{"id":"https://openalex.org/W2114980337","doi":"https://doi.org/10.1002/ijc.29263","title":"New therapeutic perspectives in CCDC 6 deficient lung cancer cells","display_name":"New therapeutic perspectives in CCDC 6 deficient lung cancer cells","publication_year":2014,"publication_date":"2014-10-10","ids":{"openalex":"https://openalex.org/W2114980337","doi":"https://doi.org/10.1002/ijc.29263","mag":"2114980337","pmid":"https://pubmed.ncbi.nlm.nih.gov/25302833"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.29263","doi":"https://doi.org/10.1002/ijc.29263","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.29263","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://stars.library.ucf.edu/facultybib2010/6712","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011546047","display_name":"Francesco Morra","orcid":"https://orcid.org/0000-0003-4293-9238","observed_orcids":["https://orcid.org/0000-0003-4293-9238","https://orcid.org/0000-0002-4430-6613"]},"institutions":[{"id":"https://openalex.org/I4210139435","display_name":"Institute for Experimental Endocrinology and Oncology","ror":"https://ror.org/04sn06036","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Morra","raw_affiliation_strings":["Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universit\u00e0 Federico II Napoli Italy","Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy","*F.M. and C.L. contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universit\u00e0 Federico II Napoli Italy","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy","institution_ids":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"*F.M. and C.L. contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103276257","display_name":"Chiara Luise","orcid":"https://orcid.org/0000-0002-0734-3511","observed_orcids":["https://orcid.org/0000-0002-0734-3511"]},"institutions":[{"id":"https://openalex.org/I4210139435","display_name":"Institute for Experimental Endocrinology and Oncology","ror":"https://ror.org/04sn06036","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Luise","raw_affiliation_strings":["Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy","*F.M. and C.L. contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy","institution_ids":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"*F.M. and C.L. contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086847238","display_name":"Roberta Visconti","orcid":"https://orcid.org/0000-0001-7613-3801","observed_orcids":["https://orcid.org/0000-0001-7613-3801","https://orcid.org/0009-0008-6682-6645"]},"institutions":[{"id":"https://openalex.org/I4210139435","display_name":"Institute for Experimental Endocrinology and Oncology","ror":"https://ror.org/04sn06036","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Visconti","raw_affiliation_strings":["Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy","institution_ids":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027952276","display_name":"Stefania Staibano","orcid":"https://orcid.org/0000-0003-4993-9388","observed_orcids":["https://orcid.org/0000-0003-4993-9388"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Staibano","raw_affiliation_strings":["Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061495027","display_name":"Francesco Merolla","orcid":"https://orcid.org/0000-0003-0711-6738","observed_orcids":["https://orcid.org/0000-0003-0711-6738"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Merolla","raw_affiliation_strings":["Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088962032","display_name":"Gennaro Ilardi","orcid":"https://orcid.org/0000-0002-9354-4087","observed_orcids":["https://orcid.org/0000-0002-9354-4087"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gennaro Ilardi","raw_affiliation_strings":["Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059030571","display_name":"Gianluca Guggino","orcid":"https://orcid.org/0000-0002-4887-5952","observed_orcids":["https://orcid.org/0000-0002-4887-5952"]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Guggino","raw_affiliation_strings":["UOC Chirurgia Toracica, Azienda Ospedaliera di Rilievo Nazionale \"A.Cardarelli\", Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Chirurgia Toracica, Azienda Ospedaliera di Rilievo Nazionale \"A.Cardarelli\", Napoli, Italy","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022860775","display_name":"Simona Paladino","orcid":"https://orcid.org/0000-0001-5332-6774","observed_orcids":["https://orcid.org/0000-0001-5332-6774"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Paladino","raw_affiliation_strings":["Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universit\u00e0 Federico II Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universit\u00e0 Federico II Napoli Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030186758","display_name":"Daniela