{"id":"https://openalex.org/W2115160551","doi":"https://doi.org/10.1085/jgp.102.4.667","title":"Activation of Ca(2+)-dependent K+ current by acetylcholine and histamine in a human gastric epithelial cell line.","display_name":"Activation of Ca(2+)-dependent K+ current by acetylcholine and histamine in a human gastric epithelial cell line.","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W2115160551","doi":"https://doi.org/10.1085/jgp.102.4.667","mag":"2115160551","pmid":"https://pubmed.ncbi.nlm.nih.gov/8270909","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2229172"},"language":"en","primary_location":{"id":"doi:10.1085/jgp.102.4.667","doi":"https://doi.org/10.1085/jgp.102.4.667","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.102.4.667","pdf_url":"http://jgp.rupress.org/content/jgp/102/4/667.full.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://jgp.rupress.org/content/jgp/102/4/667.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047740924","display_name":"Eiji Hamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E Hamada","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067605091","display_name":"Toshiaki Nakajima","orcid":"https://orcid.org/0000-0001-9545-7529","observed_orcids":["https://orcid.org/0000-0001-9545-7529"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Nakajima","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111656295","display_name":"Shinichi Ota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Ota","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076283805","display_name":"Akira Terano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Terano","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034244372","display_name":"Masao Omata","orcid":"https://orcid.org/0000-0001-7977-1497","observed_orcids":["https://orcid.org/0000-0001-7977-1497"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Omata","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030986205","display_name":"Shinji Nakade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Nakade","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035555934","display_name":"Katsuhiko Mikoshiba","orcid":"https://orcid.org/0000-0002-3487-6970","observed_orcids":["https://orcid.org/0000-0002-3487-6970"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Mikoshiba","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112173205","display_name":"Y Kurachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Kurachi","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":0.3861,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.56299359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"102","issue":"4","first_page":"667","last_page":"692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-activated-potassium-current","display_name":"calcium-activated potassium current","score":0.8149999976158142},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":1.0},{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":0.9139999747276306},{"id":"https://openalex.org/keywords/histamine-h1-receptor","display_name":"histamine H1 receptor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gastric-epithelial-cells","display_name":"gastric epithelial cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6790000200271606},{"id":"https://openalex.org/keywords/charybdotoxin","display_name":"charybdotoxin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.8870000243186951},{"id":"https://openalex.org/keywords/inositol-1-3-4-5-tetrakisphosphate","display_name":"inositol 1,3,4,5-tetrakisphosphate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6995924711227417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6598993539810181},{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.6466249823570251},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6130996942520142},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.5977452397346497},{"id":"https://openalex.org/C2780419564","wikidata":"https://www.wikidata.org/wiki/Q5087002","display_name":"Charybdotoxin","level":3,"score":0.5766090154647827},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.5733646750450134},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5689617395401001},{"id":"https://openalex.org/C2778071365","wikidata":"https://www.wikidata.org/wiki/Q3089249","display_name":"Reversal potential","level":4,"score":0.5621706247329712},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.5359711647033691},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.5276985168457031},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.48219195008277893},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.47152575850486755},{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.4291216731071472},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.42677533626556396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3534722328186035},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3398590683937073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24523663520812988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17386040091514587},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1683131754398346},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12098744511604309},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.10018876194953918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08273276686668396},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1085/jgp.102.4.667","doi":"https://doi.org/10.1085/jgp.102.4.667","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.102.4.667","pdf_url":"http://jgp.rupress.org/content/jgp/102/4/667.full.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2229172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2229172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"},{"id":"pmid:8270909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8270909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1085/jgp.102.4.667","doi":"https://doi.org/10.1085/jgp.102.4.667","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.102.4.667","pdf_url":"http://jgp.rupress.org/content/jgp/102/4/667.full.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2063053","display_name":"DIRECT G PROTEIN REGULATION OF CARDIAC K+ CHANNELS","funder_award_id":"5r01hl047360-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2685186884","display_name":null,"funder_award_id":"R01 HL 47360","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115160551.pdf","grobid_xml":"https://content.openalex.org/works/W2115160551.