{"id":"https://openalex.org/W2115137014","doi":"https://doi.org/10.1074/jbc.m600697200","title":"Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody","display_name":"Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody","publication_year":2006,"publication_date":"2006-04-06","ids":{"openalex":"https://openalex.org/W2115137014","doi":"https://doi.org/10.1074/jbc.m600697200","mag":"2115137014","pmid":"https://pubmed.ncbi.nlm.nih.gov/16597622","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8099238"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m600697200","doi":"https://doi.org/10.1074/jbc.m600697200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m600697200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m600697200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019558229","display_name":"Ponraj Prabakaran","orcid":"https://orcid.org/0000-0002-4049-4813","observed_orcids":["https://orcid.org/0000-0002-4049-4813"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ponraj Prabakaran","raw_affiliation_strings":["Protein Interactions Group, Center for Cancer Research Nanobiology Program, NCI, National Institutes of Health, Frederick, Maryland 21702, USA","Protein Interactions Group, Center for Cancer Research Nanobiology Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Interactions Group, Center for Cancer Research Nanobiology Program, NCI, National Institutes of Health, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Protein Interactions Group, Center for Cancer Research Nanobiology Program","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036147590","display_name":"Jianhua Gan","orcid":"https://orcid.org/0000-0002-8438-8852","observed_orcids":["https://orcid.org/0000-0002-8438-8852"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Gan","raw_affiliation_strings":["Biomolecular Structure Section, Macromolecular Crystallography Laboratory, Center for Cancer Research, NCI, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomolecular Structure Section, Macromolecular Crystallography Laboratory, Center for Cancer Research, NCI, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112690536","display_name":"Yang Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Feng","raw_affiliation_strings":["Protein Interactions Group, Center for Cancer Research Nanobiology Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Interactions Group, Center for Cancer Research Nanobiology Program","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103021613","display_name":"Zhongyu Zhu","orcid":"https://orcid.org/0000-0001-8384-4142","observed_orcids":["https://orcid.org/0000-0001-8384-4142"]},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongyu Zhu","raw_affiliation_strings":["Basic Research Program, Science Applications International Corp., Frederick, Maryland 21702","Protein Interactions Group, Center for Cancer Research Nanobiology Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Program, Science Applications International Corp., Frederick, Maryland 21702","institution_ids":[]},{"raw_affiliation_string":"Protein Interactions Group, Center for Cancer Research Nanobiology Program","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023766207","display_name":"Vidita Choudhry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidita Choudhry","raw_affiliation_strings":["Protein Interactions Group, Center for Cancer Research Nanobiology Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Interactions Group, Center for Cancer Research Nanobiology Program","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064642149","display_name":"Xiaodong Xiao","orcid":"https://orcid.org/0009-0007-2676-450X","observed_orcids":["https://orcid.org/0009-0007-2676-450X"]},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodong Xiao","raw_affiliation_strings":["Protein Interactions Group, Center for Cancer Research Nanobiology Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Interactions Group, Center for Cancer Research Nanobiology Program","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069231811","display_name":"Xinhua Ji","orcid":"https://orcid.org/0000-0001-6942-1514","observed_orcids":["https://orcid.org/0000-0001-6942-1514"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xinhua Ji","raw_affiliation_strings":["Biomolecular Structure Section, Macromolecular Crystallography Laboratory, Center for Cancer Research, NCI, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomolecular Structure Section, Macromolecular Crystallography Laboratory, Center for Cancer Research, NCI, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089862290","display_name":"Dimiter Stanchev