{"id":"https://openalex.org/W2115015434","doi":null,"title":"H-2/myc, E mu/myc, and c-myc transgenic mice: potent sources of early hematopoietic cell lines.","display_name":"H-2/myc, E mu/myc, and c-myc transgenic mice: potent sources of early hematopoietic cell lines.","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2115015434","mag":"2115015434","pmid":"https://pubmed.ncbi.nlm.nih.gov/8297795"},"language":"en","primary_location":{"id":"pmid:8297795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8297795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029647364","display_name":"Jacques Roland","orcid":"https://orcid.org/0000-0003-1678-405X","observed_orcids":["https://orcid.org/0000-0003-1678-405X"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Roland","raw_affiliation_strings":["Department of Immunology, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111565042","display_name":"Dominique Morello","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Morello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"11","first_page":"891","last_page":"900"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.20479999482631683,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc-oncogene","display_name":"c-myc oncogene","score":0.9559999704360962},{"id":"https://openalex.org/keywords/lymphoid-cell-lines","display_name":"lymphoid cell lines","score":0.7440000176429749},{"id":"https://openalex.org/keywords/t-lymphoblasts","display_name":"T lymphoblasts","score":0.8880000114440918},{"id":"https://openalex.org/keywords/b-lymphoblasts","display_name":"B lymphoblasts","score":1.0},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lymphoid-tumors","display_name":"lymphoid tumors","score":0.6000000238418579},{"id":"https://openalex.org/keywords/hematopoietic-cancers","display_name":"hematopoietic tumors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.5920000076293945},{"id":"https://openalex.org/keywords/h-2kb","display_name":"H-2Kb","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8719431757926941},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6349686980247498},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6013683676719666},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5620248317718506},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5569908022880554},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5042725801467896},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.49027302861213684},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4515463709831238},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4359275698661804},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.42833709716796875},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.42103147506713867},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3223303556442261},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3164132237434387},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.296580046415329},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26656436920166016},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21583247184753418},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.188393235206604},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.15281111001968384},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0833444893360138},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005805","descriptor_name":"Genes, MHC Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8297795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8297795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1014.8246","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1014.8246","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cgd.aacrjournals.org/cgi/reprint/4/11/891.pdf","raw_type":"text"},{"id":"mag:2115015434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8297795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W21751534","https://openalex.org/W62587231","https://openalex.org/W302073403","https://openalex.org/W1461294782","https://openalex.org/W1534762642","https://openalex.org/W1589525182","https://openalex.org/W1591105009","https://openalex.org/W1621064629","https://openalex.org/W1787988358","https://openalex.org/W1814650793","https://openalex.org/W1847174723","https://openalex.org/W1932241639","https://openalex.org/W1966683022