Sarnataro","orcid":"https://orcid.org/0000-0002-6094-8384","observed_orcids":["https://orcid.org/0000-0002-6094-8384"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Sarnataro","raw_affiliation_strings":["CEINGE\u2010Biotecnologie Avanzate Napoli Italy","Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universit\u00e0 Federico II Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEINGE\u2010Biotecnologie Avanzate Napoli Italy","institution_ids":["https://openalex.org/I4210128854"]},{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universit\u00e0 Federico II Napoli Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067376970","display_name":"Renato Franco","orcid":"https://orcid.org/0000-0002-8340-3184","observed_orcids":["https://orcid.org/0000-0002-8340-3184","https://orcid.org/0000-0002-6424-7841"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renato Franco","raw_affiliation_strings":["UOC Anatomia Patologica e Citopatologia , ISNT \u201cFondazione G. Pascale\u201d Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Anatomia Patologica e Citopatologia , ISNT \u201cFondazione G. Pascale\u201d Napoli Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Roberto Monaco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Monaco","raw_affiliation_strings":["UOC Anatomia Patologica, Azienda Ospedaliera di Rilievo Nazionale \"A.Cardarelli\", Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Anatomia Patologica, Azienda Ospedaliera di Rilievo Nazionale \"A.Cardarelli\", Napoli, Italy","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058807494","display_name":"Federica Zito Marino","orcid":"https://orcid.org/0000-0002-1071-757X","observed_orcids":["https://orcid.org/0000-0002-1071-757X"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Zitomarino","raw_affiliation_strings":["UOC Anatomia Patologica e Citopatologia , ISNT \u201cFondazione G. Pascale\u201d Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Anatomia Patologica e Citopatologia , ISNT \u201cFondazione G. Pascale\u201d Napoli Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073840390","display_name":"Roberto Pacelli","orcid":"https://orcid.org/0000-0002-2048-7675","observed_orcids":["https://orcid.org/0000-0002-2048-7675"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Pacelli","raw_affiliation_strings":["Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guglielmo Monaco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087768","display_name":"Ospedale Antonio Cardarelli","ror":"https://ror.org/003hhqx84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087768"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guglielmo Monaco","raw_affiliation_strings":["UOC Chirurgia Toracica, Azienda Ospedaliera di Rilievo Nazionale \"A.Cardarelli\", Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Chirurgia Toracica, Azienda Ospedaliera di Rilievo Nazionale \"A.Cardarelli\", Napoli, Italy","institution_ids":["https://openalex.org/I4210087768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002665417","display_name":"Gaetano Rocco","orcid":"https://orcid.org/0000-0003-4150-8604","observed_orcids":["https://orcid.org/0000-0003-4150-8604"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano Rocco","raw_affiliation_strings":["UOC Chirurgia Toracica, ISNT \"Fondazione G. Pascale\", Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Chirurgia Toracica, ISNT \"Fondazione G. Pascale\", Napoli, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087281898","display_name":"Aniello Cerrato","orcid":"https://orcid.org/0000-0002-8697-3027","observed_orcids":["https://orcid.org/0000-0002-8697-3027"]},"institutions":[{"id":"https://openalex.org/I4210139435","display_name":"Institute for Experimental Endocrinology and Oncology","ror":"https://ror.org/04sn06036","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aniello Cerrato","raw_affiliation_strings":["Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy","institution_ids":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052675504","display_name":"Spiros Linardopoulos","orcid":"https://orcid.org/0000-0002-6600-400X","observed_orcids":["https://orcid.org/0000-0002-6600-400X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Spiros Linardopoulos","raw_affiliation_strings":["The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111955781","display_name":"Mark Twain Muller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark T. Muller","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, College of Medicine, University of Central Florida, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, College of Medicine, University of Central Florida, Orlando, FL","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047959368","display_name":"Angela Celetti","orcid":"https://orcid.org/0000-0001-5166-3507","observed_orcids":["https://orcid.org/0000-0001-5166-3507"]},"institutions":[{"id":"https://openalex.org/I4210139435","display_name":"Institute for Experimental Endocrinology and