Dimitrov","orcid":"https://orcid.org/0000-0002-2258-1024","observed_orcids":["https://orcid.org/0000-0002-2258-1024"]},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dimiter S. Dimitrov","raw_affiliation_strings":["Protein Interactions Group, Center for Cancer Research Nanobiology Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Interactions Group, Center for Cancer Research Nanobiology Program","institution_ids":["https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069231811","https://openalex.org/A5089862290"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.7531,"has_fulltext":false,"cited_by_count":238,"citation_normalized_percentile":{"value":0.96318719,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"281","issue":"23","first_page":"15829","last_page":"15836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov","display_name":"SARS-CoV","score":0.8740000128746033},{"id":"https://openalex.org/keywords/receptor-binding-domain","display_name":"receptor binding domain","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.7710000276565552},{"id":"https://openalex.org/keywords/neutralizing-monoclonal-antibodies","display_name":"neutralizing monoclonal antibodies","score":0.7919999957084656},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7670000195503235},{"id":"https://openalex.org/keywords/antibody-epitopes","display_name":"antibody epitopes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.7649999856948853},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.6489999890327454},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.5630000233650208},{"id":"https://openalex.org/keywords/antibody-paratope","display_name":"antibody paratope","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6028228998184204},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5997841358184814},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5984249114990234},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5617194175720215},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5332465171813965},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5251897573471069},{"id":"https://openalex.org/C2910188402","wikidata":"https://www.wikidata.org/wiki/Q85438966","display_name":"Severe acute respiratory syndrome coronavirus","level":5,"score":0.5131416916847229},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.4505999684333801},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44937989115715027},{"id":"https://openalex.org/C2778859668","wikidata":"https://www.wikidata.org/wiki/Q103177","display_name":"Severe acute respiratory syndrome","level":5,"score":0.44695836305618286},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.4465904235839844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44287508726119995},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3409474790096283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17725205421447754},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0756567120552063},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06862244009971619},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.055634647607803345}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045473","descriptor_name":"Severe acute respiratory syndrome-related coronavirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m600697200","doi":"https://doi.org/10.1074/jbc.m600697200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m600697200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8099238","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8099238","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:16597622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16597622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m600697200","doi":"https://doi.org/10.1074/jbc.m600697200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m600697200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356092923","display_name":null,"funder_award_id":"N01CO12400","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G174812244","display_name":"DCTD Computer