{"id":"https://openalex.org/W2115064370","doi":"https://doi.org/10.1039/c2mt00178k","title":"Human gouty arthritis is associated with a distinct serum trace elemental profile","display_name":"Human gouty arthritis is associated with a distinct serum trace elemental profile","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2115064370","doi":"https://doi.org/10.1039/c2mt00178k","mag":"2115064370","pmid":"https://pubmed.ncbi.nlm.nih.gov/22258548"},"language":"en","primary_location":{"id":"doi:10.1039/c2mt00178k","doi":"https://doi.org/10.1039/c2mt00178k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c2mt00178k","pdf_url":null,"source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036071031","display_name":"Mingming Su","orcid":"https://orcid.org/0000-0002-9996-9094","observed_orcids":["https://orcid.org/0000-0002-9996-9094"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210107819","display_name":"David H. Murdock Research Institute","ror":"https://ror.org/01qcwgw02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107819"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Mingming Su","raw_affiliation_strings":["Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China","David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC, USA","School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Tel: +86-21-34204829"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC, USA","institution_ids":["https://openalex.org/I4210107819"]},{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Tel: +86-21-34204829","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458321","display_name":"Ting Zhang","orcid":"https://orcid.org/0000-0002-6100-8327","observed_orcids":["https://orcid.org/0000-0002-6100-8327"]},"institutions":[{"id":"https://openalex.org/I4210105514","display_name":"Capital Institute of Pediatrics","ror":"https://ror.org/00zw6et16","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105514"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhang","raw_affiliation_strings":["Capital Institute of Pediatrics, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capital Institute of Pediatrics, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210105514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110150373","display_name":"Tie Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tie Zhao","raw_affiliation_strings":["China-Japan Friendship Hospital, Beijing, People's Republic of China","School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China","School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Tel: +86-21-34204829"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Friendship Hospital, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I2801051648"]},{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Tel: +86-21-34204829","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100726654","display_name":"Fen Li","orcid":"https://orcid.org/0000-0002-4964-6991","observed_orcids":["https://orcid.org/0000-0002-4964-6991"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fen Li","raw_affiliation_strings":["School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China","School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Tel: +86-21-34204829"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Tel: +86-21-34204829","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055572946","display_name":"Yan Ni","orcid":"https://orcid.org/0000-0003-1779-7266","observed_orcids":["https://orcid.org/0000-0003-1779-7266"]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Ni","raw_affiliation_strings":["University of North Carolina at Charlotte, Charlotte, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Charlotte, Charlotte, NC, USA","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381765","display_name":"Xiaoyan Wang","orcid":"https://orcid.org/0000-0001-5568-2131","observed_orcids":["https://orcid.org/0000-0001-5568-2131"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Wang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101987223","display_name":"Tianlu Chen","orcid":"https://orcid.org/0000-0003-1798-5435","observed_orcids":["https://orcid.org/0000-0003-1798-5435"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianlu Chen","raw_affiliation_strings":["Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103203078","display_name":"Aihua Zhao","orcid":"https://orcid.org/0000-0003-0201-3940","observed_orcids":["https://orcid.org/0000-0003-0201-3940"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Aihua Zhao","raw_affiliation_strings":["School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China","School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Tel: +86-21-34204829"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Tel: +86-21-34204829","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059574252","display_name":"Yunping