Oncology","ror":"https://ror.org/04sn06036","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Angela Celetti","raw_affiliation_strings":["Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"Gaetano Salvatore\", CNR, Napoli, Italy","institution_ids":["https://openalex.org/I4210139435","https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5011546047","https://openalex.org/A5047959368"],"corresponding_institution_ids":["https://openalex.org/I4210139435","https://openalex.org/I4210155236","https://openalex.org/I71267560"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.432,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.81051067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"136","issue":"9","first_page":"2146","last_page":"2157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.3630000054836273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccdc6","display_name":"CCDC6","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9850000143051147},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.8920000195503235},{"id":"https://openalex.org/keywords/rad51-foci","display_name":"RAD51 foci","score":0.8730000257492065},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9369999766349792},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5880248546600342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4500952363014221},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.422279417514801},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26460081338882446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2639597952365875}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051135","descriptor_name":"Rad51 Recombinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/ijc.29263","doi":"https://doi.org/10.1002/ijc.29263","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.29263","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:25302833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25302833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:stars.library.ucf.edu:facultybib2010-7712","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/facultybib2010/6712","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Bibliography 2010s","raw_type":"text"},{"id":"pmh:oai:stars.library.ucf.edu:scopus2015-1533","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/scopus2015/534","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus Export 2015-2019","raw_type":"text"},{"id":"pmh:oai:iris.unicampania.it:11591/352243","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/352243","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unimol.it:11695/58651","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11695/58651","pdf_url":null,"source":{"id":"https://openalex.org/S7407055127","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi del Molise","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:stars.library.ucf.edu:facultybib2010-7712","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/facultybib2010/6712","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Bibliography 2010s","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2052032121","display_name":null,"funder_award_id":"PRIN 2009T5NKTB_002","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G3601372966","display_name":null,"funder_award_id":"11566","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W659570190","https://openalex.org/W1481421933","https://openalex.org/W1513182170","https://openalex.org/W1513191136","https://openalex.org/W1523217489","https://openalex.org/W1543661498","https://openalex.org/W1752089945","https://openalex.org/W1965531809","https://openalex.org/W1965902487","https://openalex.org/W1966193117","https://openalex.org/W1971223620","https://openalex.org/W1972769310","https://openalex.org/W1973268287","https://openalex.org/W1974744330","https://openalex.org/W1979736396","https://openalex.org/W1982745900","https://openalex.org/W1985775217","https://openalex.org/W1989389011","https://openalex.org/W1993382872","https://openalex.org/W1994504474","https://openalex.org/W1998129814","https://openalex.org/W1998594146","https://openalex.org/W1999554125","https://openalex.org/W1999659306","https://openalex.org/W2002575472","https://openalex.org/W2002962154","https://openalex.org/W2003581594","https://openalex.org/W2012026523","https://openalex.org/W2012126331","https://openalex.org/W2014260980","https://openalex.org/W2014599726","https://openalex.org/W2022811243","https://openalex.org/W2022897106","https://openalex.org/W2024645073","https://openalex.org/W2025036829","https://openalex.org/W2029304297","https://openalex.org/W2029363740","https://openalex.org/W2031482561","https://openalex.org/W2036223578","https://openalex.org/W2037322891","https://openalex.org/W2040173589","https://openalex.org/W2040498703","https://openalex.org/W2042386784","https://openalex.org/W2043103956","https://openalex.org/W2043696829","https://openalex.org/W2048305487","https://openalex.org/W2049930674","https://openalex.org/W2050646440","https://openalex.org/W2050924783","https://openalex.org/W2051003586","https://openalex.org/W2051802352","https://openalex.org/W2052179498","https://openalex.org/W2053987947","https://openalex.org/W2062750863","https://openalex.org/W2063252903","https://openalex.org/W2065799563","https://openalex.org/W2074306827","https://openalex.org/W2083960841","https://openalex.org/W2085794439","https://openalex.org/W2087239831","https://openalex.org/W2091086437","https://openalex.org/W2096136751","https://openalex.org/W2098681754","https://openalex.org/W2098737737","https://openalex.org/W2101995865","https://openalex.org/W2102971019","https://openalex.org/W2103770333","https://openalex.org/W2106969933","https://openalex.org/W2106995472","https://openalex.org/W2113211875","https://openalex.org/W2117964602","https://openalex.org/W2118509736","https://openalex.org/W2118682535","https://openalex.org/W2119805230","https://openalex.org/W2122619503","https://openalex.org/W2128036243","https://openalex.org/W2128680272","https://openalex.org/W2128746885","https://openalex.org/W2129777487","https://openalex.org/W2133605811","https://openalex.org/W2134787029","https://openalex.org/W2135195813","https://openalex.org/W2135915034","https://openalex.org/W2139229198","https://openalex.org/W2142161829","https://openalex.org/W2143618521","https://openalex.org/W2145029005","https://openalex.org/W2146132493","https://openalex.org/W2150575159","https://openalex.org/W2157824687","https://openalex.org/W2160286655","https://openalex.org/W2167092476","https://openalex.org/W2169741450","https://openalex.org/W2170507474","https://openalex.org/W2171972386","https://openalex.org/W2399911808","https://openalex.org/W2415064315","https://openalex.org/W3093265161","https://openalex.org/W4238996858"],"related_works":["https://openalex.org/W2995250906","https://openalex.org/W4400499483","https://openalex.org/W4405233774","https://openalex.org/W2041963587","https://openalex.org/W1989978689","https://openalex.org/W2898357705","https://openalex.org/W2135915034","https://openalex.org/W2810874778","https://openalex.org/W4409633276","https://openalex.org/W2767302700"],"abstract_inverted_index":{"Non-small":[0],"cell":[1,32],"lung":[2,30,80],"cancer":[3,31,81],"(NSCLC)":[4],"is":[5,136,152,174],"the":[6,35,97,107,116,125,130,133,161,178,191,199,206],"main":[7],"cause":[8],"of":[9,28,37,73,110,124,132,160,180,223],"cancer-related":[10],"death":[11],"worldwide":[12],"and":[13,49,69,187,198,230],"new":[14],"therapeutic":[15],"strategies":[16],"are":[17,60],"urgently":[18],"needed.":[19],"In":[20,91],"this":[21],"study,":[22],"we":[23,164],"have":[24],"characterized":[25],"a":[26,42,63,70,120,146,220],"panel":[27],"NSC":[29],"lines":[33],"for":[34,112,215],"expression":[36],"coiled-coil-domain":[38],"containing":[39],"6":[40],"(CCDC6),":[41],"tumor":[43,234],"suppressor":[44],"gene":[45],"involved":[46],"in":[47,85,96,157,239],"apoptosis":[48],"DNA":[50,67,86,98],"damage":[51,68,99],"response.":[52],"We":[53],"show":[54,83],"that":[55,209],"low":[56,71,155],"CCDC6":[57,78,101,151,171,210,217],"protein":[58,172],"levels":[59,156,211],"associated":[61],"with":[62,93,177],"weak":[64,170],"response":[65],"to":[66,105,118,190,225,236],"number":[72],"Rad51":[74],"positive":[75],"foci.":[76],"Moreover,":[77],"deficient":[79],"cells":[82,117],"defects":[84],"repair":[87,126],"via":[88],"homologous":[89],"recombination.":[90],"accordance":[92],"its":[94],"role":[95],"response,":[100],"attenuation":[102],"confers":[103],"resistance":[104,224],"cisplatinum,":[106],"current":[108],"treatment":[109],"choice":[111],"NSCLC,":[113],"but":[114],"sensitizes":[115],"olaparib,":[119],"small":[121],"molecule":[122],"inhibitor":[123],"enzymes":[127],"PARP1/2.":[128],"Remarkably,":[129],"combination":[131,147],"two":[134],"drugs":[135],"more":[137],"effective":[138],"than":[139],"each":[140],"agent":[141],"individually,":[142],"as":[143],"demonstrated":[144],"by":[145,166],"index":[148],"<1.":[149],"Finally,":[150],"expressed":[153],"at":[154],"about":[158],"30%":[159],"NSCL":[162],"tumors":[163],"analyzed":[165],"TMA":[167],"immunostaining.":[168],"The":[169],"staining":[173],"significatively":[175],"correlated":[176,189],"presence":[179],"lymph":[181],"node":[182],"metastasis":[183],"(p":[184,195,202],"\u2264":[185,196,203],"0.02)":[186],"negatively":[188],"disease":[192],"free":[193],"survival":[194,201],"0.01)":[197],"overall":[200],"0.05).":[204],"Collectively,":[205],"data":[207],"indicate":[208],"provide":[212],"valuable":[213],"insight":[214,232],"OS.":[216],"could":[218],"represent":[219],"predictive":[221],"biomarker":[222],"conventional":[226],"single":[227],"mode":[228],"therapy":[229],"yield":[231],"on":[233],"sensitivity":[235],"PARP":[237],"inhibitors":[238],"NSCLC.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}