{"id":"https://openalex.org/W2115106907","doi":"https://doi.org/10.1021/jm970112+","title":"Synthesis and Binding Affinity of 2-Phenylimidazo[1,2-a]pyridine Derivatives for both Central and Peripheral Benzodiazepine Receptors. A New Series of High-Affinity and Selective Ligands for the Peripheral Type","display_name":"Synthesis and Binding Affinity of 2-Phenylimidazo[1,2-a]pyridine Derivatives for both Central and Peripheral Benzodiazepine Receptors. A New Series of High-Affinity and Selective Ligands for the Peripheral Type","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W2115106907","doi":"https://doi.org/10.1021/jm970112+","mag":"2115106907","pmid":"https://pubmed.ncbi.nlm.nih.gov/9301675"},"language":"en","primary_location":{"id":"doi:10.1021/jm970112+","doi":"https://doi.org/10.1021/jm970112+","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm970112+","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111703352","display_name":"Giuseppe Trapani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Trapani","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102821058","display_name":"Massimo Franco","orcid":"https://orcid.org/0000-0001-8071-588X","observed_orcids":["https://orcid.org/0000-0001-8071-588X"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Franco","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069428436","display_name":"Laura V\u00e1squez de Ricciardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Ricciardi","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112241014","display_name":"Andrea Latrofa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Latrofa","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036500264","display_name":"Giuseppe Genchi","orcid":"https://orcid.org/0000-0003-0538-4907","observed_orcids":["https://orcid.org/0000-0003-0538-4907"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Genchi","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090548570","display_name":"Enrico Sanna","orcid":"https://orcid.org/0000-0002-5725-543X","observed_orcids":["https://orcid.org/0000-0002-5725-543X"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Sanna","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091804940","display_name":"Francesca Tuveri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Tuveri","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083993531","display_name":"Elisabetta Cagetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Cagetti","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090509427","display_name":"Giovanni Biggio","orcid":"https://orcid.org/0000-0003-2333-5535","observed_orcids":["https://orcid.org/0000-0003-2333-5535"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Biggio","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036328704","display_name":"Gaetano Liso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano Liso","raw_affiliation_strings":["Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco-Chimico and Farmaco-Biologico, Facolt\u00e0 di Farmacia, Universit\u00e0 degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy, and Dipartimento di Biologia Sperimentale, Cattedra di Farmacologia, Universit\u00e0 di Cagliari, Via Palabanda 12, 09123 Cagliari, Italy","institution_ids":["https://openalex.org/I172446870","https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.7799,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.89978951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"40","issue":"19","first_page":"3109","last_page":"3118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.4731000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.4731000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.3882000148296356,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepine-receptor","display_name":"benzodiazepine receptor","score":0.8859999775886536},{"id":"https://openalex.org/keywords/translocator-protein-tspo","display_name":"translocator protein (TSPO)","score":0.9319999814033508},{"id":"https://openalex.org/keywords/central-benzodiazepine-receptor","display_name":"central benzodiazepine receptor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/alpha2-subunit","display_name":"alpha2 subunit","score":0.5789999961853027},{"id":"https://openalex.org/keywords/alpha5-subunit","display_name":"alpha5 subunit","score":0.625},{"id":"https://openalex.org/keywords/zolpidem","display_name":"zolpidem","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8782779574394226},{"id":"https://openalex.org/C2777123777","wikidata":"https://www.wikidata.org/wiki/Q218842","display_name":"Zolpidem","level":3,"score":0.8314343690872192},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.649431586265564},{"id":"https://openalex.org/C2779485729","wikidata":"https://www.wikidata.org/wiki/Q210385","display_name":"Pyridine","level":2,"score":0.6445085406303406},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.5998889803886414},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5138056874275208},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5074438452720642},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4337746500968933},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22772470116615295},