{"id":"https://openalex.org/W2115155673","doi":"https://doi.org/10.3109/13813458509069925","title":"Preservation of myocardial oxygen balance and functional reserve by coronary vasodilators","display_name":"Preservation of myocardial oxygen balance and functional reserve by coronary vasodilators","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2115155673","doi":"https://doi.org/10.3109/13813458509069925","mag":"2115155673","pmid":"https://pubmed.ncbi.nlm.nih.gov/2416290"},"language":"en","primary_location":{"id":"doi:10.3109/13813458509069925","doi":"https://doi.org/10.3109/13813458509069925","is_oa":false,"landing_page_url":"https://doi.org/10.3109/13813458509069925","pdf_url":null,"source":{"id":"https://openalex.org/S4210201915","display_name":"Archives Internationales de Physiologie et de Biochimie","issn_l":"0003-9799","issn":["0003-9799"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives Internationales de Physiologie et de Biochimie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025085323","display_name":"S. Dvir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"S. Dvir","raw_affiliation_strings":["Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031606058","display_name":"B. A. Acad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"B.-A. Acad","raw_affiliation_strings":["Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006443061","display_name":"Judith Sonn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Judith Sonn","raw_affiliation_strings":["Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060027949","display_name":"E. Furman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Esther Furman","raw_affiliation_strings":["Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007661483","display_name":"Joseph Kedem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"J. Kedem","raw_affiliation_strings":["Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Department of Life Sciences, Bar\u2010Ilan University, Ramat Gan, Israel,","institution_ids":["https://openalex.org/I13955877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I13955877"],"apc_list":null,"apc_paid":null,"fwci":1.4588,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.82332109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"93","issue":"3","first_page":"231","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.19599999487400055,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.08100000023841858,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitroglycerin","display_name":"nitroglycerin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/coronary-vasodilators","display_name":"coronary vasodilators","score":0.8199999928474426},{"id":"https://openalex.org/keywords/myocardial-oxygen-balance","display_name":"myocardial oxygen balance","score":0.824999988079071},{"id":"https://openalex.org/keywords/tachycardia","display_name":"tachycardia","score":0.972000002861023},{"id":"https://openalex.org/keywords/hypercapnia","display_name":"hypercapnia","score":0.7020000219345093},{"id":"https://openalex.org/keywords/coronary-blood-supply","display_name":"coronary blood supply","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.8876615166664124},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6394572854042053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.62037593126297},{"id":"https://openalex.org/C81626062","wikidata":"https://www.wikidata.org/wiki/Q693784","display_name":"Oxygen balance","level":3,"score":0.5746728777885437},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.5424360632896423},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5387588143348694},{"id":"https://openalex.org/C2909076160","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Coronary vasodilator","level":3,"score":0.4587869942188263},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4388880729675293},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.41518062353134155},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.3195357918739319},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2350655198097229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15767833590507507},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/13813458509069925","doi":"https://doi.org/10.3109/13813458509069925","is_oa":false,"landing_page_url":"https://doi.org/10.3109/13813458509069925","pdf_url":null,"source":{"id":"https://openalex.org/S4210201915","display_name":"Archives Internationales de Physiologie et de Biochimie","issn_l":"0003-9799","issn":["0003-9799"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives Internationales de Physiologie et de Biochimie","raw_type":"journal-article"},{"id":"pmid:2416290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2416290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives internationales de physiologie et de biochimie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1967958612","https://openalex.org/W1975891040","https://openalex.org/W1988830958","https://openalex.org/W1997555610","https://openalex.org/W1999669982","https://openalex.org/W2004694024","https://openalex.org/W2011970057","https://openalex.org/W2018205128","https://openalex.org/W2023179446","https://openalex.org/W2024182496","https://openalex.org/W2035715433","https://openalex.org/W2036706720","https://openalex.org/W2038155773","https://openalex.org/W2044204173","https://openalex.org/W2047927686","https://openalex.org/W2049601033","https://openalex.org/W2065382915","https://openalex.org/W2069994207","https://openalex.org/W2074780913","https://openalex.org/W2086560708","https://openalex.org/W2088516078","https://openalex.org/W2149468847","https://openalex.org/W2277478118","https://openalex.org/W2334869914","https://openalex.org/W2335717713","https://openalex.org/W2413821278","https://openalex.org/W4407045192"],"related_works":["https://openalex.org/W2056349613","https://openalex.org/W2100051236","https://openalex.org/W2027647421","https://openalex.org/W2284063916","https://openalex.org/W1982952713","https://openalex.org/W2054041922","https://openalex.org/W7099792183","https://openalex.org/W2518554881","https://openalex.org/W2274729131","https://openalex.org/W2057258154"],"abstract_inverted_index":{"Reduced":[0],"myocardial":[1,166],"function":[2,31,117],"at":[3,87,156],"very":[4],"high":[5],"heart":[6,70,130,158],"rates":[7,131],"may":[8],"be":[9],"due":[10],"to":[11],"limited":[12],"coronary":[13],"blood":[14,45],"supply.":[15],"The":[16,147],"effects":[17],"of":[18,65],"the":[19,62,68,137],"vasodilators":[20],"nitroglycerin":[21,66,111,154,164],"(10":[22],"micrograms":[23],"kg-1":[24],"min-1)":[25],"and":[26,47,101],"elevated":[27],"CO2":[28,77,102],"upon":[29],"regional":[30,40],"during":[32,54,110,118,153],"tachycardia":[33,119],"were":[34,52,141,151],"studied.":[35],"In":[36],"open-chest":[37],"anaesthetized":[38],"dogs,":[39],"contractile":[41],"force,":[42],"epicardial":[43],"tissue":[44],"flow":[46,94],"local":[48],"NADH":[49,126,139,149],"redox":[50],"level":[51],"recorded":[53],"graded":[55],"ventricular":[56],"pacing.":[57],"It":[58,160],"was":[59,71,120],"found":[60],"that":[61,163],"vasodilating":[63],"action":[64],"in":[67,96],"unpaced":[69],"much":[72],"lower":[73,143],"than":[74,174],"produced":[75],"by":[76,123,169,176],"(23.6":[78],"+/-":[79,83,99,105,114],"5.8%":[80],"vs.":[81],"137.6":[82],"33.5%).":[84],"Maximal":[85],"pacing":[86],"275":[88],"bpm":[89],"caused":[90],"only":[91],"a":[92],"moderate":[93],"elevation":[95],"control":[97],"(20":[98],"6.8%)":[100],"conditions":[103],"(20.3":[104],"4.03%),":[106],"but":[107,136],"marked":[108],"vasodilation":[109],"infusion":[112],"(85.2":[113],"14.6%).":[115],"Regional":[116],"improved":[121],"similarly":[122],"both":[124],"vasodilators.":[125],"levels":[127,140,150],"increased":[128],"with":[129],"under":[132],"all":[133,157],"experimental":[134],"conditions,":[135],"absolute":[138],"consistently":[142],"following":[144],"vasodilator":[145],"treatments.":[146],"lowest":[148],"observed":[152],"treatment":[155],"rates.":[159],"is":[161],"suggested":[162],"augments":[165],"functional":[167],"reserve":[168],"preserving":[170],"oxygen":[171],"balance":[172],"more":[173],"predicted":[175],"its":[177],"vasodilatory":[178],"effect":[179],"alone.":[180]},"counts_by_year":[{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
