{"id":"https://openalex.org/W2114990508","doi":"https://doi.org/10.1001/archneur.63.8.1154","title":"Topography of Dopamine Transporter Availability in Progressive Supranuclear Palsy","display_name":"Topography of Dopamine Transporter Availability in Progressive Supranuclear Palsy","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2114990508","doi":"https://doi.org/10.1001/archneur.63.8.1154","mag":"2114990508","pmid":"https://pubmed.ncbi.nlm.nih.gov/16908744"},"language":"en","primary_location":{"id":"doi:10.1001/archneur.63.8.1154","doi":"https://doi.org/10.1001/archneur.63.8.1154","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.63.8.1154","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086819499","display_name":"Klaus Seppi","orcid":"https://orcid.org/0000-0001-6503-1455","observed_orcids":["https://orcid.org/0000-0001-6503-1455"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Klaus Seppi","raw_affiliation_strings":["Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. klaus.seppi@uibk.ac.at","Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. klaus.seppi@uibk.ac.at","institution_ids":["https://openalex.org/I143397708"]},{"raw_affiliation_string":"Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025145858","display_name":"Christoph Scherfler","orcid":"https://orcid.org/0000-0002-4885-5265","observed_orcids":["https://orcid.org/0000-0002-4885-5265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Scherfler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111871339","display_name":"Eveline Donnemiller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eveline Donnemiller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064747758","display_name":"Irene Johanna Virgolini","orcid":"https://orcid.org/0000-0001-7097-6170","observed_orcids":["https://orcid.org/0000-0001-7097-6170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Virgolini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013962169","display_name":"Michael F. H. Schocke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael F. H. Schocke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Georg Goebel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georg Goebel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088006159","display_name":"Katherina J. Mair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherina J. Mair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058514008","display_name":"Sylvia Boesch","orcid":"https://orcid.org/0000-0003-1657-7368","observed_orcids":["https://orcid.org/0000-0003-1657-7368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvia Boesch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014864323","display_name":"Christian Brenneis","orcid":"https://orcid.org/0000-0003-1814-9535","observed_orcids":["https://orcid.org/0000-0003-1814-9535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Brenneis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064715109","display_name":"Gregor Karl Wenning","orcid":"https://orcid.org/0000-0001-9077-1666","observed_orcids":["https://orcid.org/0000-0001-9077-1666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregor K. Wenning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054677591","display_name":"Werner H Poewe","orcid":"https://orcid.org/0000-0003-4367-0971","observed_orcids":["https://orcid.org/0000-0003-4367-0971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Werner Poewe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5405,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.92570281,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"63","issue":"8","first_page":"1154","last_page":"1154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.8209999799728394},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.652999997138977},{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.6729999780654907},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.796999990940094},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.6179999709129333},{"id":"https://openalex.org/keywords/striatal-dopamine-transporter","display_name":"striatal dopamine transporter","score":0.777999997138977},{"id":"https://openalex.org/keywords/statistical-parametric-mapping","display_name":"statistical parametric mapping","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.8959050178527832},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.8255159854888916},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5699194669723511},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.49933719635009766},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.482614129781723},{"id":"https://openalex.org/C39313694","wikidata":"https://www.wikidata.org/wiki/Q2940624","display_name":"Statistical parametric mapping","level":3,"score":0.48009565472602844},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.45314958691596985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44946011900901794},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4240434765815735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40749481320381165},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3947378993034363},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3804255425930023},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34102505445480347},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3405987024307251},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2213820517063141},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13220995664596558},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.12552443146705627}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013494","descriptor_name":"Supranuclear