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.20058366656303406},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15303432941436768},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1354263424873352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077334","descriptor_name":"Zolpidem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001570","descriptor_name":"Benzodiazepinones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005445","descriptor_name":"Flunitrazepam","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jm970112+","doi":"https://doi.org/10.1021/jm970112+","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm970112+","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:9301675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9301675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:iris.unica.it:11584/813","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11584/813","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W649863181","https://openalex.org/W1775749144","https://openalex.org/W1969572549","https://openalex.org/W1969730916","https://openalex.org/W1981932605","https://openalex.org/W1987422016","https://openalex.org/W1989482044","https://openalex.org/W1996007102","https://openalex.org/W2001239671","https://openalex.org/W2024119832","https://openalex.org/W2024545561","https://openalex.org/W2025867484","https://openalex.org/W2043813981","https://openalex.org/W2047212985","https://openalex.org/W2053619004","https://openalex.org/W2059864318","https://openalex.org/W2067318014","https://openalex.org/W2089215633","https://openalex.org/W2095684169","https://openalex.org/W2101073029","https://openalex.org/W2106001183","https://openalex.org/W2330762235","https://openalex.org/W4206507674","https://openalex.org/W4248596865","https://openalex.org/W4253759039"],"related_works":["https://openalex.org/W2049262563","https://openalex.org/W2126415581","https://openalex.org/W2952135624","https://openalex.org/W2133913359","https://openalex.org/W2046692006","https://openalex.org/W2291247742","https://openalex.org/W2952006245","https://openalex.org/W2410872310","https://openalex.org/W1985615487","https://openalex.org/W1974821136"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,17,47,60,78,97,134,153,157,172,174,203,220,252],"6-substituted":[3,92],"or":[4,21,72],"6,8-disubstituted":[5,110],"alkyl":[6],"2-phenylimidazo[1,2-alpha]pyridine-3-carboxylates":[7],"5a-h,":[8],"-acetates":[9],"5i-s,":[10],"6a-g,":[11],"and":[12,16,30,38,68,151,163,237,242],"-propionates":[13],"5t,":[14],"6h":[15],"N,N-dialkyl-2-phenylimidazo[1,2-alpha]pyridine-3-carboxamides":[18],"7a-d,-acetamides":[19],"7e-t":[20,62],"-propionamide":[22],"7u":[23],"were":[24,113,125,206,248],"prepared":[25],"following":[26],"new":[27],"synthetic":[28],"methods,":[29],"their":[31],"affinities":[32],"for":[33,54,70,119,239],"both":[34,55,148],"the":[35,39,48,76,85,91,109,149,154,218,257],"central":[36],"(CBR)":[37],"peripheral":[40],"(PBR)":[41],"benzodiazepine":[42,130],"receptors":[43,255],"evaluated.":[44],"The":[45,169,201],"compounds":[46,93,111,205,222,247],"ester":[49],"series":[50],"displayed":[51,95],"low":[52],"affinity":[53,67],"receptor":[56,131,137],"types.":[57],"Conversely,":[58],"most":[59],"N,N-dialkyl(2-phenylimidazo[1,2-alpha]pyridin-3-yl)acetamides":[61],"proved":[63],"to":[64,105,145,226],"possess":[65],"high":[66],"selectivity":[69],"CBR":[71],"PBR":[73,120],"depending":[74],"on":[75,84,209],"nature":[77],"substituents":[79],"at":[80,254],"C(6)-":[81],"and/or":[82],"C(8)":[83],"heterocyclic":[86],"ring":[87],"system.":[88],"In":[89],"particular,":[90],"7f-n":[94],"ratios":[96],"IC50":[98],"values":[99],"(IC50(CBR)/IC50(PBR))":[100],"ranging":[101],"from":[102],"0.32":[103],"(7m)":[104],"232":[106],"(7k),":[107],"while":[108],"7o-t":[112],"more":[114,117],"than":[115],"1000-fold":[116],"selective":[118],"versus":[121],"CBR.":[122],"Compounds":[123],"7f,m":[124],"examined":[126],"in":[127,140,165],"several":[128],"different":[129],"subtypes.":[132],"Expression":[133],"specific":[135],"GABAA,":[136],"subunit":[138],"assemblies":[139],"Xenopus":[141],"oocytes":[142],"was":[143,177,223],"utilized":[144],"evaluate":[146],"functionally":[147],"efficacy":[150],"potency":[152],"positive":[155],"modulation":[156],"GABA-evoked":[158],"Cl-":[159],"currents":[160],"by":[161,234],"7f":[162,178],"7m":[164,194],"comparison":[166],"with":[167],"Zolpidem.":[168],"rank":[170],"order":[171],"potencies":[173],"these":[175,204,221,246],"drugs":[176],"(EC50":[179,187,195],"=":[180,188,196],"3.2":[181],"x":[182,190,198],"10(-8)":[183,191],"M)":[184,192],">":[185,193],"Zolpidem":[186],"3.6":[189],"2.2":[197],"10(-7)":[199],"M).":[200],"actions":[202],"also":[207],"tested":[208],"alpha":[210,227,258],"2":[211,213,230],"beta":[212,229],"gamma":[214,231],"2s,":[215],"receptors.":[216],"However,":[217],"EC50":[219],"increased,":[224],"compared":[225],"1":[228],"2s":[232],"receptors,":[233],"30-,":[235],"4-,":[236],"5-fold":[238],"7m,":[240],"7f,":[241],"Zolpidem,":[243],"respectively.":[244],"Finally,":[245],"almost":[249],"completely":[250],"devoid":[251],"activity":[253],"containing":[256],"5":[259],"subunit.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}