Support","funder_award_id":"n01co12400-79-0-22","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6947481718","display_name":null,"funder_award_id":"N01-CO-24000","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1521025514","https://openalex.org/W1539796472","https://openalex.org/W1789264759","https://openalex.org/W1966238900","https://openalex.org/W1969773218","https://openalex.org/W1975490802","https://openalex.org/W1976528399","https://openalex.org/W1979131204","https://openalex.org/W1982533785","https://openalex.org/W1985799231","https://openalex.org/W1998383538","https://openalex.org/W1998501626","https://openalex.org/W2016028737","https://openalex.org/W2016765195","https://openalex.org/W2025170735","https://openalex.org/W2025592853","https://openalex.org/W2028113696","https://openalex.org/W2039663472","https://openalex.org/W2056034415","https://openalex.org/W2061766263","https://openalex.org/W2064570818","https://openalex.org/W2071704671","https://openalex.org/W2080476827","https://openalex.org/W2083445427","https://openalex.org/W2084874259","https://openalex.org/W2093062941","https://openalex.org/W2098924425","https://openalex.org/W2099308199","https://openalex.org/W2103503670","https://openalex.org/W2104548316","https://openalex.org/W2105626573","https://openalex.org/W2108944188","https://openalex.org/W2131859684","https://openalex.org/W2132260239","https://openalex.org/W2139509513","https://openalex.org/W2140338292","https://openalex.org/W2146476111","https://openalex.org/W2154461921","https://openalex.org/W2158785087","https://openalex.org/W2159376668","https://openalex.org/W2257478817"],"related_works":["https://openalex.org/W2086796608","https://openalex.org/W2025977980","https://openalex.org/W2061828573","https://openalex.org/W1789264759","https://openalex.org/W3129414840","https://openalex.org/W2131356259","https://openalex.org/W3092501606","https://openalex.org/W3205782097","https://openalex.org/W1975490802","https://openalex.org/W1998560561"],"abstract_inverted_index":{"The":[0,37,138,182,242],"severe":[1],"acute":[2],"respiratory":[3],"syndrome":[4],"coronavirus":[5],"(SARS-CoV,":[6],"or":[7],"SCV),":[8],"which":[9,118],"caused":[10],"a":[11,20,44,99,110,155,188,205,212,233],"world-wide":[12],"epidemic":[13],"in":[14,73,259],"2002":[15],"and":[16,49,68,126,152,154,162,200,218,230,232],"2003,":[17],"binds":[18],"to":[19,79,97,124,270],"receptor,":[21],"angiotensin-converting":[22],"enzyme":[23],"2":[24],"(ACE2),":[25],"through":[26],"the":[27,60,69,90,128,132,165,169,179,209,220,227,237,248,260],"receptor-binding":[28],"domain":[29],"(RBD)":[30],"of":[31,56,63,71,92,131,168,178,211,215,222,239],"its":[32,77],"envelope":[33],"(spike,":[34],"S)":[35],"glycoprotein.":[36],"RBD":[38,64,72,93,140,171,261],"is":[39,43,142,172,185],"very":[40],"immunogenic;":[41],"it":[42],"major":[45,213],"SCV":[46,216,223,249],"neutralization":[47],"determinant":[48,214],"can":[50],"elicit":[51],"potent":[52,112],"neutralizing":[53],"antibodies":[54],"capable":[55],"out-competing":[57],"ACE2.":[58],"However,":[59],"structural":[61,206,244],"basis":[62],"immunogenicity,":[65],"RBD-mediated":[66],"neutralization,":[67,219],"role":[70],"entry":[74,250],"steps":[75],"following":[76],"binding":[78,123],"ACE2":[80,121],"have":[81],"not":[82,173,252],"been":[83],"elucidated.":[84],"By":[85],"mimicking":[86],"immune":[87],"responses":[88],"with":[89,120,193],"use":[91],"as":[94],"an":[95],"antigen":[96],"screen":[98],"large":[100],"human":[101],"antibody":[102,183,228],"library":[103],"derived":[104],"from":[105,176],"healthy":[106],"volunteers,":[107],"we":[108],"identified":[109,272],"novel":[111],"cross-reactive":[113],"SCV-neutralizing":[114],"monoclonal":[115],"antibody,":[116],"m396,":[117],"competes":[119],"for":[122,208,236],"RBD,":[125],"determined":[127],"crystal":[129],"structure":[130,141,167],"RBD-antibody":[133],"complex":[134],"at":[135],"2.3-A":[136],"resolution.":[137],"antibody-bound":[139],"completely":[143],"defined,":[144],"revealing":[145],"two":[146,194],"previously":[147],"unresolved":[148],"segments":[149],"(residues":[150],"376-381":[151],"503-512)":[153],"new":[156],"disulfide":[157],"bond":[158],"(between":[159],"residues":[160,198],"378":[161],"511).":[163],"Interestingly,":[164],"overall":[166],"m396-bound":[170],"significantly":[174],"different":[175],"that":[177,247],"ACE2-bound":[180],"RBD.":[181],"epitope":[184],"dominated":[186],"by":[187,255],"10-residue-long":[189],"protruding":[190],"beta6-beta7":[191],"loop":[192],"putative":[195],"ACE2-binding":[196],"hotspot":[197],"(Ile-489":[199],"Tyr-491).":[201],"These":[202],"results":[203],"provide":[204],"rationale":[207],"function":[210],"immunogenicity":[217],"development":[221],"therapeutics":[224],"based":[225],"on":[226],"paratope":[229],"epitope,":[231],"retrovaccinology":[234],"approach":[235],"design":[238],"anti-SCV":[240],"vaccines.":[241],"available":[243],"information":[245],"indicates":[246],"may":[251,263],"be":[253,271],"mediated":[254],"ACE2-induced":[256],"conformational":[257,266],"changes":[258,267],"but":[262],"involve":[264],"other":[265],"or/and":[268],"yet":[269],"coreceptors.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":44},{"year":2020,"cited_by_count":93},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
