":[83],"used":[85],"an":[87],"attempt":[88],"create":[90],"mutations":[91],"DPRZ":[96],"genes.":[97],"mutants":[99],"were":[100],"successfully":[101],"created,":[102],"characterized":[103],"at":[104],"level,":[107],"preliminary":[110],"phenotypic":[111],"characterization":[112],"done.":[113],"results":[115],"suggest":[116],"that":[117],"largely":[120],"redundant":[121],"development,":[123],"but":[124],"may":[125,133],"have":[126,134],"some":[127],"role":[128],"guidance.":[131],"overlapping":[135],"functions":[136],"with":[137],"DPR2,":[138],"knocking":[140],"out":[141],"both":[142],"ACKs":[143],"will":[144],"likely":[145],"reveal":[146],"more":[147],"roles.":[148]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}