","https://openalex.org/W1966949361","https://openalex.org/W1968458490","https://openalex.org/W1980022529","https://openalex.org/W1987905586","https://openalex.org/W1990205754","https://openalex.org/W1990367849","https://openalex.org/W1994600118","https://openalex.org/W1997056931","https://openalex.org/W2003327103","https://openalex.org/W2008240385","https://openalex.org/W2008693734","https://openalex.org/W2008972719","https://openalex.org/W2012359139","https://openalex.org/W2021471413","https://openalex.org/W2021920683","https://openalex.org/W2023318533","https://openalex.org/W2027839043","https://openalex.org/W2031435888","https://openalex.org/W2034884571","https://openalex.org/W2039019845","https://openalex.org/W2041892902","https://openalex.org/W2052156572","https://openalex.org/W2069970568","https://openalex.org/W2075202068","https://openalex.org/W2089240490","https://openalex.org/W2090265641","https://openalex.org/W2130227763","https://openalex.org/W2136286807","https://openalex.org/W2154125681","https://openalex.org/W2158645388","https://openalex.org/W2158742626","https://openalex.org/W2159287501","https://openalex.org/W2172252610","https://openalex.org/W2177231732","https://openalex.org/W2213277757","https://openalex.org/W2324776779","https://openalex.org/W2397086711","https://openalex.org/W2399980567","https://openalex.org/W2412655101","https://openalex.org/W2414585454","https://openalex.org/W2465806989","https://openalex.org/W2467860489"],"related_works":["https://openalex.org/W7095672609","https://openalex.org/W2414585454","https://openalex.org/W2091745580","https://openalex.org/W1787988358","https://openalex.org/W2005956017","https://openalex.org/W62587231","https://openalex.org/W4246326307","https://openalex.org/W1968075576","https://openalex.org/W117496733","https://openalex.org/W2037586575"],"abstract_inverted_index":{"Activation":[0],"of":[1,13,18,35,43,77,82,107,116,135,152,179],"the":[2,11,75,78,83,92,108,117,124,133,141,150,180,210],"cellular":[3],"c-myc":[4,49,94,112,153],"oncogene":[5],"appears":[6],"to":[7,10,27,32,54,89,104,183,203,212],"be":[8,156],"linked":[9],"development":[12],"malignancies":[14],"in":[15,20,46,71,101,129,148,169,173],"a":[16,146,204,213],"variety":[17],"tissues,":[19],"particular,":[21],"hematopoietic":[22],"tumors.":[23],"In":[24],"an":[25],"attempt":[26],"obtain":[28],"cell":[29,162,193,200],"lines":[30,163,181],"corresponding":[31],"early":[33],"stages":[34],"lymphoid":[36,130,216],"differentiation,":[37],"we":[38],"have":[39],"derived":[40,165],"several":[41],"strains":[42],"transgenic":[44,142],"mice":[45],"which":[47,149],"human":[48],"genomic":[50],"sequences":[51,109],"were":[52,126,164],"coupled":[53],"various":[55],"regulatory":[56],"sequences,":[57],"H-2,":[58],"E":[59,80,120],"mu,":[60],"and":[61,91,166,195,209,217],"c-myc.":[62],"The":[63],"class":[64],"I":[65],"H-2Kb":[66],"5'":[67,95],"region":[68,96],"is":[69,87],"active":[70],"most":[72,106],"adult":[73],"tissues;":[74],"activity":[76],"enhancer":[79],"mu":[81],"heavy":[84],"chain":[85],"immunoglobulin":[86],"restricted":[88],"lymphocytes;":[90],"2-kilobase-long":[93],"has":[97],"been":[98],"shown":[99],"by":[100,168,191],"vitro":[102,174],"experiments":[103],"contain":[105],"required":[110],"for":[111],"regulated":[113],"expression.":[114],"Regardless":[115],"construct,":[118],"H-2/myc,":[119],"mu/myc,":[121],"or":[122,186],"c-myc,":[123],"transgenes":[125],"mainly":[127],"expressed":[128],"tissues.":[131],"However,":[132],"quantity":[134],"transgene":[136],"mRNA":[137],"differed":[138],"markedly":[139],"among":[140],"strains,":[143],"thus":[144],"providing":[145],"situation":[147],"level":[151],"expression":[154],"could":[155],"correlated":[157],"with":[158],"tumor":[159],"development.":[160],"Several":[161],"maintained":[167],"vivo":[170],"transplantation":[171],"and/or":[172],"cultures.":[175],"All":[176],"except":[177],"two":[178],"correspond":[182],"immature":[184],"T-":[185],"B-lymphoblasts,":[187],"as":[188],"revealed":[189],"both":[190],"fluorescence-activated":[192],"sorting":[194],"Southern":[196],"blot":[197],"analysis;":[198],"one":[199],"line":[201],"corresponds":[202],"gamma":[205],"delta":[206],"T-cell":[207],"population,":[208],"other":[211],"bipotential":[214],"mixed":[215],"myeloid":[218],"tumor.":[219]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
