{"id":"https://openalex.org/W2115173453","doi":"https://doi.org/10.1124/mol.107.041764","title":"High Mobility Group Protein B1 Is an Activator of Apoptotic Response to Antimetabolite Drugs","display_name":"High Mobility Group Protein B1 Is an Activator of Apoptotic Response to Antimetabolite Drugs","publication_year":2007,"publication_date":"2007-10-19","ids":{"openalex":"https://openalex.org/W2115173453","doi":"https://doi.org/10.1124/mol.107.041764","mag":"2115173453","pmid":"https://pubmed.ncbi.nlm.nih.gov/17951356","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2210013"},"language":"en","primary_location":{"id":"doi:10.1124/mol.107.041764","doi":"https://doi.org/10.1124/mol.107.041764","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.107.041764","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2210013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009358670","display_name":"Natalia F. Krynetskaia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Krynetskaia","raw_affiliation_strings":["Temple University School of Pharmacy, 3307 North Broad Street Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University School of Pharmacy, 3307 North Broad Street Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015750970","display_name":"Hongbo Michael Xie","orcid":"https://orcid.org/0000-0003-2223-0029","observed_orcids":["https://orcid.org/0000-0003-2223-0029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongbo Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059847153","display_name":"Slobodan Vu\u010deti\u0107","orcid":"https://orcid.org/0000-0001-5884-6293","observed_orcids":["https://orcid.org/0000-0001-5884-6293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Slobodan Vucetic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044038055","display_name":"Zoran Obradovic A","orcid":"https://orcid.org/0000-0002-2051-0142","observed_orcids":["https://orcid.org/0000-0002-2051-0142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zoran Obradovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036222375","display_name":"Evgeny Y. Krynetskiy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evgeny Krynetskiy","raw_affiliation_strings":["[Temple University]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Temple University]","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.456,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.804655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"73","issue":"1","first_page":"260","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.3181000053882599,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/high-mobility-group-protein-b1","display_name":"high mobility group protein B1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.6549999713897705},{"id":"https://openalex.org/keywords/p53-phosphorylation","display_name":"p53 phosphorylation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/h2ax-phosphorylation","display_name":"H2AX phosphorylation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7940000295639038},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/thiopurines","display_name":"thiopurines","score":0.9150000214576721},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8399999737739563},{"id":"https://openalex.org/keywords/puma","display_name":"PUMA","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pmaip1","display_name":"Noxa","score":0.9909999966621399},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5505774021148682},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5433881282806396},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4771263599395752},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4538598358631134},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.44304051995277405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44167184829711914},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4350596070289612},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.42858392000198364},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.42782062292099},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.395243376493454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3764236569404602},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.34519538283348083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2846148610115051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2478266954421997},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1124/mol.107.041764","doi":"https://doi.org/10.1124/mol.107.041764","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.107.041764","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:17951356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17951356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2210013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2210013","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2210013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2210013","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6281345845","display_name":"HMGB1/2 and Cellular Response to Fraudulent Nucleosides","funder_award_id":"R01CA104729","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320320946","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W95475432","https://openalex.org/W651513265","https://openalex.org/W1500340349","https://openalex.org/W1527598109","https://openalex.org/W1601385148","https://openalex.org/W1982097971","https://openalex.org/W1984328540","https://openalex.org/W1988368932","https://openalex.org/W1992082488","https://openalex.org/W1998827263","https://openalex.org/W2001446629","https://openalex.org/W2005389118","https://openalex.org/W2010645034","https://openalex.org/W2012483403","https://openalex.org/W2016047006","https://openalex.org/W2022811243","https://openalex.org/W2026428131","https://openalex.org/W2029715841","https://openalex.org/W2035768602","https://openalex.org/W2037538895","https://openalex.org/W2042119456","https://openalex.org/W2047286107","https://openalex.org/W2052357722","https://openalex.org/W2055962337","https://openalex.org/W2058565815","https://openalex.org/W2068705865","https://openalex.org/W2072173165","https://openalex.org/W2089917418","https://openalex.org/W2096588719","https://openalex.org/W2116614069","https://openalex.org/W2120865735","https://openalex.org/W2127833142","https://openalex.org/W2128680272","https://openalex.org/W2140549234","https://openalex.org/W2140927361","https://openalex.org/W2145708466","https://openalex.org/W2147426561","https://openalex.org/W2147461630","https://openalex.org/W2155698662","https://openalex.org/W2155740016","https://openalex.org/W2264315475","https://openalex.org/W2496050284","https://openalex.org/W2505364110","https://openalex.org/W4239622139","https://openalex.org/W6631520310"],"related_works":["https://openalex.org/W2130744509","https://openalex.org/W2962442907","https://openalex.org/W2521671551","https://openalex.org/W2057708863","https://openalex.org/W3158325252","https://openalex.org/W2888919844","https://openalex.org/W7140678080","https://openalex.org/W2273821714","https://openalex.org/W2148173743","https://openalex.org/W3143335378"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}