Palsy, Progressive","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D013494","descriptor_name":"Supranuclear Palsy, Progressive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/archneur.63.8.1154","doi":"https://doi.org/10.1001/archneur.63.8.1154","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.63.8.1154","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},{"id":"pmid:16908744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16908744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of neurology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W49996880","https://openalex.org/W140454404","https://openalex.org/W184227037","https://openalex.org/W1498902503","https://openalex.org/W1971979833","https://openalex.org/W1976199112","https://openalex.org/W1978925364","https://openalex.org/W1989474631","https://openalex.org/W1999551037","https://openalex.org/W2005732728","https://openalex.org/W2007279520","https://openalex.org/W2007544558","https://openalex.org/W2008560062","https://openalex.org/W2011881593","https://openalex.org/W2020125528","https://openalex.org/W2029535554","https://openalex.org/W2042895504","https://openalex.org/W2044107530","https://openalex.org/W2051567951","https://openalex.org/W2053093496","https://openalex.org/W2054399886","https://openalex.org/W2054765812","https://openalex.org/W2055346280","https://openalex.org/W2055542620","https://openalex.org/W2073874623","https://openalex.org/W2078833014","https://openalex.org/W2086120642","https://openalex.org/W2087214548","https://openalex.org/W2090215580","https://openalex.org/W2092462980","https://openalex.org/W2093977564","https://openalex.org/W2094826609","https://openalex.org/W2098167529","https://openalex.org/W2102340155","https://openalex.org/W2103224436","https://openalex.org/W2108772304","https://openalex.org/W2110324098","https://openalex.org/W2115045018","https://openalex.org/W2115192827","https://openalex.org/W2121229721","https://openalex.org/W2130668599","https://openalex.org/W2131006542","https://openalex.org/W2136557657","https://openalex.org/W2142134806","https://openalex.org/W2142525406","https://openalex.org/W2148397342","https://openalex.org/W2157689081","https://openalex.org/W2162337683","https://openalex.org/W2167204700","https://openalex.org/W2340698866"],"related_works":["https://openalex.org/W1971979833","https://openalex.org/W2057807380","https://openalex.org/W2046963670","https://openalex.org/W1986133307","https://openalex.org/W7095970824","https://openalex.org/W2058691511","https://openalex.org/W2415732161","https://openalex.org/W2036260481","https://openalex.org/W2147730137","https://openalex.org/W2005732728"],"abstract_inverted_index":{"BACKGROUND:":[0],"Dopaminergic":[1],"loss":[2],"can":[3],"be":[4],"visualized":[5],"by":[6],"means":[7],"of":[8,53,171,195,202,230,240,247],"iodine":[9],"I":[10],"123-labeled":[11],"2beta-carbomethoxy-3beta-(4-iodophenyl)tropane":[12],"([(123)I]beta-CIT)":[13],"single-photon":[14],"emission":[15],"computed":[16],"tomography":[17],"(SPECT)":[18],"in":[19,49,105,120,140,213,243],"several":[20],"neurodegenerative":[21],"parkinsonian":[22,114,162],"disorders.":[23],"Most":[24],"previous":[25],"SPECT":[26,178,193,241],"studies":[27],"have":[28],"adopted":[29],"region-of-interest":[30],"methods":[31],"for":[32,88],"analysis,":[33],"which":[34],"are":[35],"subjective":[36],"and":[37,82,90,135,147,183,209],"operator":[38],"dependent.":[39],"OBJECTIVE:":[40],"To":[41],"objectively":[42],"localize":[43],"the":[44,50,112,128,174,207,238,244],"cerebral":[45],"dopamine":[46,232],"transporter":[47,204,233],"status":[48],"early":[51],"stages":[52],"progressive":[54],"supranuclear":[55],"palsy":[56],"(PSP).":[57],"DESIGN:":[58],"Prospective":[59],"study.":[60],"SETTING:":[61],"Parkinson":[62,73],"disease":[63,74,91],"outpatient":[64],"clinic.":[65],"PATIENTS:":[66],"Fourteen":[67],"patients":[68,110,132,148,196,216,220,248],"with":[69,72,77,111,127,133,145,149,153,166,197,217,221,227,249],"PSP,":[70,136,198,214],"17":[71],"(PD),":[75],"15":[76],"Parkinson-variant":[78],"multiple-system":[79],"atrophy":[80],"(MSA-P),":[81],"13":[83],"healthy":[84],"control":[85,129],"subjects,":[86],"matched":[87],"age":[89],"duration.":[92],"INTERVENTIONS:":[93],"Statistical":[94],"parametric":[95,155,189],"mapping":[96,190],"applied":[97],"to":[98,180,191],"[(123)I]beta-CIT":[99,106,122,142,158,177,192],"SPECT.":[100],"MAIN":[101],"OUTCOME":[102],"MEASURES:":[103],"Differences":[104],"uptake.":[107],"RESULTS:":[108],"All":[109],"different":[113],"disorders":[115,163],"showed":[116],"a":[117,199],"significant":[118],"decrease":[119],"striatal":[121],"uptake":[123,159],"without":[124],"any":[125],"overlap":[126],"group.":[130],"In":[131],"MSA-P":[134],"an":[137,167],"additional":[138],"reduction":[139],"brainstem":[141,210],"signal":[143,234],"compared":[144],"controls":[146],"PD":[150,165],"was":[151,211],"identified":[152],"statistical":[154,188],"mapping.":[156],"Midbrain":[157],"discriminated":[160],"atypical":[161],"from":[164,219,225],"overall":[168],"correct":[169],"classification":[170],"91.3%.":[172],"On":[173],"other":[175],"hand,":[176],"failed":[179],"discriminate":[181],"PSP":[182,218],"MSA-P.":[184,228],"CONCLUSION:":[185],"By":[186],"applying":[187],"images":[194],"widespread":[200],"decline":[201],"monoaminergic":[203],"availability":[205],"including":[206],"striatum":[208],"localized":[212],"discriminating":[215],"PD,":[222],"but":[223],"not":[224],"those":[226],"Quantification":[229],"midbrain":[231],"may":[235],"therefore":[236],"enhance":[237],"utility":[239],"imaging":[242],"differential":[245],"diagnosis":[246],"parkinsonism.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}