Qiu","orcid":"https://orcid.org/0000-0003-1039-5264","observed_orcids":["https://orcid.org/0000-0003-1039-5264"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunping Qiu","raw_affiliation_strings":["University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA","Tel: +1 704-250-5803","University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA. Fax: +1 704-250-5809"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA","institution_ids":["https://openalex.org/I169335092"]},{"raw_affiliation_string":"Tel: +1 704-250-5803","institution_ids":[]},{"raw_affiliation_string":"University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA. Fax: +1 704-250-5809","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012709162","display_name":"Yuqian Bao","orcid":"https://orcid.org/0000-0002-4754-3470","observed_orcids":["https://orcid.org/0000-0002-4754-3470"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqian Bao","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007251193","display_name":"Weiping Jia","orcid":"https://orcid.org/0000-0002-6244-2168","observed_orcids":["https://orcid.org/0000-0002-6244-2168"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Weiping Jia","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, People's Republic of China","Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China","University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100404644","display_name":"Wei Ping Jia","orcid":"https://orcid.org/0000-0002-3739-8994","observed_orcids":["https://orcid.org/0000-0002-3739-8994"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Wei Jia","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, People's Republic of China","Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China","University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA","Tel: +1 704-250-5803","University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA. Fax: +1 704-250-5809"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA","institution_ids":["https://openalex.org/I169335092"]},{"raw_affiliation_string":"Tel: +1 704-250-5803","institution_ids":[]},{"raw_affiliation_string":"University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA. Fax: +1 704-250-5809","institution_ids":["https://openalex.org/I169335092"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100404644","https://openalex.org/A5103203078"],"corresponding_institution_ids":["https://openalex.org/I169335092","https://openalex.org/I183067930","https://openalex.org/I4210144482"],"apc_list":{"value":2653,"currency":"USD","value_usd":2653},"apc_paid":null,"fwci":1.4851,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83102677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"3","first_page":"244","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.05609999969601631,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.984000027179718},{"id":"https://openalex.org/keywords/serum-trace-elements","display_name":"serum trace elements","score":0.8820000290870667},{"id":"https://openalex.org/keywords/elemental-signatures","display_name":"elemental signatures","score":0.5659999847412109},{"id":"https://openalex.org/keywords/trace-element-homeostasis","display_name":"trace element homeostasis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.6499999761581421},{"id":"https://openalex.org/keywords/aluminum","display_name":"aluminum","score":0.9639999866485596},{"id":"https://openalex.org/keywords/uranium","display_name":"uranium","score":0.7829999923706055},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.5479999780654907},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serum-uric-acid","display_name":"serum uric acid","score":0.7680000066757202},{"id":"https://openalex.org/keywords/gout-diagnosis","display_name":"gout diagnosis","score":0.7289999723434448},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6190000176429749},{"id":"https://openalex.org/keywords/heavy-metals","display_name":"heavy metals","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2992440585","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gouty arthritis","level":3,"score":0.8355523347854614},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.7529878616333008},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6807986497879028},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6045678853988647},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.582598865032196},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5759714245796204},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4800589978694916},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45926323533058167},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.45651671290397644},{"id":"https://openalex.org/C64885871","wikidata":"https://www.wikidata.org/wiki/Q2533665","display_name":"Elemental