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W15005571","https://openalex.org/W36421804","https://openalex.org/W636335462","https://openalex.org/W842342962","https://openalex.org/W1508055552","https://openalex.org/W1675649579","https://openalex.org/W1966164797","https://openalex.org/W1987365269","https://openalex.org/W1997093700","https://openalex.org/W2001692359","https://openalex.org/W2002658312","https://openalex.org/W2003012711","https://openalex.org/W2009667219","https://openalex.org/W2011359004","https://openalex.org/W2015480034","https://openalex.org/W2016219644","https://openalex.org/W2017012024","https://openalex.org/W2017615910","https://openalex.org/W2022248060","https://openalex.org/W2025034536","https://openalex.org/W2026478305","https://openalex.org/W2041783508","https://openalex.org/W2043771449","https://openalex.org/W2065148702","https://openalex.org/W2082304034","https://openalex.org/W2084834191","https://openalex.org/W2087228735","https://openalex.org/W2089667871","https://openalex.org/W2108896220","https://openalex.org/W2113630547","https://openalex.org/W2122069928","https://openalex.org/W2126678049","https://openalex.org/W2134625663","https://openalex.org/W2134786188","https://openalex.org/W2141260882","https://openalex.org/W2143201113","https://openalex.org/W2148701127","https://openalex.org/W2152194088","https://openalex.org/W2161531330","https://openalex.org/W2167363404","https://openalex.org/W2398144818","https://openalex.org/W2418416331","https://openalex.org/W2799503982","https://openalex.org/W3126302423","https://openalex.org/W4256145457","https://openalex.org/W6629368682"],"related_works":["https://openalex.org/W7095525071","https://openalex.org/W2345823185","https://openalex.org/W2915580010","https://openalex.org/W2027733124","https://openalex.org/W1976128502","https://openalex.org/W2089589979","https://openalex.org/W2044759304","https://openalex.org/W2316437552","https://openalex.org/W2045941136","https://openalex.org/W2039189232"],"abstract_inverted_index":{"The":[0,32,40,92,123,145],"effects":[1,109],"of":[2,50,110,147,182,219,259,263,269,304,319,322,369],"acetylcholine":[3],"(ACh)":[4],"and":[5,12,47,60,88,95,112,119,129,186,193,253,283,334,375],"histamine":[6],"(His)":[7],"on":[8],"the":[9,44,48,51,65,78,82,100,170,180,204,212,224,228,235,247,254,265,270,289,297,301,323,327,332,349,364,380],"membrane":[10,42,83,298],"potential":[11],"current":[13,97,125,143],"were":[14,53,71,114],"examined":[15],"in":[16,169,200,211,337,352],"JR-1":[17,201],"cells,":[18],"a":[19,86,139,338,342,353],"mucin-producing":[20],"epithelial":[21],"cell":[22,30,35],"line":[23],"derived":[24],"from":[25,175],"human":[26],"gastric":[27],"signet":[28],"ring":[29],"carcinoma.":[31],"tight-seal,":[33],"whole":[34],"clamp":[36],"technique":[37],"was":[38,131,173,188],"used.":[39],"resting":[41],"potential,":[43],"input":[45],"resistance,":[46],"capacitance":[49],"cells":[52],"approximately":[54],"-12":[55],"mV,":[56],"1.4":[57],"G":[58],"ohms,":[59],"50":[61],"pF,":[62],"respectively.":[63,122],"Under":[64,300],"voltage-clamp":[66],"condition,":[67],"no":[68],"voltage-dependent":[69],"currents":[70],"evoked.":[72],"ACh":[73,111,128,185,192,214,236,290,311,333,365],"or":[74,306,321,366],"His":[75,101,113,130,187,194,271,313,335,367],"added":[76],"to":[77,177,223,240],"bathing":[79,206],"solution":[80,172,207],"hyperpolarized":[81],"by":[84,117,127,133,184,197],"activating":[85],"time-":[87],"voltage-independent":[89],"K+":[90,96,124,141],"current.":[91,299],"ACh-induced":[93],"hyperpolarization":[94],"persisted,":[98],"while":[99],"response":[102,237,272,351],"desensitized":[103],"quickly":[104],"(<":[105],"1":[106],"min).":[107],"These":[108,231],"mediated":[115],"predominantly":[116],"m3-muscarinic":[118],"H1-His":[120],"receptors,":[121],"induced":[126],"inhibited":[132,331,348],"charybdotoxin,":[134],"suggesting":[135],"that":[136,154,234],"it":[137],"is":[138,238],"Ca(2+)-activated":[140],"channel":[142],"(IK.Ca).":[144],"measurement":[146],"intracellular":[148],"Ca2+":[149,220,248,255,266],"([Ca2+]i)":[150],"using":[151],"Indo-1":[152],"revealed":[153],"both":[155,191],"agents":[156],"increased":[157,165,174],"[Ca2+]i":[158,199],"with":[159,282],"similar":[160],"time":[161],"courses":[162],"as":[163],"they":[164],"IK.Ca.":[166,230,260,316],"When":[167],"EGTA":[168,210],"pipette":[171],"0.15":[176],"10":[178],"mM,":[179],"induction":[181],"IK.Ca":[183,196,216],"abolished.":[189],"Thus,":[190],"activate":[195],"increasing":[198],"cells.":[202],"In":[203],"Ca(2+)-free":[205],"(0.15":[208],"mM":[209],"pipette),":[213],"evoked":[215,315],"transiently.":[217],"Addition":[218],"(1.8":[221],"mM)":[222],"bath":[225],"immediately":[226],"restored":[227],"sustained":[229,257],"results":[232],"suggest":[233],"due":[239],"at":[241],"least":[242],"two":[243],"different":[244],"mechanisms;":[245],"i.e.,":[246],"release-related":[249],"initial":[250],"transient":[251],"activation":[252,258,368],"influx-related":[256,267],"Probably":[261],"because":[262],"desensitization,":[264],"component":[268],"could":[273],"not":[274,295],"be":[275],"identified.":[276],"Intracellularly":[277],"applied":[278],"inositol":[279,285],"1,4,5-trisphosphate":[280],"(IP3),":[281],"without":[284],"1,3,4,5-tetrakisphosphate":[286],"(IP4),":[287],"mimicked":[288],"response.":[291],"IP4":[292],"alone":[293],"did":[294],"affect":[296],"steady":[302],"effect":[303],"IP3":[305,307,328],"plus":[308],"IP4,":[309],"neither":[310,357],"nor":[312,361],"further":[314],"Intracellular":[317],"application":[318],"heparin":[320],"monoclonal":[324],"antibody":[325],"against":[326],"receptor,":[329],"mAb18A10,":[330],"responses":[336],"concentration-dependent":[339,354],"fashion.":[340,355],"Neomycin,":[341],"phospholipase":[343],"C":[344],"(PLC)":[345],"inhibitor,":[346],"also":[347],"agonist-induced":[350],"Although":[356],"pertussis":[358],"toxin":[359],"(PTX)":[360],"N-ethylmaleimide":[362],"affected":[363],"IK,Ca,":[370],"GDP":[371],"beta":[372],"S":[373,378],"attenuated":[374],"GTP":[376],"gamma":[377],"enhanced":[379],"agonist":[381],"response.(ABSTRACT":[382],"TRUNCATED":[383],"AT":[384],"400":[385],"WORDS)":[386]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}