analysis","level":2,"score":0.4456101059913635},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.418311208486557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40945369005203247},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.397417813539505},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.15103229880332947}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014131","descriptor_name":"Trace Elements","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/c2mt00178k","doi":"https://doi.org/10.1039/c2mt00178k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c2mt00178k","pdf_url":null,"source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},{"id":"pmid:22258548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22258548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics : integrated biometal science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W52979433","https://openalex.org/W1637471905","https://openalex.org/W1875822748","https://openalex.org/W1976022000","https://openalex.org/W1978038282","https://openalex.org/W1980271127","https://openalex.org/W1983075523","https://openalex.org/W1991660754","https://openalex.org/W1994262289","https://openalex.org/W2010090350","https://openalex.org/W2015430190","https://openalex.org/W2018125654","https://openalex.org/W2021110479","https://openalex.org/W2026927028","https://openalex.org/W2033978865","https://openalex.org/W2034034236","https://openalex.org/W2041722048","https://openalex.org/W2044334793","https://openalex.org/W2050766479","https://openalex.org/W2059958550","https://openalex.org/W2060952451","https://openalex.org/W2061173535","https://openalex.org/W2066567543","https://openalex.org/W2080986716","https://openalex.org/W2082932662","https://openalex.org/W2086585136","https://openalex.org/W2089468765","https://openalex.org/W2089996359","https://openalex.org/W2093852546","https://openalex.org/W2098539376","https://openalex.org/W2114698729","https://openalex.org/W2116785548","https://openalex.org/W2133915381","https://openalex.org/W2134004958","https://openalex.org/W2136725886","https://openalex.org/W2165924170","https://openalex.org/W2166858338","https://openalex.org/W2169741176","https://openalex.org/W2555325264"],"related_works":["https://openalex.org/W4399920510","https://openalex.org/W2413044529","https://openalex.org/W1975334688","https://openalex.org/W2000254491","https://openalex.org/W2467439657","https://openalex.org/W4402810193","https://openalex.org/W4384298031","https://openalex.org/W2418743034","https://openalex.org/W3175652208","https://openalex.org/W4294123330"],"abstract_inverted_index":{"Homeostatic":[0],"imbalance":[1],"of":[2,22,36,63,87,97,108,129,137,212],"essential":[3],"trace":[4],"elements":[5,24],"is":[6,146],"deeply":[7],"involved":[8],"in":[9,14,27,31,159,196],"many":[10,213],"pathophysiological":[11],"states,":[12],"especially":[13],"joint":[15],"disorders":[16],"such":[17],"as":[18],"gout.":[19],"A":[20,59],"total":[21],"64":[23],"were":[25,151],"measured":[26],"the":[28,123,186],"serum":[29,193],"samples":[30],"three":[32,167],"regionally":[33],"independent":[34,106],"groups":[35,164],"patients":[37,113],"with":[38,84],"gouty":[39,64,203],"arthritis":[40,65,204],"(n":[41,50],"=":[42,51],"100)":[43],"and":[44,80,94,114,134,162,172,183,185,192,216],"an":[45],"age-matched":[46],"healthy":[47,116],"control":[48],"group":[49,107],"40)":[52],"by":[53],"inductively":[54],"coupled":[55],"plasma-mass":[56],"spectrometry":[57],"(ICP-MS).":[58],"distinct":[60],"elemental":[61,124,168,208],"profile":[62,210],"encompassing":[66],"significantly":[67],"altered":[68],"Li,":[69,170,181],"Al,":[70,171],"Ti,":[71],"Fe,":[72],"Cu,":[73],"Se,":[74],"Sr,":[75],"Ta,":[76],"Hg,":[77],"Bi,":[78],"Th,":[79],"U":[81],"was":[82,118],"obtained":[83],"a":[85,95,127,135,177,206],"sensitivity":[86,128],"0.97":[88],"(95%":[89,99,131,139],"confidence":[90],"interval":[91],"(CI):":[92],"0.92-0.99)":[93],"specificity":[96,136],"0.95":[98],"CI:":[100,132,140],"0.83-0.99)":[101],"for":[102,142],"gout":[103,112,143,197],"diagnosis.":[104],"An":[105],"52":[109],"subjects":[110],"(39":[111],"13":[115],"controls)":[117],"further":[119],"used":[120],"to":[121,153],"validate":[122],"signature,":[125],"yielding":[126],"1.00":[130,138],"0.91-1.00)":[133],"0.75-1.00)":[141],"prediction.":[144],"It":[145],"also":[147,175],"noteworthy":[148],"that":[149,202],"we":[150],"able":[152],"achieve":[154],"\u226595.7%":[155],"correct":[156],"classification":[157],"rate":[158],"both":[160],"discovery":[161],"validation":[163],"using":[165],"only":[166],"markers,":[169],"U.":[173],"We":[174],"observed":[176],"good":[178],"correlation":[179],"between":[180],"Zn,":[182],"Cu":[184],"other":[187,214],"two":[188],"risk":[189],"factors,":[190],"age":[191],"urate":[194],"concentration,":[195],"patients.":[198],"Our":[199],"findings":[200],"underscore":[201],"possesses":[205],"unique":[207],"expression":[209],"regardless":[211],"nutritional":[215],"environmental":[217],"factors.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}